Modern view on the problem of pelvic inflammatory disease in women

2017 ◽  
pp. 57-64
Author(s):  
Z.M. Dubossarskaya ◽  
◽  
Yu.A. Dubossarskaya ◽  
L.P. Grek ◽  
T.B. Ushakova ◽  
...  
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Antibacterial Therapy ◽  
Inflammatory Disease ◽  
Inflammatory Diseases ◽  
Clinical Effectiveness ◽  
Reproductive Age ◽  
Complex Treatment ◽  
Combination Drug ◽  
Anaerobic Infections ◽  
Aerobic And Anaerobic

The objective: to learn the efficacy of some fluoroquinolones II and III generation (combination drug Orcipol (ciprofloxacin with ornidazole) and Levoximed (levofloxacin) from World Medicine Pharmaceutical Company, UK) in the treatment of urogenital mixed infections in patients with pelvic inflammatory disease (PID) for vaginal sanitation and restoration of reproductive health. Patients and methods. A clinical examination and complex treatment of 50 patients of reproductive age for the first or second episode of PID of moderate severity was held. Patients of the 1st group (n=25) with mixed aerobic and anaerobic infections, Chlamydia were prescribed Levoximed for 7–14 days. Patients of the 2nd group (n=25) with mixed aerobic and anaerobic infections, bacterial vaginosis or trichomoniasis received a combined drug – Orcipol for 5–7 days. Results. The use of Levoximed and combined antibacterial therapy with Orcipol in the complex treatment of patients with PID was successful. The efficacy of Levoximed and Orcipol in the complex treatment of PID in the groups surveyed was comparable, and it was good in most cases – 92% in Group 1 and 88% in Group 2. Conclusions. The use of combined antibacterial therapy with the inclusion of drugs that overlap the spectrum of aerobic and anaerobic pathogens, protozoal sexually transmitted infections, is an important factor in the successful treatment of inflammatory diseases of the genitals in women. High clinical effectiveness of treatment with the use of drugs Levoximed and Orcipol in patients with PID can recommend them for widespread use in gynecological practice. Key words: pelvic inflammatory diseases, urogenital infections, Levoximed, Orcipol.

scholarly journals Clinical pathogenic basis for anti-adhesive treatment for appendicular-genital syndrome in women of reproductive age

2020 ◽  
Vol 3 (4) ◽  
pp. 228-232
Author(s):  
V.V. Simrok ◽  
◽  
I.A. Popova ◽  
D.V. Mel’nikova ◽  
◽  
...  
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Clinical Symptoms ◽  
Adhesion Formation ◽  
Fold Increase ◽  
Reproductive Age ◽  
Complex Treatment ◽  
Women Of Reproductive Age ◽  
Peritoneal Adhesions ◽  
Normal Ranges

Aim: to assess the efficacy of penicillamine for the complex prevention of pelvic peritoneal adhesions in appendicitis associated with the acute conditions of uterine appendages (appendicular-genital syndrome, AGS) based on the changes in the levels of hydroxyproline and the major clinical symptoms of pelvic inflammatory disease. Patients and Methods: 157 women of reproductive age with AGS who were urgently or routinely admitted to a gynecological or surgical hospital were examined. Comparison group women were prescribed with conventional anti-inflammatory treatment or surgery as needed. Study group women additionally received penicillamine 250 mg twice daily for a month. Pre- and post-treatment non-invasive assessment of the peritoneal adhesive process was performed by measuring the levels of protein-bound and free hydroxyproline. Treatment efficacy was evaluated after 1 month by the changes in hydroxyproline levels, major clinical symptoms, and ultrasound. Results: it was demonstrated that pelvic acute inflammatory disease results in > 1.5-fold increase in the levels of protein-bound and free hydroxyproline. Penicillamine as a component of the complex treatment for pelvic inflammatory disease reduces the levels of hydroxyproline to normal ranges. The changes in the major clinical symptoms and ultrasonic findings after penicillamine therapy were more significant compared to the standard treatment. Conclusions: penicillamine as a component of the complex treatment for pelvic inflammatory disease significantly accelerates the improvement of symptoms and remission as well as the formation of peritoneal adhesions. This prevents both pelvic adhesive disease and tubal- and peritoneal-factor infertility. KEYWORDS: appendicular-genital syndrome, inflammation, hydroxyproline, penicillamine, pelvic peritoneal adhesions, prevention, adhesion formation. FOR CITATION: Simrok V.V., Popova I.A., Mel’nikova D.V. Clinical pathogenic basis for anti-adhesive treatment for appendicular-genital syndrome in women of reproductive age. Russian Journal of Woman and Child Health. 2020;3(4):228–232. DOI: 10.32364/2618-8430- 2020-3-4-228-232.

scholarly journals Clinical Findings of Pelvic Inflammatory Diseases among women in Reproductive Age

2021 ◽  
Vol 7 (1) ◽  
pp. 52-55
Author(s):  
Ismat Ara Laizu ◽  
Laila Anjuman Banu ◽  
Fowzia Abul Fayez
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Vaginal Discharge ◽  
Inflammatory Diseases ◽  
Clinical Findings ◽  
Reproductive Age ◽  
Age Group ◽  
College Hospital ◽  
Medical College ◽  
Reproductive Age Group

Background: Pelvic Inflammatory disease is a very common gynaecological condition among the women in reproductive age group. Objectives: The purpose of the present study was to find out the clinical findings of Pelvic inflammatory diseases among the women during reproductive age group. Methodology: This cross-sectional study was carried out in the Department of Obstetrics and Gynaecology at Mymensingh Medical College Hospital, Mymensingh, Bangladesh from January 2008 to June 2009 for a period of one (01) and a half year. Women who were presented with pelvic inflammatory disease (PID) attended at the OPD of gynecology Department at Mymensingh Medical College Hospital, Mymensingh, Bangladesh were selected as study population. Detailed clinical history of each patient was taken and thorough physical examination was performed. Result: A total number of 300 cases were recruited. The mean age with SD was 30.3±9.57 years. Majority of the patients had tenderness in the lower abdomen which was 96(64.0%) cases. However, 152(50.7%) patients had vaginal discharge and 34(11.3%) patients had uterovaginal proplapse. However, cervical tear was present in 96(32.0%) cases and chronic cervicitis was present in 138(46.0%) cases. Conclusion: In conclusion most common clinical feature is lower abdominal tenderness followed by vaginal discharge. Journal of National Institute of Neurosciences Bangladesh, January 2021, Vol. 7, No. 1, pp. 52-55

scholarly journals Socio-demographic Characteristics of Pelvic Inflammatory Diseases Patients attended at a Tertiary Care Hospital in Dhaka City

2019 ◽  
Vol 5 (2) ◽  
pp. 41-44
Author(s):  
Nadira Khan ◽  
Firoza Rahman ◽  
Nilufar Jahan ◽  
Fahmida Hafez ◽  
Shimul Akter ◽  
...  
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Inflammatory Diseases ◽  
Demographic Characteristics ◽  
Medical College Hospital ◽  
Reproductive Age ◽  
Care Hospital ◽  
Age Group ◽  
College Hospital ◽  
Medical College

Background: Pelvic Inflammatory disease is a very common gynaecological condition among the women. Objectives: The purpose of the present study was to see the socio-demographic characteristics of pelvic inflammatory diseases patients. Methodology: This cross-sectional study was carried out in the Department of Obstetrics and Gynaecology at Dhaka Medical College Hospital, Dhaka, Bangladesh from November 2001 to April 2002 during the period of six (06) months and December 2002 to February 2003 for three (03) months with the total duration of nine (09) months. Women at any age who were suffering from chronic pelvic inflammatory disease (PID) attended at the OPD of gynecology Department at Dhaka Medical College Hospital, Dhaka, Bangladesh were selected as study population. Detailed history of each patient was taken and thorough physical examination was performed. Result: A total number of 150 cases were recruited for this study. Among 150 case of chronic pelvic inflammatory disease (PID) majority of the patients (54%) belonged to the age group of 26 to 35 years of age group. Majority of the patients were married (90.7%). Among 150 cases 80.0% patients were house wife. Regarding husbands’ occupation, 13.3% cases were businessman. Illiterate was in 44.7% cases. Among all patients 48.0% cases were found to be from lower socioeconomic status. Majority of the patients were from urban area (78.7% cases). Conclusion: In conclusion young reproductive age married illiterate women with low socio0-economic condition are the mostly suffering from pelvic inflammatory diseases Bangladesh Journal of Infectious Diseases, December 2018; 5(2): 41-44

scholarly journals 183. chlamydia Trachomatis Seroprevalence with a pgp3 Serologic Assay and Association with Pelvic Inflammatory Disease Among Women, United States, 2013–2016

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S220-S220
Author(s):  
Gloria E Anyalechi ◽  
Damien Danavall ◽  
Brian H Raphael ◽  
Katherine E Bowden ◽  
Jaeyoung Hong ◽  
...  
Keyword(s):  
Black Women ◽  
Chlamydia Trachomatis ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
White Women ◽  
Transmitted Disease ◽  
Population Level ◽  
Reproductive Age ◽  
Nucleic Acid Amplification ◽  
Sexually Transmitted

Abstract Background Chlamydia trachomatis (CT) causes pelvic inflammatory disease (PID) and other sequelae; however, these associations are not fully characterized. CT serologic assays including Pgp3 ELISA may detect prior CT infection and may better elucidate these associations. We used a serologic Pgp3 multiplex bead array assay (Pgp3MBA) to measure CT seroprevalence in reproductive-age US women and assess the association with PID. Methods We performed CT Pgp3MBA on sera collected from women 18–39 years old during the 2013–2016 cycles of the National Health and Nutrition Examination Survey (NHANES) who had available urine CT nucleic acid amplification test results. Weighted Pgp3MBA CT seroprevalence and 95% confidence intervals (95% CI) were calculated. We also determined weighted prevalence ratios (PRs) and 95% CIs of self-reported lifetime PID among women with and without detectable Pgp3MBA and other characteristics to estimate these US national statistics. Results Among 2,339 women, 1,725 (73.7%) had available sera. Of these women, 1,425 (or 93.4% of those with data) were sexually experienced and had a CT seroprevalence of 35.9% (95% CI 33.4–38.4). When weighted for US women, CT seroprevalence was 30.5% (95% CI 26.6–34.4%), ranging from 16.9% (95% CI 11.0–22.8%) among non-Hispanic Asian women to 70.2% (95% CI 62.4–78.0%) among non-Hispanic black women. PID was reported by 4.2% (95% CI 3.1–5.2) of 1,413 sexually-experienced women with PID data or an estimated 3.8% (95% CI 2.6–5.0) of US women. Among US women, estimated PID varied by Pgp3MBA status; 7.3% (95% CI 4.3–10.2) of Pgp3MBA-positive women were estimated to report PID versus 2.3% (95% CI 1.3–3.4) of Pgp3MBA-negative women (PR 3.1; 95% CI 1.7–5.9). PID prevalence did not vary by age, nor self-reported recent sexually transmitted disease among US women, but was higher among non-Hispanic black women compared to non-Hispanic white women (PR 2.2; 95% CI 1.4–3.5). Conclusion Nearly one-third of US women have had CT by Pgp3MBA, with differences by race/ethnicity. Women with prior CT had three times the reported PID prevalence of women without CT. Further serologic research may refine the population-level impact of CT prevention activities, such as recommended annual CT screening, on PID incidence, particularly among non-Hispanic black women. Disclosures All Authors: No reported disclosures

Vaginal microbiomes in women with infertility that was surgical treatment on the uterine appendages

2018 ◽  
pp. 98-102
Author(s):  
A.E. Dubchak ◽  
◽  
A.V. Milevsky ◽  
N.N. Obeid ◽  
◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Antimicrobial Agents ◽  
Inflammatory Diseases ◽  
Reproductive Age ◽  
Anaerobic Microorganisms ◽  
Normal Microflora ◽  
Vaginal Tract ◽  
High Degree ◽  
Aerobic And Anaerobic ◽  
Group 1

The objective: of the study was to study the microbial vaginal tract in women with infertility, who had undergone surgical treatment on the uterine appendages. Materials and methods. An examination of vaginal discharge on flora and STIs was conducted in 120 women of reproductive age with infertility and benign ovarian formations, ectopic pregnancy, which was organ-retained surgical intervention on the appendages of the uterus. Of these, 76 (1 group) patients were surgically treated in a planned manner, 44 (in 2 groups) – in urgent cases. Results. Inflammatory diseases of the genital area were more common in women with infertility, who had surgical treatment in an urgent manner than in women of group 1 (p<0.05), especially inflammatory diseases of the cervix – almost twice as likely as in group 1. The vaginal microbial examination of women with infertility who were hospitalized for surgical treatment in an urgent manner indicates a significant imbalance between the parameters of contamination of the genital tract by conditionally pathogenic and normal microflora. This, above all, was manifested by the high frequency of determination in women of the 2nd group of representatives of optional aerobes and anaerobes (p<0.05). The concentration of facultative-aerobic and anaerobic microorganisms was in patients of the 2nd group, mostly of high degree of microbial dissemination, and in women of the 1 group, medium and low. STIs were found mainly in association with anaerobic and aerobic microorganisms in patients who were operated in an urgent manner. Conclusion. It is necessary to correct the vaginal biotope in women with infertility before surgical treatment – to promptly influence pathogenic microorganisms with antimicrobial agents and restore physiological vaginal microbial vagina. Key words: women, infertility, vaginal microbial, appendages of the uterus, surgical treatment.

scholarly journals Clinico-Ultrasonographic Profile of Ectopic Pregnancy in Western Nepal

2018 ◽  
Vol 8 (1) ◽  
pp. 2-6
Author(s):  
Sangeeta Devi Gurung ◽  
Prakash Sharma
Keyword(s):  
Ectopic Pregnancy ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Radiological Finding ◽  
Previous History ◽  
First Trimester ◽  
Reproductive Age ◽  
Age Group ◽  
Type Iii ◽  
Reproductive Age Group

Introduction: Ectopic pregnancy (EP) is one of the major complications in first trimester pregnancy, resulting in increased maternal morbidity and mortality. It accounts for 1.3-2.4% of all pregnancies. Previously, though laparoscopy was considered as the gold standard for diagnosis of ectopic pregnancy, due to availability of high resolution ultrasound, it has become the first line investigation for the diagnosis of ectopic pregnancy.Methods: It is a prospective study conducted in Manipal Teaching Hospital, Pokhara, from January 2015 till December 2017. All the cases diagnosed with ectopic pregnancy were included in the study.  Ultrasonological and intraoperative findings were recorded. Data was analyzed using SPSS (VERSION 16).Results: Twenty six patients were diagnosed with ectopic pregnancies. The incidence was 0.35%. It was most common among the reproductive age group between 20-40 years with mean age of 30.50 years. Pelvic inflammatory disease (n=10, 38.5%) was considered as risk factor. Radiological finding of Type III ectopic pregnancy (n=21, 80.8%) was the most common type.Conclusion: Ectopic pregnancy is common among reproductive age group with previous history of pelvic inflammatory disease. Type III is the most common type.

scholarly journals Novel treatment modalities for pelvic inflammatory disease using immunomodulating therapy

2021 ◽  
Vol 4 (2) ◽  
pp. 149-154
Author(s):  
Yu.E. Dobrokhotova ◽  
◽  
P.A. Shadrova ◽  
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Antibacterial Agents ◽  
Bacterial Flora ◽  
Treatment Modalities ◽  
Complex Treatment ◽  
Inosine Pranobex ◽  
Good Tolerability ◽  
Immunomodulating Therapy ◽  
Novel Treatment

Pelvic inflammatory disease (PID) is a significant issue of public health due to its devastating effects on female reproductive health and fertility. Despite extensive development of medicine and the emergence of novel groups of antibacterial agents, the risks of antibacterial resistance rapidly grow, thus requiring complex treatment of infectious inflammatory disorders caused by bacterial flora. The modulation of immune response is the heart of recently developed treatment modalities for various diseases (infections, oncology etc.). A detailed understanding of molecular immunology contributes to the rational development of novel types of immunotherapy, which can be successfully introduced into clinical practice. Numerous findings demonstrate the efficacy of inosine pranobex for various diseases, in particular, in immunocompromised patients. This medication has proven itself due to good tolerability and the lack of serious side effects. Inosine pranobex being a safe drug that can be used in many treatment schedules, including complex treatment for chronic PID with antibacterial agents. KEYWORDS: inosine pranobex, pelvic inflammatory disease, salpingo-oophoritis, infertility, immunotherapy, sexually transmitted infections, bacterial vaginosis. FOR CITATION: Dobrokhotova Yu.E., Shadrova P.A. Novel treatment modalities for pelvic inflammatory disease using immunomodulating therapy. Russian Journal of Woman and Child Health. 2021;4(2):149–154. DOI: 10.32364/2618-84 30-2021-4-2-149-154.

scholarly journals Effect of Sharbat-e-Deenarin uncomplicated Pelvic Inflammatory Disease- A Clinical study

2020 ◽  
Vol 11 (4) ◽  
pp. 7634-7643
Author(s):  
Ghazala Ahmad ◽  
Ismath Shameem
Keyword(s):  
Clinical Study ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
White Blood Cells ◽  
Female Genital Tract ◽  
Lower Abdominal Pain ◽  
Reproductive Age ◽  
Gynecologic Surgery ◽  
Discharge Data ◽  
Vas Score

Pelvic inflammatory disease (Waram al-Rahim)is one of the most serious gynaecological infections of the upper female genital tract with the worldwide annual rate of 10-20/1000 women of reproductive age.  The objective planned for the study was to evaluate the effect of Sharbat-e-Deenar in uncomplicated Pelvic Inflammatory Disease (uPID).  A pre and post observational single group clinical study was carried out in the Department of IlmulQabalatwaAmrazeNiswan, National Institute of Unani Medicine, Hospital, Bengaluru. Diagnosed cases (n=30) of uPID were included in the study. Patients with complicated PID, history of antibiotic therapy within seven days of recruitment; delivery, abortion or gynecologic surgery within the last 30 days,  systemic diseases, malignancies, pregnancy & lactation were excluded. Sharbat-e-Deenarconsists of Poste baikhekasniandTukhmekasni(Cichorium intybus  Linn.), Gulesurkh (Rosa damascene mill.), Tukhmekasoos(CuscutareflexaRoxb.)  and Rewandchini (Rheum emodiWall. ex Meissn) were administered orally in a dose of 20 ml twice daily for 14 days. Outcome measures were 30-70% clinical improvement in Visual Analogue Scale (VAS) score for lower abdominal pain and McCormack Pain Scale (McPS) score for abdominopelvic tenderness and White Blood Cells (WBCs) count <10 on saline microscopy of discharge. Data were analyzed using paired Student ‘t’ test, Wilcoxon Signed rank test and Paired Proportion test.Clinical improvement of 30-70% in McPS and VAS score was achieved in 96.7% (p<0.001**) and 93.3% (p<0.001**) patients respectively. WBCs count <10 on saline microscopy of discharge was achieved in 70% patients (p<0.001**).Sharbat-e-Deenarwas effective in improving the sign & symptoms of PID due to its anti-microbial, anti-inflammatory, anti-spasmodic and anti-oxidant properties. No adverse effect of the research drug was encountered during the study. Hence, Sharbat-e-Deenar serves as an effective alternative in patients with PID, proving the research hypothesis.

Experimental Use of the Selenase in Complex Treatment of Purulent and Inflammatory Diseases of the Small Pelvis Organs with Peritonitis

10.12737/2731 ◽  
2013 ◽  
Vol 20 (4) ◽  
pp. 65-68
Author(s):  
Нурмагомедова ◽  
P. Nurmagomedova ◽  
Магомедова ◽  
Z. Magomedova ◽  
Магомедов ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Inflammatory Disease ◽  
Phagocytic Activity ◽  
Inflammatory Diseases ◽  
Intensive Therapy ◽  
Clinical Status ◽  
Complex Treatment ◽  
Results Of Treatment ◽  
Inflammatory Processes ◽  
Experimental Use

An analysis of the results of treatment of 48 patients with acute purulent and inflammatory disease of the small pelvis organs with endolymphatic introduction of the Selenase is presented. The age of the patients was from 20 to 45 years. Course of treatment was 5-10 days. The use of the Selenase in the scheme of intensive therapy facilitated substantial positive dynamics of clinical status. A distinct reduction of paresis of the gastrointestinal tract and decrease phenomena endotoxemia were observed clinically in most cases (94,2±2,1%). In laboratory indicators after 5-10 daily courses of intensive therapy with use of the Selenase, a tendency to normalization of the blood formula and reduce the number of leukocytes, the increase in 2 times the number of lymphocytes were noted. The use of CRT was neutralized antioxidant and immunological imbalance, increased phagocytic activity. Endolymphatic introduction of preparation contributed cleansing of wounds and cavities, regress of purulent and inflammatory processes. Application of the Selenase is significantly important factor in improving the prediction of treatment patients with purulent and inflammatory disease of the organs of small pelvis. Results of this research can be the basis for further research to develop new approaches in the field of endolymphatic therapy. Complications and cases of mortality from endolymphatic therapy by the Selenase didn&#180;t revealed.

Sign in / Sign up

Export Citation Format

Share Document