scholarly journals Hormonal monitoring of the function of the corpus luteum, trophoblast and placenta in pregnant women with a history of different types of infertility

2020 ◽  
pp. 6-12
Author(s):  
L.E. Tumanova ◽  
◽  
E.V. Kolomiets ◽  
Keyword(s):  
Surgical Treatment ◽  
Pregnant Women ◽  
Corpus Luteum ◽  
Enzyme Linked Immunosorbent Assay ◽  
Group I ◽  
Rate Of Increase ◽  
History Of ◽  
Natural Conception ◽  
Β Hcg ◽  
Conservative And Surgical Treatment

Purpose — to investigate hormonal monitoring of the function of the corpus luteum, trophoblast and placenta in pregnant women with a history of various types of infertility. Materials and methods. We have studied hormonal parameters from 8 to 14 weeks of pregnancy in 420 women. The study of hormonal parameters was carried out in three groups (six subgroups): Group I — pregnant women with a history of endocrine infertility: Ia — 50 patients after IVF, Ib — 50 patients who became pregnant on their own after conservative and surgical treatment of infertility, but without IVF; Group II — pregnant women with a history of inflammatory infertility: IIa — 100 patients after IVF, IIb — 100 patients who became pregnant independently after conservative and surgical treatment of inflammatory infertility, but without IVF; Group III — pregnant women with a history of combined infertility, inflammatory genesis with endocrine, IIIa — 30 patients after IVF, IIIb — 30 patients who became pregnant on their own after conservative and surgical treatment of combined infertility, but without IVF. A study of the content of placental hormones in the dynamics of pregnancy at 7–10 and 11–14 weeks was carried out: estradiol (E2), progesterone, human chorionic gonadotropin (β-hCG) and pregnancy-associated plasmoprotein (PAPP-A). Determination of E2, progesterone was carried out by the enzyme-linked immunosorbent assay using standard kits of the Delfia system on a 1420 Victor 2 analyzer from Perken Elmer (USA). β-hCG and PAPP-A were determined by the immunochemiluminescent method using test systems manufactured by Siemens. Results. We carried out hormonal monitoring of the corpus luteum and trophoblast function and analyzed the results of fetal biochemical markers in 276 pregnant women. The data obtained indicate that in the period of 7–10 weeks of pregnancy, the concentration of progesterone was significantly higher in women after IVF relative to the indicators of patients with natural conception. At this stage of pregnancy, the level of progesterone did not depend on the form of infertility. Similar changes were observed with respect to estradiol levels. So the level of estradiol in pregnant women of 7–10 weeks during natural pregnancy was ≈5.0 nmol/L, while the same level of estradiol in pregnant women with one fetus after IVF was 8.4±1.1 nmol/L. The progesterone/estradiol ratio was virtually the same across the groups. The level of estradiol and progesterone in the blood of women at 11–14 weeks of gestation also practically did not differ, and did not depend on the form of infertility and the method of conception. It should be especially noted that at 11–14 weeks there was a decrease in the progesterone/estradiol ratio, which represents a progressive pronounced relative progesterone deficiency and hyperestrogenism in women with infertility. The indicators were especially low in pregnant women of groups I and III, who had endocrine and combined infertility in the anamnesis. We also investigated the indicators of β-hCG and PAPP-A in pregnant women 11–14 weeks. by groups, as classic markers of screening for congenital malformations of the fetus and the risk of complications of pregnancy. So the level of PAPP-A in pregnant women did not significantly differ in groups, both from the method of conception and the type of infertility in the anamnesis. The level of β-hCG in pregnant women 11–14 weeks of singleton pregnancy after IVF is significantly higher than in women with natural conception. The highest rates were in the group after combined infertility. Conclusions. The level of hormones: estradiol and progesterone in pregnant women after IVF at 7–10 weeks was higher than in women with a history of infertility during natural conception. Already at 11–14 weeks, the same indicators in the same groups did not differ. After natural conception, the rate of increase in estradiol significantly outpaced the increase in progesterone levels in pregnant women with a history of infertility. The concentration of PAPP-A in the first trimester in pregnant women after IVF did not significantly differ from those in women with natural conception. The content of β-hCG at 11–14 weeks in groups of pregnant women after IVF was 1.5–2 times higher. The highest rates were in pregnant women with a history of concomitant infertility. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of these Institutes. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: estradiol, progesterone, β-hCG, PAPP-A, pregnancy after infertility.

scholarly journals Hormonal function of the corpus luteum, trophoblast and placenta in pregnant twins who were previously treated for infertility

2021 ◽  
pp. 22-29
Author(s):  
L.E. Tumanova ◽  
◽  
E.V. Kolomiets ◽  
Keyword(s):  
Growth Rate ◽  
Surgical Treatment ◽  
Pregnant Women ◽  
First Trimester ◽  
Multiple Pregnancies ◽  
Hormonal Function ◽  
History Of ◽  
Self Fertilization ◽  
Β Hcg ◽  
Conservative And Surgical Treatment

Purpose — to study the hormonal function of the corpus luteum, trophoblast. Materials and methods. We have studied hormonal parameters from 7 to 14 weeks of pregnancy in 87 women with twins. The study of hormonal parameters was carried out in three groups (six subgroups): Group I — pregnant women who had a history of endocrine infertility: Ia — 21 patients after IVF, Ib — 10 patients who became pregnant on their own after conservative and surgical treatment of infertility, but without IVF; Group II — pregnant women with a history of infertility of inflammatory genesis: IIa — 35 patients after IVF, IIb — 6 patients who became pregnant on their own after conservative and surgical treatment of infertility, but without IVF; Group III — pregnant women who had a history of combined infertility, inflammatory genesis with endocrine, IIIa — 10 patients after IVF, IIIb — 5 patients who became pregnant on their own after conservative and surgical treatment of infertility, but without IVF. The content of placental hormones in the dynamics of pregnancy at 7–10 and 11–14 weeks was studied: estradiol (E2), progesterone, human chorionic gonadotropin (β-hCG) and pregnancy-associated plasmoprotein (PAPP-A). Determination of E2, progesterone was carried out by enzyme immunoassay using standard kits of the «Delfia» system on an analyzer «1420 Victor 2» from Perken Elmer (USA). β-hCG and PAPP-A were determined by the immunochemiluminescent method using test systems manufactured by Siemens. Results. During dynamic monitoring of hormonal parameters in the blood of women of all three groups during the first trimester, we revealed a progressive increase in the content of estradiol and progesterone. At the same time, the rate of increase in the content of estradiol in the blood in the dynamics of pregnancy was greater than that of progesterone. With twins (after IVF), the increase in progesterone reached more than 50%, and the increase in estradiol up to 30–40%, practically did not depend on the cause of infertility. With multiple independent pregnancies, the increase in progesterone reached ≈40–60% (the lowest increase was with combined infertility), and the increase in estradiol ≈75% and practically did not differ across groups. At 7–10 weeks of gestation, the progesterone concentration was significantly higher in women after IVF compared to those in patients after spontaneous fertilization. In this period, the level of progesterone did not depend on the form of infertility. Similar changes were observed with the level of estradiol in the surveyed women. The progesterone/estradiol ratio was virtually the same across the groups. The level of estradiol in the blood of women (11–14 weeks of pregnancy) also practically did not differ, both depending on the form of infertility and the method of fertilization. At 11–14 weeks, comparing progesterone levels, it is necessary to note reliably high rates in women with multiple pregnancies after IVF, which indicates an intense hormone-producing function due to the placentas of two fetuses. It should be noted that with endocrine and combined infertility in women after IVF with twins, there were significantly higher rates compared to those of women in similar groups after self-fertilization. The content of sex hormones at both 7–10 and 11–14 weeks in all groups during pregnancies after IVF was higher than during pregnancies with natural fertilization. The content of sex hormones at both 7–10 and 11–14 weeks in all groups during pregnancies after IVF was higher than during pregnancies with natural fertilization. The progesterone level in pregnant women at 11–14 weeks with a two-fetal natural pregnancy was 256.45±27.6 nmol/L, while the same indicator in pregnant women with two fetuses after IVF was 337.5±26.7 nmol/L. A longer (up to 13 weeks) decrease in the progesterone/estradiol ratio represents a more pronounced relative progesterone deficiency and hyperestrogenism in women after IVF. High levels of progesterone in the first trimester of pregnancy, especially in women after IVF (Ia, IIa, IIIa groups) were the result of intensive maintenance therapy with progestogens, which is necessary to ensure the gestational process in the I trimester in the IVF program. We also studied the indicators of β-hCG and PAPP-A in pregnant women 11–14 weeks. by groups, as classic markers of screening for congenital malformations of the fetus and the risk of complications of pregnancy. Thus, PAPP-A in pregnancies after IVF did not significantly differ from pregnancies with natural fertilization, but had a tendency to increase in multiple pregnancies. Conclusions. At 7 10 weeks of pregnancy, women with twins after IVF had higher levels of estradiol and progesterone than in women with twins after natural fertilization. At 11 14 weeks of pregnancy in women with twins, estradiol did not differ between groups and did not depend on the method of fertilization, and the level of progesterone was higher in pregnant women after IVF. With twins (after IVF), the growth rate of progesterone is higher than that of estradiol. With self-fertilization, the growth rate of estradiol significantly outpaced the growth of progesterone levels in pregnant women with a history of endocrine and concomitant infertility. The concentration of pregnancy-associated plasmoprotein (PAPP-A) in pregnancies after IVF did not significantly differ from pregnancies with natural fertilization and did not depend on the cause of infertility. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of these Institutes. The informed consent of the patient was obtained for conducting the studies. The authors declare that they have no conflicts of interest. Key words: estradiol, progesterone, β-hCG, PAPP-A, twin pregnancy after infertility.

scholarly journals ANTINUCLEAR ANTIBODIES IN PATIENTS WITH UNEXPLAINED RECURRENT ABORTIONS

2017 ◽  
Vol 10 (8) ◽  
pp. 256 ◽  
Author(s):  
Anupriya Asaithambi ◽  
Manjula Gunasekaran ◽  
Manivelan S ◽  
Palaniappan Nainar
Keyword(s):  
Pregnant Women ◽  
Antinuclear Antibodies ◽  
Antibody Test ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cell Substrate ◽  
Simple Alternative ◽  
History Of ◽  
Recurrent Abortions ◽  
Control Study ◽  
Indirect Fluorescence Antibody

Objective:This study aims to determine the prevalence of antinuclear antibodies in pregnant women with bad obstetric history (BOH) against healthy multigravid women in and around Tirunelveli districtMethods: This is a case-control study comprising 60 antenatal women with BOH against 60 multiparous pregnant women with no history of abortions. Antinuclear antibodies (ANA) were detected using indirect immunofluorescence with Hep-2 cell substrate, and enzyme-linked immunosorbent assay (ELISA).Results: Among BOH cases 19 (82.6%), 18 (78.26%) were positive by ELISA and indirect fluorescence antibody test (IFAT) method, respectively. Among controls, 4(17.39%) and 5(21.73%) individuals were positive by ELISA and IFAT methods, respectively. Of the 18 positives, homogenous pattern was most common followed by anticentromere pattern, fine speckled and coarse speckled patternConclusion: IFAT is considered to be gold standard in the diagnosis of autoimmune disorders, but ELISA appears to be a suitable simple alternative for testing rheumatological disorders.

scholarly journals The relation between the anterior pituitary body and the gonads.- Part I. The factors concerned in the formation of the corpus luteum

1930 ◽  
Vol 107 (748) ◽  
pp. 30-38 ◽  
Keyword(s):  
Pregnant Women ◽  
Corpus Luteum ◽  
Anterior Pituitary ◽  
Ovarian Tissue ◽  
Pituitary Tissue ◽  
Extraneous Stimulus ◽  
History Of ◽  
Set Up

Ovulation in the normal rabbit is dependent upon copulation (Heape, 1905). Since the same correlation is found with grafted ovarian tissue, as shown by Friedman (1929 a ) and previously found by Asdell (1926), the stimulus (presumably nervous in nature) set up by coitus does not act directly upon the ovary. In view of the part which the anterior pituitary body is now known to play in controlling ovulation (Zondek and Aschheim, 1927, Smith and Engle, 1927) it is natural to suppose that copulation stimulates the anterior pituitary, which in turn reacts upon the ovary to cause ovulation. It has, in fact, been shown that hypophysectomy of the rabbit within I hour after copulaion inhibits the ovulation which would normally occur 10—12 hours later (Fee and Parkes, 1929). Furthermore, Bellerby (1929) was able to induce ovulation in the unmated œstrous rabbit by the injection of acid extracts of anterior pituitary tissue. Later, Friedman (1929 b ) obtained the same result with extracts prepared from urine of pregnant women. Both of these authors were able to obtain the effect by one injection, and the influence of this on administration of hormone must have passed off by the time of ovulation. Neither author, however, appears to have studies the subsequent history of the follicle caused to ovulate without the preceding influence of copulation and free from the extraneous stimulus of further injection. It is evident that such a study would indicate something of the factors concerned in initiating the stimulus (presumably hypophyseal in origin) responsible for the luteinisation of the ruptured follicle.

Risk stratification and heparin prophylaxis to prevent venous thromboembolism in pregnant women

2007 ◽  
Vol 98 (12) ◽  
pp. 1237-1245 ◽  
Author(s):  
Joachim Dudenhausen ◽  
Andree Faridi ◽  
Thorsten Fischer ◽  
Samson Fung ◽  
Ulrich Geisen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Venous Thromboembolism ◽  
Pregnant Women ◽  
Management Strategies ◽  
Prospective Trial ◽  
High Risk Group ◽  
Group I ◽  
Increased Risk ◽  
History Of ◽  
Heparin Prophylaxis

SummaryWomen with a history of venous thromboembolism (VTE), thrombophilia or both may be at increased risk of thrombosis during pregnancy, but the optimal management strategy is not well defined in clinical guidelines because of limited trial data. A strategy of risk assessment and heparin prophylaxis was evaluated in pregnant women at increased risk of VTE. In a prospective trial (Efficacy of Thromboprophylaxis as an Intervention during Gravidity [EThIG]), 810 pregnant women were assigned to one of three management strategies according to pre-defined risk factors related to history of VTE and thrombophilic profile. Low-risk women (group I), received 50–100 IU dalteparin/ kg body weight/ day for 14 days postpartum, or earlier when additional risk factors occurred. Women at high (group II) or very high risk (group III) received dalteparin from enrolment until six weeks postpartum (50–100 IU and 100–200 IU/ kg/ day, respectively). Objectively confirmed, symptomatic VTE occurred in 5/810 women (0.6%; 95% confidence interval [CI], 0.2 to 1.5%) (group I, 0 of 225; II, 3/469; III, 2/116). The rate of serious bleeding was 3.0% (95 % CI, 1.9 to 4.4%); 1.1% (95 % CI, 0.5 to 2.2%) was possibly dalteparin-related. There was no evidence of heparin- induced thrombocytopenia, one case of osteoporosis, and rates of miscarriage and stillbirth were similar to previous, retrospective studies. Risk-stratified heparin prophylaxis was associated with a low incidence of symptomatic VTE and few clinically important adverse events. Antepartum heparin prophylaxis is, therefore, warranted in pregnant women with idiopathic thrombosis or symptomatic thrombophilia.

scholarly journals Determinants of gestational night blindness in pregnant women from Rio de Janeiro, Brazil

2015 ◽  
Vol 19 (5) ◽  
pp. 851-860 ◽  
Author(s):  
Cláudia Saunders ◽  
Maria do Carmo Leal ◽  
Paulo Augusto Ribeiro Neves ◽  
Patricia de Carvalho Padilha ◽  
Letícia Barbosa Gabriel da Silva ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Rio De Janeiro ◽  
Night Blindness ◽  
Maternity Hospital ◽  
Cross Sectional Study ◽  
Postpartum Women ◽  
Cross Sectional ◽  
Group I ◽  
History Of ◽  
Nutritional Monitoring

AbstractObjectiveTo describe the prevalence and determinants of gestational night blindness in pregnant women receiving care in a hospital in Rio de Janeiro, Brazil.DesignCross-sectional study of pregnant and postpartum women receiving care in a public hospital in Rio de Janeiro from 1999 to 2001 (group I; n 225) or from 2005 to 2008 (group II; n 381). Night blindness was identified through a standardized and validated interview (WHO, 1996). The determinants of gestational night blindness were identified through a hierarchical logistic regression model.SettingPublic maternity hospital in Rio de Janeiro, RJ, Brazil.SubjectsAdult pregnant and postpartum women (n 606), aged ≥20 years.ResultsThe prevalence of gestational night blindness was 9·9 %. The final model revealed that not living in the South Zone of Rio de Janeiro (distal level: adjusted OR=1·846; 95 % CI 1·002, 3·401), belonging to group I (intermediate level: adjusted OR=2·183; 95 % CI 1·066, 4·471) and for the proximal level, having a history of abortion (adjusted OR=2·840; 95 % CI 1·134, 7·115) and having anaemia during the first and second trimesters of pregnancy (adjusted OR=3·776; 95 % CI 1·579, 9·029) were determinants of gestational night blindness.ConclusionGestational night blindness should be assessed for during the prenatal care of all pregnant women, especially those living in deprived areas of the city and/or who have a history of abortion or anaemia. Nutritional monitoring is recommended during pregnancy to control gestational night blindness.

scholarly journals Seroprevalence of Subclinical HEV Infection in Healthy Pregnant Urban Dwellers of Bangladesh: Identification of Possible Risk Factors

2018 ◽  
Vol 8 (2) ◽  
pp. 85-89
Author(s):  
Gazi Zakia Sultana ◽  
Md Moniruzzaman ◽  
Tania Mannan ◽  
Rosy Sultana
Keyword(s):  
Risk Factors ◽  
Socioeconomic Status ◽  
Pregnant Women ◽  
Low Socioeconomic Status ◽  
Economic Status ◽  
Education Level ◽  
Enzyme Linked Immunosorbent Assay ◽  
Igg Antibody ◽  
Cross Sectional ◽  
History Of

Background: Hepatitis caused by hepatitis E Virus (HEV) is not uncommon in developing countries. It is usually a self-limiting conferring immunity against subsequent infection. However, HEV infection during pregnancy results in varying degree of morbidity, often fatal. The present study was designed to find out the seroprevalence of subclinical HEV infection during pregnancy at different trimesters without history of hepatitis.Materials and Methods: A total 255 asymptomatic healthy pregnant women of three trimesters (85×3=255) with no history of jaundice were included in this cross-sectional study. The subjects were sub-grouped according to socioeconomic status and education level. HEV IgG antibody in serum was determined by enzyme linked immunosorbent assay (ELISA). Results were expressed as number (percent). Chi-square, Odds Ratio and 95% CI were calculated as applicable. Data analyses were carried out using statistical package for social science for Windows Version 15.0. A p<0.05 was taken as level of significance.Results: Seropositivity for HEV IgG was 38% (96/255) in pregnant women; the higher percentages were recorded in the 2nd and 3rd trimesters − 41% and 46% respectively. The seropositivity of HEV IgG was significantly high in pregnant women with low education level ((p=0.001; OR=2.70, 95% CI=1.602−4.575) and low socioeconomic status (OR=7.54, 95% CI=4.118−13.029) having monthly income below 27,000 taka (p=0.001).Conclusion: Data concluded that seroprevalence of anti-HEV IgG is higher at third trimester in pregnant women in Bangladesh where low socio-economic status and less education level were identified as possible risk factors. Appropriate measures may diminish the possible exposure to infection and reduce maternal mortality.J Enam Med Col 2018; 8(2): 85-89

Sero-epidemiology of human T-cell lymphotropic viruses-1 and -2 infection among pregnant women attending Abuja Teaching Hospital, Nigeria

2021 ◽  
pp. 1-8
Author(s):  
Amos Dangana ◽  
Idris Nasir Abdullahi ◽  
Olasoji Matthew Adeyemi Billyrose ◽  
Anthony Uchenna Emeribe ◽  
Joel Monday Abu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Teaching Hospital ◽  
Hiv Infections ◽  
Demographic Variables ◽  
Enzyme Linked Immunosorbent Assay ◽  
Multiple Sexual Partners ◽  
Human T Cell ◽  
Increased Risk ◽  
History Of

BACKGROUND: There is the paucity of HTLV-1/-2 studies on Nigerian pregnant women despite the medical and public health significance of maternal-to-child transmission of HTLV-1/-2. OBJECTIVE: This study aims to determine the seroprevalence and risk factors of HTLV-1/-2 infections among pregnant women attending the University of Abuja Teaching Hospital (UATH), Abuja, Nigeria. MATERIALS AND METHODS: Blood samples were collected from consented pregnant women and analysed for ant-HTLV-1/-2 total antibodies using a commercial Enzyme-Linked Immunosorbent Assay (ELISA) kit. Pretested structured questionnaires were used to collate participants’ socio-demographic variables and risk factors of HTLV infection. RESULTS: Out of the 156 pregnant women tested for HTLV-1/-2 antibodies, 16 (10.3%) were seropositive. There was no significant association between the socio-demographic variables collated and seroprevalence of HTLV-1/-2 infection among pregnant women (p> 0.05). Pregnant women with HIV infection had a lower prevalence of HLTV-1/-2 infection than those without HIV infections (7.5% versus 11.7%). Pregnant women with multiple sexual partners had a higher risk of HTLV-1/-2 infection than those who had single (OR = 2.08, 95% CI: 0.53–8.18). Women with a history of needles injury had a higher risk of HTLV-1/-2 infection than those who do not (OR = 1.24, 95% CI: 0.38–4.08). The history of blood transfusion was significantly associated with HTLV-1/-2 infection (p= 0.027). However, no significant association existed between other risk factors of HTLV-1/-2 infection among pregnant women (p> 0.05). CONCLUSION: Considering the 3% pooled national prevalence of HTLV-1/-2 infection in Nigeria, the seroprevalence reported in this study is relatively high. Thus, there is a need for more large cohort studies and routine screening of population at increased risk of infection.

scholarly journals Biochemical Markers for Prediction of Pregnancy Outcome in Cases of Recurrent Pregnancy Loss

2021 ◽  
Vol 5 (1) ◽  
Keyword(s):  
Pregnant Women ◽  
Pregnancy Outcome ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
First Trimester ◽  
Serum Progesterone ◽  
Study Results ◽  
Routine Basis ◽  
History Of ◽  
Β Hcg

Objective: To predict pregnancy outcome by studying the relation between serum βHCG, progesterone and CA125 and the occurrence of miscarriage in the first trimester, in cases with history of recurrent pregnancy loss. Methods: Serum βHCG, progesterone and CA125 levels in fifty pregnant women with history of recurrent pregnancy loss were compared to 50 pregnant women with no history of abortion, and to another group of women (No=50) who failed to complete the 1st trimester of pregnancy during the study. Results: Serum B-hCG showed a sensitivity of 100%, a specificity of 50%, a PPV of 50% and a NPV of 100%. Serum progesterone showed a sensitivity of 24%, a specificity of 73%, a PPV of 55.07% and a NPV of 85.18%, while serum CA125 showed a sensitivity of 15.6%, a specificity of 58.59%, a PPV of 16.32% and a NPV of 57.42%. Conclusion: The value of CA125 in recurrent abortions is still unclear and cannot recommended on routine basis. On the other hand, β-HCG is highly sensitive as a single serum measurement for the prediction of pregnancy outcome.

Obstetric and perinatal outcomes in women with threatened interruption of pregnancy, living in the armed conflict zone

2020 ◽  
pp. 21-24
Author(s):  
I.Yu. Romanenko ◽  
Keyword(s):  
Pregnant Women ◽  
Inflammatory Diseases ◽  
Perinatal Outcomes ◽  
Control Group ◽  
Operative Delivery ◽  
Pregnancy And Childbirth ◽  
Group I ◽  
History Of ◽  
Complicated Course ◽  
Female Genital

The objective: was to evaluate the course of pregnancy, childbirth and perinatal outcomes of delivery of women with threatened interruption of pregnancy (TIP), living in the Lugansk region, to improve treatment and preventive measures and prevent obstetric and perinatal complications in such women. Materials and methods. A prospective clinical and statistical analysis of the course of pregnancy and childbirth of 86 pregnant women in first and second trimesters of pregnancy were hospitalized regarding TIP in the hospitals located in the Luhansk region was performed (group I). The control group consisted of 64 pregnant women with non-complicated obstetric anamnesis and physiological course of pregnancy with similar gestational period of pregnancy and place of residence (group II). Results. In women of group I, a history of female genital inflammatory diseases was significantly more frequent, and a complicated course of pregnancy and childbirth was registered. The number of cases of acute respiratory viral infection (ARVI) was in 4, isthmic-cervical insufficiency (ICI) was in 3 times more often than in healthy pregnant women, asymptomatic bacteriuria, recurring TIP, gestational pyelonephritis and ureaplasma infection were found only in pregnant women of group I, the number of cases of anemia there was no significant difference. 13 (15.12%) of women of group I and 3 (4.69%) of group II (p=0.041) had spontaneous preterm birth at 33–37 weeks of gestation; operative delivery was registered in 23 (26.74%) and 8 (12.50%) cases, respectively (p=0.033). It was established that recurrent TIP, ARVI during this pregnancy, ICI, gestational pyelonephritis are statistically significant risk factors for preterm delivery and operative delivery. Premature rupture of the membranes was found in 1.58, weakness of labor – in 2.2, premature detachment of a normally located placenta – in 6, fetal distress – in 1.9 times more often in women of group I, central placenta previa was noted only in group I. Conclusions. The complicated course of the first and second trimesters of pregnancy, in particular, recurrent TIP, ARVI during this pregnancy, ICI, gestational pyelonephritis, had a direct effect on frequency increase of premature termination of pregnancy and operative delivery in patients of the main group compared with women of the control group. The presence of a history of chronic female genital inflammatory diseases, sexually transmitted infections, ARVI during this pregnancy, TIP in the first and second trimesters, allows pregnant women to be at high risk of developing gestational complications in order to conduct timely treatment. Key words: pregnancy, the threat of abortion, childbirth, the condition of newborns.

scholarly journals Anti-annexin V Antibodies in Women with Recurrent Miscarriage

2010 ◽  
Vol 4 ◽  
pp. CMRH.S5835
Author(s):  
M.N. EL-Gharib ◽  
T.M. Elhawary ◽  
S.H. Elshourbagy ◽  
M.A. Morad
Keyword(s):  
Pregnant Women ◽  
Recurrent Miscarriage ◽  
Characteristic Curve ◽  
Annexin V ◽  
Mean Value ◽  
Control Group ◽  
Etiologic Factor ◽  
Group I ◽  
History Of ◽  
The Mean

Objective To determine the role of anti-annexin V antibodies (a-A5) as an etiologic factor in recurrent pregnancy failure. Study design Prospective observational study. Material and methods The study included ninety first trimester pregnant women who had a history of unexplained recurrent miscarriage (group I) with ninety well-matched pregnant women with a history of normal reproductive outcome allocated as control group (GII) and another ninety nonpregnant women (GIII). Sera from all women controls were analyzed for anti-annexin antibody measured by Elisa. Results The mean value of a-A5 was 11.37 ± 6.78, 7.7 ± 1.40 and 6.20 ± 0.95 ng/ml in groups I, II and III respectively. There was a significant increase in the mean value a-A5 among women with a history of recurrent miscarriage, compared with controls. The mean value was 13.92 ± 2.42 ng/ml among patients with unfavourable outcome, compared with a corresponding value of 6.95 V 0.58 ng/ml among women with favourable outcome. The receiver operator characteristic curve revealed that the cutoff value of a-A5 was 8.61 ng/ml. Conclusion This study emphasizes the relationship between anti-annexin V antibodies and recurrent miscarriage.

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