scholarly journals Pathogenesis of Type 1 Diabetes Mellitus and Rodent Experimental Models

Acta Naturae ◽  
2018 ◽  
Vol 10 (1) ◽  
pp. 24-33 ◽  
Author(s):  
I. G. Gvazava ◽  
O. S. Rogovaya ◽  
M. A. Borisov ◽  
E. A. Vorotelyak ◽  
A. V. Vasiliev
Keyword(s):  
Diabetes Mellitus ◽  
Scientific Literature ◽  
Therapeutic Agents ◽  
Experimental Models ◽  
Experimental Animal Models ◽  
Advantages And Disadvantages ◽  
Diabetes Model ◽  
Prevalence Of Diabetes Mellitus ◽  
Methods Of Treatment

The global prevalence of diabetes mellitus and its severe complications is on the rise. The study of the pathogenesis of the onset and the progression of complications related to the disease, as well as the search for new therapeutic agents and methods of treatment, remains relevant. Experimental models are extremely important in the study of diabetes. This survey contains a synthesis of the most commonly used experimental animal models described in scientific literature. The mechanisms of the streptozotocin model are also analyzed and discussed, as it is considered as the most adequate and easily reproducible diabetes model. A review of the significant advantages and disadvantages of the described models has also been conducted.

scholarly journals Experimental models of type 1 diabetes

2019 ◽  
Vol 68 (2) ◽  
pp. 109-118 ◽  
Author(s):  
Maria I. Yarmolinskaya ◽  
Nelly Yu. Andreyeva ◽  
Elena I. Abashova ◽  
Elena V. Misharina
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Animal Models ◽  
Type 1 Diabetes Mellitus ◽  
Experimental Models ◽  
Preclinical Research ◽  
Experimental Animal Models ◽  
Advantages And Disadvantages ◽  
Morphological Patterns

This article describes currently used experimental animal models of type 1 diabetes. The literature data on the pathogenesis of clinical and morphological patterns of the disease and the possibility of extrapolation have been summarized in the review. In addition, the advantages and disadvantages of each of the models have been evaluated. Based on the reported results, it can be concluded that preclinical research is essential as fundamental basis for the investigation of type 1 diabetes mellitus.

scholarly journals Experimental Diabetes Mellitus in Different Animal Models

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Amin Al-awar ◽  
Krisztina Kupai ◽  
Médea Veszelka ◽  
Gergő Szűcs ◽  
Zouhair Attieh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Animal Models ◽  
Critical Role ◽  
Therapeutic Agents ◽  
High Blood Glucose ◽  
Advantages And Disadvantages ◽  
Limited Effectiveness ◽  
Akita Mice

Animal models have historically played a critical role in the exploration and characterization of disease pathophysiology and target identification and in the evaluation of novel therapeutic agents and treatments in vivo. Diabetes mellitus disease, commonly known as diabetes, is a group of metabolic disorders characterized by high blood glucose levels for a prolonged time. To avoid late complications of diabetes and related costs, primary prevention and early treatment are therefore necessary. Due to its chronic symptoms, new treatment strategies need to be developed, because of the limited effectiveness of the current therapies. We overviewed the pathophysiological features of diabetes in relation to its complications in type 1 and type 2 mice along with rat models, including Zucker Diabetic Fatty (ZDF) rats, BB rats, LEW 1AR1/-iddm rats, Goto-Kakizaki rats, chemically induced diabetic models, and Nonobese Diabetic mouse, and Akita mice model. The advantages and disadvantages that these models comprise were also addressed in this review. This paper briefly reviews the wide pathophysiological and molecular mechanisms associated with type 1 and type 2 diabetes, particularly focusing on the challenges associated with the evaluation and predictive validation of these models as ideal animal models for preclinical assessments and discovering new drugs and therapeutic agents for translational application in humans.

Exceptional case of disseminated necrobiosis lipoidica similar to a sarcoidosis form at the child affected by diabetes type I

2016 ◽  
Vol 19 (4) ◽  
pp. 227-230
Author(s):  
V. T Bazaev ◽  
M. B Tseboeva ◽  
M. S Tsarueva
Keyword(s):  
Diabetes Mellitus ◽  
Short Review ◽  
Exceptional Case ◽  
Diabetes Type ◽  
Type I ◽  
Necrobiosis Lipoidica ◽  
Modern Methods ◽  
Diabetes Type I ◽  
Methods Of Treatment

The article describes the infrequent disseminated necrobiosis lipoidica similar to a sarcoidosis form which developed at the five-year-old child affected by type 1 diabetes mellitus. The short review concerns the questions of an etiology, pathogenesis, clinical forms, diagnostics and the modern methods of treatment of the described pathology. In the review 26 sources of literature are used. The case is of interest to dermatovenereologists, endocrinologists, pediatricians.

Prospects of antigen-specific therapy in type 1 diabetes mellitus

2012 ◽  
Vol 15 (4) ◽  
pp. 28-32
Author(s):  
Tatiana Vasil'evna Nikonova ◽  
Yulia Viktorovna Alekseeva
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Pancreatic Beta Cells ◽  
Large Scale ◽  
Specific Immunotherapy ◽  
Preventive Measures ◽  
Therapeutic Agents ◽  
Specific Therapy

Type 1 diabetes mellitus is commonly recognized as an autoimmune disease characterized by progressive destruction of pancreatic ?-beta-cells. Progress in diagnostics at preclinical stage is accompanied with active development of preventive measures. So far, there are no specific therapeutic agents approved for clinical practice. However, ongoing large-scale studies have outlined some promising solutions, antigen-specific immunotherapy being one of them.

scholarly journals Environments for the development of disease management competencies of children with diabetes mellitus: Children's experience

2020 ◽  
Vol 85 ◽  
pp. 02008
Author(s):  
Vida Gudzinskiene ◽  
Indre Cergelyte–Podgrusienei
Keyword(s):  
Diabetes Mellitus ◽  
Disease Management ◽  
Learning Environments ◽  
Family Environment ◽  
Scientific Literature ◽  
Structured Interview ◽  
Management Competencies ◽  
Interview Method ◽  
Medical Institutions

Type 1 diabetes mellitus alters the child's and their parents' life. The child must acquire necessary competencies that would help manage the disease. The child with diabetes mellitus can receive information from a variety of learning environments. Research object is – environments for the development of disease management competencies of children with diabetes mellitus. Research aim is to reveal environments for the development of disease management competencies of children with diabetes mellitus by highlighting what helps a child with diabetes to acquire disease management competencies, and the challenges occurring while acquiring those competencies. Research methods: theoretical – analysis, comparison and generalization of scientific literature; empirical – a semi-structured interview method has been used for the collection of data; method of content analysis has been applied for the study of research data. Participants of the research were children with diabetes mellitus. The empirical study revealed that environments for the development of disease management competencies of children with diabetes mellitus are the following: environment of medical institutions and the professionals working there, family environment (family members), and the environment of camps for children with diabetes mellitus, including organizers of camps and specialists and volunteers invited. The research determined challenges of developing disease management competencies of children with diabetes mellitus in various learning environments.

scholarly journals Experimental Models of Spinal Cord Injury in Laboratory Rats

Acta Naturae ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 4-10 ◽  
Author(s):  
A. N. Minakov ◽  
A. S. Chernov ◽  
D. S. Asutin ◽  
N. A. Konovalov ◽  
G. B. Telegin
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Experimental Studies ◽  
Therapeutic Agents ◽  
Experimental Models ◽  
Biodegradable Materials ◽  
Topical Issue ◽  
Laboratory Rats ◽  
Advantages And Disadvantages ◽  
Cord Injury

Pathologies associated with spinal cord injury are some of the leading diseases in the world. The search for new therapeutic agents and 3D biodegradable materials for the recovery of spinal cord functions is a topical issue. In this review, we have summarized the literature data on the most common experimental models of spinal cord injury in laboratory rats and analyzed the experience of using 3D biodegradable materials (scaffolds) in experimental studies of spinal trauma. The advantages and disadvantages of the described models are systematically analyzed in this review.

scholarly journals NEEDS AND SOURCES OF INFORMATION ON DISEASE MANAGEMENT FOR PARENTS OF CHILDREN WITH DIABETES MELLITUS

2020 ◽  
Vol 6 ◽  
pp. 181
Author(s):  
Indrė Čergelytė - Podgrušienė ◽  
Vida Gudžinskienė
Keyword(s):  
Diabetes Mellitus ◽  
Disease Management ◽  
Scientific Literature ◽  
Sources Of Information ◽  
Daily Routines ◽  
Medical Institutions ◽  
Children And Parents ◽  
Search For Information ◽  
And Control

Type 1 diabetes mellitus in children alters the rhythm and daily routines of children and parents, as there appears a need to treat and control this disease. Parents need to learn how to optimally care for the health of their children: monitor levels of blood glucose, follow a diet plan, inject insulin and organize the child’s schedule. Research object: needs and sources of information for parents of children with diabetes mellitus on the management of their child’s disease. Research aim is to reveal the needs and sources of information on the disease and its management for parents of children with diabetes mellitus. Research tasks: 1) to identify the needs of parents of children with diabetes mellitus for information on the disease management; 2) to reveal how and in what ways parents search for information on the child’s disease and its management. Research methods: theoretical – analysis, generalization and systematization of scientific literature; empirical – a semi-structured method of interview has been used for the collection of data; method of content analysis has been applied to the study of research data. There were 6 women of children with diabetes mellitus, who agreed to participate in the research. Participants of the research raise children who have diabetes mellitus up to 3 years after diagnosis; children’s age ranges from 3 to 11 years old. All women had higher education. The empirical study revealed that mothers of children with diabetes mellitus require information on the child’s disease and its control. Participants of the research mentioned that they try to obtain information from various sources: medical institutions, relatives, the Internet, social networks, etc. 

Prevalence of Diabetes Mellitus types 1 and 2 in Erbil City and related factors

2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Galawezh Othman
Keyword(s):  
Diabetes Mellitus ◽  
Blood Group ◽  
Diabetic Patients ◽  
Related Factors ◽  
Family Strain ◽  
Different Types ◽  
The Relationship ◽  
Prevalence Of Diabetes Mellitus

This study aimed to investigate the prevalence of different types of Diabetes Mellitus; the data collected from 84 patients randomly in Layla Qasem Diabetic center in Erbil city to study some genetic factors on Diabetes Mellitus disease by depend on their ages, gender, family history, Blood group and albumin in urine. In case of age average of their age was 40% between 50_60 years old and by depending on their Gender, average of genders 70% was female and 30% male in type 2, while in type 1 40% female and 60% male. The relationship between their family strain 43% of them was positive in type 2DM, and 50% positive in type 1DM. Then we compared their blood group according to our results 39 % of them was O blood group,  and in case of albumin in their urine ,in type 2 DM 35% was 30mg/l ,37% was 10mg/l, 9% was 150mg/l, and  19% was 80 mg/l .also in type 1DM 43% was 10mg/l, 11% was 150mg/l, 33% was 30 mg/l, and  13% 80mg/l . We concluded that Diabetes Mellitus in our area is more common in female than male, the percentage of the diabetes increased with age and most diabetic patients have O blood Group.

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