scholarly journals Occupational exposure to pesticides and hematological alterations: A survey of farm residents in the South of Brazil

2019 ◽  
Vol 24 (6) ◽  
pp. 2325-2340 ◽  
Author(s):  
Camila Piccoli ◽  
Cleber Cremonese ◽  
Rosalina Koifman ◽  
Sérgio Koifman ◽  
Carmen Freire
Keyword(s):  
Hematological Parameters ◽  
White Blood Cells ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Farm Workers ◽  
Pesticide Use ◽  
Cross Sectional ◽  
South Of Brazil ◽  
Farm Residents ◽  
Hematological Alterations

Abstract This study sought to investigate the association of exposure to organochlorine (OC) and non-persistent pesticides with hematological parameters in an agricultural population in Southern Brazil. A cross-sectional study was conducted with a random sample of 275 farm workers and their families in Farroupilha-RS. A questionnaire was used to collect information on sociodemographic and lifestyle factors, duration, frequency and type of pesticide used, among others. Blood samples were collected and analyzed for serum concentration of 24 OC pesticides and hematological parameters. Associations were explored through linear regression, controlling for confounders. Lifetime use of chemical classes other than organophosphates and dithiocarbamates were associated with decreased number of lymphocytes, while subjects sampled in the high pesticide use season showed higher number of erythrocytes and hemoglobin level. Detectable serum levels of many OC pesticides were associated with lower counts of white blood cells, particularly eosinophils. Although mostly null associations were observed between pesticide use and hematological parameters, findings may suggest that OC pesticides could lead to hematological alterations among agricultural workers.

scholarly journals The Association of N-Glycan and Alpha Fetal Protein in Hepatitis B Associated Hepatic Disease

2020 ◽  
Author(s):  
Li Guo ◽  
Lijun Wan ◽  
Youwen Hu ◽  
Bo He ◽  
Moran Zhang ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Hematological Parameters ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Hepatic Disease ◽  
Cellular Functions ◽  
Cross Sectional ◽  
Hepatic Diseases ◽  
B Virus ◽  
Serum Alpha Fetoprotein

Abstract Objective: Chronic hepatic disease caused by hepatitis B virus (HBV) is a serious threat to health in worldwide. There is evidence that the change of N-glycan is involved in the mechanism of hepatic fibrosis, liver cirrhosis (LC) and hepatocellular carcinoma (HCC) in patients with hepatitis B. The level of serum alpha-fetoprotein (AFP) is elevated in many patients with hepatitis B infection. AFP is not only a fetal carrier protein and tumor marker, but also participates in the regulation of a variety of important cellular functions, such as cell growth, differentiation, apoptosis, angiogenesis and immune regulation. However, the mechanism between AFP and N-glycan is not clear. The study investigated the association of N-glycan and AFP in Hepatitis B associated hepatic disease.Patients and Methods: Sixty patients with Hepatitis B associated hepatic diseases and twenty healthy individuals were selected in this study. Serum AFP, N-glycan, hematological parameters, and clinical data were assessed in this cohort. The Spearman rank method was used to evaluate the associations among them. The study was designed as a retrospective cross-sectional study. Results：Serum levels of N-glycan and AFP were significantly higher in Patients with hepatic disease compared with the controls; levels of both were elevated with development of the disease. In patients with hepatic disease, N-glycan was positively correlated with AFP, Age, AST, GGT, PT, CA125, while negatively correlated with ALB, CHE, RBC (P < 0.05 for all). AFP was positively correlated with HBV DNA, TBIL, DBIL, AST, ALT, ALP, GGT (P < 0.05 for all), while negatively correlated with ALB and CHE in hepatic disease patients (P < 0.05 for both). In addition, there was a trend of increasing N-glycan with elevated AFP level in the combined hepatic disease group. In LC, the level of N-glycan in the decompensatory was significant higher than in the control (P = 0.007), and AFP level in the compensatory increased than the controls (P = 0.003). In HCC, levels of both N-glycan and AFP in the compensatory and decompensatory groups elevated than those in the control (P < 0.001 and P = 0.004 for N-glycan and P < 0.001 for both in AFP, respectively).Conclusion: Our data suggest that high AFP levels in Hepatitis B related hepatic disease are closely related to the development of liver disease through interaction with N-glycan.

scholarly journals Evaluation of C-reactive protein and hematological parameters in smokeless tobacco users: A comparative cross-sectional study

2021 ◽  
Vol 37 (4) ◽  
Author(s):  
Sikander Munir Memon ◽  
Naresh Kumar ◽  
Aneela Atta Ur Rahman ◽  
Binafsha Manzoor Syed
Keyword(s):  
Smokeless Tobacco ◽  
Hematological Parameters ◽  
White Blood Cells ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Long Term Effects ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Significant Difference

Objective: To investigate the changes in levels of C-reactive protein (CRP) and hematological parameters among smokeless tobacco (SLT) users. Methods: A comparative cross-sectional study was conducted at the community level in the coastal districts of Sindh province namely Badin, Thatta, and Sujawal from January 2017 to December 2019. The CRP and hematological parameters were evaluated by well-established methods among SLT and non-SLT users. Results: There was a statistically significant difference between SLT users (mean CRP = 0.77) versus non-users (mean CRP = 0.18), p = <0.001. Among hematological parameters, white blood cells (SLT users median = 7.85 versus non-SLT users median = 8.50, p = 0.004), monocytes (SLT users median = 6.00 versus non-SLT users median = 6.00, p = 0.001) and erythrocyte sedimentation rate (SLT users median = 15.00 versus non-SLT users median = 10.00, p = 0.006) showed statistically significant difference. Conclusions: Significantly elevated CRP was observed in SLT users similarly hematological parameters also showed changes. WBCs, monocytes and ESR were significantly deranged among SLT users. Further studies looking into long term effects of these changes would be helpful. doi: https://doi.org/10.12669/pjms.37.4.3841 How to cite this:Memon SM, Kumar N, Atta-Ur-Rahman A, Syed BM. Evaluation of C-reactive protein and hematological parameters in smokeless tobacco users: A comparative cross-sectional study. Pak J Med Sci. 2021;37(4):---------.    doi: https://doi.org/10.12669/pjms.37.4.3841 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Establishment of Hematological Reference intervals for healthy Children in Elobied City, Sudan

2021 ◽  
Vol 2 (4) ◽  
pp. 24-31
Author(s):  
Tarig Osman Khalafallah Ahmed ◽  
Malaz Elfatih Abd-elkareem Ahmed ◽  
Ream Elzain Abdelgadir ◽  
Hiba Awadelkareem Osman Fadl ◽  
Assad MA. Babker
Keyword(s):  
Blood Cells ◽  
Hematological Parameters ◽  
Venous Blood ◽  
White Blood Cells ◽  
Reference Interval ◽  
Cross Sectional Study ◽  
Reference Intervals ◽  
Healthy Population ◽  
Healthy Children ◽  
Cross Sectional

Hemogram Reference intervals are established since a healthy population is critical to accurately interpret laboratory tests, which include Hemoglobin estimation, Red blood cells count and indices, White blood cells count and differential in addition to Platelets count. This study aims to establish the reference interval of the complete hemogram amongst healthy Sudanese children in Elobied city, Sudan. A descriptive cross-sectional study  included 354 healthy children, aged between 3 to 17 years, who were categorized into three groups according to age. A questionnaire was fulfilled, EDTA anti-coagulated venous blood sample was collected from each child then the complete hemogram was performed automated hematological analyzer (Sysmex Xp 300), Finally, Data was analyzed by a software program (SPSS version 21). The hematological reference intervals for healthy children [Hb g/dl, HCT%, RBCs count x106μL, MCV/fL ,MCH /pg., MCHC g/dl ,WBCs count x10³/μL, Neutrophil count%, Eosinophil count %, Basophile count %, lymphocyte count ,Monocytes count%, RDW CV and PLTs count×10³/μL] are [(12.4±1.2),(37±4),(5.0 ±0.4), (82±5.0), (26±3.0), (32±3.0) ,(7.0±2.0) (47±10), (1±0.1) ,(0±0),(45± 10),(7 ± 4), (13±1.8) &(227±91)] respectively. The hematological RI for healthy children in Elobied was established in this study to be representative of this population, there was a significant gender-based difference in all the evaluated hematological parameters, they were found to be higher in males than in females except for basophil (%). Finally, the results of this study would shed a light on the importance of establishing RI for the children population in Elobied.

scholarly journals Pesticide Use and Serum Acetylcholinesterase Levels among Flower Farm Workers in Ethiopia—A Cross-Sectional Study

2020 ◽  
Vol 17 (3) ◽  
pp. 964 ◽  
Author(s):  
Meaza Gezu Shentema ◽  
Abera Kumie ◽  
Magne Bråtveit ◽  
Wakgari Deressa ◽  
Aiwerasia Vera Ngowi ◽  
...  
Keyword(s):  
Pesticide Exposure ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Serum Cholinesterase ◽  
Pesticide Use ◽  
Sectional Study ◽  
Structured Interviews ◽  
Cross Sectional ◽  
Routine Monitoring ◽  
Trade Names

The flower industry in East Africa has grown in recent years, especially in the production and export of roses. The aim of this study was to assess pesticide use on selected flower farms in Ethiopia. Serum cholinesterase levels in workers were used as a marker of pesticide exposure. This study was a cross-sectional study involving 588 workers from 15 different flower farms. It had a response rate of 95.5%. The participants included 277 males (mean age 26 years; 148 pesticide sprayers and 129 non-sprayers) and 311 females (mean age 25 years; 156 working in greenhouses and 155 working outside the greenhouses). The researchers undertook structured interviews, blood sampling, and walkthrough surveys. Descriptive statistics and Poisson regression were used in the statistical analyses. A total of 154 different trade names of pesticides were found. Of them, 31 (27%) were classified as moderately hazardous by the WHO, and 9% were organophosphates. Serum levels of cholinesterase deviating from 50–140 Michel units were considered abnormal. Abnormal serum cholinesterase levels (above 140 Michel units) were found in 97 participants (16.5%, 95% confidence interval 13.7–19.7%). There were no differences between the four job groups regarding cholinesterase levels. The high prevalence of abnormal serum cholinesterase levels might indicate the presence of pesticide intoxication. Thus, there is a need for routine monitoring of all workers exposed to pesticides, not only sprayers.

scholarly journals Self-Reported Symptoms and Pesticide Use among Farm Workers in Arusha, Northern Tanzania: A Cross Sectional Study

Toxics ◽  
2017 ◽  
Vol 5 (4) ◽  
pp. 24 ◽  
Author(s):  
Wilbert Manyilizu ◽  
Robbinson Mdegela ◽  
Arnfinn Helleve ◽  
Eystein Skjerve ◽  
Rudovick Kazwala ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Farm Workers ◽  
Pesticide Use ◽  
Sectional Study ◽  
Cross Sectional ◽  
Northern Tanzania

scholarly journals Diagnostic value of serum procalcitonin level in the diagnosis of the spontaneous bacterial peritonitis

2020 ◽  
Vol 6 (2) ◽  
pp. e19-e19
Author(s):  
Rasoul Estakhri ◽  
Lachin Bartari ◽  
Morteza Ghojazadeh
Keyword(s):  
Ascitic Fluid ◽  
Sensitivity And Specificity ◽  
Spontaneous Bacterial Peritonitis ◽  
White Blood Cells ◽  
Serum Levels ◽  
Diagnostic Value ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Bacterial Peritonitis ◽  
Cirrhotic Patients

Introduction: Spontaneous bacterial peritonitis (SBP) is an infectious ascitic fluid with an unknown intraabdominal source. Rapid diagnosis of infection can improve prognosis in cirrhotic patients. Objectives: We aim to determine the diagnostic value of serum procalcitonin (PCT) and C-reactive protein (CRP) in SBP. Patients and Methods: In this cross-sectional study, we included 120 cirrhotic patients with possible diagnosis of SBP asities. Serum and ascitic fluid samples were taken from the patient before initiating antibiotics. The ascitic fluid parameters, serum levels of CRP, PCT and white blood cells were measured and the diagnostic value of the CRP and PCT were evaluated. Results: Of 120 patients, 59.16% had confirmed SBP. PCT with a cutoff of 0.8 ng/mL and CRP with cutoff of 10.5 mg/L had a sensitivity of 90.91% and 86.11% and specificity of 91.5% and 81.25% respectively in diagnosing of SBP. Considering PCT above 0.8 ng/mL and CRP above 10.5 mg/L both, they had the sensitivity and specificity of 96.87% and 83.92% in detecting SBP in cirrhotic patients. Conclusion: Serum PCT and CRP levels could predict SBP in cirrhotic patients while PCT had the most sensitivity and specificity. Considering both parameters, the sensitivity will increase, but the specificity is decreasing. Both PCT and CRP levels could be used as a less invasive method compared to ascites fluid analysis in diagnosing SBP.

scholarly journals Risk factors for cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage

Open Medicine ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. 598-604
Author(s):  
Valentina Opancina ◽  
Snezana Lukic ◽  
Slobodan Jankovic ◽  
Radisa Vojinovic ◽  
Milan Mijailovic
Keyword(s):  
Risk Factors ◽  
Subarachnoid Hemorrhage ◽  
Cerebral Vasospasm ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Medical Center ◽  
White Blood Cells ◽  
Cerebral Aneurysms ◽  
International Normalized Ratio ◽  
Cross Sectional Study ◽  
Cross Sectional

AbstractIntroductionAneurysmal subarachnoid hemorrhage is a type of spontaneous hemorrhagic stroke, which is caused by a ruptured cerebral aneurysm. Cerebral vasospasm (CVS) is the most grievous complication of subarachnoid hemorrhage (SAH). The aim of this study was to examine the risk factors that influence the onset of CVS that develops after endovascular coil embolization of a ruptured aneurysm.Materials and methodsThe study was designed as a cross-sectional study. The patients included in the study were 18 or more years of age, admitted within a period of 24 h of symptom onset, diagnosed and treated at a university medical center in Serbia during a 5-year period.ResultsOur study showed that the maximum recorded international normalized ratio (INR) values in patients who were not receiving anticoagulant therapy and the maximum recorded white blood cells (WBCs) were strongly associated with cerebrovascular spasm, increasing its chances 4.4 and 8.4 times with an increase of each integer of the INR value and 1,000 WBCs, respectively.ConclusionsSAH after the rupture of cerebral aneurysms creates an endocranial inflammatory state whose intensity is probably directly related to the occurrence of vasospasm and its adverse consequences.

scholarly journals Evaluation of the Blood Level of Adiponectin in Pregnant Adolescents

2021 ◽  
Vol 43 (06) ◽  
pp. 429-435
Author(s):  
Elaine Cristina Rocha Pádua ◽  
Silvia Daher ◽  
Isa de Pádua Cintra Sampaio ◽  
Edward Araujo Júnior ◽  
Cristina Falbo Guazzelli
Keyword(s):  
Serum Levels ◽  
Cross Sectional Study ◽  
Serum Adiponectin ◽  
Enzyme Linked Immunosorbent Assay ◽  
Sectional Study ◽  
Pregnant Adolescents ◽  
Cross Sectional ◽  
Adolescent Group ◽  
Gestational Weight ◽  
Intergroup Comparison

Abstract Objective To evaluate serum levels of adiponectin in pregnant adolescents between 30 and 36 weeks of gestation. Method: A prospective cross-sectional study enrolled 67 normal pregnant women between 30 and 36 weeks of gestation and eutrophic (body mass index [BMI]: 18.5–25 kg/m2), of which 36 were adolescents (< 20 years old) and 31 adults (≥ 20 years old). Serum adiponectin levels were determined by enzyme-linked immunosorbent assay (ELISA). The t-student or Mann-Whitney tests were used for intergroup comparison. Results Pregnant adolescents showed significantly higher serum adiponectin concentrations compared with pregnant adults (p = 0.04). No differences were observed in adiponectin levels in younger pregnant adolescents (< 16 years old) compared with older pregnant adolescents (≥ 16 years old). Adiponectin values were divided into 3 subgroups: < 3,000 ng/mL, between 3,000 and 5,000 ng/mL, and > 5,000 ng/mL. Birthweight was significantly higher in women > 5,000 ng/mL when compared with < 3,000 ng/mL in the adolescent group. No association between pregestational adiponectin levels and BMI, gestational weight gain, and gestational age was observed; however, there was a positive relation with birthweight (p = 0.0239). Conclusion Serum adiponectin values in pregnant adolescents between 30 and 36 weeks of gestation were higher compared with pregnant adults; however, no differences between younger and older pregnant adolescents were observed.

Decreased soluble IFN-β receptor (sIFNAR2) in multiple sclerosis patients: A potential serum diagnostic biomarker

2016 ◽  
Vol 23 (7) ◽  
pp. 937-945 ◽  
Author(s):  
Teresa Órpez-Zafra ◽  
Jose Pavía ◽  
Isaac Hurtado-Guerrero ◽  
Maria J Pinto-Medel ◽  
Jose Luis Rodriguez Bada ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
First Year ◽  
Diagnostic Biomarker ◽  
Lower Serum ◽  
Cross Sectional ◽  
Treatment Naïve ◽  
Β Receptor ◽  
Multiple Sclerosis Patients

Background: The soluble isoform of the interferon-β (IFN-β) receptor (sIFNAR2) could modulate the activity of both endogenous and systemically administered IFN-β. Previously, we described lower serum sIFNAR2 levels in untreated multiple sclerosis (MS) than in healthy controls (HCs). Objective: To assess sIFNAR2 levels in a new cohort of MS patients and HCs, as well as in patients with clinically isolated syndrome (CIS) and with other inflammatory neurological disorders (OIND) and to assess its ability as a diagnostic biomarker. Methods: The cross-sectional study included 148 MS (84 treatment naive and 64 treated), 87 CIS, 42 OIND, and 96 HCs. Longitudinal study included 94 MS pretreatment and after 1 year of therapy with IFN-β, glatiramer acetate (GA), or natalizumab. sIFNAR2 serum levels were measured by a quantitative ELISA developed and validated in our laboratory. Results: Naive MS and CIS patients showed significantly lower sIFNAR2 levels than HCs and OIND patients. The sensitivity and specificity to discriminate between MS and OIND, for a sIFNAR2 cutoff value of 122.02 ng/mL, were 70.1%, and 79.4%, respectively. sIFNAR2 increased significantly in IFN-β-treated patients during the first year of therapy in contrast to GA- and natalizumab-treated patients who showed non-significant changes. Conclusion: The results suggest that sIFNAR2 could be a potential diagnostic biomarker for MS.

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