Optical Properties of Carbon Nanotubes: Near-Infrared Induced Hyperthermia as Therapy for Brain Tumors

2007 ◽  
Vol 1065 ◽  
Author(s):  
Lewis Gomez-De Arco ◽  
Meng-Tse Chen ◽  
Weijun Wang ◽  
Thomas Vernier ◽  
Paul Pagnini ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Optical Properties ◽  
Brain Tumors ◽  
Tumor Cells ◽  
Near Infrared ◽  
Primary Brain Tumor ◽  
Fluorescent Imaging ◽  
Brain Tumor Cells ◽  
Functionalization Of Carbon Nanotubes ◽  
Organic Fluorophore

ABSTRACTIn this work chemical functionalization of carbon nanotubes was conducted with the aim of improving their ability to be integrated into biological systems. Functionalized SWNT demonstrated to be an excellent vehicle to translocate a highly conjugated organic fluorophore across the cell membrane while causing little toxicity to the cells. Functionalized SWNT were introduced into different lines of the primary brain tumor cells Glioblastoma Multiforme (GBM). Once within the cell interior, the optical properties of the SWNT were used for both fluorescent imaging characterization and selective killing of tumor cells that had exhibited high SWNT uptake levels upon exposure to NIR radiation. Propidium iodide (PI) was employed as an indicator to determine the number of cells with compromised plasma membrane. Cell surviving ratio of as little as 10-20 percent were found in samples with intracellular nanotubes exposed to NIR radiation while a cell surviving ratio of about 95 percent was typical in irradiated samples without intracellular nanotubes. Control samples showed cell surviving ratios comparable to exposed samples without intracellular nanotubes. This study reveals new insights upon the influence of SWNT optical properties in the physicochemical processes within cells and how they can be used to develope therapy for cancerous brain tumors.

Optical properties of hemicyanines with terminal amino groups and their applications in near-infrared fluorescent imaging of nucleoli

2014 ◽  
Vol 2 (40) ◽  
pp. 7065-7072 ◽  
Author(s):  
Jia-Tao Miao ◽  
Chen Fan ◽  
Ru Sun ◽  
Yu-Jie Xu ◽  
Jian-Feng Ge
Keyword(s):  
Optical Properties ◽  
Near Infrared ◽  
Water Solubility ◽  
Stokes Shift ◽  
Fluorescent Imaging ◽  
Amino Groups ◽  
Long Wave ◽  
Terminal Amino ◽  
Wave Emission ◽  
Low Cytotoxicity

A cellular dye with properties of long-wave emission, large Stokes shift, water solubility, low cytotoxicity, and good photostability is reported.

scholarly journals STUDY OF THE NEAR INFRARED-MEDIATED HEATING OF DISPERSIONS OF PROTEIN-COATED PRISTINE AND CARBOXYLATED SINGLE-WALLED CARBON NANOTUBES

2012 ◽  
Vol 11 (05) ◽  
pp. 1250034
Author(s):  
ALEX T. SHEARDY ◽  
JEREMY J. TAYLOR ◽  
JENNIFER L. CHILEK ◽  
SYNYOUNG LI ◽  
RUHUNG WANG ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Tumor Cells ◽  
Near Infrared ◽  
Irradiation Time ◽  
Single Walled Carbon Nanotubes ◽  
Single Walled Carbon ◽  
Carbonaceous Species ◽  
Carbon Impurities ◽  
Walled Carbon Nanotubes

Previously, we demonstrated the selective NIR-mediated ablation of tumor cells in vitro using pristine single-walled carbon nanotubes (SWNTs) with adsorbed tumor-targeting ligands and carboxylated SWNTs with covalently-attached ligands. The covalent approach is advantageous in ensuring that protein ligands remain associated with the NIR-absorbing SWNTs in biological matrices and the noncovalent approach has the advantage of enabling SWNT functionalization without perturbation of the SWNT lattice and photothermal properties. Herein, we compare the ability of moderately-carboxylated (~ 4 at.% carboxylic acid groups) and pristine SWNT materials to absorb 808 nm radiation and convert it to heat. Under conditions of a constant 808 nm laser power density, the approach involved measuring the temperature of aqueous dispersions of protein-coated SWNTs as a function of the irradiation time. Nearly identical temperature profiles were observed for dispersions of moderately-carboxylated and pristine SWNTs possessing matched 808 nm optical densities and equivalent concentrations of carbonaceous species (i.e., SWNTs and amorphous carbon impurities). The results indicate that the amount of carbonaceous species in purified dispersions of protein-coated SWNTs is more important for converting absorbed 808 nm radiation into heat than whether or not the SWNTs were moderately carboxylated, and that moderately-carboxylated SWNTs could be the SWNT-material of choice for the targeted photothermal ablation of tumor cells.

Photothermal Therapy of Glioma in a Mouse Model With Near-Infrared Excited Nanoshells

2010 ◽  
Author(s):  
Emily S. Day ◽  
Linna Zhang ◽  
Nastassja A. Lewinski ◽  
Patrick A. Thompson ◽  
Rebekah A. Drezek ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Primary Brain Tumor ◽  
Treatment Modalities ◽  
Photothermal Ablation ◽  
Spherical Silica ◽  
Cancerous Cells ◽  
The Brain

Glioblastoma multiforme is the most common and aggressive primary brain tumor, with median survival of approximately 10 months and only 5% of patients surviving greater than 5 years after treatment (1). Surgery and radiotherapy are the main treatment modalities for primary brain tumors, but the associated risks are high when infiltrative tumors are positioned near sensitive regions in the brain. Nanoshells, nanoparticles characterized by a spherical silica core and a gold shell, may provide the opportunity to treat brain tumors in a minimally invasive manner, reducing the risk associated with treatment. Upon exposure to a near-infrared laser, nanoshells convert light energy into heat that can thermally ablate cancerous cells (2). Targeted photothermal ablation of human glioma and medulloblastoma cells has already been demonstrated with this technique in vitro (3).

scholarly journals The Methanol Extract ofAngelica sinensisInduces Cell Apoptosis and Suppresses Tumor Growth in Human Malignant Brain Tumors

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Yu-Ling Lin ◽  
Wen-Lin Lai ◽  
Horng-jyh Harn ◽  
Pei-Hsiu Hung ◽  
Ming-Chang Hsieh ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Brain Tumor ◽  
Brain Tumors ◽  
Cell Cycle Arrest ◽  
Tumor Cells ◽  
Methanol Extract ◽  
Cycle Arrest ◽  
Anticancer Effects ◽  
Brain Tumor Cells

Glioblastoma multiforme (GBM) is a highly vascularized and invasive neoplasm. The methanol extract ofAngelica sinensis(AS-M) is commonly used in traditional Chinese medicine to treat several diseases, such as gastric mucosal damage, hepatic injury, menopausal symptoms, and chronic glomerulonephritis. AS-M also displays potency in suppressing the growth of malignant brain tumor cells. The growth suppression of malignant brain tumor cells by AS-M results from cell cycle arrest and apoptosis. AS-M upregulates expression of cyclin kinase inhibitors, including p16, to decrease the phosphorylation of Rb proteins, resulting in arrest at the G0-G1phase. The expression of the p53 protein is increased by AS-M and correlates with activation of apoptosis-associated proteins. Therefore, the apoptosis of cancer cells induced by AS-M may be triggered through the p53 pathway. Inin vivostudies, AS-M not only suppresses the growth of human malignant brain tumors but also significantly prolongs patient survival. In addition, AS-M has potent anticancer effects involving cell cycle arrest, apoptosis, and antiangiogenesis. Thein vitroandin vivoanticancer effects of AS-M indicate that this extract warrants further investigation and potential development as a new antibrain tumor agent, providing new hope for the chemotherapy of malignant brain cancer.

scholarly journals Precision Revisited: Targeting Microcephaly Kinases in Brain Tumors

2019 ◽  
Vol 20 (9) ◽  
pp. 2098 ◽  
Author(s):  
Gianmarco Pallavicini ◽  
Gaia E. Berto ◽  
Ferdinando Di Cunto
Keyword(s):  
Brain Tumors ◽  
Tumor Cells ◽  
Acquired Resistance ◽  
Cell Types ◽  
Beneficial Effects ◽  
First Case ◽  
Brain Tumor Cells ◽  
Adults And Children ◽  
Critical Requirement ◽  
Congenital Microcephaly

Glioblastoma multiforme and medulloblastoma are the most frequent high-grade brain tumors in adults and children, respectively. Standard therapies for these cancers are mainly based on surgical resection, radiotherapy, and chemotherapy. However, intrinsic or acquired resistance to treatment occurs almost invariably in the first case, and side effects are unacceptable in the second. Therefore, the development of new, effective drugs is a very important unmet medical need. A critical requirement for developing such agents is to identify druggable targets required for the proliferation or survival of tumor cells, but not of other cell types. Under this perspective, genes mutated in congenital microcephaly represent interesting candidates. Congenital microcephaly comprises a heterogeneous group of disorders in which brain volume is reduced, in the absence or presence of variable syndromic features. Genetic studies have clarified that most microcephaly genes encode ubiquitous proteins involved in mitosis and in maintenance of genomic stability, but the effects of their inactivation are particularly strong in neural progenitors. It is therefore conceivable that the inhibition of the function of these genes may specifically affect the proliferation and survival of brain tumor cells. Microcephaly genes encode for a few kinases, including CITK, PLK4, AKT3, DYRK1A, and TRIO. In this review, we summarize the evidence indicating that the inhibition of these molecules could exert beneficial effects on different aspects of brain cancer treatment.

scholarly journals Immunostimulatory CpG on Carbon Nanotubes Selectively Inhibits Migration of Brain Tumor Cells

2018 ◽  
Vol 29 (5) ◽  
pp. 1659-1668 ◽  
Author(s):  
Darya Alizadeh ◽  
Ethan E. White ◽  
Teresa C. Sanchez ◽  
Shunan Liu ◽  
Leying Zhang ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Brain Tumor ◽  
Tumor Cells ◽  
Brain Tumor Cells

Near-infrared nonlinear optical properties of single-wall carbon nanotubes embedded in polymer film

2004 ◽  
Vol 464-465 ◽  
pp. 368-372 ◽  
Author(s):  
Aleksey G. Rozhin ◽  
Youichi Sakakibara ◽  
Madoka Tokumoto ◽  
Hiromichi Kataura ◽  
Yohji Achiba
Keyword(s):  
Carbon Nanotubes ◽  
Optical Properties ◽  
Polymer Film ◽  
Nonlinear Optical ◽  
Near Infrared ◽  
Nonlinear Optical Properties ◽  
Single Wall Carbon Nanotubes ◽  
Single Wall Carbon

scholarly journals Vaccination with dendritic cells loaded with allogeneic brain tumor cells for recurrent malignant brain tumors induces a CD4+IL17+ response

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Michael R Olin ◽  
Walter Low ◽  
David H McKenna ◽  
Stephen J Haines ◽  
Tambra Dahlheimer ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Brain Tumor ◽  
Brain Tumors ◽  
Tumor Cells ◽  
Malignant Brain Tumors ◽  
Brain Tumor Cells
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