Evaluation of vitamin D status in suspected cases of metabolic syndrome

Background: Metabolic syndrome is associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. Vitamin D has been linked to glucose metabolism and insulin regulation. Hence, this study aims to evaluate the association between the serum level of vitamin D and metabolic syndrome. This may help generate additive strategies in the prevention and management of this syndrome. The objective of the study was to compare the levels of serum vitamin D in subjects with metabolic syndrome and subjects without metabolic syndrome.Methods: A prospective study with 80 subjects was conducted at a tertiary care hospital in Southern India. The sample comprised 40 subjects in the age group of (18-60 years) with metabolic syndrome as cases and 40 subjects without metabolic syndrome in the age groups of (18-60 years) as controls. The presence of any 3 of the following- fasting blood glucose (FBS ≥100mg/dl), triglycerides (TGL≥150mg/dl) and high-density lipoprotein cholesterol (HDL-C ≤40mg/dl-men, ≤50mg/dl-women) levels, blood pressure (≥130/85mmHg or drug treatment) and abdominal waist circumference (>94 cm (37 in) in men and >80 cm (31 in) in women) were used as criteria to screen for the presence (cases) or absence (controls) of metabolic syndrome. Serum vitamin D (25-hydroxy vitamin D) levels were compared between the two groups.Results: Mann Whitney U test was used to compare the vitamin D levels between the two groups. Significantly (p=0.05) lower vitamin D levels were seen in the cases compared to the controls.Conclusions: Metabolic syndrome is associated with significantly lower serum vitamin D levels. We suggest that further studies with a larger sample size be undertaken to confirm the same.

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Vitamin D: A Silent Cofactor for Allergic Rhinitis

Bengal Journal of Otolaryngology and Head Neck Surgery ◽

10.47210/bjohns.2019.v27i2.236 ◽

2019 ◽

Vol 27 (2) ◽

pp. 107-112

Author(s):

Rabi Hembrom ◽

Somnath Patra ◽

Rupam Sinha ◽

Indranil Sen ◽

Satadal Mandal ◽

...

Keyword(s):

Vitamin D ◽

Allergic Rhinitis ◽

Tertiary Care ◽

Serum Vitamin ◽

Blood Eosinophil ◽

Cell Mediated Immunity ◽

Care Hospital ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Low Serum

Introduction Allergic rhinitis affects around 50% of atopies in India. Vitamin D is related to both humoral and cell mediated immunity and its receptors are found in inflammatory mediators. This study was conducted to assess any possible association between Allergic rhinitis and serum Vitamin D. Materials and Methods A cross sectional study was conducted amongst 41patients with Allergic rhinitis as per ARIA guidelines attending the Otolaryngology outpatient Department of a peripheral tertiary care hospital. Vitamin D levels were assessed in patients with allergic rhinitis in terms of serum Ig-E level and absolute blood eosinophil count (ABEC). Results Among 41 patients, 31 patients (75.6%) had deficiency of vitamin D with mean Vitamin D level of 14.87±1.56ng/ml (normal vitamin D level-30-100ng/ml and low <20ng/ml), mean serum Ig-E level was 1040±303.83Iu/ml (normal-1.90-170 IU/ml by CLIA method) and mean ABEC 1226.77±397.89 (normal-30-350/ml). Conclusion Low serum Vitamin D is common in Allergic rhinitis patients. Low serum Vitamin D seems to be a significant cofactor in aetiopathogenesis of Allergic rhinitis in most of the cases.

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CORRELATION OF SERUM VITAMIN D LEVEL WITH MORTALITY IN PATIENTS WITH SEPSIS

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v3i4.206 ◽

2019 ◽

Vol 3 (4) ◽

Author(s):

Pramod Sood ◽

Manpreet Kaur

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Critically Ill ◽

Critically Ill Patients ◽

Tertiary Care ◽

Serum Vitamin ◽

Medical Emergency ◽

Serum Vitamin D ◽

Increased Risk ◽

Vitamin D Levels

Background: Vitamin D insufficiency is a common global phenomenon. Its insufficiency is also reported to be common in hospitalized patients and particularly in critically ill patients. Methods: Following ethical approval, consent will be sought from either the patient or assent from a near relative. Successive patients admitted to the medical emergency and ICU at tertiary care health center who fulfill the following criteria for sepsis, within a 24 h time window, were included in the study. Results: A total of 50 patients were enrolled in the study, 37 (74.00%) were discharged whereas 13(26.00%) patients expired. The majority of patients, irrespective of outcome had Vitamin D deficiency. Although normal Vitamin D levels were observed in relatively higher proportion of patients who were discharged (29 patients) as compared to those who expired (12 patients) yet this difference was not significant statistically (P = 0.481). Conclusion: Vitamin D deficiency leads to increased risk of mortality in the critically ill patients. Keywords: Sepsis, Vitamin D deficiency, Mortality.

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Prevalence of vitamin D deficiency and effect of vitamin D supplementation on feto-maternal outcome in tertiary care centre

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20184939 ◽

2018 ◽

Vol 7 (12) ◽

pp. 4912

Author(s):

Munmun Yadav ◽

Mahendra Kumar Verma ◽

Mohan Bairwa ◽

Govardhan Meena ◽

Lata Rajoria

Keyword(s):

Vitamin D ◽

Pregnant Women ◽

Vitamin D Deficiency ◽

Tertiary Care ◽

Serum Vitamin ◽

Vitamin D Supplementation ◽

Serum Vitamin D ◽

Increased Risk ◽

Vitamin D Levels ◽

Risk Of Preeclampsia

Background: Vitamin D deficiency is widely prevalent throughout the world. Pregnant women, neonates and infants form most vulnerable groups for vitamin D deficiency. Hypovitaminosis D in pregnancy has been reported to cause various fetomaternal effect, i.e. increased risk of preeclampsia (PE), gestational diabetes mellitus (GDM), caesarean section, hypocalcemia, subclinical myopathy, neonatal tetany, hyperbilirubinemia congenital rickets and infantile rickets, etc. Only few Indian studies are available in this regard. The objectives are to find prevalence of vitamin D deficiency in pregnant women and to evaluate the effect of supplementation with cholecalciferol in improving vitamin D levels in pregnant women and evaluate its correlation with feto-maternal outcome.Methods: A prospective observational was conducted on 120 Pregnant women on their first visit to hospital irrespective of gestational age were offered the test and on the basis of inclusion and exclusion criteria are included in study and vitamin D level was done to know the prevalence of vitamin D deficiency. Apart from routine obstetrical investigation, serum vitamin D (total) level was estimated. All results were recorded and analyzed statically.Results: Out of 120 patients 101 (84.1%) were found to be vitamin D deficient. Mean age of vitamin D deficient group was 28.31±3.86 and sufficient group was 26.37±2.83.81 (67.5%) were vegetarian and 39 (32.5%) were nonvegetarian.75 (92.59%) vegetarian and 26 (66.66%) non-vegetarian found to be vitamin D deficient. (p<0.05). Vitamin D supplementation has been observed to reduce risk of preeclampsia. (p<0.05) and vitamin D sufficiency associated with reduced risk of low birth weight babies.Conclusions: Vitamin D supplementation reduces risk of maternal comorbidities and helps improve neonatal outcomes.

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Relationship between Serum Vitamin D Levels and HDL Cholesterol in Postmenopausal Women from Colombian Caribbean

Journal of Nutrition and Metabolism ◽

10.1155/2018/9638317 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6 ◽

Cited By ~ 3

Author(s):

Luz Adriana Sarmiento-Rubiano ◽

José Armando Angarita Ruidiaz ◽

Héctor Fernando Suarez Dávila ◽

Alfonso Suarez Rodríguez ◽

Roberto C. Rebolledo-Cobos ◽

...

Keyword(s):

Metabolic Syndrome ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Postmenopausal Women ◽

Serum Vitamin ◽

Hdl Cholesterol ◽

Serum Vitamin D ◽

The Metabolic Syndrome ◽

Increased Risk ◽

Vitamin D Levels

Background. Previous evidence suggests that metabolic disorders in postmenopausal women could be related with low serum vitamin D levels. For example, vitamin D deficiency has been associated with increased risk factors for cardiovascular disease (CVD), mainly those related with metabolic syndrome.Objective. To assess the relationship between the serum vitamin D (25-OH-D) levels and the metabolic syndrome markers in postmenopausal women.Methods. This descriptive and cross-sectional study was conducted in 183 postmenopausal women of four municipalities from Colombian Caribbean. The serum 25-OH-D levels and the anthropometric and biochemical markers were assessed and correlated with metabolic syndrome.Results. The average value of serum vitamin D (25-OH-D) was 26.34 ± 9.08 ng/mL, and 69.95% of the women had vitamin D levels <30 ng/mL, of which 43.72% were with insufficiency (<30 to >20 ng/mL) and 26.23% with deficiency (<20 ng/mL). Of the evaluated women, the 81.42% seemed to have metabolic syndrome. Through the linear regression, one significant positive association was observed between the HDL cholesterol and the 25-OH-D levels (P=0.014).Conclusion. In the evaluated population in this study, vitamin D deficiency is related with low HDL cholesterol levels.

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A Study on Vitamin D Levels in Patients Attended at OPD of A Tertiary Care Hospital of Chattogram

Chattagram Maa-O-Shishu Hospital Medical College Journal ◽

10.3329/cmoshmcj.v18i2.47771 ◽

2020 ◽

Vol 18 (2) ◽

pp. 37-40

Author(s):

Shaheda Ahmed ◽

Md Jalal Uddin ◽

AYM Masud Reza Khan

Keyword(s):

Vitamin D ◽

Tertiary Care ◽

Serum Vitamin ◽

Hypovitaminosis D ◽

Whole Body ◽

Care Hospital ◽

Mineral Density ◽

Female Ratio ◽

Serum Vitamin D ◽

Vitamin D Levels

Background: Vitamin D is a fat soluble vitamin, having important role in calcium and phosphorous metabolism. Many researches support the role of vitamin D against cancer, cardiovascular diseases, fractures and falls, cognitive disorders, Parkinsonism, auto-immune diseases, respiratory ailments and depression. Thus Vitamin D Deficiency (VDD) is an alarming public problem. Purpose of this study was to measure the frequency of hypovitaminosis D among different age and sex group of Chattogram, Bangladesh. Materials and methods: A cross sectional hospital based observational study was conducted over a period of six months from February 2018 to July 2018 at a leading diagnostic complex and hospital of Chattogram. A total of 243 patients were included in the study. Number of male and female respondents were 86 and 157 respectively. Age range was 15-85 years. Blood samples were collected aseptically after an oral informed consent. Serum vitamin D levels were estimated using standard laboratory technique (Chemiluminescent microparticle immunoassay method). Results: Among 243 respondents, male female ratio was 1:1.83, mean age was 47± 16.3 years, prevalence of hypovitaminosis was 82%, among male hypovitaminosis was found in 78% cases, whereas among female it was a bit higher with 84%. Sex difference was strongly significant with p value of < 0.01. Conclusion: The present study has limitation with estimation of only vitamin D, in absence of valuable indicators of bone health like serum calcium, bone mineral density and parathyroid hormone. Factors like, less outdoor activities, obesity or covering whole body (Abaiya or burkah) in case of Muslim women, which could be responsible for more hypovitaminosis in case of female was not noticed. But it was very much clear that 45-60 years age group was the most vulnerable with highest level of hypovitaminosis-D in both sexes. Chatt Maa Shi Hosp Med Coll J; Vol.18 (2); July 2019; Page 37-40

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Association of serum vitamin D levels and transient tachypnea of newborn: a case control study

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20171526 ◽

2017 ◽

Vol 4 (3) ◽

pp. 827 ◽

Cited By ~ 1

Author(s):

Gurmeet Singh ◽

Reena Sood ◽

Gursharan Singh Narang ◽

Harnoorjit Kaur Brar ◽

Amanjeet Kaur Bagga

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Transient Condition ◽

Control Group ◽

Term Neonates ◽

Serum Vitamin D ◽

Increased Risk ◽

Vitamin D Levels ◽

Control Study ◽

Structured Questionnaire

Background: Transient tachypnea of newborn (TTN) is a common cause of respiratory distress in newborns with estimated incidence of 1-2% of all newborns. Although a self-limiting transient condition but it may cause severe morbidities. This study was conducted to find association of serum vitamin D levels in neonates who develop TTN as compared to normal healthy neonates.Methods: With thorough history with structured questionnaire and lab tests, serum vitamin D levels of 45 neonates who develop TTN were compared with 56 healthy neonates in control group.Results: Out of 45 neonates who develop TTN 39(86.7%) were deficient in vitamin D as compared to control group where 33(58.9%) out of 56 healthy neonates were deficient in vitamin D.Conclusions: Lower vitamin D levels at birth in term neonates is associated with increased risk of developing TTN and vitamin D may have a role in its pathogenesis.

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Correlation of Serum Vitamin D and Metabolic Disturbances in Polycystic Ovarian Syndrome

Indonesian Journal of Obstetrics & Gynecology Science ◽

10.24198/obgynia/v4.n1.253 ◽

2021 ◽

Vol 4 (1) ◽

pp. 64-71

Author(s):

Shasya Aniza Santoso ◽

◽

Tita Husnitawati Madjid ◽

Anita Rachmawati

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Blood Glucose ◽

Waist Circumference ◽

Fasting Blood Glucose ◽

Serum Vitamin ◽

Metabolic Disturbances ◽

Cross Sectional ◽

Serum Vitamin D ◽

Vitamin D Levels

Objective: This study was aimed to determine the correlation between vitamin D and insulin resistance in women with PCOS. Method: This study was correlational analytic with cross-sectional approach to 34 women diagnosed with PCOS based on ultrasonography. Waist circumference and fasting blood glucose (FBG) represented insulin resistance. Women with hormonal therapy and vitamin D supplementation were not included to this study. This study used consecutive sampling method. Result: The average of age was 25.6±6.1 years old. Waist circumference and fasting blood glucose (FBG) represented insulin resistance. The average of waist circumference and FBG were 87.6±12.4 cm and 86.2±27.9 mg/dl, respectively. The mean of vitamin D levels was 11,5±3,6 ng/ml. According to Spearman’s correlation, vitamin D levels were weak negative correlated with waist circumference (r=-0.2; p>0.05) and FBG (r= -0,1; p>0,05), it statistically was not significant. Conclusion: There is weak negative correlation between vitamin D and metabolic syndrome in PCOS patients.

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Influence of serum vitamin D status on severe sarcopenia among female patients with rheumatoid arthritis: the KURAMA database

10.21203/rs.3.rs-697981/v1 ◽

2021 ◽

Author(s):

Hiroto Minamino ◽

Masao Katsushima ◽

Mie Torii ◽

Wataru Yamamoto ◽

Yoshihito Fujita ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Vitamin D ◽

Muscle Mass ◽

Gait Speed ◽

Serum Vitamin ◽

Vitamin D Status ◽

Serum Vitamin D ◽

Increased Risk ◽

Vitamin D Levels ◽

High Prevalence

Abstract Sarcopenia is an age-related disease with an increased risk of mortality. It is emerging that low serum vitamin D (25(OH)D) affects the sarcopenic state in general, but in rheumatoid arthritis (RA), these associations are not understood although the prevalence of vitamin D insufficiency is high in RA. We conducted a cross-sectional study of older female outpatients from our cohort (KURAMA) database. We measured skeletal muscle mass, handgrip strength, and gait-speed to diagnose severe sarcopenia. The serum 25(OH)D concentration was measured using electrochemiluminescence immunoassay. A total of 156 Patients (sarcopenia:44.9%, severe sarcopenia: 29.5%, and without sarcopenia: 25.6%) were enrolled. Classification of vitamin D status at a cutoff point of median 25(OH)D concentration revealed that low 25(OH)D status was associated with a high prevalence of severe sarcopenia and with low measured values of muscle mass, handgrip, and gait-speed. Furthermore, multiple regression analysis identified that low 25(OH)D status was associated with a high prevalence of severe sarcopenia (OR 6.00; 95% CI 1.99–18.08). In components of sarcopenia, both low physical performance and muscle mass were associated with low 25(OH) status. In conclusion, vitamin D levels are associated with severe sarcopenia and its components, and modification of vitamin D status including vitamin D supplementation may play a role in improving sarcopenia in RA.

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