scholarly journals Serum Myokines Levels in Patients with Endogenous Cushing Syndrome and Acromegaly: Cross-Sectional Case−Control Study

2016 ◽  
Vol 71 (3) ◽  
Author(s):  
T. T. Tsoriev ◽  
Z. E. Belaya ◽  
L. Y. Rozhinskaya ◽  
G. A. Melnitchenko ◽  
T. A. Grebennikova ◽  
...  
Keyword(s):  
Young Adults ◽  
Grip Strength ◽  
Cushing Syndrome ◽  
Serum Levels ◽  
Serum Samples ◽  
Cross Sectional ◽  
Hand Grip ◽  
Free Cortisol ◽  
The Difference ◽  
Control Study

Background: Myokines are produced and released by muscle cells in response to muscular contractions. Endogenous Cushing syndrome (CS) and acromegaly cause significant changes in muscle tissue leading to atrophy or hypertrophy. However, there is no data whether these endocrine abnormalities influence myokine secretion. Aims: To evaluate serum levels of myostatin, interleukin-6 (IL6) and irisin in patients with CS and acromegaly. Materials and methods: Fasting serum samples were taken and stored in aliquot at ≤-20°C from consecutive subjects with clinically evident and biochemically confirmed active CS, acromegaly and healthy volunteers matched by age, sex and body mass index (BMI). Commercially available kits were used to assay serum myokine levels. Grip strength was measured by a dynamometer. Insulin-like growth factor-1 (IGF1) was measured by immunochemiluminescence assay (Liaison), twenty-four hours urine free cortisol (24hUFC) ― by immunochemiluminescence assay (Vitros ECi), salivary free cortisol ― by electrochemiluminescence assay (Cobas). One-way ANOVA was utilized to assess the difference between groups. Results: We enrolled 88 subjects: 30 patients suffered from CS (group 1), 28 ― acromegaly (2) and 30 matched healthy controls (3) with no difference among the groups in sex, age and BMI (p=0.492, 0.062 and 0.174 respectively). Mean 24hUFC in subjects with CS and mean IGF1 in subjects with acromegaly were significantly higher as compared to other groups (p0.001). Right-hand grip strength was lower in patients with CS as compared to both patients with acromegaly and healthy subjects (p=0.04). However, among these young adults we did not find statistically significant differences in measured myokines levels: irisin ― p=0.15; IL6 ― p=0.34; myostatin ― p=0.50. There was a significant correlation between myostatin and irisin in the whole group of people and in every separately analyzed subset of patients (p0.001), but no correlation was found between any measured myokines and 24hUFC or IGF1.Conclusions: Hypercortisolism or supraphysiological IGF1 levels do not significantly influence serum levels of myostatin, IL6 and irisin in young adults.

scholarly journals Effect of forward head and rounded shoulder posture on hand grip strength in asymptomatic young adults: a cross-sectional study

2020 ◽  
Vol 25 (1) ◽  
Author(s):  
Dalia Mohammed Mosaad ◽  
Amr Almaz Abdel-aziem ◽  
Ghada Ismail Mohamed ◽  
Enas Anwr Abd-Elaty ◽  
Karima Salah Mohammed
Keyword(s):  
Young Adults ◽  
Grip Strength ◽  
Cross Sectional Study ◽  
Hand Grip Strength ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hand Grip

scholarly journals Association of Water Intake with Hand Grip Strength in Community-Dwelling Older Adults

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1756
Author(s):  
Hyeonmok Kim ◽  
Sun Hee Beom ◽  
Tae Ho Kim ◽  
Beom-Jun Kim
Keyword(s):  
Older Adults ◽  
Muscle Strength ◽  
Grip Strength ◽  
Water Intake ◽  
Population Based ◽  
Hand Grip Strength ◽  
Community Dwelling ◽  
Cross Sectional ◽  
Hand Grip ◽  
The Difference

Although recent clinical studies have suggested that water intake enhances muscle mass, its impact on muscle strength remain unclear, especially in older adults. This cross-sectional, population-based study using a representative sample of Koreans investigated the relationship of water intake with hand grip strength (HGS) in 4443 older adults, including 2090 men aged ≥50 years and 2253 postmenopausal women. A digital grip strength dynamometer was used for HGS assessment. Low muscle strength was defined by the Korean-specific HGS cut-off value and adequate water intake was defined according to the Korean dietary reference intakes. In an unadjusted model, water intake was significantly higher in men and women without than with low muscle strength (both p < 0.001), but this difference disappeared after adjustment for confounding variables in both men (p = 0.050) and women (p = 0.245). Similarly, the correlation between water intake and HGS, the difference in HGS depending on adequate water intake status, and the risk of low muscle strength depending on water intake quartile were significant only in the unadjusted model. These data indicate that factors such as age, body size, and resistance exercise contribute to improvements in HGS in older adults, whereas water intake may not.

scholarly journals Effects of Head-Neck Positions on the Hand Grip Strength in Healthy Young Adults: A Cross-Sectional Study

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Hamayun Zafar ◽  
Ahmad Alghadir ◽  
Shahnawaz Anwer
Keyword(s):  
Young Adults ◽  
Grip Strength ◽  
Cross Sectional Study ◽  
Hand Grip Strength ◽  
Neutral Position ◽  
Cross Sectional ◽  
Hand Grip ◽  
Significant Difference ◽  
Left And Right ◽  
Head Neck

Background.Assessment of hand grip strength is vital for the evaluation of upper limb impairments and effective exercise prescription. Present study primarily aimed to investigate the effect of head-neck positions on the hand grip strength in healthy young adults. Secondarily, the present study compared hand grip strength between left versus right hand in different head-neck positions.Methods.Healthy young adults (age 19 – 30 year; n = 40) participated in this cross-sectional study. Hand grip strength was assessed in three head-neck positions (neutral, rotation left, and rotation right) using the standard adjustable Jamar hand dynamometer.Results. Hand grip strength in both sides (left and right) was greatest in the head-neck neutral position. Hand grip strength measured in head-neck left rotation position displayed the least strength in both sides. There was no significant difference noted between left and right side hand grip strength measured in head-neck neutral and right rotation positions. However, there was a significant difference noted between left and right side hand grip strength measured in head-neck left rotation positions. There was no significant effect of head-neck positions on hand grip strength noted in both sides.Conclusions. Hand grip strength was highest in the head-neck neutral position followed by head-neck rotation to the right. However, head-neck positions did not significantly affect hand grip strength in healthy young adults. Further studies assessing the hand grip strength in different neck positions in patients with neck pain and upper limb dysfunction may have significant implications for the assessment of hand grip strength.

scholarly journals INVESTIGATION ON YOUNG ADULT HAND GRIP STRENGTH

2020 ◽  
Vol 20 (Special1) ◽  
pp. 45-50
Author(s):  
Nor Julahah J ◽  
Ummi Noor Nazahiah A ◽  
M. Asyraf CD ◽  
Norashiken O ◽  
Ahmad Faizal Salleh
Keyword(s):  
Young Adults ◽  
Young Adult ◽  
Grip Strength ◽  
Hand Grip Strength ◽  
Whole Body ◽  
Sitting Position ◽  
Adult Males ◽  
Hand Grip ◽  
The Difference ◽  
Hand Length

It is believed that exposure to whole-body vibration (WBV) may increase seated occupant drowsiness and seated. The purpose of this paper is to investigate the strength of the hand grip among the young adults in Malaysia. Also, to examine the correlation between anthropometry factors such as hand length (HL), hand breadth (HB), wrist circumference (WC) and body mass index (BMI) with average full hand grip strength of young adults. 40 Malaysian young adults with equal females and males and the range age of 23 to 28 years old voluntarily basis participated in this study. Three experiments were conducted in sitting position according to American Standard Hand Therapist (ASHT) with 45º, 90o and 135o of hand flexion using dynamometer. The results show the significant different full hand grip strength between Malaysian young adult females and females, the difference full hand grip strength for different hand flexion angles in sitting position and difference correlations between anthropometry factors and full hand grip strength for both young adult males and females.

Serum otolin-1 as a biomarker for benign paroxysmal positional vertigo: a case-control study

2021 ◽  
pp. 1-4
Author(s):  
D V K Irugu ◽  
A Singh ◽  
H Yadav ◽  
H Verma ◽  
R Kumar ◽  
...  
Keyword(s):  
Serum Level ◽  
Benign Paroxysmal Positional Vertigo ◽  
Case Control Study ◽  
Serum Levels ◽  
Case Control ◽  
Control Group ◽  
Positional Vertigo ◽  
The Difference ◽  
Control Study ◽  
Paroxysmal Positional Vertigo

Abstract Objectives This study aimed to evaluate serum otolin-1 levels in patients with benign paroxysmal positional vertigo and to compare these levels with healthy individuals. Method This was a case-control study. After obtaining institutional ethical committee clearance, the serum level of otolin-1 was calculated in adult individuals (18–75 years old) who were divided into group 1 (patients presenting with benign paroxysmal positional vertigo) and group 2 (healthy patients without benign paroxysmal positional vertigo as the control group). Data analysis was carried out to compare the serum levels in the cases and controls. A p-value less than 0.05 was considered significant. Results A total of 70 age-matched individuals (cases, n = 40; controls, n = 30) were included in the study. The mean serum level of otolin-1 was 636.8 pg/ml (range, 259–981 pg/ml) in the group of patients with benign paroxysmal positional vertigo and 236.2 pg/ml (range, 189–370 pg/ml) in the control group. The difference was statistically significant (p = 0.0000). Conclusion The serum levels of otolin-1 in patients with benign paroxysmal positional vertigo are significantly higher compared with individuals without benign paroxysmal positional vertigo.

Relationship between HOMA-IR and serum vitamin D in Chinese children and adolescents

2016 ◽  
Vol 29 (7) ◽  
Author(s):  
Lingli Wang ◽  
Huiyan Wang ◽  
Huaikai Wen ◽  
Hongqun Tao ◽  
Xiaowei Zhao
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Chinese Children ◽  
Model Assessment ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
The Difference ◽  
Chinese Children And Adolescents

AbstractThe objective of this study was to examine the cross-sectional relationship between homeostasis model assessment for insulin resistance (HOMA-IR) and serum 25-hydroxyvitamin D (25-OHD) level in Chinese children and adolescents.Anthropometric indices, lipid metabolic profile, and serum levels of glucose, insulin and 25-OHD were determined among 278 healthy prepubertal and pubertal, normal and overweight/obese children and adolescents aged 8–18 years between March 2014 and February 2015.HOMA-IR was significantly different across vitamin D statuses (p<0.001), even after adjusting for body mass index (BMI) (p=0.035) and waist-to-height ratio (p=0.044); the difference was not significant between the vitamin D deficient and insufficient groups (p=0.120). HOMA-IR negatively correlated with serum 25-OHD level for all subjects (ROur findings supported that lower vitamin D status is strongly associated with worse HOMA-IR.

scholarly journals Serum levels of allopregnanolone, progesterone and testosterone in menstrually-related and postmenopausal migraine: A cross-sectional study

Cephalalgia ◽  
2020 ◽  
Vol 40 (12) ◽  
pp. 1355-1362
Author(s):  
Cecilia Rustichelli ◽  
Elisa Bellei ◽  
Stefania Bergamini ◽  
Emanuela Monari ◽  
Carlo Baraldi ◽  
...  
Keyword(s):  
Linear Regression Analysis ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Serum Samples ◽  
Cross Sectional ◽  
Menstrually Related Migraine ◽  
Headache Centre ◽  
Post Menopause ◽  
Novel Strategy ◽  
Post Hoc

Background Reduced blood or cerebrospinal fluid levels of allopregnanolone are involved in menstrual cycle-linked CNS disorders, such as catamenial epilepsy. This condition, like menstrually-related migraine, is characterized by severe, treatment-resistant attacks. We explored whether there were differences in allopregnanolone, progesterone and testosterone serum levels between women with menstrually-related migraine (MM, n = 30) or postmenopausal migraine without aura who had suffered from menstrually-related migraine during their fertile age (PM, n = 30) and non-headache control women in fertile age (FAC, n = 30) or post-menopause (PC, n = 30). Methods Participants were women with migraine afferent to a headache centre; controls were female patients’ acquaintances. Serum samples obtained were analyzed by HPLC-ESI-MS/MS. Results In menstrually-related migraine and postmenopausal migraine groups, allopregnanolone levels were lower than in the respective control groups (fertile age and post-menopause) ( p < 0.001, one-way analysis of variance followed by Tukey-Kramer post-hoc comparison test) while progesterone and testosterone levels were similar. By grouping together patients with migraine, allopregnanolone levels were inversely correlated with the number of years and days of migraine/3 months ( p ≤ 0.005, linear regression analysis). Conclusion Decreased GABAergic inhibition, due to low allopregnanolone serum levels, could contribute to menstrually-related migraine and persistence of migraine after menopause. For the management of these disorders, a rise in the GABAergic transmission by increasing inhibitory neurosteroids might represent a novel strategy.

scholarly journals Grip strength among Indigenous and non-Indigenous Australian adults: a longitudinal study of the effects of birth size and current size

BMJ Open ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. e024749
Author(s):  
Timothy Howarth ◽  
Belinda Davison ◽  
Gurmeet Singh
Keyword(s):  
Young Adults ◽  
Grip Strength ◽  
Lean Mass ◽  
Low Birthweight ◽  
Indigenous Australians ◽  
Birth Size ◽  
Indigenous Australian ◽  
Cross Sectional ◽  
Increased Risk ◽  
Lower Grip

ObjectivesIndigenous Australians are born smaller than non-Indigenous Australians and are at an increased risk of early onset of frailty. This study aimed to identify the relationship between birth size, current size and grip strength, as an early marker of frailty, in Indigenous and non-Indigenous young adults.DesignCross sectional data from two longitudinal studies: Aboriginal birth cohort (Indigenous) and top end cohort (non-Indigenous).SettingParticipants reside in over 40 urban and remote communities across the Northern Territory, Australia.ParticipantsYoung adults with median age 25 years (IQR 24–26); 427 participants (55% women), 267 (63%) were remote Indigenous, 55 (13%) urban Indigenous and 105 (25%) urban non-Indigenous.Outcome measuresReliable birth data were available. Anthropometric data (height, weight, lean mass) and grip strength were directly collected using standardised methods. Current residence was classified as urban or remote.ResultsThe rate of low birthweight (LBW) in the non-Indigenous cohort (9%) was significantly lower than the Indigenous cohort (16%) (−7%, 95% CI −14 to 0, p=0.03). Indigenous participants had lower grip strength than non-Indigenous (women, −2.08, 95% CI −3.61 to –0.55, p=0.008 and men, −6.2, 95% CI −9.84 to –2.46, p=0.001). Birth weight (BW) was associated with grip strength after adjusting for demographic factors for both women (β=1.29, 95% CI 0.41 to 2.16, p=0.004) and men (β=3.95, 95% CI 2.38 to 5.51, p<0.001). When current size (lean mass and body mass index [BMI]) was introduced to the model BW was no longer a significant factor. Lean mass was a positive indicator for grip strength, and BMI a negative indicator.ConclusionsAs expected women had significantly lower grip strength than men. Current size, in particular lean mass, was the strongest predictor of adult grip strength in this cohort. BW may have an indirect effect on later grip strength via moderation of lean mass development, especially through adolescence and young adulthood.

Most Comfortable Listening Levels, Background Noise Levels, and Acceptable Noise Levels for Children and Adults with Normal Hearing

2011 ◽  
Vol 22 (05) ◽  
pp. 286-293 ◽  
Author(s):  
Robert Moore ◽  
Susan Gordon-Hickey ◽  
Alisha Jones
Keyword(s):  
Young Adults ◽  
Noise Level ◽  
Background Noise ◽  
Developmental Change ◽  
Pediatric Population ◽  
Strong Predictor ◽  
Normal Hearing ◽  
Noise Levels ◽  
Cross Sectional ◽  
The Difference

Background: For adults the acceptable noise level (ANL) has been shown to be a strong predictor of hearing aid success. ANL is calculated as the difference between most comfortable listening level (MCL) and background noise level (BNL). No studies have made direct comparisons of these measures between adults and children. Purpose: To evaluate and compare MCLs, BNLs, and ANLs in children and young adults. Research Design: A cross-sectional design was used in this study. Two groups (children and adults) were tested for each dependent variable. MCLs and BNLs were measured for each participant, and ANLs were computed from these two measurements. Study Sample: The participants were 34 children (8–10 yr) and 34 young adults (19–29 yr) with normal hearing. Results: Significant main effects were found for MCLs and BNLs. There was no main effect for ANLs. MCLs and BNLs were significantly lower for the children than for the adults. Conclusions: These results suggest that while ANLs are unchanged from childhood to adulthood, there appears to be a developmental change in MCLs and BNLs. These findings have implications for the use of ANLs in the pediatric population.

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