scholarly journals Aortic thromboembolism. A different predisposing disease in four dogs: a case report

2019 ◽  
Vol 64 (No. 9) ◽  
pp. 417-421
Author(s):  
JO Ahn ◽  
SC Park ◽  
WJ Song ◽  
MO Ryu ◽  
Q Li ◽  
...  
Keyword(s):  
Cardiac Disease ◽  
Doppler Ultrasonography ◽  
Clinical Signs ◽  
The Other ◽  
Two Dimensional ◽  
Imaging Studies ◽  
Iliac Arteries ◽  
Tissue Plasminogen ◽  
Pelvic Limb ◽  
Concurrent Disease

Four dogs had signs of pelvic limb lameness, pain, and collapse resulting from an occlusion of the distal aorta or the iliac arteries by thrombi. The diagnosis of an aortic thromboembolism was based on the absence or weakness of a femoral pulse, and the two-dimensional and Doppler ultrasonography of the abdominal aorta, iliac, and femoral arteries. Three dogs had a concurrent disease predisposing to thrombosis, including hyperadrenocorticism, protein losing nephropathy, neoplasia, and cardiac disease. Three dogs were treated with a tissue plasminogen activator (t-PA) in an attempt to lyse the thrombosis; two regained pelvic limb function. The other two dogs died shortly after the diagnosis of a thrombosis. A complete description of the history, clinical signs, laboratory analysis and imaging studies is included. Moreover, a review of the aortic thromboembolism, a diagnosis protocol and the options for its treatment are discussed.

Three-Dimensional Reconstruction of Two Forms of the Chaperonin GRO EL

1990 ◽  
Vol 48 (1) ◽  
pp. 258-259
Author(s):  
J.L. Carrascosa ◽  
G. Abella ◽  
S. Marco ◽  
M. Muyal ◽  
J.M. Carazo
Keyword(s):  
Three Dimensional ◽  
The Other ◽  
Two Dimensional ◽  
Series Method ◽  
Three Dimensional Reconstruction ◽  
Structural Components ◽  
E Coli ◽  
Dimensional Reconstruction ◽  
Morphogenetic Factors ◽  
Tilt Series

Chaperonins are a class of proteins characterized by their role as morphogenetic factors. They trantsiently interact with the structural components of certain biological aggregates (viruses, enzymes etc), promoting their correct folding, assembly and, eventually transport. The groEL factor from E. coli is a conspicuous member of the chaperonins, as it promotes the assembly and morphogenesis of bacterial oligomers and/viral structures.We have studied groEL-like factors from two different bacteria:E. coli and B.subtilis. These factors share common morphological features , showing two different views: one is 6-fold, while the other shows 7 morphological units. There is also a correlation between the presence of a dominant 6-fold view and the fact of both bacteria been grown at low temperature (32°C), while the 7-fold is the main view at higher temperatures (42°C). As the two-dimensional projections of groEL were difficult to interprete, we studied their three-dimensional reconstruction by the random conical tilt series method from negatively stained particles.

Immunological Relationship Between Plasminogen Activator Inhibitors from Different Sources

1987 ◽  
Vol 57 (01) ◽  
pp. 029-034 ◽  
Author(s):  
Göran Urdén ◽  
Joanna Chmielewska ◽  
Tomas Carlsson ◽  
Björn Wiman
Keyword(s):  
Plasminogen Activator ◽  
Polyclonal Antibodies ◽  
Active Form ◽  
Polyclonal Antiserum ◽  
The Other ◽  
Hep G2 ◽  
Inhibitor Activity ◽  
Tissue Plasminogen ◽  
Immunological Relationship ◽  
Different Sources

SummaryPolyclonal antibodies have been raised against the inhibitor moiety in the purified complex between tissue plasminogen activator and its fast inhibitor (PA-inhibitor) in human plasma/ serum. A radioimmunoassay for quantitation of PA-inhibitor antigen was developed. The polyclonal antiserum and a previously described monoclonal antibody against the PA-inhibitor (14) have been used to study the immunological relationship between PA-inhibitors from plasma, serum, platelets, placenta extract and conditioned media from Hep G2 and HT 1080 cells. It was demonstrated that the ratio between PA-inhibitor activity and antigen varied considerably between the different sources. In the plasma samples studied, similar activity and antigen concentrations were found, suggesting that the PA-inhibitor in these samples mainly was in an active form. On the other hand the other sources seemed to contain variable amounts of inactive PA-inhibitor forms. Immunoadsorption experiments revealed that the PA-inhibitor (activity and antigen) from all the sources were specifically bound to the insolubilized antibodies (polyclonal and monoclonal). In no case, however, could active PA-inhibitor be eluted from the immunoadsorption columns. Also the competitive radioimmunoassays suggested that the PA-inhibitors from the different sources studied, were closely immunologically related.

Polymer-Graphene Nanoassemblies and their Applications in Cancer Theranostics

2020 ◽  
Vol 20 (11) ◽  
pp. 1340-1351 ◽  
Author(s):  
Ponnurengam M. Sivakumar ◽  
Matin Islami ◽  
Ali Zarrabi ◽  
Arezoo Khosravi ◽  
Shohreh Peimanfard
Keyword(s):  
Mechanical Stability ◽  
Chemical Properties ◽  
The Other ◽  
Hydrophilic Polymer ◽  
Two Dimensional ◽  
Normal Tissues ◽  
Physical Chemical ◽  
Anti Cancer ◽  
Good Biocompatibility ◽  
Cancer Theranostics

Background and objective: Graphene-based nanomaterials have received increasing attention due to their unique physical-chemical properties including two-dimensional planar structure, large surface area, chemical and mechanical stability, superconductivity and good biocompatibility. On the other hand, graphene-based nanomaterials have been explored as theranostics agents, the combination of therapeutics and diagnostics. In recent years, grafting hydrophilic polymer moieties have been introduced as an efficient approach to improve the properties of graphene-based nanomaterials and obtain new nanoassemblies for cancer therapy. Methods and results: This review would illustrate biodistribution, cellular uptake and toxicity of polymergraphene nanoassemblies and summarize part of successes achieved in cancer treatment using such nanoassemblies. Conclusion: The observations showed successful targeting functionality of the polymer-GO conjugations and demonstrated a reduction of the side effects of anti-cancer drugs for normal tissues.

scholarly journals On the Kirchhoff-Love Hypothesis (Revised and Vindicated)

2021 ◽  
Author(s):  
Olivier Ozenda ◽  
Epifanio G. Virga
Keyword(s):  
Free Energy ◽  
Dimension Reduction ◽  
Three Dimensional ◽  
Energy Functional ◽  
The Other ◽  
Variational Model ◽  
Two Dimensional ◽  
Elastic Plates ◽  
Kinematic Constraint ◽  
Free Energy Functional

AbstractThe Kirchhoff-Love hypothesis expresses a kinematic constraint that is assumed to be valid for the deformations of a three-dimensional body when one of its dimensions is much smaller than the other two, as is the case for plates. This hypothesis has a long history checkered with the vicissitudes of life: even its paternity has been questioned, and recent rigorous dimension-reduction tools (based on standard $\varGamma $ Γ -convergence) have proven to be incompatible with it. We find that an appropriately revised version of the Kirchhoff-Love hypothesis is a valuable means to derive a two-dimensional variational model for elastic plates from a three-dimensional nonlinear free-energy functional. The bending energies thus obtained for a number of materials also show to contain measures of stretching of the plate’s mid surface (alongside the expected measures of bending). The incompatibility with standard $\varGamma $ Γ -convergence also appears to be removed in the cases where contact with that method and ours can be made.

scholarly journals Long way to Ricci flatness

2020 ◽  
Vol 2020 (10) ◽  
Author(s):  
Jin Chen ◽  
Chao-Hsiang Sheu ◽  
Mikhail Shifman ◽  
Gianni Tallarita ◽  
Alexei Yung
Keyword(s):  
Sigma Model ◽  
Ultra Violet ◽  
The Other ◽  
Target Space ◽  
Linear Sigma Model ◽  
Close Relative ◽  
Two Dimensional ◽  
World Sheet ◽  
Ricci Flat ◽  
The World

Abstract We study two-dimensional weighted $$ \mathcal{N} $$ N = (2) supersymmetric ℂℙ models with the goal of exploring their infrared (IR) limit. 𝕎ℂℙ(N,$$ \tilde{N} $$ N ˜ ) are simplified versions of world-sheet theories on non-Abelian strings in four-dimensional $$ \mathcal{N} $$ N = 2 QCD. In the gauged linear sigma model (GLSM) formulation, 𝕎ℂℙ(N,$$ \tilde{N} $$ N ˜ ) has N charges +1 and $$ \tilde{N} $$ N ˜ charges −1 fields. As well-known, at $$ \tilde{N} $$ N ˜ = N this GLSM is conformal. Its target space is believed to be a non-compact Calabi-Yau manifold. We mostly focus on the N = 2 case, then the Calabi-Yau space is a conifold. On the other hand, in the non-linear sigma model (NLSM) formulation the model has ultra-violet logarithms and does not look conformal. Moreover, its metric is not Ricci-flat. We address this puzzle by studying the renormalization group (RG) flow of the model. We show that the metric of NLSM becomes Ricci-flat in the IR. Moreover, it tends to the known metric of the resolved conifold. We also study a close relative of the 𝕎ℂℙ model — the so called zn model — which in actuality represents the world sheet theory on a non-Abelian semilocal string and show that this zn model has similar RG properties.

Sight distance red zones on combined horizontal and sag vertical curves

1998 ◽  
Vol 25 (4) ◽  
pp. 621-630 ◽  
Author(s):  
Yasser Hassan ◽  
Said M Easa
Keyword(s):  
Quantitative Analysis ◽  
Three Dimensional ◽  
The Other ◽  
Two Dimensional ◽  
Horizontal Curve ◽  
Sight Distance ◽  
Stopping Sight Distance ◽  
Three Dimensional Models ◽  
Highway Alignment ◽  
Current Standards

Coordination of highway horizontal and vertical alignments is based on subjective guidelines in current standards. This paper presents a quantitative analysis of coordinating horizontal and sag vertical curves that are designed using two-dimensional standards. The locations where a horizontal curve should not be positioned relative to a sag vertical curve (called red zones) are identified. In the red zone, the available sight distance (computed using three-dimensional models) is less than the required sight distance. Two types of red zones, based on stopping sight distance (SSD) and preview sight distance (PVSD), are examined. The SSD red zone corresponds to the locations where an overlap between a horizontal curve and a sag vertical curve should be avoided because the three-dimensional sight distance will be less than the required SSD. The PVSD red zone corresponds to the locations where a horizontal curve should not start because drivers will not be able to perceive it and safely react to it. The SSD red zones exist for practical highway alignment parameters, and therefore designers should check the alignments for potential SSD red zones. The range of SSD red zones was found to depend on the different alignment parameters, especially the superelevation rate. On the other hand, the results showed that the PVSD red zones exist only for large values of the required PVSD, and therefore this type of red zones is not critical. This paper should be of particular interest to the highway designers and professionals concerned with highway safety.Key words: sight distance, red zone, combined alignment.

Determination of multidirectional myocardial deformations in cats with hypertrophic cardiomyopathy by using two-dimensional speckle-tracking echocardiography

2017 ◽  
Vol 19 (12) ◽  
pp. 1283-1289 ◽  
Author(s):  
Ryohei Suzuki ◽  
Yohei Mochizuki ◽  
Hiroki Yoshimatsu ◽  
Takahiro Teshima ◽  
Hirotaka Matsumoto ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Speckle Tracking ◽  
Speckle Tracking Echocardiography ◽  
Contractile Function ◽  
Radial Strain ◽  
Clinical Signs ◽  
Myocardial Deformation ◽  
Radial Deformation ◽  
Two Dimensional

Objectives Hypertrophic cardiomyopathy, a primary disorder of the myocardium, is the most common cardiac disease in cats. However, determination of myocardial deformation with two-dimensional speckle-tracking echocardiography in cats with various stages of hypertrophic cardiomyopathy has not yet been reported. This study was designed to measure quantitatively multidirectional myocardial deformations of cats with hypertrophic cardiomyopathy. Methods Thirty-two client-owned cats with hypertrophic cardiomyopathy and 14 healthy cats serving as controls were enrolled and underwent assessment of myocardial deformation (peak systolic strain and strain rate) in the longitudinal, radial and circumferential directions. Results Longitudinal and radial deformations were reduced in cats with hypertrophic cardiomyopathy, despite normal systolic function determined by conventional echocardiography. Cats with severely symptomatic hypertrophic cardiomyopathy also had lower peak systolic circumferential strain, in addition to longitudinal and radial strain. Conclusions and relevance Longitudinal and radial deformation may be helpful in the diagnosis of hypertrophic cardiomyopathy. Additionally, the lower circumferential deformation in cats with severe hypertrophic cardiomyopathy may contribute to clinical findings of decompensation, and seems to be related to severe cardiac clinical signs. Indices of multidirectional myocardial deformations by two-dimensional speckle-tracking echocardiography may be useful markers and help to distinguish between cats with hypertrophic cardiomyopathy and healthy cats. Additionally, they may provide more detailed assessment of contractile function in cats with hypertrophic cardiomyopathy.

scholarly journals THE ENERGY EIGENVALUES OF THE TWO DIMENSIONAL HYDROGEN ATOM IN A MAGNETIC FIELD

2006 ◽  
Vol 15 (06) ◽  
pp. 1263-1271 ◽  
Author(s):  
A. SOYLU ◽  
O. BAYRAK ◽  
I. BOZTOSUN
Keyword(s):  
Magnetic Field ◽  
Hydrogen Atom ◽  
Iteration Method ◽  
Weak Magnetic Field ◽  
The Other ◽  
Asymptotic Iteration Method ◽  
Iterative Approach ◽  
Two Dimensional ◽  
Energy Eigenvalues ◽  
The Magnetic Field

In this paper, the energy eigenvalues of the two dimensional hydrogen atom are presented for the arbitrary Larmor frequencies by using the asymptotic iteration method. We first show the energy eigenvalues for the case with no magnetic field analytically, and then we obtain the energy eigenvalues for the strong and weak magnetic field cases within an iterative approach for n=2-10 and m=0-1 states for several different arbitrary Larmor frequencies. The effect of the magnetic field on the energy eigenvalues is determined precisely. The results are in excellent agreement with the findings of the other methods and our method works for the cases where the others fail.

Clinical signs and histopathology of brain, spinal cord and muscle of the pelvic limb of rats experimentally infected with Trypanosoma evansi

2012 ◽  
Vol 208 (1) ◽  
pp. 39-44 ◽  
Author(s):  
Aleksandro S. Da Silva ◽  
Camila B. Oliveira ◽  
Claudia M. Bertoncheli ◽  
Rosmarine P. Santos ◽  
Diego V. Beckmann ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Clinical Signs ◽  
Trypanosoma Evansi ◽  
Pelvic Limb

Coupled systems of two-dimensional turbulence

2013 ◽  
Vol 732 ◽  
Author(s):  
Rick Salmon
Keyword(s):  
Hamiltonian System ◽  
Energy Conservation ◽  
Strong Correlation ◽  
Conservation Law ◽  
Hamiltonian Dynamics ◽  
Coupled Systems ◽  
The Other ◽  
Two Dimensional ◽  
Coherent Vortices ◽  
Fluid Particles

AbstractOrdinary two-dimensional turbulence corresponds to a Hamiltonian dynamics that conserves energy and the vorticity on fluid particles. This paper considers coupled systems of two-dimensional turbulence with three distinct governing dynamics. One is a Hamiltonian dynamics that conserves the vorticity on fluid particles and a quantity analogous to the energy that causes the system members to develop a strong correlation in velocity. The other two dynamics considered are non-Hamiltonian. One conserves the vorticity on particles but has no conservation law analogous to energy conservation; the other conserves energy and enstrophy but it does not conserve the vorticity on fluid particles. The coupled Hamiltonian system behaves like two-dimensional turbulence, even to the extent of forming isolated coherent vortices. The other two dynamics behave very differently, but the behaviours of all four dynamics are accurately predicted by the methods of equilibrium statistical mechanics.

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