Osteosarcopenia: pathogenesis, diagnosis and therapeutic approaches

Osteosarcopenia was identified as a separate syndrome in 2009, and is defined as a combination of sarcopenia and osteopenia/osteoporosis. Osteosarcopenia develops mainly in old age, leads to a decrease in quality of life, an increased risk of falls and low-traumatic fractures. Patients with osteosarcopenia have worse indicators of physical functions, compared with people suffering from only one of the components of the syndrome. An important role in the osteosarcopenia prevention is played by the lifestyle of patients, Adherence to diet with the consumption of adequate amount of protein, physical activity and preventive prescription of calcium and vitamin D are important for osteosarcopenia prevention. The article summarizes data on the prevalence, pathogenesis and risk factors of osteosarcopenia, provides diagnostic criteria for the disease and discusses therapeutic approaches.

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Analysis of quality of life in elderly practitioners of physical activity and relationship with risk of falls.

Manual Therapy Posturology & Rehabilitation Journal ◽

10.17784/mtprehabjournal.2014.12.181 ◽

2014 ◽

Vol 12 ◽

pp. 181 ◽

Cited By ~ 1

Author(s):

Deise Aparecida de Almeida Pires-Oliveira ◽

André Wilson Oliveira Gil ◽

Laís Campos De Oliveira ◽

Felipe Micheletti Bento ◽

Camila Silva Tomioto Mendes ◽

...

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Old Age ◽

The Elderly ◽

Assistive Device ◽

Elderly Subjects ◽

Increased Risk ◽

Sf 36 ◽

Risk Of Falls

Introduction: Old age brings several factors that alter the physiological system, which results in loss of functionality in the elderly. Falls are a leading cause of death in this population or activity restrictions, social isolation, decline in health and increased risk of institutionalization. The quality of life in old age is a major challenge, it is necessary for improvement in all aspects of daily. Analyze physical exercise on quality of life of older physically active drives to see how exercise influences the improvement of the basic aspects to a healthier life, referring to physical and mental aspects of the elderly, prevention of the consequences arising from the process natural aging, such as falls. Objective: The objective of this study is to analyze quality of life in elderly practitioners of physical activity and relationship with risk of falls. Method: The sample was 84 seniors, recruited from the community of Londrina PR, physical activity practitioners, aged over 60 years who roam with or without assistive device, of both sexes . The evaluation was through structured questionnaires that focused on socioeconomic - demographic questionnaire falls which was used the Timed Up and Go (TUGT), analysis of quality of life (SF-36) and analysis of the risk of falls. Results: In relationship the anthropometrics characteristics of elderly subjects analyzed, the same presentation mean age 68 years, weight 63.5 kg, height 1.52, and body mass index 27.10. Was regarding correlation between TUGT and falls in the last year (P=0,048) e correlation between TUGT and Physicals Components of SF-36 (P=0,001), and was regarding that elderly with better scores in TUGT were better scores of Physical Components of SF-36 (P=0,003). Conclusion: The quality of life is directly linked to the physical condition of the elderly, elderly practicing physical exercises have a better quality of life and less prone to falls.

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Potential of Beetroot and Blackcurrant Compounds to Improve Metabolic Syndrome Risk Factors

Metabolites ◽

10.3390/metabo11060338 ◽

2021 ◽

Vol 11 (6) ◽

pp. 338

Author(s):

Cameron Haswell ◽

Ajmol Ali ◽

Rachel Page ◽

Roger Hurst ◽

Kay Rutherfurd-Markwick

Keyword(s):

Quality Of Life ◽

Diabetes Mellitus ◽

Risk Factors ◽

Metabolic Syndrome ◽

Metabolic Abnormalities ◽

Dietary Nitrate ◽

Increased Risk ◽

High Concentrations

Metabolic syndrome (MetS) is a group of metabolic abnormalities, which together lead to increased risk of coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM), as well as reduced quality of life. Dietary nitrate, betalains and anthocyanins may improve risk factors for MetS and reduce the risk of development of CHD and T2DM. Beetroot is a rich source of dietary nitrate, and anthocyanins are present in high concentrations in blackcurrants. This narrative review considers the efficacy of beetroot and blackcurrant compounds as potential agents to improve MetS risk factors, which could lead to decreased risk of CHD and T2DM. Further research is needed to establish the mechanisms through which these outcomes may occur, and chronic supplementation studies in humans may corroborate promising findings from animal models and acute human trials.

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Early and Late Postoperative Seizures in Meningioma Patients and Prediction by a Recent Scoring System

Cancers ◽

10.3390/cancers13030450 ◽

2021 ◽

Vol 13 (3) ◽

pp. 450

Author(s):

Peter Baumgarten ◽

Mana Sarlak ◽

Daniel Monden ◽

Andrea Spyrantis ◽

Simon Bernatz ◽

...

Keyword(s):

Quality Of Life ◽

Risk Factors ◽

Tumor Volume ◽

Total Risk ◽

Increased Risk ◽

Independent Risk Factors ◽

Temporal Location ◽

Meningioma Surgery ◽

Impaired Quality

Seizures are among the most common symptoms of meningioma. This retrospective study sought to identify risk factors for early and late seizures in meningioma patients and to evaluate a modified STAMPE2 score. In 556 patients who underwent meningioma surgery, we correlated different risk factors with the occurrence of postoperative seizures. A modified STAMPE2 score was applied. Risk factors for preoperative seizures were edema (p = 0.039) and temporal location (p = 0.038). For postoperative seizures preoperative tumor size (p < 0.001), sensomotory deficit (p = 0.004) and sphenoid wing location (p = 0.032) were independent risk factors. In terms of postoperative status epilepticus; sphenoid wing location (p = 0.022), tumor volume (p = 0.045) and preoperative seizures (p < 0.001) were independent risk factors. Postoperative seizures lead to a KPS deterioration and thus an impaired quality of life (p < 0.001). Late seizures occurred in 43% of patients with postoperative seizures. The small sub-cohort of patients (2.7%) with a STAMPE2 score of more than six points had a significantly increased risk for seizures (p < 0.001, total risk 70%). We concluded that besides distinct risk factors, high scores of the modified STAMPE2 score could estimate the risk of postoperative seizures. However, it seems not transferable to our cohort

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Exercise and Physical Activity for Older Adults

Kinesiology Review ◽

10.1123/kr.2014-0043 ◽

2014 ◽

Vol 3 (1) ◽

pp. 101-106 ◽

Cited By ~ 33

Author(s):

Wojtek J. Chodzko-Zajko

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Risk Factors ◽

Older Adults ◽

Chronic Diseases ◽

Successful Aging ◽

Healthy Aging ◽

Improve Quality ◽

Reduce Risk

For more than half a century fellows of the National Academy of Kinesiology have enthusiastically advocated for the promotion and adoption of physically active lifestyles as an affordable and effective means to prevent chronic diseases and conditions, and enhance independence and high quality of life for older adults. It is possible to discern distinct evolutionary stages when examining scholarship related to the role of physical activity in the promotion of healthy aging. Research into physical activity and aging began with critical early studies that established the underlying scientific evidence for a relationship between physical activity and healthy aging. More recent work has addressed such topics as building consumer demand, developing policies and legislation to support active aging, and understanding the complex interrelationships between physical activity and other lifestyle factors in the prevention and treatment of chronic diseases and conditions. It is increasingly apparent that strategies to promote active and successful aging must be integrated into an effective public policy. Kinesiologists and other health professionals, working in collaboration with colleagues from other disciplines, can help to reduce risk factors for chronic disease and improve quality of life for older adults by building awareness of the importance of physical activity and by assisting with the development and implementation of appropriate and effective interventions that reduce risk factors and improve quality of life.

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Analysis of risk factors for vitamin D deficiency by results of the first stage of Russian non-interventional register study

Medical Council ◽

10.21518/2079-701x-2021-7-109-118 ◽

2021 ◽

pp. 109-118

Author(s):

L. A. Suplotova ◽

V. A. Avdeeva ◽

L. Y. Rozhinskaya ◽

E. A. Pigarova ◽

E. A. Troshina

Keyword(s):

Quality Of Life ◽

Risk Factors ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Russian Federation ◽

Direct Sunlight ◽

Cross Sectional ◽

Wide Range ◽

Smoking Duration

Introduction. In Russian Federation, there are no comprehensive studies assessing the quality of life and risk factors for vitamin D deficiency and insufficiency, taking into account its status in different geographic latitudes.Aim. To assess the quality of life and risk factors for vitamin D deficiency and insufficiency among the population living in the regions of the Russian Federation located at latitudes from 45 ° to 70 °.Materials and methods. The first stage of the Russian multicenter non-interventional registry study using the “cross-sectional” method was carried out from March 2020 to May 2020.Results and discussion. According to the results of the correlation analysis, qualitative and quantitative factors were identified, presumably being risk factors for vitamin D deficiency and deficiency. Qualitative risk factors include: education; alcohol consumption; being in direct sunlight for more than 30 minutes a day; visit to the solarium; using sunscreen; drinking coffee; taking medications (not vitamin-mineral complexes). Quantitative factors include: visits to specialists (total per year); smoking (duration, years); exercise for more than 30 minutes a day, once a week; being in direct sunlight for more than 30 minutes a day.Conclusion. A wide range of risk factors for vitamin D deficiency dictates the need for their further study to clarify the category of persons who are shown targeted biochemical screening with subsequent drug correction.

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Obesity and low levels of physical activity are associated with a decreased health-related quality of life in postmenopausal women: a Wroclaw pilot study

HIGHER SCHOOL’S PULSE ◽

10.5604/01.3001.0015.3944 ◽

2021 ◽

Vol 15 (SUPPLEMENT 2) ◽

pp. 1-8

Author(s):

Joanna Lewandowska ◽

Mateusz Tomaczak ◽

Iwona Wilk ◽

Felicja Lwow

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Waist Circumference ◽

Postmenopausal Women ◽

Chronic Diseases ◽

Short Form ◽

Increased Risk ◽

Health Related ◽

Low Levels

Background: Menopause is associated with numerous somatic dysfunctions, an increased risk of chronic diseases, and complications in the mental and social components of health that lower the quality of life (QoL). Obesity and related comorbidities affect over 60% of postmenopausal women in Poland. A significant role for systematic physical activity (PA) in the prevention of dysfunctions and chronic diseases, including obesity and mental disorders, has been observed previously. A low level of PA is observed across the Polish population, especially in postmenopausal women. Aim of the study: To examine QoL in postmenopausal women participating in a community health promotion program as it relates to obesity and levels of PA. Material and methods: The study sample consisted of 76 postmenopausal women (aged 65.75±5.14 years) participating in the Active Wrocław 55+ program. Before starting the program, anthropometric measurements were taken, and QoL and PA were assessed using the 36-Item Short Form Health Survey (SF-36) and the International Physical Activity Questionnaire-Short Form (IPAQ-SF), respectively. Results: Most women had a PA level above 600 MET -min/week (78.95%), and were overweight or obese (86.84%). A waist circumference over 80 cm, indicating an increased risk for metabolic syndrome, was observed in 85.89% of the participants. BMI and waist circumference negatively correlated with the level of PA (p=0.001 and p=0.017, respectively). Women exhibiting low levels of PA and higher BMIs showed a significantly lower QoL compared to those with higher PA and lower BMIs, particularly with regard to the physical domains of QoL. Conclusions: Obesity and a low level of PA are associated with a significant decline in the health-related QoL (especially in the PF and PCS domains) of postmenopausal women an urban setting.

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A Randomized Clinical Trial to Evaluate the Efficacy and Safety of the ACTLIFE Exercise Program for Women with Post-menopausal Osteoporosis: Study Protocol

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17030809 ◽

2020 ◽

Vol 17 (3) ◽

pp. 809 ◽

Cited By ~ 2

Author(s):

Laura Bragonzoni ◽

Giuseppe Barone ◽

Francesco Benvenuti ◽

Veronica Canal ◽

Claudio Ripamonti ◽

...

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Force Balance ◽

Life Questionnaire ◽

Advantages And Disadvantages ◽

Post Menopausal Osteoporosis ◽

Increased Risk ◽

Post Menopausal ◽

Menopausal Osteoporosis

Osteoporosis (OP) is a systemic disease of the skeleton characterized by increased risk of fracture. There is a general consensus on the efficacy of physical activity in the prevention of bone loss, falls and fractures, but there is no agreement on the best setting to exercise. The aim of the study is to evaluate the efficacy of a 12-months exercise protocol for women with post-menopausal OP when administered as individual home training (IHT) versus gym group training (GGT). The study is a randomized trial with two parallel groups. Sedentary patients with primary post-menopausal osteoporosis are recruited at the Istituto Ortopedico Rizzoli of Bologna. In the first group, the 12-month ACTLIFE program is performed as IHT, while in the second as GGT. The program is aimed at improving joint mobility, muscle force, balance, motor coordination and endurance. The study is single blinded. Patients are assessed at baseline and after 6 and 12 months. The primary outcome is the modification of quality of life measured with the Short Osteoporosis Quality of Life Questionnaire (ECOS-16). The findings of this study will highlight advantages and disadvantages of exercising in the two different settings and provide evidence on how to increase physical activity in osteoporotic women.

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