scholarly journals Effects of health education in the elderly with mild cognitive impairment

2018 ◽  
Vol 71 (suppl 2) ◽  
pp. 801-810 ◽  
Author(s):  
Francine Golghetto Casemiro ◽  
Diana Monteiro Quirino ◽  
Maria Angélica Andreotti Diniz ◽  
Rosalina Aparecida Partezani Rodrigues ◽  
Sofia Cristina Iost Pavarini ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Health Education ◽  
The Elderly ◽  
Anxiety Symptoms ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Cognitive State ◽  
Paired Samples ◽  
Education Group

ABSTRACT Objective: to analyze the effects of health education on both cognition and depressive/anxiety symptoms in the elderly with Mild Cognitive Impairment (MCI). Method: this is a randomized and controlled clinical trial. Participants (n=22) were recruited from a specialized outpatient clinic, and assigned into two groups: a Health Education Group (HEG) (n=10) and a Control Group (CG) (n=12). The participants were evaluated before and after the intervention, which was composed of classes and dynamics. The intervention consisted of 20 meetings, over a period of five months. The assessment was performed by means of the Addenbrooke’s Cognitive Examination – Revised (ACER), the Mini-Mental State Examination to access participant’s cognitive state, and the Beck’s Scale to access depressive/anxiety symptoms. A Memory Complaints Scale (EQM) was also used. The analysis was carried out using the Student’s t test for paired samples. Results: the HEG group demonstrated an improvement in attention/orientation (p= 0,026), memory (p=0.001), language (p= 0.033), and ACE-R (p= 0.003). On the other hand, the CG did not present improvement. Conclusion: the results highlight the importance of non-pharmacological interventions in older adults with MCI to reduce cognitive deficits.

scholarly journals Blueberry Extracts Supplementation Improves Cognitive Function in Elderly Patients with Mild Cognitive Impairment (P14-013-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Yugang Jiang ◽  
Shoudan Sun
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
Elderly Patients ◽  
Natural Science ◽  
Intervention Study ◽  
The Elderly ◽  
The State ◽  
Control Group ◽  
Cognitive Aptitude

Abstract Objectives An intervention study was performed to determine if supplement containing blueberry extracts could improve cognitive function in the elderly patients with mild cognitive impairment (MCI). Methods Forty six MCI patients participated in the intervention study were paired based on their age, education level and initial the basic cognitive aptitude test (BCAT) scores and then randomly assigned to the intervention group (n = 23, which received 1.0 g/day of blueberry extracts) or blank control group (n = 23) . The endpoint was the improvement in cognitive function as evaluated by BCATs. All parameters were measured before and after the treatment period of 12 weeks. Results After 12 weeks of intervention, we observed significant improvement in their total BCAT score, space imagery efficiency, working memory and recognition memory of subjects in patients with blueberry extracts supplementation comparing to those in the control group (P = 0.006, 0.023, 0.000, 0.005, respectively). However the levels of inflammatory factors (IL-6 and TNF-α in serum) showed no significant changes after intervention. Conclusions The data indicated that blueberry has a beneficial effect on cognitive function of the elderly MCI patients, which might provide therapeutic potential for Alzheimer's disease. Funding Sources This work was supported by the State Key Program of National Natural Science Foundation of China and the State Key Program of National Natural Science Foundation of Tianjin. Supporting Tables, Images and/or Graphs

scholarly journals Combining functional scales and cognitive tests in screening for mild cognitive impairment at a university-based memory clinic in Brazil

2008 ◽  
Vol 30 (4) ◽  
pp. 346-349 ◽  
Author(s):  
Izabella Dutra de Abreu ◽  
Paula Villela Nunes ◽  
Breno Satler Diniz ◽  
Orestes Vicente Forlenza
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Diagnostic Accuracy ◽  
Cognitive Decline ◽  
Mental State ◽  
Mini Mental State Examination ◽  
The Elderly ◽  
Elderly Subjects ◽  
Cognitive State ◽  
State Examination

OBJECTIVE: To determine the diagnostic accuracy of the Mini-Mental State Examination combined to the Informant Questionnaire on Cognitive Decline in the Elderly for the identification of mild cognitive impairment. METHOD: 191 elderly subjects were assessed with the Mini-Mental State Examination, and their informants were assessed with the Informant Questionnaire on Cognitive Decline in the Elderly. Subjects were divided into three groups according to their cognitive state (controls: n = 67, mild cognitive impairment: n = 65 and dementia: n = 59), which was ascertained by clinical and neuropsychological evaluation. The diagnostic accuracy of each test in the discrimination of diagnostic groups (mild cognitive impairment vs. controls, mild cognitive impairment vs. dementia and dementia vs. controls) was examined with the aid of ROC curves. We additionally verified if the combination of both tests would increase diagnostic accuracy for mild cognitive impairment and control identification. RESULTS: The combination of the Mini-Mental State Examination and the Informant Questionnaire on Cognitive Decline in the Elderly scores did not increase the Mini-Mental State Examination diagnostic accuracy in the identification of patients with mild cognitive impairment. CONCLUSIONS: The present data do not warrant the combination of the Mini-Mental State Examination and the Informant Questionnaire on Cognitive Decline in the Elderly as a sufficient diagnostic tool in the diagnostic screening for mild cognitive impairment.

scholarly journals Study on Adjuvant Medication for Patients with Mild Cognitive Impairment Based on VR Technology and Health Education

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Huiling Liu ◽  
Xiaona Yang ◽  
Xinkun Wang ◽  
Xiaoyu Yang ◽  
Xusheng Zhang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
Health Education ◽  
Lung Function ◽  
Walking Distance ◽  
Control Group ◽  
Study Group ◽  
Rehabilitation Training ◽  
Moca Score

In order to improve the efficiency of auxiliary medication for patients with mild cognitive impairment, this paper proposes a method based on VR technology and health education. Sixty elderly patients with COPD and MCI admitted to a hospital from January 2019 to February 2020 were randomly divided into a control group and study group, with 50 cases in each group. On the basis of conventional drug therapy, health education, and respiratory muscle training, patients in the control group received routine lung rehabilitation training, while patients in the study group received lung rehabilitation training using the BioMaster virtual scene interactive rehabilitation training system. Both groups continued training for 12 weeks. Lung function indexes, 6-minute walking distance, COPD assessment test (CAT) score, and Montreal Cognitive Function Assessment Scale (MoCA) score were compared between the 2 groups before training and 4, 8, and 12 weeks after training. The experimental results show that, in the study group, the percentage of FEV1 in the predicted value at 8 weeks after training, the percentage of FEV1 in the predicted value at 12 weeks after training, and FEV1/FVC were higher than those in the control group ( P < 0.05 ). There was no significant difference in 6-minute walking distance, CAT score, and MoCA score between the two groups before training ( P > 0.05 ). Twelve weeks after training, patients in the study group had a longer 6-minute walking distance, a lower CAT score, and a higher MoCA score than those in the control group ( P < 0.05 ). It is proved that the application of virtual reality technology in lung rehabilitation training of elderly COPD patients with MCI is effective, which can effectively improve the lung function, cognitive function, and exercise tolerance of the patients and reduce the symptoms of dyspnea and the efficiency of medication.

scholarly journals Effect and Neuroimaging Mechanism of Electroacupuncture for Vascular Cognitive Impairment No Dementia: Study Protocol for a Randomized, Assessor-Blind, Controlled Clinical Trial

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Ruizhu Lin ◽  
Jia Huang ◽  
Jianfeng Xu ◽  
Jing Tao ◽  
Ying Xu ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Cognitive Impairment ◽  
Health Education ◽  
Controlled Trial ◽  
Verbal Learning ◽  
Vascular Cognitive Impairment ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Basic Treatment ◽  
Cognitive Impairment No Dementia

Vascular cognitive impairment no dementia (VCIND) is likely to develop into vascular dementia (VD) without intervention. The clinical efficacy of electroacupuncture (EA) for VCIND has been previously demonstrated. However, the neuroimaging mechanism of EA for VCIND has not been elucidated clearly. This trial is designed to provide solid evidence for the efficacy and neuroimaging mechanism of EA treatment for patients with VCIND. This ongoing study is an assessor-blind, parallel-group, randomized controlled trial. 140 eligible subjects will be recruited from the General Hospital of Ningxia Medical University and randomized into either the electroacupuncture (EA) group or the control group (CG). All subjects will receive basic treatment, and participants in the CG will receive health education performed weekly. Except for basic treatment and health education, participants in the EA group will receive treatment 5 times per week for a total of 40 sessions over 8 weeks. The primary outcome in this study is Montreal Cognitive Assessment (MoCA), and the secondary outcomes are Auditory Verbal Learning Test (AVLT), Stroop color-naming condition (STROOP), Rey–Osterrieth Complex Graphics Testing, and resting-state functional magnetic resonance imaging (rs-fMRI). All of the outcome measures will be assessed at baseline and 8 weeks of intervention. The medical abstraction of adverse events will be done at each visit. The results of this trial will demonstrate the efficacy and neuroimaging mechanism of EA treatment for VCIND, thus supporting EA treatment as an ideal choice for VCIND treatment. The trial was registered at the Chinese Clinical Trial Registry on 28 July 2018 (ChiCTR1800017398).

scholarly journals Bacterial rhamnolipids (RLs) in saliva of Alzheimer's disease and Mild Cognitive Impairment patients and correlation with neuroinflammation and cognitive state

2021 ◽  
Vol 06 (03) ◽  
pp. 209-219
Author(s):  
Eleni G. Andreadou ◽  
Georgios Katsipis ◽  
Magda Tsolaki ◽  
Anastasia A. Pantazaki
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Mental State ◽  
Biological Fluids ◽  
Pilot Trial ◽  
Control Group ◽  
Cognitive State ◽  
Cox 2

Alzheimer’s disease (AD) is increasingly affecting the aging population and the estimated prevalence reaches 50 million people worldwide. The need for the discovery of new biomarkers for AD diagnosis is urgent and especially in biological fluids other than cerebrospinal fluid (CSF), as its collection is invasive. Arguments are numerous that chronic bacterial infections might be considered as one of the possible causes of AD. Rhamnolipids (RLs) are bacterial virulence factors, suspicious for dysfunctions and disorders including AD. The aim of this pilot trial was to investigate RLs levels in saliva of Mild Cognitive Impairment (MCI) and AD patients with indirect ELISA. Specifically, salivary RLs were determined in 30 AD patients, 24 MCI patients and 15 cognitively healthy individuals and were found elevated in AD and MCI patients compared to those of the control group. The established biomarkers of AD, tau and Aβ42 amyloid, and the inflammatory markers cyclooxygenases (COX-1 and COX-2) were also determined, to evaluate their possible interdependence from RLs levels. Levels of RLs positively correlate with COX-2 levels and negatively with the mental state according to Mini–Mental State Examination (MMSE) score of donors. Multilinear regression verified the tight interrelation of RLs with COX-2 in saliva of MCI and AD patients. The results of this study stand by the hypothesis of inflammatory involvement in AD and indicate that RLs could be suggested as eventual biomarkers for AD diagnosis using saliva as biological fluid.

scholarly journals Prevalence of hearing impairment in patients with mild cognitive impairment

2007 ◽  
Vol 1 (3) ◽  
pp. 253-259 ◽  
Author(s):  
Leonardo da Costa Lopes ◽  
Regina Miksian Magaldi ◽  
Mara Edwirges Rocha Gândara ◽  
Ana Carolina de Barros Reis ◽  
Wilson Jacob-Filho
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Hearing Impairment ◽  
Hearing Threshold ◽  
The Elderly ◽  
Control Group ◽  
Contributory Factor ◽  
Clinical Dementia Rating ◽  
Mini Mental Status Examination ◽  
And Control

Abstract The correlation between hearing and cognition is well established in dementia, but not in mild cognitive impairment (MCI). Objective: The aim of the present study was to define the prevalence of hearing impairment in elderly patients with MCI and in controls. Methods: Twenty-nine patients with MCI and 24 control subjects were analyzed. We evaluated memory and hearing impairments through clinical tests, including the Mini Mental Status Examination, Clinical Dementia Rating (CDR) and Hearing Handicap Inventory for the Elderly Screening (HHIE-S). Audiometries were performed in 22 patients with MCI and 19 subjects in a control group. Results: MCI patients showed more hearing complaints (68.9%) compared to the control group (25%) (p=0.001). No differences in the intensity of hearing complaints, measured by the HHIE-S, were detected. Nonetheless, differences between mean hearing threshold (MCI group=23.4±11.3 dB and control group=16.0±10.1dB) (p=0.03) were identified. Conclusions: There is a significant association between MCI and hearing impairment. Hearing impairment in MCI patients may be a contributory factor to cognitive decline. This may however be related to the same neuropathological process, due to lesions of cortical areas related to hearing. The early diagnosis of hearing impairment in MCI patients may offer a more appropriate approach to this disease.

scholarly journals Effects of a Trans-Theoretical Model-Based Health Education Program on the Management of Cognitive Dysfunction in Older Adults With Mild Cognitive Impairment: Study Rationale and Protocol Design for a Randomized Controlled Trial

2021 ◽  
Vol 11 ◽  
Author(s):  
Xiaoshen Liu ◽  
Lina Wang ◽  
Hong Tao ◽  
Chenxi Ge ◽  
Xueting Zhen ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Health Education ◽  
Cognitive Dysfunction ◽  
Education Program ◽  
Management Strategies ◽  
Education Programs ◽  
Health Education Program ◽  
Education Group

Introduction: Recent studies have confirmed that the management of cognitive dysfunction produces considerable positive effects in individuals with mild cognitive impairment (MCI), however, compliance with participation in various cognitive dysfunction management strategies remains scant in older adults with MCI. Health education programs can improve the level of knowledge of the disease effectively, though it remains unclear as to whether health education programs are sufficient to promote behavior changes of older adults with MCI in the community.Objective: The study aims to provide insight into the effect of a trans-theoretical Model (TTM)-based health education program on increasing knowledge about mild cognitive impairment (MCI), compliance in cognitive dysfunction management, and other cognition-related health outcomes (general cognitive function, sleep quality, depression symptoms, apathy symptoms) for older adults with MCI.Methods: This study is a single-blinded, randomized, prospective clinical trial. We will recruit 132 participants with MCI who will be randomly assigned to a TTM-based health education group and a standard health education group in a ratio of 1:1. The intervention group will receive a TTM-based health education program (1 session/week, 4–560 min/session for 8 weeks), while the control group will receive standard health education. Assessors blinded to participant allocation will conduct baseline, post-intervention, and 3-month follow-up assessments. Statistical analyses will consist of the Wilcoxon test, the Chi-square test, the T-test, and 2 (group) × 3 (time) ANOVA with a 5% cut-off for significance.Discussion: Supposing the TTM-based health education program will provide validated community-based cognitive dysfunction management strategies for older adults with MCI, this would be a feasible approach to improve the compliance of participation in cognitive dysfunction management and the cognition-related health outcomes.Clinical Trial Registration: ChiCTR1900028351. Registered on December 19, 2019. http://www.chictr.org.cn/edit.aspx?pid=47223&amp;htm=4.

scholarly journals TERAPI STIMULASI KOGNITIF UNTUK LANSIA DENGAN MILD COGNITIVE IMPAIRMENT: STUDI EKSPERIMENTAL DI PANTI WREDA

2020 ◽  
Vol 36 (4) ◽  
Author(s):  
Nathalie Sanchia ◽  
Magdalena Surjaningsih Halim
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
The Elderly ◽  
Cognitive Stimulation ◽  
Control Group ◽  
Trail Making Test ◽  
Not Given ◽  
Cognitive Stimulation Therapy ◽  
Trail Making

 COGNITIVE STIMULATION THERAPY FOR ELDERLY WITH MILD COGNITIVE IMPAIRMENT: AN EXPERIMENTAL STUDY IN NURSING HOMEABSTRACTIntroduction: Mild cognitive impairment (MCI) is a transitional stage between the elderly’s normal (expected) cognitive decline and the more serious decline caused by dementia that needs interventions. One of the non-pharmacological interventions that can be done is cognitive stimulation therapy (CST). Research has shown that CST can stabilize and/ improve cognitive function in the elderly with MCI.Aims: To find out the differences in cognitive functions in the elderly with MCI and given CST intervention and elderly with MCI not given CST intervention.Methods: This was an experimental study that included elderly aged 60 years old divided into experimental and control group, each consists of four subjects. The experimental group was given CST twice a week with a total of fifteen meetings, but not on the control group. All subjects were subjected to cognitive examinations using neuropsychological instruments before, after, and one month after CST was completed. The statistical analysis performed in this study was Mann-Whitney U Test.Results: There was a significant difference in cognitive function in the attention domain with the trail making test sub-test and the memory domain with the digit pan sub-test after the CST is finished. One month after CST is completed, there were significant differences in cognitive function, in the memory domain.Discussion: The elderly group with MCI given CST has a different cognitive function than elderly group who are not given CST.Keywords: Cognitive function, elderly, mild cognitive impairment, nursing houseABSTRAKPendahuluan: Gangguan kognitif ringan atau mild cognitive impairment (MCI) merupakan proses transisi antara penurunan kognitif normal dan demensia yang perlu diintervensi. Salah satu intervensi non-farmakologis yang dapat dilakukan adalah cognitive stimulation therapy (CST). Banyak penelitian menunjukkan bahwa CST dapat menstabilkan dan/meningkatkan fungsi kognitif pada lansia dengan MCI.Tujuan: Untuk mengetahui pengaruh intervensi CST terhadap fungsi kognitif lansia dengan MCI.Metode: Studi eksperimental pada subjek lansia usia 60 tahun yang dibagi menjadi kelompok eksperimen dan kontrol yang masing-masing terdiri dari 4 subjek. Kelompok eksperimen dilakukan CST dua kali seminggu sebanyak lima belas kali pertemuan, tidak pada kelompok kontrol. Seluruh subjek dilakukan pemeriksaan kognitif dengan menggunakan instrumen neuropsikologi sebelum, sesudah, dan satu bulan setelah CST selesai. Analisis statistik menggunakan Mann- Whitney U test.Hasil: Terdapat perbedaan fungsi kognitif yang signifikan pada domain atensi dengan subtes Trail Making Test dan domain memori dengan subtes digit span setelah CST selesai. Satu bulan setelah CST selesai, terdapat perbedaan fungsi kognitif yang signifikan pada domain memori.Diskusi: Kelompok lansia dengan MCI yang diberikan CST memiliki fungsi kognitif yang berbeda dengan kelompok lansia yang tidak diberikan CST.Kata kunci: Fungsi kognitif, gangguan kognitif ringan, lansia, panti wreda  

scholarly journals Validation of the Argentine version of the Montreal Cognitive Assessment Test (MOCA): A screening tool for Mild Cognitive Impairment and Mild Dementia in Elderly

2020 ◽  
Vol 14 (2) ◽  
pp. 145-152
Author(s):  
Cecilia M. Serrano ◽  
Marcos Sorbara ◽  
Alexander Minond ◽  
John B. Finlay ◽  
Raul L. Arizaga ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Educational Level ◽  
Single Point ◽  
Normal Subjects ◽  
The Elderly ◽  
Control Group ◽  
Mild Dementia ◽  
Sensory Disturbances ◽  
Cognitively Normal Subjects

ABSTRACT. The MoCA is a brief useful test to diagnose mild cognitive impairment (MCI) and mild dementia (MD). To date, no Argentine cross-cultural adapted validations of the Spanish version have been reported. Objective: To validate the MoCA in the elderly and study its usefulness in MCI and MD. Methods: This study included 399 individuals over 60 years old evaluated in the Cognitive-Behavioral Department (2017-2018). Patients with<3 years of education, sensory disturbances, psychiatric disorders, or moderate-severe dementia were excluded. The control group comprised cognitively normal subjects. Participants were classified according to neuropsychological assessment and clinical standard criteria into Control, MCI or MD groups. A locally adapted MoCA (MOCA-A) was administered to the patients and controls. Results: Mean educational level was 10.34 years (SD 3.5 years). MoCA-A score differed significantly among groups (p<0.0001). MoCA-A performance correlated with educational level (r: 0.406 p<0.00001). Adopting a cut-off score ≥25 (YI=0.55), the sensitivity for MCI was 84.8% and for MD 100%, with specificity of 69.7%. When adding a single point to the score in patients with ≤12 years of education, the specificity of the test reached 81%. Conclusion: The MoCA-A is an accurate reliable screening test for MCI and MD in Argentina.

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