scholarly journals Towards the creation of a unified glossary of Russian biobanks

2020 ◽  
Vol 19 (6) ◽  
pp. 2710
Author(s):  
A. A. Mikhailova ◽  
Yu. A. Nasykhova ◽  
A. I. Muravyov ◽  
A. Yu. Efimenko ◽  
A. S. Glotov
Keyword(s):  
Clinical Trials ◽  
Personalized Medicine ◽  
Biological Samples ◽  
National Association ◽  
Research Projects ◽  
High Quality ◽  
Wide Range ◽  
Biomedical Technologies ◽  
The Creation

To carry out research projects, clinical trials and other studies in the field of personalized medicine, it is necessary to have collections of high-quality biological samples of various types. With the development of biomedical technologies, the need for large collections of biological samples will grow every year, which necessitates the creation of various biobanks for standardized collection, storage and distribution of such samples. One of the goals of the National Association of Biobanks and Biobanking Specialists is the development of a network of Russian biobanks interacting with each other at various levels, as well as the development and implementation of organizational and legal tools for its regulation. It is required not only to standardize the access and exchange of biological samples and data, but also to create a unified terminology that will be used by biobanks throughout Russia. The main aim is to create an accurate, professional and legally correct tool containing information accessible and understandable to a wide range of researchers.

scholarly journals Vino, turismo e innovación: las Rutas del Vino de España, una estrategia integrada de desarrollo rural

2020 ◽  
Vol 29 (1) ◽  
pp. 129
Author(s):  
Belén Miranda Escolar ◽  
Ricardo Fernández Morueco
Keyword(s):  
High Quality ◽  
Complementary Products ◽  
Agricultural Economy ◽  
Wine Tourism ◽  
Tourism Product ◽  
Wide Range ◽  
The World ◽  
The Creation ◽  
Globalized World

The importance of the vineyard in the agricultural economy throughout history is unquestionable. The quest for quality wines in a market increasingly competitive and globalized world is a goal of all wine regions in the world. In this context, the effort to innovate and to  provide consumers more diversified  and complementary products to the wine itself has led to the creation of a wide range of wine tourism, articulated on many occasions about the so-called wine routes. With the aim to guarantee the visitor a  high quality tourism product, it has created the product Wine Routes of Spain, based on  the  idea that wine can be defined as a “territorial intensive product” (TIP) since it contains a strong reference in the territory in which it is produced.

scholarly journals Towards Continuous Quality Control for Spoken Language Corpora

2020 ◽  
Vol 15 (1) ◽  
pp. 13
Author(s):  
Anne Ferger ◽  
Hanna Hedeland
Keyword(s):  
Quality Control ◽  
Cultural Heritage ◽  
Systematic Approach ◽  
Spoken Language ◽  
Intangible Cultural Heritage ◽  
Research Projects ◽  
High Quality ◽  
Linguistic Resources ◽  
Continuous Quality ◽  
The Creation

This paper describes the development of a systematic approach to the creation, management and curation of linguistic resources, particularly spoken language corpora. It also presents first steps towards a framework for continuous quality control to be used within external research projects by non-technical users, and discuss various domain and discipline specific problems and individual solutions. The creation of spoken language corpora is not only a time-consuming and costly process, but the created resources often represent intangible cultural heritage, containing recordings of, for example, extinct languages or historical events. Since high quality resources are needed to enable re-use in as many future contexts as possible, researchers need to be provided with the necessary means for quality control. We believe that this includes methods and tools adapted to Humanities researchers as non-technical users, and that these methods and tools need to be developed to support existing tasks and goals of research projects.

scholarly journals Biobanking in oncology and radiology

2018 ◽  
Vol 11 (4) ◽  
pp. 170-177 ◽  
Author(s):  
Pavel O. Roumiantsev ◽  
Ali M. Mudunov
Keyword(s):  
Personalized Medicine ◽  
Biological Samples ◽  
Evidence Based ◽  
Thyroid Tumors ◽  
International Evidence ◽  
Information Logistics ◽  
Wide Range ◽  
The World ◽  
Methodological Guidelines

The first biobank in Russia was created in 1998 to investigate post-Chernobyl thyroid tumors. The number of biobanks in the world is growing. Infrastructure and collaboration are improving. Ethical, legal and methodological guidelines for biobanking have been developed and are regularly reviewed. Biobanking objects are now not only biological samples of patients but also their dynamic biomedical characteristics. Comparison of genetics, proteome and tumour metabolism and in vivo radiological visualization is necessary to improve personalized diagnostics, treatment and its effectiveness. The article focuses on international evidence-based experience of sample preparation and cryopreservation of biological samples, information logistics, and integration solutions in biobanking. Guiding principles and the model of a modern biobank, integrating up-to-date technologies of digital personalized medicine and telemedicine in oncology and radiology are reported. The article may be of interest to a wide range of experts in biomedicine, especially oncologists, radiologists, pathologists, geneticists, and IT specialists.

Unexpectedness

2019 ◽  
Vol 6 (1) ◽  
Author(s):  
John-Carlos Perea ◽  
Jacob E. Perea
Keyword(s):  
American Indian ◽  
San Francisco ◽  
Interdisciplinary Research ◽  
Ethnic Studies ◽  
College Of Education ◽  
Present Moment ◽  
State University ◽  
Research Projects ◽  
Short Survey ◽  
Wide Range

The concepts of expectation, anomaly, and unexpectedness that Philip J. Deloria developed in Indians in Unexpected Places (2004) have shaped a wide range of interdisciplinary research projects. In the process, those terms have changed the ways it is possible to think about American Indian representation, cosmopolitanism, and agency. This article revisits my own work in this area and provides a short survey of related scholarship in order to reassess the concept of unexpectedness in the present moment and to consider the ways my deployment of it might change in order to better meet the needs of my students. To begin a process of engaging intergenerational perspectives on this subject, the article concludes with an interview with Dr. Jacob E. Perea, dean emeritus of the Graduate College of Education at San Francisco State University and a veteran of the 1969 student strikes that founded the College of Ethnic Studies at San Francisco State University.

AMPCOLOY 570

Alloy Digest ◽  
1980 ◽  
Vol 29 (3) ◽  
Keyword(s):  
Corrosion Resistance ◽  
Cast Iron ◽  
Iron Alloy ◽  
Heat Treating ◽  
Nickel Aluminum ◽  
High Quality ◽  
Glass Making ◽  
Temperature Performance ◽  
Wide Range ◽  
Cobalt Iron

Abstract AMPCOLOY 570 is a cast copper-nickel-aluminum-cobalt-iron alloy specially developed for applications involving severe stresses and high temperatures, such as glass-making molds and plate-glass rolls. It is significantly superior to cast iron which has been commonly used for glass-making molds. Good foundry techniques will yield high-quality castings of Ampcoloy 570 in a wide range of section sizes. This datasheet provides information on composition, physical properties, hardness, elasticity, and tensile properties. It also includes information on high temperature performance and corrosion resistance as well as casting, heat treating, machining, and joining. Filing Code: Cu-392. Producer or source: Ampco Metal Inc..

Modern prevention and active longevity programs on the basis of disruptive domestic technologies: positive experience and prospects for application

2020 ◽  
pp. 66-73
Author(s):  
A. Simonova ◽  
S. Chudakov ◽  
R. Gorenkov ◽  
V. Egorov ◽  
A. Gostry ◽  
...  
Keyword(s):  
Personalized Medicine ◽  
Early Detection ◽  
Laboratory Diagnostics ◽  
Positive Experience ◽  
Practical Application ◽  
Wide Range ◽  
Integrated Program ◽  
Long Term Experience ◽  
Early Detection And Prevention

The article summarizes the long-term experience of practical application of domestic breakthrough technologies of preventive personalized medicine for laboratory diagnostics of a wide range of socially significant non-infectious diseases. Conceptual approaches to the formation of an integrated program for early detection and prevention of civilization diseases based on these technologies are given. A vision of the prospects for the development of this area in domestic and foreign medicine has been formed.

Prerequisites to support high-quality clinical trials in children and young people

2020 ◽  
pp. archdischild-2019-318677
Author(s):  
Steven Hirschfeld ◽  
Florian B Lagler ◽  
Jenny M Kindblom
Keyword(s):  
Clinical Trials ◽  
Healthcare Delivery ◽  
Paediatric Population ◽  
Ecosystem Functions ◽  
Healthcare Delivery System ◽  
High Quality ◽  
Children And Young People ◽  
The Right ◽  
Support Decision Making

Children have the right to treatment based on the same quality of information that guides treatment in adults. Without the proper evaluation of medicinal products and devices in paediatric clinical trials that are designed to meet the rigorous standards of the competent authorities, children are discriminated from advances in medicine. There are regulatory, scientific and ethical incentives to address the knowledge gap regarding efficacy and safety of medicines in the paediatric population. High-quality clinical trials involving children of all ages can generate data that will ultimately close the knowledge gaps and support decision making.For clinical trials that enrol children, the needs are specialised and often resource intensive. Prerequisites for successful paediatric clinical trials are personnel with training in both paediatrics and neonatology and expertise in clinical trials in these populations. Moreover, national and international networks for efficient collaboration, dissemination of information, and sharing of resources and expertise are also needed, together with competent, efficient and high-quality local infrastructure with effective processes. Monitoring and oversight bodies with the relevant competence, including expertise in paediatrics, is also an important prerequisite for paediatric clinical trials. Compromise in any of these components will compromise the downstream results.This paper discusses the structures and competences needed in order to perform effective, high-quality paediatric clinical trials with the ultimate goal of better medicines and treatments for children. We propose a model of examining the process as a series of components that each has to be optimised, then all the components are actively optimised to function together as an ecosystem, and the resulting ecosystem functions well with the general research system and the healthcare delivery system.

scholarly journals In silico imaging clinical trials: cheaper, faster, better, safer, and more scalable

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Aldo Badano
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Medical Devices ◽  
In Silico ◽  
Lessons Learned ◽  
Patient Access ◽  
High Quality ◽  
Virtual Imaging ◽  
Regulatory Evaluation

AbstractImaging clinical trials can be burdensome and often delay patient access to novel, high-quality medical devices. Tools for in silico imaging trials have significantly improved in sophistication and availability. Here, I describe some of the principal advantages of in silico imaging trials and enumerate five lessons learned during the design and execution of the first all-in silico virtual imaging clinical trial for regulatory evaluation (the VICTRE study).

scholarly journals What Is New in the Treatment of Smoldering Multiple Myeloma?

2021 ◽  
Vol 10 (3) ◽  
pp. 421
Author(s):  
Niccolo’ Bolli ◽  
Nicola Sgherza ◽  
Paola Curci ◽  
Rita Rizzi ◽  
Vanda Strafella ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Clinical Trials ◽  
High Risk ◽  
Early Treatment ◽  
Individual Case ◽  
Symptomatic Disease ◽  
Plasma Cell Neoplasm ◽  
Smoldering Multiple Myeloma ◽  
Wide Range ◽  
Critical Issues

Smoldering multiple myeloma (SMM), an asymptomatic plasma cell neoplasm, is currently diagnosed according to the updated IMWG criteria, which reflect an intermediate tumor mass between monoclonal gammopathy of undetermined significance (MGUS) and active MM. However, SMM is a heterogeneous entity and individual case may go from an “MGUS-like” behavior to “early MM” with rapid transformation into symptomatic disease. This wide range of clinical outcomes poses challenges for prognostication and management of individual patients. However, initial studies showed a benefit in terms of progression or even survival for early treatment of high-risk SMM patients. While outside of clinical trials the conventional approach to SMM generally remains that of close observation, these studies raised the question of whether early treatment should be offered in high-risk patients, prompting evaluation of several different therapeutic approaches with different goals. While delay of progression to MM with a non-toxic treatment is clearly achievable by early treatment, a convincing survival benefit still needs to be proven by independent studies. Furthermore, if SMM is to be considered less biologically complex than MM, early treatment may offer the chance of cure that is currently not within reach of any active MM treatment. In this paper, we present updated results of completed or ongoing clinical trials in SMM treatment, highlighting areas of uncertainty and critical issues that will need to be addressed in the near future before the “watch and wait” paradigm in SMM is abandoned in favor of early treatment.

scholarly journals Measurement properties of patient-reported outcome measures (PROMs) in hyperhidrosis: a systematic review

2021 ◽  
Author(s):  
Michaela Gabes ◽  
Helge Knüttel ◽  
Gesina Kann ◽  
Christina Tischer ◽  
Christian J. Apfelbacher
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Measurement Properties ◽  
High Quality ◽  
High Quality Evidence ◽  
Patient Reported ◽  
Quality Evidence

Abstract Purpose To critically appraise, compare and summarize the quality of all existing PROMs that have been validated in hyperhidrosis to at least some extend by applying the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology. Thereby, we aim to give a recommendation for the use of PROMs in future clinical trials in hyperhidrosis. Methods We considered studies evaluating, describing or comparing measurement properties of PROMs as eligible. A systematic literature search in three big databases (MEDLINE, EMBASE and Web of Science) was performed. We assessed the methodological quality of each included study using the COSMIN Risk of Bias checklist. Furthermore, we applied predefined quality criteria for good measurement properties and finally, graded the quality of the evidence. Results Twenty-four articles reporting on 13 patient-reported outcome measures were included. Three instruments can be further recommended for use. They showed evidence for sufficient content validity and moderate- to high-quality evidence for sufficient internal consistency. The methodological assessment showed existing evidence gaps for eight other PROMs, which therefore require further validation studies to make an adequate decision on their recommendation. The Hyperhidrosis Disease Severity Measure-Axillary (HDSM-Ax) and the short-form health survey with 36 items (SF-36) were the only questionnaires not recommended for use in patients with hyperhidrosis due to moderate- to high-quality evidence for insufficient measurement properties. Conclusion Three PROMs, the Hyperhidrosis Quality of Life Index (HidroQoL), the Hyperhidrosis Questionnaire (HQ) and the Sweating Cognitions Inventory (SCI), can be recommended for use in future clinical trials in hyperhidrosis. Results obtained with these three instruments can be seen as trustworthy. Nevertheless, further validation of all three PROMs is desirable. Systematic review registration PROSPERO CRD42020170247

Sign in / Sign up

Export Citation Format

Share Document