Evaluation of Serum 25(OH)D Levels in Obese and Normal-Weight Children with Carious and Hypomineralized Teeth

2021 ◽  
Vol 45 (1) ◽  
pp. 35-40
Author(s):  
Gülçin Doğusal ◽  
Işıl Sönmez ◽  
Tolga Ünüvar
Keyword(s):  
Vitamin D ◽  
Dental Caries ◽  
Age Groups ◽  
Normal Weight ◽  
Controlled Study ◽  
Molar Incisor Hypomineralisation ◽  
Obese Children ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
Significant Difference

Aim: The aim of this study was to assess the association between dental caries, molar incisor hypomineralisation (MIH) and obesity in relationship with different vitamin D levels in children. Study design: This retrospective case-controlled study enrolled 455 children aged 6–18 years, who attended to both pediatric endocrinology and pediatric dentistry clinics at the Aydin Adnan Menderes University Hospital, Turkey. Vitamin D status was measured with serum (25(OH)D) concentrations. Body mass index (BMI) were used to determine adiposity. Caries status was assessed using the decayed-missing-filled teeth (dft) and (DMFT) index for primary and permanent dentitions using WHO standard methodology. MIH were diagnosed according to the EAPD criteria. Results: DMFT did not show any significant difference between obese and normal weight children in both age groups. However, in 6–11 age group, obese children had lower dft and the difference was statistically significant (p<0.001). Median caries index values and MIH prevelance among the obese and normal weight children found similar with deficient, insufficient and sufficient levels of serum 25(OH) D in both age groups. Conclusion: Our analyses provide no evidence to suggest that obese children are at increased risk for dental caries. Serum 25(OH)D concentrations would not seem to have a significant effect on dental caries and MIH in children.

scholarly journals Vitamin D Deficiency in Children and Adolescents: Role of Puberty and Obesity on Vitamin D Status

2021 ◽  
Vol 14 ◽  
pp. 117863882110187
Author(s):  
Hedyeh Saneifard ◽  
Marjan Shakiba ◽  
Ali Sheikhy ◽  
Leila Baniadam ◽  
Fatemeh Abdollah Gorji ◽  
...  
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Tanner Stage ◽  
Additional Risk Factor ◽  
Healthy Children ◽  
Vitamin D Status ◽  
Obese Children ◽  
Increased Risk ◽  
Vitamin D Levels

Background: Vitamin D deficiency is common among children and adolescents and can be affected by several factors such as puberty and obesity. Objective: The aim of this study was to evaluate vitamin D status in children and adolescents and to analyse the influence of puberty and obesity on its level. Method: A cross-sectional study was carried-out, in which clinical and biochemical data were gathered from 384 healthy children and adolescents between May 2019 to May 2020. Results: 220 females and 164 males were enrolled (aged 7-16 years; mean ± SD: 11 ± 2.5). Vitamin D deficiency was found in 49% of the total cases and was significantly more prevalent in females than males (33.1% in female; 15.9% in male, P < .001). Mean vitamin D level was lower in obese children compared with non-obese ( P < .001). Non-obese group had significantly higher levels of vitamin D in Tanner stage IV of puberty than obese individuals (20.1 ± 17.0 vs 5.4 ± 2.0) ( P = .03). Vitamin D levels were significantly lower in females than males only in Tanner stage II (12.3 ± 9.0 vs 19.6 ± 16.6) ( P = .005). The lowest level of Vitamin D was in Tanner stage Ⅳ-Ⅴ in boys and in Tanner stage Ⅱ-Ⅲ in girls ( P < .001). Conclusion: Puberty is an additional risk factor for vitamin D deficiency especially in girls and obese children. This increased risk, together with the fact that most important time for building a proper skeleton is during childhood and adolescent, makes it essential to monitor vitamin D in these age groups.

Serum vitamin D status does not correlate with the severity of obstructive sleep apnea in male adults: A controlled study design with minimized factors influencing serum vitamin D levels

2020 ◽  
Vol 90 (5-6) ◽  
pp. 470-476 ◽  
Author(s):  
Ozge Yagcioglu Yassa ◽  
Saime Fusun Domac ◽  
Gulay Kenangil
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Significant Relationship ◽  
Serum Vitamin ◽  
Controlled Study ◽  
Vitamin D Status ◽  
Anthropometric Measures ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Significant Difference

Abstract. Observational studies performed in homogeneous groups to objectively investigate the cause and effect relationship between vitamin D deficiency and sleep disorders are scarce. In this study, it was aimed to analyze the relationship between the severity of OSAS and vitamin-D levels among the participants whose features affecting serum vit-D levels were minimised. Serum 25-OH vitamin-D levels in 121 OSAS Male patients diagnosed by polysomnography without any systemic disease or vitamin-D supplement that may effect the vitamin-D metabolism were measured. The study was conducted in winter (latitude: 41°). Anthropometric measures and biochemical tests were also performed. The distribution of vitamin-D levels was determined as severe deficiency, deficiency, insufficiency and sufficiency. Apnea-hypopne index (AHI) < 5 was considered as a control group. Patients were categorized into four groups according to AHI as control, mild, moderate and severe. The groups were similar in terms of age, BMI, lipid profile, serum calcium, anthropometric measures and smoking. There was no significant difference in the distribution of vitamin-D levels between the patient and control groups and also within OSAS subgroups (p = 0.57, p = 0.86, respectively). Odds ratio to have OSAS in patients with vitamin-D deficiency was found as 0.745 (95 %CI: 0.33–1.7). Multinominal regression analysis showed no significant relationship between the OSAS severity and the extent of vitamin-D status. Correlation analysis showed no significant relationship between vitamin-D and AHI (r = 0.017, p = 0.877). Vitamin-D status does not alter the severity of OSAS. Vitamin-D deficiency might be the result of lifestyle changes due to OSAS rather than a cause.

scholarly journals AB0641 EFFECT OF AGE ON PARATHYROID HORMONE RESPONSE TO VITAMIN D INSUFFICIENCY IN PRIMARY HYPERPARATHYROIDISM

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1354.1-1354
Author(s):  
V. Deshani ◽  
M. Khalid ◽  
K. Jadoon
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Primary Hyperparathyroidism ◽  
Vitamin D Deficiency ◽  
Age Groups ◽  
Vitamin D Insufficiency ◽  
Hormone Response ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
The Impact

Background:Primary hyperparathyroidism (PHPT) is a common endocrine condition, commonly seen with increasing age. In vast majority, it is diagnosed incidentally and causes no particular symptoms. Symptoms are usually related to acute hypercalcaemia or the complications of chronically elevated serum calcium level. Vitamin D deficiency is common among general population and in patients with PHPT. Studies in secondary hyperparathyroidism (SHPT) have shown that parathyroid hormone (PTH) response is affected by age, with those over 80 showing greater rise in PTH levels. We wanted to see if age has a similar impact on PTH response to vitamin D in those with PHPT.Objectives:To evaluate the impact of age on PTH response to vitamin D insufficiency in those with PHPT.Methods:Patients with primary hyperparathyroidism (PHPT), attending general endocrine clinic of a district general hospital, were divided into two groups based on age; less than 70 (n=73) and 70 and above (n=61).Each group was subdivided into vitamin D insufficient (VDI) and vitamin D sufficient (VDS) subgroups. We compared calcium and parathyroid hormone levels and forearm BMD (presented as T score) in VDI and VDS subgroups in the two age groups, at the time of diagnosis. Data were analyzed using unpaired t-test and presented as mean ± SEM, using Graphpad Prism 9.0.1.Results:There was significant difference in Vitamin D levels in VDI and VDS subgroups, in both age groups (<70; mean vitamin D 27.98 vs. 68.44, p<0.0001; ≥70; mean vitamin D 34.44 vs. 75.74, p<0.0001). The two groups were significantly different in terms of age (mean age 58 vs. 76, p<0.0001). Although there was no difference in calcium and forearm BMD in VDI and VDS, in both age groups, those under 70 showed a greater PTH response to vitamin D insufficiency (mean PTH 19.29 vs. 12.91 respectively, p<0.001).Conclusion:While in SHPT, those with increasing age show greater rise in PTH levels, our data show that in PHPT, younger patients show a greater PTH rise in response to vitamin D insufficiency. Further work is needed to elucidate the underlying mechanisms.References:[1]Wyskida et al., Parathyroid hormone response to different vitamin D levels in population-based old and very-old Polish cohorts, Experimental Gerontology, Volume 127, 2019, 110735, ISSN 0531-5565, https://doi.org/10.1016/j.exger.2019.110735.[2]Malik M Z, Latiwesh O B, Nouh F, et al. (August 15, 2020) Response of Parathyroid Hormone to Vitamin D Deficiency in Otherwise Healthy Individuals. Cureus 12(8): e9764. doi:10.7759/cureus.9764Disclosure of Interests:None declared.

Metabolic Imbalance and Vitamin D Deficiency in Type 1 Diabetes in the Algerian Population

2019 ◽  
Vol 19 (8) ◽  
pp. 1172-1176 ◽  
Author(s):  
Esma Mihoubi ◽  
Rachida Raache ◽  
Habiba Amroun ◽  
Malha Azzouz ◽  
Assia Galleze ◽  
...  
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
World Health ◽  
Diabetic Patients ◽  
Algerian Population ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Metabolic Imbalance

Background: We aimed to assess Vitamin D levels in patients with Type 1 Diabetes (T1D) and to investigate the correlation between vitamin D and metabolic imbalance. Material and Methods: For our study, we selected thirty-one patients with T1D without complications and fifty-seven healthy controls. Diabetic patients were diagnosed using the criteria of the World Health Organization/American Diabetes Association. Vitamin D, Parathyroid Hormone (PTH), insulin and C peptide assay were performed using chimilunescence. Glucose level, lipid profile, glycated haemoglobin (HbA1c) and ionogram were also analysed. Results: Vitamin D, HbA1c and Gly levels were found to be significant in T1D patients than in controls (P<0.5). However, for PTH, no significant difference was observed (P > 0. 05) and the results show a non-significant difference of total cholesterol potassium, sodium, phosphor and calcium concentration averages. Conclusion: Our results indicate that the deficiency of VD is associated with an increased risk of T1DM in Algerian population.

scholarly journals Increased Risk for Vitamin D Deficiency in Obese Children with Both Celiac Disease and Type 1 Diabetes

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Nithya Setty-Shah ◽  
Louise Maranda ◽  
Benjamin Udoka Nwosu
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Vitamin D Deficiency ◽  
Normal Weight ◽  
Obese Children ◽  
Prepubertal Children ◽  
Increased Risk ◽  
Post Hoc

Background. It is unknown whether the coexistence of type 1 diabetes (T1D) and celiac disease (CD) increases the risk for vitamin D deficiency.Aims. To determine the vitamin D status and the risk for vitamin D deficiency in prepubertal children with both T1D and CD compared to controls, TID, and CD.Subjects and Methods. Characteristics of 62 prepubertal children of age 2–13 y with either CD + T1D (n=22, 9.9 ± 3.1 y), CD only (n=18, 8.9 ± 3.3 y), or T1D only (n=22, 10.1 ± 2.8 y) were compared to 49 controls of the age of 8.0 ± 2.6 years. Vitamin D deficiency was defined as 25(OH)D < 50 nmol/L, overweight as BMI of >85th but <95th percentile, and obesity as BMI > 95th percentile.Results. The 4 groups had no difference in 25(OH)D (ANOVAP=0.123) before stratification into normal-weight versus overweight/obese subtypes. Following stratification, 25(OH)D differed significantly between the subgroups (F(3,98)=10.109, ANOVAP<0.001). Post-hoc analysis showed a significantly lower 25(OH)D in the overweight/obese CD + T1D compared to the overweight/obese controls (P=0.039) and the overweight/obese CD (P=0.003). Subjects with CD + T1D were 3 times more likely to be vitamin D deficient (OR = 3.1 [0.8–11.9],P=0.098), compared to controls.Conclusions. The coexistence of T1D and CD in overweight/obese prepubertal children may be associated with lower vitamin D concentration.

The Relationship Between the Serum Level of Vitamin D and Vitiligo

2015 ◽  
Vol 20 (2) ◽  
pp. 139-145 ◽  
Author(s):  
Huma Khurrum ◽  
Khalid M. AlGhamdi
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Controlled Study ◽  
Serum Vitamin D ◽  
Control Subjects ◽  
Younger Age ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
And Gender

Background: Low vitamin D levels have been associated with several autoimmune diseases. Vitiligo could be associated with low vitamin D levels. Objective: To determine the level of serum vitamin D in vitiligo patients compared to controls and reveal the possible association of vitamin levels with the pathogenesis of vitiligo. Patients and Methods: A case-controlled study was conducted. After excluding factors that may affect serum vitamin D levels, blood samples were taken from vitiligo patients and controls. The association between vitamin D levels and various vitiligo subgroups (duration of vitiligo, site of onset, age, etc) was measured and correlated. Results: A total of 150 vitiligo patients, 90 (60%) males with a mean age of 30.6 ± 11.4 years, were recruited. The study also had 150 age- and gender-matched vitiligo-free control subjects. There was no significant difference in median serum vitamin D levels between the cases and the controls ( P = .25). The serum levels of vitamin D of the vitiligo patients were found to be lower in males ( P = .01), the younger age group ( P = .01), and patients not treated with ultraviolet (UV) treatment ( P = .01). Conclusion: There is no difference between the vitamin D levels of the vitiligo patients and the control subjects. However, deficiency of 25(OH)D levels within the vitiligo subgroups may be linked to younger age, male gender, short duration of vitiligo, and non-use of phototherapy.

scholarly journals STUDY OF T-SCORE ACROSS DIFFERENT AGE GROUPS AND GENDER IN APPARENTLY HEALTHY POPULATION IN INDIA

2020 ◽  
pp. 1-3
Author(s):  
Abhishek Sinha
Keyword(s):  
Vitamin D ◽  
Age Groups ◽  
Analysis Data ◽  
Healthy Population ◽  
Mineral Density ◽  
Cross Sectional ◽  
T Score ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Males And Females

INTRODUCTION: Bone mineral density(BMD) is a common test done in our country. Traditionally, BMD has been reserved for postmenopausal females to check for risk of osteoporosis. The aim of this study is to check whether BMD score showed difference between males and females and across different age groups. Also, we tried to examine any correlation between Vitamin D and BMD values. MATERIAL AND METHODS: It was a cross-sectional observational study.118 healthy subjects of both genders were recruited. BMD was measured by dual energy X-ray absorptiometry(DEXA). Vitamin D was estimated by electrochemiluminescence. Statistical Analysis: Data was entered in to MS Excel and analyzed by STATA 12 software. Normality was analyzed. Mean and SD for all variables were calculated. Difference in T-score between males and females were calculated using T-test and T-score in different age groups was compared using one-way ANOVA test. Vitamin D levels were correlate with T-scores by Spearman's correlation test. RESULTS: Mean age of subjects was 51.31 years. Mean T-score was -1.40. Mean Vitamin D was 23.45 ng/ml. There was no significant difference between T-score of males and females. T-score was also not significantly different across age groups from 20 to 80 years. Vitamin D was not correlated with T-score in same subjects. Osteopenia was present in 74 subjects and osteoporosis in 11 subjects. DISCUSSION: Contrary to popular opinion, T-score was not different between males and females, therefore there is a need for uniform BMD criteria for both genders. Vitamin D levels alone are unreliable as they do not correlate with T-score. CONCLUSION: Thus, there is a need for revised T-score guidelines and additional tests like serum calcium, BMI, serum parathormone which needs to be done and examined together with BMD and Vitamin D to identify bone demineralization in the population.

scholarly journals SAT-389 Clinical and Biochemical Characterization of Risk Factors for Vertebral Fractures in Patients with Hypoparathyroidism

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Anna Maria Formenti ◽  
Luigi Di Filippo ◽  
Agnese Allora ◽  
Raffaele Giubbini ◽  
Andrea Giustina
Keyword(s):  
Vitamin D ◽  
Vertebral Fractures ◽  
Biochemical Characterization ◽  
Normal Weight ◽  
Predicting Factors ◽  
Increased Risk ◽  
Significant Difference ◽  
Positive Linear Correlation ◽  
25 Oh Vitamin D ◽  
One Year

Abstract Background: Persistent hypoparathyroidism (PH) is a rare disease due to an impaired secretion of PTH, mostly occurring as a complication of total thyroidectomy. Calcium and calcitriol are currently the most common and inexpensive therapies, although not all the patients easily achieve control of the disease. Recently, our group has reported that BMI at diagnosis can predict calcitriol resistance in PH. Very few studies have been performed with fractures as primary endpoint in hypoparathyroidism, and we still not know if PH could be predisposing to an increased risk of morphometric fractures and possible clinical and biochemical predicting factors. Patients and methods: To that end we retrospectively evaluated the anthropometric, biochemical and fracture characteristics in 71 consecutive patients with PH (F/M= 62/9; median age 58.7 yrs, range: 29-87; 67 with post-surgical PH and 4 with autoimmune PH). All patients were hypoparathyroid from at least one year (median duration of disease: 9 yrs., range: 1-41) and were under standard treatment with calcium and active vitamin D analogs (calcitriol). For each patient anthropometric data (BMI=kg/m2; N= Normal weight patients &lt;25; OO= Obese and overweight patients with BMI &gt; 25) were collected, as well as biochemical parameters, such as calcium (mg/dl) and 25 OH vitamin D (25OHD expressed as ng/ml). We considered well controlled (C) patients with calcium between 8.2 and 9.2 mg/dl and not controlled (NC) under 8.2 or above 9.2 mg/dl. Vertebral fractures (VF) were assessed by a quantitative morphometric approach by using images provided by DXA and classified according to Genant classification. Results: Thirteen out of 71 patients (18%) were fractured. We showed a positive linear correlation in the overall population between BMI and calcitriol intake (p=0.006, CI 95% [1.2-6.9]) while no significant difference in prevalence of VF in OO vs N group (8/40 vs 5/31, p=0.76) was found. However, almost half (6/13, 45%) of patients with VF were OO NC. Moreover, 86% of NC vs only 30% of C fractured patients (6/7 vs 2/6) were OO Discussion: We report a high prevalence of VF in hypoparathyroidism. Moreover, we confirm that increased BMI is associated with higher needs of calcitriol to obtain calcium control. Interestingly, our data suggest for the first time that OO hypoparathyroid patients with NC disease are those at highest risk of fracture. Therefore, in this subset of patients a more intensive and proactive biochemical and bone monitoring should be adviced if these results will be confirmed in larger studies.

scholarly journals Evaluation of vitamin D status in suspected cases of metabolic syndrome

2019 ◽  
Vol 7 (5) ◽  
pp. 1515
Author(s):  
Radhika Krishnaswamy ◽  
Shelomith K. Chawang ◽  
Priyadharshini Krishnaswamy
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Tertiary Care ◽  
Fasting Blood Glucose ◽  
Age Groups ◽  
Serum Vitamin ◽  
Care Hospital ◽  
Serum Vitamin D ◽  
Increased Risk ◽  
Vitamin D Levels

Background: Metabolic syndrome is associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. Vitamin D has been linked to glucose metabolism and insulin regulation. Hence, this study aims to evaluate the association between the serum level of vitamin D and metabolic syndrome. This may help generate additive strategies in the prevention and management of this syndrome. The objective of the study was to compare the levels of serum vitamin D in subjects with metabolic syndrome and subjects without metabolic syndrome.Methods: A prospective study with 80 subjects was conducted at a tertiary care hospital in Southern India. The sample comprised 40 subjects in the age group of (18-60 years) with metabolic syndrome as cases and 40 subjects without metabolic syndrome in the age groups of (18-60 years) as controls. The presence of any 3 of the following- fasting blood glucose (FBS ≥100mg/dl), triglycerides (TGL≥150mg/dl) and high-density lipoprotein cholesterol (HDL-C ≤40mg/dl-men, ≤50mg/dl-women) levels, blood pressure (≥130/85mmHg or drug treatment) and abdominal waist circumference (>94 cm (37 in) in men and >80 cm (31 in) in women) were used as criteria to screen for the presence (cases) or absence (controls) of metabolic syndrome. Serum vitamin D (25-hydroxy vitamin D) levels were compared between the two groups.Results: Mann Whitney U test was used to compare the vitamin D levels between the two groups. Significantly (p=0.05) lower vitamin D levels were seen in the cases compared to the controls.Conclusions: Metabolic syndrome is associated with significantly lower serum vitamin D levels. We suggest that further studies with a larger sample size be undertaken to confirm the same.

scholarly journals Investigation of Serum Calcium and 25-Hydroxy Vitamin D Levels in Benign Paroxysmal Positional Vertigo Patients

2021 ◽  
pp. 014556132198945
Author(s):  
Hakkı Caner Inan ◽  
Cuma Mertoğlu ◽  
Zülküf Burak Erdur
Keyword(s):  
Vitamin D ◽  
Serum Calcium ◽  
Benign Paroxysmal Positional Vertigo ◽  
Controlled Study ◽  
Hydroxyvitamin D ◽  
Positional Vertigo ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
25 Hydroxyvitamin D ◽  
Paroxysmal Positional Vertigo

Objective: Benign paroxysmal positional vertigo (BPPV) is characterized by recurrent attacks of vertigo caused by head movements. It occurs as a result of otoconia falling into the semicircular canal. Calcium and 25 hydroxyvitamin D [25(OH)D] metabolism in the inner ear play an important role in otoconia formation and degeneration. Our aim in this study was to investigate the relationship between 25(OH)D levels and BPPV. Methods: This retrospective, case–controlled study included 52 patients with posterior canal BPPV and 52 controls aged 18 to 80 years. Age, sex, serum calcium, corrected calcium, and 25(OH)D levels of the BPPV and control group were compared. Results: Twenty-three of the patients were male (44.2%) and 29 were female (55.8%). The average age was 55.6 years. The 25(OH)D level was 15.3 ng/mL in the BPPV group and 20.2 ng/mL in controls. There was no significant difference in 25(OH)D and albumin-corrected calcium values ( P = .394; P = .084, respectively). In 80.7% of the BPPV group and 61.5% of the controls, 25(OH)D levels were 20 ng/mL and below. 25 hydroxyvitamin D deficiency was found statistically significantly more frequently in patients with BPPV ( P = .030). Conclusion: In our study, serum 25(OH)D levels were found to be lower in patients with BPPV, and the rate of vitamin D deficiency was higher in these patients. Based on these results, it is recommended to examine the 25(OH)D levels of patients with BPPV at the time of diagnosis.

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