scholarly journals Central activities of hydroalcoholic extract from Lafoensia pacari A. St.-Hil. stem bark

2010 ◽  
Vol 46 (3) ◽  
pp. 455-462 ◽  
Author(s):  
Pablinny Moreira Galdino ◽  
Marcus Vinícius Mariano Nascimento ◽  
Fábio Borges de Sousa ◽  
Reginaldo Nassar Ferreira ◽  
José Realino de Paula ◽  
...  
Keyword(s):  
Elevated Plus Maze ◽  
Field Tests ◽  
Sleep Time ◽  
Stem Bark ◽  
Rio Grande Do Sul ◽  
Hydroalcoholic Extract ◽  
Sleeping Time ◽  
Plus Maze ◽  
Immobility Time ◽  
Time Test

Lafoensia pacari A. St.-Hil. can be found from Amapá to Rio Grande do Sul states, and also in Paraguay and Bolivia. It is popularly known as pacari or mangava-brava and is used to promote weight loss, as an anti-thermal or tonic, to treat gastritis, ulcers, scarring, itching, discouragement, and cancer. In the open field tests, the hydroalcoholic extract from L. pacari stem bark (HEP) decreased the number of rearings, number of invaded squares, and increased immobility time compared to control animals. In the pentobarbital-induced sleep time test, HEP decreased latency time to sleep and increased sleeping time. In the rota-rod test, no changes in the studied parameters were observed. In the elevated plus maze, HEP increased the percentage time and percentage entries in the open arms, indicating that this extract exerts an anxiolytic-like activity.

scholarly journals Dose-Dependent, Antidepressant, and Anxiolytic Effects of a Traditional Medicinal Plant for the Management of Behavioral Dysfunctions in Animal Models

Dose-Response ◽  
2019 ◽  
Vol 17 (4) ◽  
pp. 155932581989126 ◽  
Author(s):  
Hafiz Muhammad Asif ◽  
Abdul Hayee ◽  
Muhammad Rahil Aslam ◽  
Khalil Ahmad ◽  
Abdul Sattar Hashmi
Keyword(s):  
Open Field ◽  
Elevated Plus Maze ◽  
Tail Suspension Test ◽  
Antidepressant Effect ◽  
Tail Suspension ◽  
Hydroalcoholic Extract ◽  
Elevated Plus Maze Test ◽  
Plus Maze ◽  
Immobility Time ◽  
Dose Dependent

The present work was carried out to assess the Onosma bracteatum anxiolytic and antidepressant properties. Swiss albino mice (male) were fed orally with hydroalcoholic extract at different doses 50, 100, and 200 mg 1 hour prior to test with the standard diazepam and fluoxetine. Anxiolytic and antidepressant activities were evaluated by using open field, elevated plus maze, force swimming, and tail suspension test. Results of open field test showed an increase in number of line crossing as well as number of rearing in dosage-dependent design. Although results of elevated plus maze test evidently showed antianxiety effect of O bracteatum by increasing the time spent in open arms along with decreasing the time spent in closed arms in dosage-dependent way. For the evaluation of antidepressant effect, O bracteatum diminished the immobility time and expanded mobility time in forced swim model in dosage-dependent way. Likewise, O bracteatum expanded time span of mobility along with diminished immobility time in tail suspension method in dosage-dependent way. Outcome demonstrated that plant at the dose of 200 mg/kg body weight showed significant potential which was similar to that standard diazepam and fluoxetine. Hence, O bracteatum may be used as potent natural psychotherapeutic agent against the mental disorders.

scholarly journals Synergistic Action of Sodium Selenite with some Antidepressants and Diazepam in Mice

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 270
Author(s):  
Ewa Kędzierska ◽  
Lila Dąbkowska ◽  
Paweł Obierzyński ◽  
Magdalena Polakowska ◽  
Ewa Poleszak ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Sodium Selenite ◽  
Elevated Plus Maze ◽  
Synergistic Action ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze ◽  
Immobility Time ◽  
Combined Administration ◽  
Antidepressant Action

Background: The antidepressant and anxiolytic effects of selenium (Se) have been proven in many studies. This work was aimed at confirming these activities of its inorganic form—sodium selenite—and examining the possible synergy of action with antidepressants and diazepam. Methods: The antidepressant- and anxiolytic-like activity of Se was assessed using forced swim tests (FSTs) and elevated plus-maze test (EPMs). Spontaneous locomotor activity was measured using photoresistor actimeters. The experiments were conducted on male Albino Swiss mice. Results: Sodium selenite (0.5 mg/kg) reduced the immobility time in the FSTs and extended time spent in the open arms of EPMs without affecting locomotor activity The combined administration of Se at an ineffective dose (0.25 mg/kg) together with imipramine (15 mg/kg), fluoxetine (5 mg/kg), tianeptine (10 mg/kg), but not with reboxetine (2.5 mg/kg), resulted in a reduction of immobility time in FSTs, and with a threshold dose of diazepam (0.25 mg/kg) led to the prolongation of time spent in the open arms of the EPM. Moreover, the antidepressant-like effect of Se (0.5 mg/kg) was significantly reduced by pretreatment with p-chlorophenylalanine (100 mg/kg). Conclusions: The results may indicate the participation of serotonergic transmission to antidepressant action of Se and GABA-ergic transmission to its anxiolytic effects.

Potentials of Mangifera indica in the treatment of depressive-anxiety disorders: possible mechanisms of action

2016 ◽  
Vol 13 (3) ◽  
Author(s):  
Ismail O. Ishola ◽  
Olufunsho Awodele ◽  
Chinedum O. Eluogu
Keyword(s):  
Elevated Plus Maze ◽  
Forced Swim Test ◽  
Mangifera Indica ◽  
Tail Suspension Test ◽  
Mechanisms Of Action ◽  
Tail Suspension ◽  
Swim Test ◽  
Plus Maze ◽  
Immobility Time ◽  
Therapeutic Doses

Abstract:: HeMI (12.5–100 mg/kg, p.o.) was administered 1 h before subjecting the animal to the forced swim test (FST), tail suspension test (TST) and elevated plus maze tests (EPM).: HeMI (12.5–100 mg/kg, p.o.) treatment produced significant reduction in immobility time [F(6.56)=8.35, p<0.001], [F(6,56)=7.55, p<0.001] in the FST and TST, respectively. Moreover, co-administration of sub-therapeutic doses of imipramine or fluoxetine with HeMI (3.125 mg/kg) elicited significant reduction in time spent immobile in the FST. However, pretreatment of mice with parachlorophenylalanine, metergoline, yohimbine or sulpiride abolished the antidepressant-like effect elicited by HeMI. In the EPM, HeMI produced significant [F(5,42)=8.91, p<0.001] increase in open arms exploration by 75.55 % and this effect was blocked by pretreatment of mice with flumazenil or metergoline.: Findings from this study showed antidepressant-like effect of

Evaluation of the elevated plus-maze and open-field tests for the assessment of anxiety-related behaviour in inbred mice

2002 ◽  
Vol 134 (1-2) ◽  
pp. 49-57 ◽  
Author(s):  
Valeria Carola ◽  
Francesca D'Olimpio ◽  
Emiliano Brunamonti ◽  
Franco Mangia ◽  
Paolo Renzi
Keyword(s):  
Open Field ◽  
Elevated Plus Maze ◽  
Inbred Mice ◽  
Field Tests ◽  
Plus Maze

SCREENING OF STEM BARK EXTRACT OF BAUHINIA VARIEGATA LINN. FOR PHYTOCHEMICAL CONSTITUENTS AND PHARMACOLOGICAL ACTIVITY

2020 ◽  
Vol 9 (3) ◽  
Author(s):  
Shubham S. Gawas ◽  
M.H.S. Godinho
Keyword(s):  
Elevated Plus Maze ◽  
Methanolic Extract ◽  
Stem Bark ◽  
Bark Extract ◽  
Albino Rats ◽  
Stress Model ◽  
Plus Maze ◽  
Stem Bark Extract ◽  
Bauhinia Variegata ◽  
Dunnett's Test

Bauhinia variegata named orchid tree, belongs to the family leguminosae. The methanolic extract of Bauhinia variegata (MEBV) revealed the presence of carbohydrates, proteins, tannins, steroids, triterpenoids and flavonoids. Various CNS models were used to find out the antianxiety activity of Bauhinia variegata. The study was designed to evaluate the antianxiety activity of stem bark extract of Bauhinia variegata. The effect of dried stem bark of Bauhinia variegata (200 mg/kg and 400 mg/kg) was evaluated using Elevated Plus Maze, Light and Dark Box, Restrained Stress Model and Novelty Suppressed Feeding Test using a wistar albino rats (n=6) and was statistically analyzed using ONE WAY Annova followed by Dunnett’s test. Oral administration of the methanolic extract of Bauhinia variegata (200 mg/kg and 400 mg/kg) showed significant increase in %OAE and %TSOA values for EPM, NEL and TSL values in Light and Dark Box, Restrained Stress Model showed  significant increase in %OAE and %TSOA and NEL and TSL values. Novelty suppressed feeding behaivior test showed significantly lower values for latency to feed.From the present study it may be concluded that among both the test groups, MEBV at a dose of 400 mg/kg was found to possess significant anti-anxiety activity. Keywords: EPM- Elevated Plus Maze, NEL- Number of Entries in Light, TSL- Time spent in light.

scholarly journals Neuroanatomical pathways underlying the effects of hypothalamo-hypophysial-adrenal hormones on exploratory activity

2017 ◽  
Vol 28 (6) ◽  
pp. 617-648
Author(s):  
Robert Lalonde ◽  
Catherine Strazielle
Keyword(s):  
Nucleus Accumbens ◽  
Open Field ◽  
Basolateral Amygdala ◽  
Elevated Plus Maze ◽  
Field Tests ◽  
Lateral Septum ◽  
Target Region ◽  
Bed Nucleus ◽  
Adrenal Hormones ◽  
Plus Maze

AbstractWhen injected via the intracerebroventricular route, corticosterone-releasing hormone (CRH) reduced exploration in the elevated plus-maze, the center region of the open-field, and the large chamber in the defensive withdrawal test. The anxiogenic action of CRH in the elevated plus-maze also occurred when infused in the basolateral amygdala, ventral hippocampus, lateral septum, bed nucleus of the stria terminalis, nucleus accumbens, periaqueductal grey, and medial frontal cortex. The anxiogenic action of CRH in the defensive withdrawal test was reproduced when injected in the locus coeruleus, while the amygdala, hippocampus, lateral septum, nucleus accumbens, and lateral globus pallidus contribute to center zone exploration in the open-field. In addition to elevated plus-maze and open-field tests, the amygdala appears as a target region for CRH-mediated anxiety in the elevated T-maze. Thus, the amygdala is the principal brain region identified with these three tests, and further research must identify the neural circuits underlying this form of anxiety.

scholarly journals Anxiolytic and Anticonvulsant Effects on Mice of Flavonoids, Linalool, and -Tocopherol Presents in the Extract of Leaves ofCissus sicyoidesL. (Vitaceae)

2009 ◽  
Vol 2009 ◽  
pp. 1-6 ◽  
Author(s):  
Edvaldo Rodrigues de Almeida ◽  
Krissia Rayane de Oliveira Rafael ◽  
Geraldo Bosco Lindoso Couto ◽  
Ana Beatriz Matos Ishigami
Keyword(s):  
Elevated Plus Maze ◽  
Sodium Pentobarbital ◽  
Hydroalcoholic Extract ◽  
Male And Female ◽  
Aerial Parts ◽  
Plus Maze ◽  
Marble Burying ◽  
Males And Females ◽  
Behavioral Assays ◽  
Anticonvulsant Effects

The aim of the present study is to demonstrate the anxiolytic and anticonvulsant effects of a hydroalcoholic extract obtained from the aerial parts ofCissus sicyoidesL. (CS) (Vitaceae) on male and female mice using several behavioral assays. Groups of males and females treated via intraperitoneal (IP) with doses of 300, 600, and 1000 mg/kg of the extract showed significant action in the elevated plus-maze (EPM), time spent in the open arms, and number of entries in the open arms. The board-hole test also showed a significant increase in the time spent in head-dipping and in marble-burying test of the number of marbles buried. The same treatment increased the duration of sleeping time induced by sodium pentobarbital and also showed a significant increase in protection against pentylenotetrazole-induced convulsions. These results indicate an anxiolytic and anticonvulsant-like action fromC. sicyoidesL. extract on mice, probably due to the action of flavonoid(s), Linalool, and -tocopherol present in theC. sicyoidesleaves.

scholarly journals Neuropharmacological Profile of Fractions of Actaea acuminata H. Hara Roots

2018 ◽  
Vol 6 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Deepak Kumar ◽  
Suresh Kumar
Keyword(s):  
Ethyl Acetate ◽  
Methanol Extract ◽  
Elevated Plus Maze ◽  
Ethyl Acetate Fraction ◽  
Extension Phase ◽  
Butanol Fraction ◽  
Swim Test ◽  
Plus Maze ◽  
Immobility Time ◽  
Tonic Extension

The methanol extract of Actaea acuminata roots have beenpreviously reported to exhibit significant antianxiety, anticonvulsant andantidepressant activities. In present study fractionation of crude bioactivemethanol extract was carried out using different solvents employing standardprocedure. Various fractions were evaluated for antianxiety, anticonvulsantand antidepressant activities using elevated plus maze model (EPM), maximalelectroshock-induced convulsions model (MES) and forced / despair swim test(FST) respectively. Successive partitioning of bioactive methanol extract wasdone with ethyl acetate and 1-butanol. The ethyl acetate fraction (EAF; 100mg/kg), 1-butanol fraction (BF; 25 mg/kg) and remaining methanol extract(RME; 70 mg/kg) were subjected to neuropharmacological activities. TheEAF significantly enhanced entries and average time spent in open arms;significantly decreased duration of MES-induced tonic extension phase andsignificantly decreased duration of immobility time of rats in comparisonto control. BF and RME did not exhibit any neuropharmacological activity.Qualitative chemical tests confirmed presence of alkaloids and polyphenolsin EAF. It is finally concluded that alkaloids and/or polyphenols are bioactiveconstituents of A. acuminata which are responsible for neuropharmacologicalactivities.

scholarly journals NEUROPHARMACOLOGICAL SCREENING, ANTI-STRESS ACTIVITY, AND TOXICITY STUDIES OF STANDARDIZED EXTRACT OF THE SEEDS OF CELASTRUS PANICULATUS WILLD

2021 ◽  
pp. 52-56
Author(s):  
SWATI SINGH ◽  
ASHUTOSH UPADHYAY ◽  
ANUP KUMAR SIRBAIYA
Keyword(s):  
Elevated Plus Maze ◽  
Ethanolic Extract ◽  
Tolerance Test ◽  
Control Group ◽  
Tail Suspension ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze ◽  
Immobility Time ◽  
Swimming Endurance

Objective: Celastrus paniculatus Willd, family Celastraceae is an important medicinal plant distributed all over India. Due to the presence of antioxidative polyphenols in C. paniculatus Willd have received much attention for health-promoting properties by scavenging the free radicals, the purpose of this study is to understand neuropharmacological, anti-stress activity, and toxicity studies of standardized seeds extract of “C. paniculatus Willd. Methods: The sun dried C. paniculatus Willd seeds were collected and extracted with ethanol by maceration. Then, the ethanolic extract was subjected to phytochemical screening. The acute toxicity of the ethanolic extract of C. paniculatus was observed as per the Organization for Economic Co-operation and Development guideline no. 423. Neuropharmacological and anti-stress effects were analyzed and evaluated by using physical stress models such as Swimming endurance test, Anoxic tolerance test, Tail suspension test (TST), and Elevated plus maze test. For this study, Swiss albino mice (20–30 g) were divided into five groups of six animals each. Distilled water administered as vehicle in control group and standard group received Withania somnifera (100 mg/kg) while C. paniculatus Willd ethanolic extract (100, 200, and 400 mg/kg) was given orally for 7 days. Results and Discussion: Change in immobility time in swim endurance, first clonic convulsion produced in anoxic tolerance test, immobility time in TST and open arms entry in elevated plus maze test was recorded as parameters. The ethanolic extracts of C. paniculatus Willd significantly reduces the immobility timing along with increases the swimming endurance time, and clonic convulsion timing in anoxic tolerance test in comparison of control group. In tail suspension significant decrease in immobility time and increased open arm entry in elevated plus maze were observed as compare to control group. Conclusion: C. paniculatus Willd has potential as a medicinal plant and it showed protective effect for the stress prevention as the alkaloids are present as main constituents.

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