scholarly journals Otoacoustic emissions and biomarkers of oxidative stress in students of a tobacco-producing region

CoDAS ◽  
2014 ◽  
Vol 26 (3) ◽  
pp. 219-225 ◽  
Author(s):  
Letícia Regina Kunst ◽  
Michele Vargas Garcia ◽  
Alencar Kolinski Machado ◽  
Fernanda Barbisan ◽  
Aron Ferreira da Silveira
Keyword(s):  
Oxidative Stress ◽  
Otoacoustic Emissions ◽  
Micronucleus Test ◽  
Normal Hearing ◽  
Control Group ◽  
Response Level ◽  
Distortion Product ◽  
Significant Difference ◽  
The Mean ◽  
Biomarkers Of Oxidative Stress

PURPOSE: To verify the association between the amplitude of distortion-product otoacoustic emissions (DPOAE) and biomarkers of oxidative stress (OS) in resident students of the tobacco-producing region. METHODS: Participated in the study group (SG) 21 normal-hearing students from the tobacco-producing region, and in the control group (CG) 25 normal-hearing students who did not live in the countryside. The auditory system was assessed by DPOAE and the following biomarkers: dichlorofluorescein diacetate (DCFH-DA) and micronucleus test (MN). RESULTS: Both groups showed DPOAE present in both ears. Significant difference was detected between groups - in the right ear in the frequency of 4.000 Hz and in the left ear in the frequency of 2.000 Hz - with the mean amplitude of the DPOAE of the SG lower than the one found in the CG. Considering both ears, the SG presented lower mean across all frequencies and it was found a significant difference in the frequencies of 2.000 and 4.000 Hz. The overall mean of DPOAE, by ear, no significant differences were observed. In relation to the rate of production of free radicals, the mean of the SG was significantly higher than that of the mean of the CG. For the frequency of abnormal cells in the MN test, the mean of the SG was also considerate significantly higher than the mean of the CG. CONCLUSION: The SG showed a lower response level of DPOAE at all frequencies and high levels of biomarkers of EO, however there was no association between assessments.

scholarly journals Otoacoustic emissions and contralateral suppression in tinnitus sufferers with normal hearing

2020 ◽  
Vol 36 (1) ◽  
Author(s):  
Doaa Elmoazen ◽  
Hesham Kozou ◽  
Basma Elabassiery
Keyword(s):  
Otoacoustic Emissions ◽  
Pure Tone Audiometry ◽  
Normal Hearing ◽  
Outer Hair Cells ◽  
Control Group ◽  
Efferent System ◽  
Distortion Product ◽  
Contralateral Suppression ◽  
Significant Difference

Abstract Background The general consensus on the role of hearing loss in generating tinnitus is not relevant in tinnitus patients with normal hearing thresholds. One source of tinnitus may be related to damage to outer hair cells (OHC) of the cochlea. If the OHC of the human cochlea are to be involved in the generation of tinnitus, testing of Otoacoustic emissions (OAE) could provide a reliable means of recording OHC dysfunction. We investigated the role of OHC and cochlear efferent system in tinnitus development in normal hearing ears through studying of Distortion Product Otoacoustic Emissions (DPOAE) and Transient Evoked Otoacoustic Emissions (TEOAE) amplitudes, contralateral suppression amplitudes and suppression value in 15 normal hearing tinnitus patients and 15 control subjects. Results Mean f2 DPOAE amplitudes and contralateral suppression were significantly lower in tinnitus group compared to controls for all frequencies from 1001 to 6348 Hz. Suppression values of DPOAEs revealed lower but not significant difference between tinnitus and control groups for all frequencies except 1587 and 6348 Hz. TEOAE amplitudes and contralateral suppression were significantly lower in tinnitus groups for all frequencies from 1000 to 4000 Hz compared to the control group. Suppression value of TEOAEs revealed no significant difference between the two groups for all frequencies except 3000 and 4000 Hz were significantly lower in the tinnitus group compared to the control group. Conclusions Normal hearing manifested by pure tone audiometry in non-vascular tinnitus sufferers does not exclude OHC and/or cochlear efferent pathology.

Clinical characteristics and audiological significance of spontaneous otoacoustic emissions in tinnitus patients with normal hearing

2010 ◽  
Vol 125 (3) ◽  
pp. 246-250 ◽  
Author(s):  
D-K Kim ◽  
S-N Park ◽  
K-H Park ◽  
H G Choi ◽  
E-J Jeon ◽  
...  
Keyword(s):  
Otoacoustic Emissions ◽  
Early Stage ◽  
Otoacoustic Emission ◽  
Normal Hearing ◽  
Control Group ◽  
Study Group ◽  
Distortion Product Otoacoustic Emission ◽  
Spontaneous Otoacoustic Emissions ◽  
Distortion Product ◽  
The Mean

AbstractObjective:To define the clinical and audiological features of normal-hearing tinnitus patients with spontaneous otoacoustic emissions, and to evaluate the role of spontaneous otoacoustic emissions in tinnitus generation.Materials and methods:Thirty-two patients with spontaneous otoacoustic emissions were compared with 29 patients without spontaneous otoacoustic emissions, regarding clinical and audiological aspects.Results:The mean age of the study group subjects was significantly lower, and they experienced the kindling effect less frequently than the control group. The mean tinnitus handicap inventory score of the study group was considerably higher than that of the controls, although the difference was not statistically significant. The study group had significantly quieter tinnitus, and higher transient evoked and distortion product otoacoustic emission responses, compared with the control group.Conclusions:Normal-hearing tinnitus patients with spontaneous otoacoustic emissions have different clinical and audiological characteristics, compared with those without spontaneous otoacoustic emissions. Appropriate evaluation and treatment should be considered at an early stage in these patients.

Comparison of auditory electrophysiological responses in normal-hearing patients with and without tinnitus

2011 ◽  
Vol 125 (7) ◽  
pp. 668-672 ◽  
Author(s):  
S Singh ◽  
S K Munjal ◽  
N K Panda
Keyword(s):  
Hearing Loss ◽  
Otoacoustic Emissions ◽  
Auditory Brainstem ◽  
Normal Hearing ◽  
Auditory Brainstem Responses ◽  
Control Group ◽  
Distortion Product ◽  
Significant Difference ◽  
Central Activity ◽  
Middle Latency

AbstractIntroduction:Tinnitus is a disturbing symptom and is often the main reason for otology referral. It is usually associated with hearing loss of varying aetiology, and is thought to begin in the cochlea, with later abnormal central activity. We hypothesise that tinnitus without hearing loss may be caused by central and subcortical abnormalities and altered outer hair cell function.Aim:To compare the auditory brainstem responses, middle latency responses and otoacoustic emissions in normal-hearing individuals with and without tinnitus.Methodology:The audiological test results of 25 normal hearing subjects with tinnitus (age 18–45 years) were determined, and compared with those of a control group.Results:A statistically significant difference was found between study group tinnitus ears vs control group ears, as regards wave I latency prolongation, shortening of wave V and absolute I–III and I–V interpeak latency, enlargement of wave Na and Pa amplitude, and distortion product and transient evoked otoacoustic emission signal-to-noise ratios. There was no statistically significant difference between unilateral vs bilateral tinnitus ears.Conclusion:The pathogenesis and optimum management of tinnitus are still unclear. It often occurs with primary ear disease, usually associated with hearing loss, but may occur in patients with normal hearing. Observed changes in auditory brainstem and middle latency responses indicate central auditory alterations. Tinnitus involves both peripheral and central activity, and complete audiological and neurophysiological investigation is required. Management should be based on both audiological and neurophysiological findings.

scholarly journals Evaluation of Oxidative Stress in Patients with Fracture Admitted to Khatam Al-Anbia Hospital in Zahedan

2020 ◽  
Vol 18 (3) ◽  
Author(s):  
Mansour Karajibani ◽  
Farzaneh Montazerifar ◽  
Faezeh Kazemi ◽  
Ali Reza Dashipour
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activities ◽  
Control Group ◽  
Case Group ◽  
Cross Sectional ◽  
Stress Markers ◽  
Significant Difference ◽  
Before And After ◽  
Markers Of Oxidative Stress ◽  
The Mean

Background: Caused by an imbalance in the body’s oxidant and antioxidant status, oxidative stress can give rise to tissue damage and exacerbation of many diseases. Objectives: This study investigated the oxidative stress markers in patients with fractures and healthy subjects. Methods: In a cross-sectional case-control study, 40 patients with fractures admitted to an orthopedic ward and 40 healthy, non-fractured patients were selected using convenience sampling. Serum was analyzed for oxidant and antioxidant activities based on standard methods. P < 0.05 was considered statistically significant. Results: There was a significant difference in mean TAC between the case (748.2 ± 302.83 μmol/L) and control (984.90 ± 207.02 μmol/L) groups (P = 0.003). The mean MDA was 16.61 ± 4.16 µmol/L in the case group and 18.45 ± 5.43 µmol/L in the control group (P = 0.09). The mean SOD was 63.41 ± 16.67 U/g Hb in the case group and 58.54 ± 21.83 U/g Hb in the control group (P = 0.2). There was no significant difference between the two groups in terms of BMI and other variables. Conclusions: A significant difference existed in TAC between the two groups, which indicated increased oxidative stress in patients. However, oxidative stress could occur before and after undergoing fractures. The results suggested a slight, but not significant, difference between the two groups in the SOD and MDA scores. More conclusive results are required to determine the enzymatic and non-enzymatic markers of oxidative stress in larger sample sizes and during different stages of treatment.

Distortion Product Emissions in Normal-Hearing and Low-Frequency Hearing Loss Carriers of Genes for Waardenburg's Syndrome

1997 ◽  
Vol 106 (3) ◽  
pp. 220-225 ◽  
Author(s):  
Xue Zhong Liu ◽  
Valerie E. Newton
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Low Frequency ◽  
Normal Hearing ◽  
Distortion Product Otoacoustic Emissions ◽  
Control Group ◽  
Distortion Product ◽  
Initial Results

Eight patients with Waardenburg's syndrome (WS) with normal hearing and 3 additional patients exhibiting a low-frequency hearing loss were tested for the level of the acoustic distortion product 2f1-f2 by means of the Otodynamics Distortion Product Analyser (ILO92). Wide notches in distortion product otoacoustic emissions (DPOAEs) between 1,000 and 3,000 Hz were found in 7 (12 ears, 87.5%) examined patients with normal audiograms, which was a significantly higher rate than that found in the control group (10%). The 3 patients with low-frequency hearing loss gave a consistent pattern in audiometric configuration shown by both pure tone audiograms and DPOAEs. It is concluded from these initial results that DPOAEs may be a useful approach to identifying subclinical pathologic aberrations in the inner ear in WS patients, and may be a predictor of low-frequency sensorineural hearing loss.

Distortion product otoacoustic emissions following stapedectomy versus stapedotomy

2009 ◽  
Vol 124 (1) ◽  
pp. 16-18
Author(s):  
L Migirov ◽  
M Wolf
Keyword(s):  
Otoacoustic Emissions ◽  
Surgical Techniques ◽  
Otoacoustic Emission ◽  
Normal Hearing ◽  
Stapes Surgery ◽  
Distortion Product Otoacoustic Emissions ◽  
Control Group ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product ◽  
Gap Closure

AbstractObjectives:To evaluate distortion product otoacoustic emissions following stapes surgery in patients with otosclerosis, and to compare in this respect two surgical techniques used in our department.Method:This retrospective study included 17 stapedectomy and 23 stapedotomy patients aged 16–68 years who had been followed up for at least 12 months. Distortion product otoacoustic emission results at 2, 3, 4 and 5 kHz (i.e. =f2, with 2f1 − f2 = 0.6f2) were obtained pre-operatively and four weeks post-operatively. The control group included 13 volunteers aged 18–50 years with normal hearing and normal otoscopic findings.Results:Distortion product otoacoustic emissions were detected pre-operatively in 34.8 per cent of stapedotomy patients and 29.4 per cent of stapedectomy patients, and post-operatively in 91.3 per cent of stapedotomy patients and 88.2 per cent of stapedectomy patients. The differences between the stapedotomy and stapedectomy groups were statistically insignificant for each tested frequency, both pre- and post-operatively. The patients' post-operative distortion product otoacoustic emission amplitudes were less than those of normal hearing individuals, even in patients with complete air–bone gap closure and a significant improvement in hearing.Conclusion:Distortion product otoacoustic emissions were detected in most of our patients following successful stapes surgery, and appeared to be unaffected by the surgical technique or prosthesis used.

scholarly journals Distortion Product Otoacoustic Emissions (DPOAEs) In Tinnitus Patients

2021 ◽  
Author(s):  
Hend F. Alshabory ◽  
Takwa A. Gabr ◽  
Mona A. Kotait
Keyword(s):  
Otoacoustic Emissions ◽  
Direct Consequence ◽  
Normal Hearing ◽  
Distortion Product Otoacoustic Emissions ◽  
Control Group ◽  
Study Group ◽  
Input Output ◽  
Sound Stimulation ◽  
Hearing Sensitivity ◽  
Distortion Product

Abstract Introduction Tinnitus is the perception of sound in the absence of external sound stimulation. There is a general agreement that it is a direct consequence of irreversible and permanent cochlear damage. Objectives The present work is designed to study the distortion product otoacoustic emissions (DPOAEs) in tinnitus patients with normal hearing in comparison with normal hearing control and to study any possible correlation between DPOAEs recording and patients' complaints. Methods The present study included 80 subjects divided into 2 groups: Control group: consisted of 30 normal-hearing adults not complaining of tinnitus and Study group: consisted of 50 normal-hearing adults complaining of tinnitus. The methodology includes full audiological history, otoscopic examination, basic audiological evaluation, DPOAEs including both DP-gram and DPOAEs input/output functions. Results Basic audiological evaluation showed within normal hearing sensitivity in both groups, however, with significant higher hearing thresholds in tinnitus patients at all frequency ranges. The Tinnitus Handicap Inventory Questionnaire showed mean scores of 35.2 ± 16.9 in the study group. The DP-gram showed higher amplitudes in the control group when compared with tinnitus patients. The DPOAEs input-output functions at different frequencies (1, 2, 4 and 6kHz) also showed higher amplitudes at all frequencies and different input levels. The slope of the I/O function tends to be steeper in tinnitus cases. Conclusion Patients with tinnitus might have neural dysfunction at either the level of the cochlea, as shown in reduced DPOAE levels, and changes in the normal DP-I/O function recorded in the present work.

scholarly journals Comparison of Otoacoustic Emissions in Asymptomatic Diabetes Mellitus and Normal Hearing Control Groups

2019 ◽  
Vol 42 (2) ◽  
pp. 12-20
Author(s):  
Suwimol Ruencharoen ◽  
Chanchai Jariengprasert ◽  
Montip Tiensuwan ◽  
Chardpraorn Ngarmukos
Keyword(s):  
Diabetes Mellitus ◽  
Hearing Impairment ◽  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Normal Hearing ◽  
Control Group ◽  
Diabetic Patients ◽  
Control Groups ◽  
Cochlear Function ◽  
Distortion Product

Background: Diabetes mellitus (DM) is a chronic metabolic disorder. Previous studies reported the hearing impairment of diabetes patients as a progressive bilateral symmetrical sensorineural hearing loss (SNHL) of gradual onset which predominantly affected the higher frequencies, and found that diabetic patients had unsatisfactory hearing thresholds than nondiabetics in the same age group. For the use of evoked otoacoustic emissions (EOAEs) as a clinical test of hearing, EOAEs are sound which can be recorded in the outer ear canal and give objective information about preneural, mechanical elements of the cochlear function. Objective: To compare the otoacoustic emissions of asymptomatic DM patients with a normal hearing control group. Methods: All subjects received a routine audiologic evaluation which consisted of pure-tone air-bone conduction tests, tympanograms, and stapedius acoustic reflex tests. OAEs were measured in 30 asymptomatic diabetic patients with a mean age of 55.73 years and an age-matched 30 subjects normal hearing control group with a mean age of 50.87 years. Results: The pure-tone thresholds at 3, 4, 6, and 8 kHz; transient-evoked otoacoustic emissions (TEOAEs) amplitudes at 1, 1.5, 2, and 3 kHz; and the distortion product otoacoustic emissions (DPOAEs) amplitudes at 1, 1.5, 2, 3, 4, and 6 kHz were significantly different (P < .05) between the asymptomatic and control groups. Conclusions: This study suggested that diabetic patients had a significant hearing impairment. SNHL is gradually progressive and is a common condition in DM patients and their thresholds for hearing are higher at higher frequencies.

scholarly journals Cochlear And Vestibular Involvement In Children With Henoch Schönlein Vasculitis

2021 ◽  
Author(s):  
Abdulkadir Bucak ◽  
Ayşegül Bükülmez ◽  
Selcuk Kuzu ◽  
Çağlar Günebakan ◽  
Erkan Yıldız ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Otoacoustic Emissions ◽  
Vestibular Function ◽  
Tertiary Hospital ◽  
Control Group ◽  
Healthy Children ◽  
Vestibular Evoked Myogenic Potential ◽  
Distortion Product ◽  
Significant Difference ◽  
And Control

Abstract Purpose: In this study, our purpose is to evaluate cochlear and vestibular function in juveniles with HSV using audiometry, DPOAEs, and cVEMP tests.Methods: 40 children diagnosed with HSV from the pediatry clinic and 40 age and sex-matched healthy children were evaluated with distortion product otoacoustic emissions, audiometry, and cervical vestibular evoked myogenic potential (cVEMP) test in a tertiary hospital.Results: The audiometry average values ​​for both ears of HSV group and the control subjects were compared, and as a result, median 4.7 dB sensorineural hearing loss (SHL) was found for HSV group compared to control group at 250 Hz and it was statistically significant (p <0.001). An average of 6.4 dB SHL was detected at 8000 Hz (p <0.001). There was a statistically significant difference among HSV and control group regarding measurement results of average p1-n1 latency time of both ears (0.9 milliseconds (ms) increase, P = 0.035). In HSV patients, the median amplitude difference of both ears' average p1 n1 was found to be 5,6 millivolt, statistically significantly decreased compared to the control group (p = 0.003).Conclusion: This study, firstly in literature, demonstrated that HSV may cause hearing loss and vestibular dysfunction in children. We think this might be due to autoimmune mechanisms.

scholarly journals Effect of laser photocoagulation and bevacizumab intravitreal in proliferative diabetic retinopathy: review on biomarkers of oxidative stress

2014 ◽  
Vol 23 (2) ◽  
pp. 79-86 ◽  
Author(s):  
Andi A. Victor ◽  
Tjahjono D. Gondhowiardjo ◽  
Sarwono Waspadji ◽  
Septelia I. Wanandi ◽  
Adang Bachtiar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Laser Photocoagulation ◽  
Combination Group ◽  
Control Group ◽  
Combined Treatments ◽  
Significant Difference ◽  
Vegf Level ◽  
Biomarkers Of Oxidative Stress

Background: This study was aimed to compare the effect of laser photocoagulation (LF), intravitreal bevacizumab (IVB) and combined treatments on biomarkers of oxidative stress such as aldehhyde dehidrogenase (ALDH), malondialdehyde (MDA) level, superoxide dismutase (SOD) activities, and vitreal vascular endothelial growth factor (VEGF) on proliferative diabetic retinopathy (DR) patients.Methods: In this single blind randomized clinical trial, 72 eyes from 69 cases of proliferative DR in Cipto Mangunkusumo Hospital between February 2011 - June 2013 were randomized into 4 groups : 1) control (n = 18); 2) LF pre-vitrectomy (n = 18); 3) IVB pre-vitrectomy (n = 18); and 4) combined IVB and LF pre-vitrectomy (n = 18). One-way ANOVA was used to compare oxidative stress parameters in the four groups.Results: There were no statistically significant differences in the average plasma ALDH activity (0.034 ± 0.02; 0.027 ± 0.02; 0.025 ± 0.02; 0.031 ± 0.11 IU/mg protein; p = 0.66), vitreal MDA level (1.661 ± 1.21; 1.557 ± 1.32; 1.717 ± 1.54; 1.501 ± 1.09 nmol/mL; p = 0.96) and SOD activity) (0.403 ± 0.50; 0.210 ± 0.18; 0.399 ± 0.49; 0.273 ± 0.32 U/mL; p = 0.38) among these four groups, respectively. However, the VEGF vitreal level (pg/mL) showed a statistically significant difference (0.356 ± 0.60; 0.393 ± 0.45; 0.150 ± 0.24; 0.069 ± 0.13; p = 0.05). The VEGF level in combination group was five times lower than the control group (p = 0.05).Conclusion: Combined treatments of DR by IVB and LF were correlated with lower vitreal MDA and plasma VEGF level, but did not have any effect on plasma ALDH and vitreal SOD in proliferative DR. Combined treatments with IVB and LF are recommended for the management of proliferative DR patients.  

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