scholarly journals Cutaneous sporotrichosis treatment with potassium iodide: a 24 year experience in São Paulo state, Brazil

2011 ◽  
Vol 53 (2) ◽  
pp. 89-93 ◽  
Author(s):  
Karin Yamada ◽  
Clarisse Zaitz ◽  
Valéria Maria De Souza Framil ◽  
Laura Hitomi Muramatu
Keyword(s):  
Side Effects ◽  
Potassium Iodide ◽  
Sporothrix Schenckii ◽  
Low Frequency ◽  
Positive Culture ◽  
Effective Drug ◽  
Frequency Resolution ◽  
Dimorphic Fungus ◽  
Drug Of Choice ◽  
Length Of Treatment

BACKGROUND: Sporotrichosis is a subacute or chronic disease caused by a dimorphic fungus, Sporothrix schenckii. The first and most traditional treatment is potassium iodide in satured solution (SSKI) used by DE BEURMANN in 1907. For its effectiveness, it is still used for cutaneous sporotrichosis. OBJECTIVE: To evaluate the treatment of cutaneous sporotrichosis with SSKI in relation to clinical cure, side effects, length of treatment and reactivation. METHODS: We conducted a retrospective analysis of medical records over a 24-year period (1981-2005). Patients of all ages who were treated in the hospital´s division of dermatology were included in the study providing that they had a positive culture of S. schenckii. Satured solution of potassium iodide (3 to 6g per day) was the treatment prescribed. For children, half of the dose was prescribed. RESULTS: The lymphocutaneous disease was prevalent, the cure rate was 94.7%, side effects were described in 5.5% of the cases, mean length of treatment was 3.5 months and possible reactivation was observed in 11.1%. CONCLUSION: SSKI is an effective drug, with many side effects, but with low frequency. Resolution was for maximum six months of treatment. SSKI has been found to be a very effective drug in this retrospective study of culture-proven cases of cutaneous and lymphocutaneous sporotrichosis. It should be used as first drug of choice especially in resource-limited settings.

scholarly journals Isolated Sporothrix schenckii Monoarthritis

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Aram Barbaryan ◽  
Wissam El Atrouni ◽  
Stefania Bailuc ◽  
Matthew W. Jones ◽  
Maharshi Bhakta ◽  
...  
Keyword(s):  
Soft Tissues ◽  
Organ Transplant ◽  
Sporothrix Schenckii ◽  
Pulmonary Involvement ◽  
Lymph Node Involvement ◽  
Delayed Presentation ◽  
Dimorphic Fungus ◽  
Transplant Patients ◽  
Drug Of Choice ◽  
Node Involvement

Sporothrix schenkii sensu lato is a rare cause of arthritis. Its course is indolent with lack of constitutional symptoms resulting in delayed presentation and diagnosis. It is a dimorphic fungus found ubiquitously in sphagnum moss, decaying vegetation, soil, and hay. Inoculation of dirt into the skin and soft tissues and, in rare instances, inhalation of aerosolized conidia from soil and plants can lead to infection. Subacute and chronic involvement of skin and subcutaneous tissues is the most common manifestation of sporotrichosis in immunocompetent hosts. In patients with underlying risk factors (HIV, alcoholism, diabetes mellitus, organ transplant patients, immunosuppressive medications, steroids, and malignancies), it can often have disseminated visceral, osteoarticular, meningeal, and pulmonary involvement. Sporothrical arthritis most commonly infects knee joint followed by hand and wrist joints. A culture of Sporothrix schenkii sensu lato is the gold standard for the diagnosis of sporotrichosis. Itraconazole is the drug of choice for osteoarticular sporotrichosis. We present a case of sporotrichal arthritis in a patient without skin or lymph node involvement who underwent treatment with itraconazole resulting in resolution of his symptoms.

scholarly journals Estimation of the Noise Source Level of a Commercial Ship Using On-Board Pressure Sensors

2021 ◽  
Vol 11 (3) ◽  
pp. 1243
Author(s):  
Hongseok Jeong ◽  
Jeung-Hoon Lee ◽  
Yong-Hyun Kim ◽  
Hanshin Seol
Keyword(s):  
Noise Source ◽  
Pressure Sensors ◽  
Low Frequency ◽  
Frequency Resolution ◽  
Source Strength ◽  
Recording Time ◽  
Source Level ◽  
The One ◽  
Hydrophone Array ◽  
Good Agreement

The dominant underwater noise source of a ship is known to be propeller cavitation. Recently, attempts have been made to quantify the source strength using on-board pressure sensors near the propeller, as this has advantages over conventional noise measurement. In this study, a beamforming method was used to estimate the source strength of a cavitating propeller. The method was validated against a model-scale measurement in a cavitation tunnel, which showed good agreement between the measured and estimated source levels. The method was also applied to a full-scale measurement, in which the source level was measured using an external hydrophone array. The estimated source level using the hull pressure sensors showed good agreement with the measured one above 400 Hz, which shows potential for noise monitoring using on-board sensors. A parametric study was carried out to check the practicality of the method. From the results, it was shown that a sufficient recording time is required to obtain a consistent level at high frequencies. Changing the frequency resolution had little effect on the result, as long as enough data were provided for the one-third octave band conversion. The number of sensors affected the mid- to low-frequency data.

A High Efficient Baseband GNSS Signal Narrow Band Anti-Jamming Approach in Frequency Domain

2014 ◽  
Vol 926-930 ◽  
pp. 1857-1860
Author(s):  
Zhou Zheng ◽  
Meng Yuan Li ◽  
Wei Jiang Wang
Keyword(s):  
Signal Processing ◽  
Frequency Domain ◽  
Narrow Band ◽  
Low Frequency ◽  
Frequency Resolution ◽  
Interference Rejection ◽  
High Efficient ◽  
Digital Down Conversion ◽  
Down Conversion ◽  
Low Rate

In order to reduce the burden of the calculation and the low frequency resolution of the tradition GNSS signal intermediate narrow band anti-jamming method, it introduces a high efficient approach of narrow band interference rejection based on baseband GNSS signal processing. After digital down conversion to baseband and down sampling to a low rate, the interference is removed in frequency domain. According to the theoretical analysis and simulation, it claims that the method can reduce the calculation and increase the detection resolution in frequency domain which will realize a high efficient interference rejection.

Clozapine Induced Rash: Case Report of Successful Desensitization

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
R. Singh ◽  
K. Raju ◽  
J. Southern ◽  
J. Darroch
Keyword(s):  
Side Effects ◽  
Drug Hypersensitivity ◽  
Effective Means ◽  
Drug Dose ◽  
Delayed Type Hypersensitivity ◽  
Psychotic Symptoms ◽  
Hypersensitivity Reactions ◽  
Treatment Resistant ◽  
Drug Of Choice ◽  
Cutaneous Hypersensitivity

Aim:Clozapine is the drug of choice for patients with treatment-resistant schizophrenia. However a minority of them have been unable to continue with Clozapine due to side-effects, for example rash. This report looks at the use of graded desensitization in a patient who developed cutaneous reactions to Clozapine.Method:This report describes the management of a patient with treatment resistant-schizophrenia, mild learning disabilities and epilepsy, following a cutaneous reaction to Clozapine. Having been maintained on Clopixol depot until 4 years ago, he required a change in antipsychotics following a relapse of psychotic symptoms. He was then treated unsuccessfully with various anti-psychotics, before starting Clozapine, to which he showed a good response. Unfortunately he developed an eczematous rash on two separate occasions when the drug was introduced. Again he was tried on other anti-psychotics, to which he also developed a rash. He was then put on a graded desensitization regimen of liquid Clozapine.Results:Graded desensitization, using incremental increases in drug dose, allowed maintenance treatment with therapeutic doses of Clozapine to be achieved in the absence of cutaneous hypersensitivity reactions. the patient's previously treatment-resistant psychotic symptoms were improved by this method.Conclusion:We should be aware of possibilities for the management of both the common and uncommon side-effects associated with Clozapine, as the result might vastly improve the patients’ quality of life. Desensitisation regimens can be an effective means of overcoming drug hypersensitivity but should be used with great caution, especially when patients exhibit delayed-type hypersensitivity reactions.

Toward High-Resolution Mechanical Spectroscopy HRMS - Logarithmic Decrement

2012 ◽  
Vol 184 ◽  
pp. 467-472 ◽  
Author(s):  
Leszek B. Magalas ◽  
M. Majewski
Keyword(s):  
High Resolution ◽  
Low Frequency ◽  
Logarithmic Decrement ◽  
Frequency Resolution ◽  
Mechanical Spectroscopy ◽  
Spectral Leakage ◽  
Experimental Noise ◽  
Relative Errors ◽  
The Way

In this work, we present the comparison between different methods used to compute the logarithmic decrement,δ. The parametric OMI method and interpolated DFT (IpDFT) methods are used to compute theδfrom free decaying oscillations embedded in an experimental noise typical for low-frequency mechanical spectrometers. The results are reported forδ= 5×10-4, = 1.12345 Hz and different sampling frequencies, = 1 kHz and 4 kHz. A new YM algorithm yields the smallest dispersion in experimental points of the logarithmic decrement and the smallest relative errors among all investigated IpDFT methods. In general, however, the IpDFT methods suffer from spectral leakage and frequency resolution. Therefore it is demonstrated that the performance of different methods to compute theδcan be listed in the following order: (1) OMI, (2) YM, (3) YMC, and (4) the Yoshida method, Y. For short free decays the order of the best performers is different: (1) OMI and (2) YMC. It is important to emphasize that IpDFT methods (including the Yoshida method, Y) are discouraged for signals that are too short. In conclusion, the best methods to compute the logarithmic decrement are the OMI and the YM. These methods will pave the way toward high-resolution mechanical spectroscopy HRMS.

INM investigations into drugs for seasickness prophylaxis

1994 ◽  
Vol 80 (2) ◽  
pp. 76-80
Author(s):  
B J W Pingree
Keyword(s):  
Side Effects ◽  
Motion Sickness ◽  
Effective Drug ◽  
Royal Navy ◽  
Comparative Efficacy ◽  
Sea Trial

AbstractA summary is presented of a programme of work investigating the comparative efficacy of the two drugs most commonly used for seasickness prophylaxis in the Royal Navy, hyoscine and cinnarizine. The programme had both laboratory and sea-trial components. It was shown that hyoscine was a more effective drug than cinnarizine, but cinnarizine had less marked side effects. This comparative superior tolerability of cinnarizine decreased as motion sickness increased. Guidance is given as to the optimum indications for each drug, together with prophylactic regimens.

Delirium on clozapine: A tale of friend turned foe-A case report

2020 ◽  
pp. 009121742097282 ◽  
Author(s):  
Aparna Das ◽  
Rebecca Minner ◽  
Lewis Krain ◽  
John Spollen
Keyword(s):  
Case Report ◽  
Clinical Practice ◽  
Side Effects ◽  
Adverse Effects ◽  
Older Adult ◽  
Psychiatric Illness ◽  
Management Strategies ◽  
Treatment Resistant ◽  
Drug Of Choice ◽  
Life Threatening

Treatment resistant schizophrenia (TRS) is often encountered in clinical practice. Clozapine remains the drug of choice in the management of TRS. Several studies have shown that clozapine is the most effective antipsychotic medication to date for TRS. But it is also well known that it has multiple side effects. Some side effects are transient and relatively benign, while other adverse effects are menacing, serious and life-threatening. Delirium may occur with clozapine and is a therapeutic challenge as there is always a risk of precipitating delirium on clozapine rechallenge. Limited management strategies are available as alternatives for the management of psychiatric illness stabilized on clozapine. In this case report, we describe an older adult patient who developed delirium on clozapine. The aims of this case report are to discuss the mechanism by which clozapine leads to delirium, revisit various factors which could possibly lead to delirium, and discuss the different management strategies available for management of psychiatric illness for a patient previously stabilized on clozapine.

Airframe noise measurements on JAXA Jet Flying Test Bed “Hisho” using a phased microphone array

2017 ◽  
Vol 16 (4-5) ◽  
pp. 255-273 ◽  
Author(s):  
Takehisa Takaishi ◽  
Hiroki Ura ◽  
Kenichiro Nagai ◽  
Yuzuru Yokokawa ◽  
Mitsuhiro Murayama ◽  
...  
Keyword(s):  
Microphone Array ◽  
Low Frequency ◽  
Landing Gear ◽  
Frequency Resolution ◽  
Test Bed ◽  
Noise Sources ◽  
Low Frequencies ◽  
Airframe Noise ◽  
Noise Measurements ◽  
Wooden Platform

In 2015, the Japan Aerospace Exploration Agency launched the Flight demonstration of QUiet technology to Reduce nOise from High-lift configurations project to verify by flight demonstration the feasibility of practical noise-reducing aircraft modification concepts. In order to serve as a baseline for comparison before modification, airframe noise sources of the JAXA Jet Flying Test Bed “Hisho” were measured with a 30 m diameter array of 195 microphones mounted on a wooden platform built temporary beside the runway of Noto Satoyama Airport in Japan. A classical Delay and Sum in the time domain beamforming algorithm was adapted for the present study, with weight factors introduced to improve the low-frequency resolution and autocorrelations eliminated to suppress wind noise at high frequencies. In the landing configuration at idle thrust, the main landing gear, nose landing gear, and side edges of the six extended flap panels were found to be the dominant “Hisho” airframe noise sources. Deconvolution by the DAMAS and CLEAN-SC algorithms provided clearer positions of these sound sources at low frequencies. Integration of acoustical maps agreed well with the sound pressure level measured by a microphone placed at the center of the microphone array and gave detailed information about the contribution of each noise source.

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