scholarly journals Myasthenia gravis and thymoma: evaluation of 41 patients

1999 ◽  
Vol 57 (1) ◽  
pp. 6-13 ◽  
Author(s):  
JOSÉ LAMARTINE DE ASSIS ◽  
ANTONIO ALBERTO ZAMBON ◽  
PATRICIA S. SOUZA ◽  
PAULO EURIPEDES MARCHIORI
Keyword(s):  
Myasthenia Gravis ◽  
Striated Muscle ◽  
Clinical Laboratory ◽  
Anterior Mediastinum ◽  
Clinical Findings ◽  
Malignant Thymoma ◽  
Results Of Treatment ◽  
Clinical Investigations ◽  
Immunological Tests ◽  
And Control

We evaluated the epidemiological, clinical, laboratory and therapeutical aspects of 41 patients with thymomatous myasthenia gravis. Thirty five patients (85.36%) were submitted to thymectomy. Follow-up ranged from two to 18 years. Diagnosis of thymoma was based upon clinical investigations and CT scan of the anterior mediastinum and in 11 patients supported by immunological tests of anti-striated muscle antibodies with a positive result in more than 80% of cases. Histopathologic examination of all thymomectomized patients confirmed the diagnosis of thymoma. There was a significant predominance of benign over malignant thymoma. Occurred higher prevalence of male patients and of patients over 40 years of age. The therapeutical strategy to control myasthenic clinical findings was the same as that for non-thymomatous myasthenia gravis. The corticosteroids associated to cytotoxic drugs were less often used. Radiotherapy of the anterior mediastinum was more often used in patients having invasive tumors submitted to surgery or not. With regard to survival and control of myasthenia gravis, especially in younger patients and in those submitted to early surgery, results of treatment were surprisingly favorable.

scholarly journals Myasthenia Gravis in a Patient with Chronic Myeloid Leukemia Treated by Busulfan

Blood ◽  
1968 ◽  
Vol 32 (2) ◽  
pp. 336-340 ◽  
Author(s):  
MEIR DJALDETTI ◽  
JACK PINKHAS ◽  
ANDRE DE VRIES ◽  
EDNA KOTT ◽  
HENRY JOSHUA ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myasthenia Gravis ◽  
Myeloid Leukemia ◽  
Mediastinal Mass ◽  
Anterior Mediastinum ◽  
Anterior Mediastinal Mass ◽  
Surgical Removal ◽  
Autoimmune Process ◽  
X Ray ◽  
Malignant Thymoma

Abstract Myasthenia gravis and roentgenologic evidence of a mass in the anterior mediastinum appeared in a patient with chronic myeloid leukemia following busulfan treatment. X-ray irradiation of the thymic area and subsequent surgical removal of the anterior mediastinal mass were followed by remission from the myasthenia gravis. Histologic examination of the mass showed involuted thymic remnants without evidence of leukemic infiltration or of malignant thymoma. The possible etiology of the myasthenia gravis in this patient, with special reference to a busulfan-induced autoimmune process, is discussed.

Obesity management through Ayurveda - A Case Study

2017 ◽  
Vol 2 (4) ◽  
Author(s):  
Dheeraj Kumar Tyagi ◽  
Shivakumar .
Keyword(s):  
Clinical Findings ◽  
Dietary Habit ◽  
Unhealthy Lifestyle ◽  
Lifestyle Management ◽  
Before And After ◽  
Effect Of Treatment ◽  
And Control

Lifestyle disorders are one of the biggest threats for the population living unhealthy lifestyle. Sthoulya (Obesity) is one such disorder which creates lot of physical as well as mental disorder to the sufferer. Due to changing lifestyle, comforts and dietary habit lots of individuals changed their life totally. Obesity is a growing disease in developed and developing countries. Prevalence is drastically hike in past few years. Ayurveda, the science of life with which we can manage and control lots of lifestyle disorders. Focusing on dietary and lifestyle management along with treatment, we can overcome the hazards of obesity which is growing in a uncontrolled manner. The available data is based on the clinical findings only. Aim and objective: To assess the effect of “Guru Cha Atarpanam Chikitsa” in the management of Sthoulya. Setting: Swastharakshana evam Yoga, OPD and IPD, SDMCAH, Hassan. Method: Udwarthana, Parisheka, Shamana Aushadhis, Ahara, and Vihara was followed within the treatment duration and effect of treatment was assessed before and after treatment, advised for follow up. Results: The treatment adopted is effective in the management of Sthoulya and to improve the quality of life.

CAT SCRATCH SYNDROME

PEDIATRICS ◽  
1952 ◽  
Vol 10 (3) ◽  
pp. 311-318
Author(s):  
WILLIAM J. WATERS ◽  
SEYMOUR S. KALTER ◽  
JOHN T. PRIOR
Keyword(s):  
Skin Test ◽  
Laboratory Tests ◽  
Complement Fixation Test ◽  
Complement Fixation ◽  
Clinical Laboratory ◽  
Clinical Course ◽  
Diagnostic Value ◽  
Clinical Findings ◽  
Pathologic Findings ◽  
History Of

The clinical, laboratory and pathologic findings of a series of cases of cat scratch syndrome have been reviewed. In spite of a variable clinical course, certain features associated with a selected group of laboratory tests appear to be constant enough to be of diagnostic value. A history of contact with a cat and/or scratch which is usually associated with a peripheral skin lesion, lack of lymphangitis, presence of regional lymphadenopathy with tenderness to palpation are the most constant clinical findings. Fever, so frequently emphasized as a characteristic clinical sign, may be extremely variable in type and duration or entirely absent. A skin test with cat scratch antigen has been positive in all cases. Lacking this antigen, a negative Frei skin test in conjunction with a positive complement fixation test (Lygranum C. F.) is suggestive evidence for the diagnosis. With positive evidence from the above data, biopsy of an affected gland with its relatively nonspecific pathologic picture is not considered essential for the establishment of the diagnosis of cat scratch syndrome.

Optimization of tactics of auxiliary genesial technologies at married couples with the burdened genetic anamnesis

2018 ◽  
pp. 103-106
Author(s):  
O.S. Darii ◽  
Keyword(s):  
Risk Factors ◽  
Correlation Analysis ◽  
Clinical Laboratory ◽  
Genetic Research ◽  
Married Couples ◽  
Control Group ◽  
Scientific Justification ◽  
Sterility Treatment ◽  
Laboratory Tool ◽  
And Control

The objective: rising of efficiency of treatment of sterility at married couples with the burdened genetic anamnesis on the basis of scientific justification and introduction of advanced algorithm of prognostic and treatment-and-prophylactic actions. Materials and methods. For the purpose of detection of risk factors of development of sterility and carrying out the correlation analysis were allocated the main group – 100 married couples with sterility in the anamnesis and control group of patients who had labors (n=100) in the anamnesis. The complex of the conducted researches included clinical, laboratory, tool and statistical methods of research. Results. Rising of efficiency of treatment of sterility at married couples with the burdened genetic anamnesis requires carrying out medicogenetic consultation with simultaneous planned preimplantation genetic research in programs of auxiliary genesial technologies. At a choice of this or that method of auxiliary genesial technologies at women with the burdened genetic anamnesis it is necessary to use a technique at which one spermatozoon is entered into an oocyte cytoplasma by means of equipment of a micromanipulation. In the program of training of doctors the obstetrician-gynecologists and urologists of an out-patient link it is necessary to loop thematic improvement concerning sterility treatment at married couples with use of auxiliary genesial technologies. Conclusion. Results of the conducted researches testify to need of rising of efficiency of auxiliary genesial technologies at married couples with the burdened genetic anamnesis. Use by our algorithm of prognostic and treatment-and-prophylactic actions allows to increase efficiency of auxiliary genesial technologies at married couples with the burdened genetic anamnesis for 26.7%. Key words: sterility at married couples, the auxiliary genesial technologies, the burdened genetic anamnesis.

Azathioprine-Induced Pancytopenia and Septic Complications: A Probable Cause of Death

2017 ◽  
Vol 31 (5) ◽  
pp. 510-513 ◽  
Author(s):  
Bijoy K. Panda ◽  
Siddhi Umarje ◽  
Arundhati Diwan
Keyword(s):  
Chronic Kidney Disease ◽  
Septic Shock ◽  
Myasthenia Gravis ◽  
Blood Count ◽  
Neuromuscular Disorder ◽  
Suspected Drug ◽  
Septic Complications ◽  
Clinical Investigations ◽  
Severe Pancytopenia ◽  
Relationship Of

Azathioprine, an immunosuppressant which is widely used in the management of the autoimmune neuromuscular disorder. Myasthenia gravis is known to cause myelotoxicity. A 55-year-old male recently diagnosed with myasthenia gravis and chronic kidney disease was put on azathioprine (100 mg/d) along with pyridostigmine and prednisolone. When the treatment was initiated, the hematological reports revealed normal levels of blood count. However, approximately within 3 weeks of continuing the prescribed drugs, the patient was readmitted for complaints of loose watery stools, weakness, and giddiness. Clinical investigations revealed severe pancytopenia, suspecting to be related to azathioprine. The suspected drug (azathioprine) was withdrawn, and the management for pancytopenia was initiated. However, on the second day of hospitalization, the patient underwent cardiac arrest and septic shock which lead to death. Adverse drug reaction assessment revealed a plausible and causal relationship of azathioprine with pancytopenia and other adverse effects seen in this patient.

RESULTS OF TREATMENT OF MYASTHENIA GRAVIS WITH PLAS-MAPHERESIS AND IMMUNOSUPPRESIVE THERAPY

1981 ◽  
Vol 9 (3) ◽  
pp. 175
Author(s):  
Maurice Goulon ◽  
Philippe Gajdos ◽  
Evelyue Morel ◽  
Françoise Raimond ◽  
Catherine Goulon ◽  
...  
Keyword(s):  
Myasthenia Gravis ◽  
Results Of Treatment

ACUTE BENIGN PERICARDITIS IN CHILDHOOD: COMPARISONS WITH RHEUMATIC PERICARDITIS, AND THERAPEUTIC EFFECTS OF ACTH AND CORTISONE

PEDIATRICS ◽  
1952 ◽  
Vol 9 (5) ◽  
pp. 551-564
Author(s):  
SIDNEY FRIEDMAN ◽  
RACHEL ASH ◽  
T. N. HARRIS ◽  
HENRY F. LEE
Keyword(s):  
Clinical Findings ◽  
Therapeutic Effects ◽  
Results Of Treatment ◽  
Negative Findings ◽  
Pericardial Involvement

Six cases of acute benign pericarditis in childhood have been studied. The importance in childhood of the differentiation of acute benign pericarditis from acute rheumatic pericarditis has been emphasized and demonstrated by a comparison of the clinical findings and subsequent courses in patients with these two types of pericardial involvement. The results of treatment of acute primary pericarditis with the hormones ACTH and cortisone are presented and discussed. Some negative findings in the study of the etiology of this disease are presented.

EFFECTІVENESS OF LASER THERAPY ІN COMPLEX TREATMENT OF HERPETIC STOMATITIS

2021 ◽  
Vol 74 (6) ◽  
pp. 1331-1335
Author(s):  
Yulia G. Kolenko ◽  
Tetiana O. Timokhina ◽  
Nina S. Khrol ◽  
Oksana V. Kononova ◽  
Olesya V. Lynovytska
Keyword(s):  
T Lymphocytes ◽  
Laser Therapy ◽  
Pain Syndrome ◽  
Control Group ◽  
Complex Treatment ◽  
Results Of Treatment ◽  
Clinical Observations ◽  
Immunological Tests ◽  
T Helpers ◽  
Positive Effect

The aim: The purpose of research is to improve the effectiveness of treatment by applying laser in complex treatment in patients with herpetic stomatitis. Materials and methods: Were examined 47 people (22 men and 25 women) with acute herpetic stomatitis. The patіents’ age was from 20 to 72 years. All patients underwent immunological tests such as (T-lymphocytes (CD3 +), T-helpers (CD4 +), cytotoxic T-lymphocytes (CD8 +), the content of immunoglobulins IgM, IgG, IgA and slgA in saliva to assess the іmmunological reactivity of the organism. Results: Clinical observations have shown that when using laser therapy, the results of treatment were better than in the control group. Positive dynamics was observed as early as 1-2 days after the start of laser use and was more pronounced when used in the early stages of the disease. The use of the laser promoted a more rapid suspension of new lesions, a decrease in pain syndrome, and a more rapid regression of herpetic lesions. We have found significant improvements in the arameters of cellular and humoral іmmunity in patients of the main group. Conclusions: Treatment of herpetic stomatitis is relevant and requires further improvement and the search for new methods. The use of a laser in the complex treatment of herpetic stomatitis has a positive effect on the course and іmmunological status of patients with herpetic stomatіtis. The manifestations of the disease healed faster, and the pain syndrome was less severe. Duration between іllness and treatment decreased on 19.7% and 26%. It is advіsable to include the method of treatment using a laser in the complex therapy of herpetic stomatitis.

scholarly journals Clinical Characteristics of Asymptomatic and Symptomatic Pediatric Coronavirus Disease 2019 (COVID-19): A Systematic Review

Medicina ◽  
2020 ◽  
Vol 56 (9) ◽  
pp. 474
Author(s):  
Sojung Yoon ◽  
Han Li ◽  
Keum Hwa Lee ◽  
Sung Hwi Hong ◽  
Dohoon Kim ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Clinical Laboratory ◽  
Case Reports ◽  
Meta Analysis ◽  
Clinical Findings ◽  
Chest Ct ◽  
Therapeutic Interventions ◽  
Symptomatic Infection ◽  
Abnormal Chest ◽  
Study Designs

Background and objectives: Characterization of pediatric coronavirus disease 2019 (COVID-19) is necessary to control the pandemic, as asymptomatic or mildly infected children may act as carriers. To date, there are limited reports describing differences in clinical, laboratory, and radiological characteristics between asymptomatic and symptomatic infection, and between younger and older pediatric patients. The objective of this study is to compare characteristics among: (1) asymptomatic versus symptomatic and (2) less than 10 versus greater or equal to 10 years old pediatric COVID-19 patients. Materials and Methods: We searched for all terms related to pediatric COVID-19 in electronic databases (Embase, Medline, PubMed, and Web of Science) for articles from January 2020. This protocol followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Results: Eligible study designs included case reports and series, while we excluded comments/letters, reviews, and literature not written in English. Initially, 817 articles were identified. Forty-three articles encompassing 158 confirmed pediatric COVID-19 cases were included in the final analyses. Lymphocytosis and high CRP were associated with symptomatic infection. Abnormal chest CT more accurately detected asymptomatic COVID-19 in older patients than in younger ones, but clinical characteristics were similar between older and younger patients. Conclusions: Chest CT scan findings are untrustworthy in younger children with COVID-19 as compared with clinical findings, or significant differences in findings between asymptomatic to symptomatic children. Further studies evaluating pediatric COVID-19 could contribute to potential therapeutic interventions and preventive strategies to limit spreading.

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