scholarly journals THE ROLE OF OXIDATIVE STRESS IN THE ETIOPATHOGENESIS OF DEPRESSION

2019 ◽  
Vol 17 (1) ◽  
pp. 81-93 ◽  
Author(s):  
D. Komsiiska ◽  
Y. Petkov
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Central Nervous System ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Cytotoxic Effects ◽  
Negative Effect ◽  
The Central Nervous System ◽  
The Brain

In recent years, the role of oxidative stress in the etiopathogenesis of depression has been increasingly discussed. The mechanisms by which stress has a negative effect on the brain are not yet fully understood. Free radicals cause rapid damage to certain cellular macromolecules that may be involved in cytotoxic effects in the central nervous system. The effectiveness of new types of supplementation therapy with antioxidants - vitamins A, E, C, Omega-3 fatty acids, Coenzyme Q10 and Zn are being studied.

scholarly journals Omega – 3 fatty acids in schizophrenia – part I: importance in the pathophysiology of schizophrenia

2016 ◽  
Vol 17 (3) ◽  
pp. 198-213
Author(s):  
Joanna Róg ◽  
Hanna Karakuła-Juchnowicz
Keyword(s):  
Fatty Acids ◽  
Nervous System ◽  
Essential Fatty Acids ◽  
Dry Weight ◽  
Omega 3 ◽  
Metabolic Complications ◽  
The Central Nervous System ◽  
David Horrobin ◽  
The Brain

AbstractDespite the increasing offer of antipsychotic drugs, the effectiveness of pharmacotherapy in schizophrenia is still unsatisfactory. Drug resistance, lack of complete remission and the increasing risk of metabolic complications are the reasons why the new forms of therapy in schizophrenia among which unsaturated essential fatty acids omega 3 (EFAs ω-3) affecting the proper functioning of nervous system, are mentioned, are being looked for.Fatty acids represent 50-60% of the dry weight of the brain and diet is one of the factors that influence the value of each of the fat fractions in the neuron membranes. Patients with schizophrenia tend to have irregular nutritional status concerning essential fatty acids ω-3, which might result from metabolic disorders or irregular consumption of fatty acids.Apart from being a review of the literature on this subject, this very paper characterizes essential fatty acids ω-3, their metabolism, the most important sources in the diet and the opinions of experts in the field about the recommended intake. It pays attention to the role of essential fatty acids in both the structure and functioning of the central nervous system is, as well as their role in the pathophysiology of schizophrenia, with particular emphasis on the membrane concept by David Horrobin. The assessment of the errors in consumption and metabolism of essential fatty acids are described as well.The evidence was found both in epidemiological and modeling studies. It supports the participation of EFAs in etiopathogenesis and pathophysiology of schizophrenia. Further research is needed, both observational and interventional, as to the role of essential fatty acids ω-3 in the functioning of the CNS as well as the development and course of schizophrenia.

Prevention of Oxidative Stress by Omega-3 Fatty Acids in the Brain

2016 ◽  
pp. 239-249 ◽  
Author(s):  
Akhlaq A. Farooqui ◽  
Tahira Farooqui
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
The Brain

scholarly journals The Role of Flavonoids on Oxidative Stress in Epilepsy

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Tâmara Coimbra Diniz ◽  
Juliane Cabral Silva ◽  
Sarah Raquel Gomes de Lima-Saraiva ◽  
Fernanda Pires Rodrigues de Almeida Ribeiro ◽  
Alessandra Gomes Marques Pacheco ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Central Nervous System ◽  
Nervous System ◽  
Chemical Structure ◽  
Free Radical Production ◽  
Radical Production ◽  
The Central Nervous System ◽  
The Brain ◽  
Benzodiazepine Site

Backgrounds. Oxidative stress can result from excessive free-radical production and it is likely implicated as a possible mechanism involved in the initiation and progression of epileptogenesis. Flavonoids can protect the brain from oxidative stress. In the central nervous system (CNS) several flavonoids bind to the benzodiazepine site on the GABAA-receptor resulting in anticonvulsive effects.Objective. This review provides an overview about the role of flavonoids in oxidative stress in epilepsy. The mechanism of action of flavonoids and its relation to the chemical structure is also discussed.Results/Conclusions. There is evidence that suggests that flavonoids have potential for neuroprotection in epilepsy.

Omega-3 fatty acids and mood stabilizers alter behavioral and oxidative stress parameters in animals subjected to fenproporex administration

2016 ◽  
Vol 32 (2) ◽  
pp. 519-528 ◽  
Author(s):  
Lara M. Gomes ◽  
Milena Carvalho-Silva ◽  
Letícia J. Teixeira ◽  
Joyce Rebelo ◽  
Isabella T. Mota ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Mood Stabilizers ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Oxidative Stress Parameters ◽  
And Oxidative Stress ◽  
Stress Parameters

Jumping on the Omega-3 Bandwagon: Distinguishing the Role of Long-Chain and Short-Chain Omega-3 Fatty Acids

2012 ◽  
Vol 52 (9) ◽  
pp. 795-803 ◽  
Author(s):  
Giovanni M. Turchini ◽  
Peter D. Nichols ◽  
Colin Barrow ◽  
Andrew J. Sinclair
Keyword(s):  
Fatty Acids ◽  
Short Chain ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Long Chain

Immunometabolic role of long-chain omega-3 fatty acids in obesity-induced inflammation

2013 ◽  
Vol 29 (6) ◽  
pp. 431-445 ◽  
Author(s):  
Michael R. Flock ◽  
Connie J. Rogers ◽  
K. Sandeep Prabhu ◽  
Penny M. Kris-Etherton
Keyword(s):  
Fatty Acids ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Long Chain

PP299 EFFECT OF ORAL SUPPLEMENTATION ENRICHED WITH OMEGA-3 FATTY ACIDS IN INFLAMATORY PARAMETERS AND OXIDATIVE STRESS IN PATIENTS WITH OTOLARYNGOLOGIST CANCER TREATED WITH RADIOTHERAPY

2010 ◽  
Vol 5 (2) ◽  
pp. 140 ◽  
Author(s):  
J.M. Garcia-Almeida ◽  
M. Murri-Pierri ◽  
Y. Lupiéñez ◽  
J.M. Rico-Pérez ◽  
H. Saracho-dominguez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Oral Supplementation ◽  
And Oxidative Stress

scholarly journals Fish consumption, contaminants and sudden unexpected death in epilepsy: many more benefits than risks

2010 ◽  
Vol 70 (3) ◽  
pp. 665-670 ◽  
Author(s):  
FA. Scorza ◽  
RM. Cysneiros ◽  
RM. Arida ◽  
VC. Terra ◽  
HR. Machado ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fish Consumption ◽  
Sudden Unexpected Death ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Unexpected Death ◽  
Positive Effects ◽  
Increased Risk ◽  
Fish And Shellfish

People with epilepsy have an increased risk of dying prematurely and the most common epilepsy-related category of death is sudden unexpected death in epilepsy (SUDEP). SUDEP is mainly a problem for patients with chronic uncontrolled epilepsy. The ultimate goal of research in SUDEP is to develop new methods to prevent it and actions other than medical and surgical therapies that could be very useful. Nutritional aspects, i.e., omega-3 fatty acids deficiency, could have an interesting role in this scenario. Some animal and clinical studies have suggested that omega-3 fatty acids could be useful in the prevention and treatment of epilepsy and hence SUDEP. It has been ascertained that the only foods that provide large amounts of omega-3 are seafood (fish and shellfish); however, some fish are contaminated with methylmercury, which may counteract the positive effects of omega-3 fatty acids. Our update review summarises the knowledge of the role of fish consumption on epilepsy research.

scholarly journals The Role of Micronutrients in Support of the Immune Response against Viral Infections

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3198 ◽  
Author(s):  
Francesco Pecora ◽  
Federica Persico ◽  
Alberto Argentiero ◽  
Cosimo Neglia ◽  
Susanna Esposito
Keyword(s):  
Fatty Acids ◽  
Immune Response ◽  
Immune System ◽  
Viral Infections ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Optimal Function ◽  
The Impact

Viral infections are a leading cause of morbidity and mortality worldwide, and the importance of public health practices including handwashing and vaccinations in reducing their spread is well established. Furthermore, it is well known that proper nutrition can help support optimal immune function, reducing the impact of infections. Several vitamins and trace elements play an important role in supporting the cells of the immune system, thus increasing the resistance to infections. Other nutrients, such as omega-3 fatty acids, help sustain optimal function of the immune system. The main aim of this manuscript is to discuss of the potential role of micronutrients supplementation in supporting immunity, particularly against respiratory virus infections. Literature analysis showed that in vitro and observational studies, and clinical trials, highlight the important role of vitamins A, C, and D, omega-3 fatty acids, and zinc in modulating the immune response. Supplementation with vitamins, omega 3 fatty acids and zinc appears to be a safe and low-cost way to support optimal function of the immune system, with the potential to reduce the risk and consequences of infection, including viral respiratory infections. Supplementation should be in addition to a healthy diet and fall within recommended upper safety limits set by scientific expert bodies. Therefore, implementing an optimal nutrition, with micronutrients and omega-3 fatty acids supplementation, might be a cost-effective, underestimated strategy to help reduce the burden of infectious diseases worldwide, including coronavirus disease 2019 (COVID-19).

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