scholarly journals SAT-389 Clinical and Biochemical Characterization of Risk Factors for Vertebral Fractures in Patients with Hypoparathyroidism

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Anna Maria Formenti ◽  
Luigi Di Filippo ◽  
Agnese Allora ◽  
Raffaele Giubbini ◽  
Andrea Giustina
Keyword(s):  
Vitamin D ◽  
Vertebral Fractures ◽  
Biochemical Characterization ◽  
Normal Weight ◽  
Predicting Factors ◽  
Increased Risk ◽  
Significant Difference ◽  
Positive Linear Correlation ◽  
25 Oh Vitamin D ◽  
One Year

Abstract Background: Persistent hypoparathyroidism (PH) is a rare disease due to an impaired secretion of PTH, mostly occurring as a complication of total thyroidectomy. Calcium and calcitriol are currently the most common and inexpensive therapies, although not all the patients easily achieve control of the disease. Recently, our group has reported that BMI at diagnosis can predict calcitriol resistance in PH. Very few studies have been performed with fractures as primary endpoint in hypoparathyroidism, and we still not know if PH could be predisposing to an increased risk of morphometric fractures and possible clinical and biochemical predicting factors. Patients and methods: To that end we retrospectively evaluated the anthropometric, biochemical and fracture characteristics in 71 consecutive patients with PH (F/M= 62/9; median age 58.7 yrs, range: 29-87; 67 with post-surgical PH and 4 with autoimmune PH). All patients were hypoparathyroid from at least one year (median duration of disease: 9 yrs., range: 1-41) and were under standard treatment with calcium and active vitamin D analogs (calcitriol). For each patient anthropometric data (BMI=kg/m2; N= Normal weight patients <25; OO= Obese and overweight patients with BMI > 25) were collected, as well as biochemical parameters, such as calcium (mg/dl) and 25 OH vitamin D (25OHD expressed as ng/ml). We considered well controlled (C) patients with calcium between 8.2 and 9.2 mg/dl and not controlled (NC) under 8.2 or above 9.2 mg/dl. Vertebral fractures (VF) were assessed by a quantitative morphometric approach by using images provided by DXA and classified according to Genant classification. Results: Thirteen out of 71 patients (18%) were fractured. We showed a positive linear correlation in the overall population between BMI and calcitriol intake (p=0.006, CI 95% [1.2-6.9]) while no significant difference in prevalence of VF in OO vs N group (8/40 vs 5/31, p=0.76) was found. However, almost half (6/13, 45%) of patients with VF were OO NC. Moreover, 86% of NC vs only 30% of C fractured patients (6/7 vs 2/6) were OO Discussion: We report a high prevalence of VF in hypoparathyroidism. Moreover, we confirm that increased BMI is associated with higher needs of calcitriol to obtain calcium control. Interestingly, our data suggest for the first time that OO hypoparathyroid patients with NC disease are those at highest risk of fracture. Therefore, in this subset of patients a more intensive and proactive biochemical and bone monitoring should be adviced if these results will be confirmed in larger studies.

Evaluation of Serum 25(OH)D Levels in Obese and Normal-Weight Children with Carious and Hypomineralized Teeth

2021 ◽  
Vol 45 (1) ◽  
pp. 35-40
Author(s):  
Gülçin Doğusal ◽  
Işıl Sönmez ◽  
Tolga Ünüvar
Keyword(s):  
Vitamin D ◽  
Dental Caries ◽  
Age Groups ◽  
Normal Weight ◽  
Controlled Study ◽  
Molar Incisor Hypomineralisation ◽  
Obese Children ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
Significant Difference

Aim: The aim of this study was to assess the association between dental caries, molar incisor hypomineralisation (MIH) and obesity in relationship with different vitamin D levels in children. Study design: This retrospective case-controlled study enrolled 455 children aged 6–18 years, who attended to both pediatric endocrinology and pediatric dentistry clinics at the Aydin Adnan Menderes University Hospital, Turkey. Vitamin D status was measured with serum (25(OH)D) concentrations. Body mass index (BMI) were used to determine adiposity. Caries status was assessed using the decayed-missing-filled teeth (dft) and (DMFT) index for primary and permanent dentitions using WHO standard methodology. MIH were diagnosed according to the EAPD criteria. Results: DMFT did not show any significant difference between obese and normal weight children in both age groups. However, in 6–11 age group, obese children had lower dft and the difference was statistically significant (p<0.001). Median caries index values and MIH prevelance among the obese and normal weight children found similar with deficient, insufficient and sufficient levels of serum 25(OH) D in both age groups. Conclusion: Our analyses provide no evidence to suggest that obese children are at increased risk for dental caries. Serum 25(OH)D concentrations would not seem to have a significant effect on dental caries and MIH in children.

Study the Relation between Peripheral Arterial Disease and vitamin D Level among Maintenance Hemodialysis Patients

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Walid Ahmed Bichari ◽  
Ashraf Hassan Abdelmobdy ◽  
Amr Abd Elshafy Aboud
Keyword(s):  
Vitamin D ◽  
Renal Failure ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Health Concern ◽  
Dialysis Patients ◽  
Increased Risk ◽  
Significant Difference ◽  
25 Oh Vitamin D ◽  
Peripheral Arterial

Abstract Background Chronic kidney disease (CKD) represents a global health concern. The Global Burden of Disease study stated that, worldwide mortality attributed to renal failure showed a tremendous rise with around 1.2 million deaths from renal failure in 2015. Hemodialysis (HD) patients are at increased risk for atherosclerotic disorders including peripheral arterial disease (PAD). Among dialysis patients, many of the risk factors for PAD are the same as for the general population, but there are associations that seem to be unique to dialysis patients. Objective To study the relation between PAD assessed by ankle brachial index (ABI) and serum level of 25(OH) vitamin D among Maintenance HD Patients. Patients and Methods The present study included 90 subjects, 45 end stage renal disease patients patients(ESRD) on maintenance HD with PAD assessed by ABI (value less than 0.9) and 45 ESRD patients on maintenance HD without PAD assessed by ABI (value more than or equal 0.9). Results There was a statistically significant difference between the two studied groups as regard serum 25(OH) vitamin D level (P = 0.000). We also found a statistically significant positive correlation between ABI and serum vitamin D level in both patients and control groups (P = 0.000). Conclusion Vitamin D deficiency is associated with PAD among maintenance HD patients.

Risk of venous thromboembolism following surgical treatment of superficial venous incompetence

VASA ◽  
2017 ◽  
Vol 46 (6) ◽  
pp. 484-489 ◽  
Author(s):  
Tom Barker ◽  
Felicity Evison ◽  
Ruth Benson ◽  
Alok Tiwari
Keyword(s):  
Venous Thromboembolism ◽  
Varicose Vein ◽  
Lower Incidence ◽  
Varicose Veins ◽  
Secondary Data ◽  
Foam Sclerotherapy ◽  
Increased Risk ◽  
Significant Difference ◽  
Chi Squared ◽  
One Year

Abstract. Background: The invasive management of varicose veins has a known risk of post-operative deep venous thrombosis and subsequent pulmonary embolism. The aim of this study was to evaluate absolute and relative risk of venous thromboembolism (VTE) following commonly used varicose vein procedures. Patients and methods: A retrospective analysis of secondary data using Hospital Episode Statistics database was performed for all varicose vein procedures performed between 2003 and 2013 and all readmissions for VTE in the same patients within 30 days, 90 days, and one year. Comparison of the incidence of VTEs between procedures was performed using a Pearson’s Chi-squared test. Results: In total, 261,169 varicose vein procedures were performed during the period studied. There were 686 VTEs recorded at 30 days (0.26 % incidence), 884 at 90 days (0.34 % incidence), and 1,246 at one year (0.48 % incidence). The VTE incidence for different procedures was between 0.15–0.35 % at 30 days, 0.26–0.50 % at 90 days, and 0.46–0.58 % at one year. At 30 days there was a significantly lower incidence of VTEs for foam sclerotherapy compared to other procedures (p = 0.01). There was no difference in VTE incidence between procedures at 90 days (p = 0.13) or one year (p = 0.16). Conclusions: Patients undergoing varicose vein procedures have a small but appreciable increased risk of VTE compared to the general population, with the effect persisting at one year. Foam sclerotherapy had a lower incidence of VTE compared to other procedures at 30 days, but this effect did not persist at 90 days or at one year. There was no other significant difference in the incidence of VTE between open, endovenous, and foam sclerotherapy treatments.

scholarly journals Body mass index and clinical outcomes in patients with intracerebral haemorrhage: results from the China Stroke Center Alliance

2021 ◽  
pp. svn-2020-000534
Author(s):  
Zhentang Cao ◽  
Xinmin Liu ◽  
Zixiao Li ◽  
Hongqiu Gu ◽  
Yingyu Jiang ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Hospital Mortality ◽  
Body Mass ◽  
Intracerebral Haemorrhage ◽  
Final Analysis ◽  
Normal Weight ◽  
Discharge Disposition ◽  
Increased Risk ◽  
Significant Difference ◽  
Stroke Center

Background and aimObesity paradox has aroused increasing concern in recent years. However, impact of obesity on outcomes in intracerebral haemorrhage (ICH) remains unclear. This study aimed to evaluate association of body mass index (BMI) with in-hospital mortality, complications and discharge disposition in ICH.MethodsData were from 85 705 ICH enrolled in the China Stroke Center Alliance study. Patients were divided into four groups: underweight, normal weight, overweight and obese according to Asian-Pacific criteria. The primary outcome was in-hospital mortality. The secondary outcomes included non-routine discharge disposition and in-hospital complications. Discharge to graded II or III hospital, community hospital or rehabilitation facilities was considered non-routine disposition. Multivariable logistic regression analysed association of BMI with outcomes.Results82 789 patients with ICH were included in the final analysis. Underweight (OR=2.057, 95% CI 1.193 to 3.550) patients had higher odds of in-hospital mortality than those with normal weight after adjusting for covariates, but no significant difference was observed for patients who were overweight or obese. No significant association was found between BMI and non-disposition. Underweight was associated with increased odds of several complications, including pneumonia (OR 1.343, 95% CI 1.138 to 1.584), poor swallow function (OR 1.351, 95% CI 1.122 to 1.628) and urinary tract infection (OR 1.532, 95% CI 1.064 to 2.204). Moreover, obese patients had higher odds of haematoma expansion (OR 1.326, 95% CI 1.168 to 1.504), deep vein thrombosis (OR 1.506, 95% CI 1.165 to 1.947) and gastrointestinal bleeding (OR 1.257, 95% CI 1.027 to 1.539).ConclusionsIn patients with ICH, being underweight was associated with increased in-hospital mortality. Being underweight and obese can both increased risk of in-hospital complications compared with having normal weight.

scholarly journals The Vitamin D Receptor (VDR) Gene Polymorphisms in Turkish Brain Cancer Patients

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Bahar Toptaş ◽  
Ali Metin Kafadar ◽  
Canan Cacina ◽  
Saime Turan ◽  
Leman Melis Yurdum ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cancer Patients ◽  
Vitamin D Receptor ◽  
Brain Cancer ◽  
Gene Polymorphisms ◽  
Vdr Gene ◽  
Increased Risk ◽  
Vdr Gene Polymorphisms ◽  
Significant Difference ◽  
Healthy Control

Objective. It has been stated that brain cancers are an increasingly serious issue in many parts of the world. The aim of our study was to determine a possible relationship between Vitamin D receptor (VDR) gene polymorphisms and the risk of glioma and meningioma.Methods. We investigated the VDR Taq-I and VDR Fok-I gene polymorphisms in 100 brain cancer patients (including 44 meningioma cases and 56 glioma cases) and 122 age-matched healthy control subjects. This study was performed by polymerase chain reaction-based restriction fragment length polymorphism (RF LP).Results. VDR Fok-I ff genotype was significantly increased in meningioma patients (15.9%) compared with controls (2.5%), and carriers of Fok-I ff genotype had a 6.47-fold increased risk for meningioma cases. There was no significant difference between patients and controls for VDR Taq-I genotypes and alleles.Conclusions. We suggest that VDR Fok-I genotypes might affect the development of meningioma.

Validation of a locally derived serum calcium adjustment equation: relationship with total 25(OH) vitamin D and PTH levels

2016 ◽  
Vol 70 (1) ◽  
pp. 69-74 ◽  
Author(s):  
Jonathan Joseph Scargill ◽  
John Mark Guy
Keyword(s):  
Vitamin D ◽  
Fold Increase ◽  
Reference Interval ◽  
Albumin Concentration ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
25 Oh Vitamin D ◽  
New Equation ◽  
The Uk ◽  
Adjustment Equation

AimsMany clinical laboratories in the UK use a standard equation to adjust total calcium for albumin concentration. To assess the validity of this practice, we assessed the effect of the use of a traditional and locally derived calcium adjustment equation on parathyroid hormone (PTH) and 25(OH, hydroxy) vitamin D levels.MethodsSamples requested for calcium and albumin measurement over a 6 month period that met inclusion criteria were used to derive a calcium adjustment equation (n=60 941). The traditional and locally derived calcium adjustment equations were then applied to a second cohort of adult patients that underwent calcium measurement over a 1 year period (n=275 456). Patients were classified as hypocalcaemic, normocalcaemic or hypercalcaemic using a UK Pathology Harmony adjusted calcium reference interval (2.2–2.6 mmol/L).ResultsThe local calcium adjustment equation provided a 7.1-fold reduction in the prevalence of hypocalcaemia. Patients classified as hypocalcaemic using the locally derived equation had statistically significantly lower 25(OH) vitamin D and higher PTH levels. A 2.4-fold increase in the prevalence of hypercalcaemia was also observed using the new equation, but with no significant difference in 25(OH) vitamin D or PTH levels.ConclusionsA locally derived calcium adjustment equation reclassified the calcium status of 61 278 (22%) patients. Patients classified as hypocalcaemic by the locally derived equation had significantly lower 25(OH) vitamin D and significantly higher PTH values, providing evidence that use of this adjustment equation generates adjusted calcium results of greater clinical relevance. This study provides further and novel evidence that individual laboratories should determine local equations for adjusted calcium where possible.

Evaluation of the Relationship between Vitamin D Deficiency and Atherogenic Factors in Diabetic Patients with Metabolic Syndrome

2021 ◽  
Author(s):  
Leila Akbarbaglu ◽  
Elham Nozari Mirarkolaei ◽  
Massoumeh Hotelchi ◽  
Abbas Khonakdar-Tarsi ◽  
Mahboobeh Ghanbari ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Serum Level ◽  
Total Cholesterol ◽  
Vitamin D3 ◽  
Atherogenic Index ◽  
Control Group ◽  
Diabetic Patients ◽  
Significant Difference ◽  
25 Oh Vitamin D

Introduction: Metabolic syndrome includes a range of disorders that increase the risk of cardiovascular disease and diabetes mellitus. In this study, we examined the serum level of vitamin D3 in diabetic individuals with metabolic syndrome compared with non-diabetic individuals without metabolic syndrome and the association of serum vitamin D3 levels with metabolic syndrome and atherogenic factor (LDL/HDL). Material and Methods: In a case-control study, we included 110 women with metabolic syndrome according to ATP III criteria and 127 healthy women as a control group. Serum concentration of total cholesterol, LDL-C, FBS, HDL-C and serum triglyceride determined by enzymatic method and colorimetric and, serum level 25-(OH) vitamin D determined by ELISA. Results: It was found that the two healthy and metabolic groups were significantly different in terms of total cholesterol levels, LDL and triglyceride levels, HDL, VLDL, FBS, atherogenic index (LDL/HDL) and vitamin D levels (p<0.05). All participants in the control group and the patient and the whole study population were divided into two categories of insufficient and sufficient based on their measured serum concentrations of 25-(OH) vitamin D. There was a significant difference between the group with insufficient levels of vitamin D in comparison with the group with sufficient levels of vitamin D in terms of total cholesterol, LDL and triglyceride levels, HDL, VLDL, FBS and atherogenic index (LDL/HDL) (p=0.000). Conclusion: The present results showed that there is a significant relationship between level 25-(OH) D and atherogenic index (LDL/HDL) and the incidence of metabolic syndrome.

Management of bone metabolism in epilepsy

2021 ◽  
Vol 74 (7-8) ◽  
pp. 257-265
Author(s):  
Firdevs Ezgi Uçan Tokuç ◽  
Fatma Genç ◽  
Abidin Erdal ◽  
Yasemin Biçer Gömceli
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Outpatient Clinic ◽  
Bone Mineralization ◽  
Mineral Density ◽  
Low Bone Mineral Density ◽  
Increased Risk ◽  
Significant Difference

Many systemic problems arise due to the side effects of antiepileptic drugs (AEDs) used in epilepsy patients. Among these adverse effects are low bone mineral density and increased fracture risk due to long-term AED use. Although various studies have supported this association with increased risk in recent years, the length of this process has not been precisely defined and there is no clear consensus on bone density scanning, intervals of screening, and the subject of calcium and vitamin D supplementation. In this study, in accordance with the most current recommendations, our applications and data, including the detection of possible bone mineralization disorders, treatment methods, and recommendations to prevent bone mineralization disorders, were evaluated in epilepsy patients who were followed up at our outpatient clinic. It was aimed to draw attention to the significance of management of bone metabolism carried out with appropriate protocols. Epilepsy patients were followed up at the Antalya Training and Research Hospital Department of Neurology, Epilepsy Outpatient Clinic who were at high risk for osteoporosis (use of valproic acid [VPA] and enzyme-inducing drugs, using any AED for over 5 years, and postmenopausal women) and were evaluated using a screening protocol. According to this protocol, a total of 190 patients suspected of osteoporosis risk were retrospectively evaluated. Four patients were excluded from the study due to secondary osteoporosis. Of the 186 patients who were included in the study, 97 (52.2%) were women and 89 (47.8%) were men. Prevalence of low bone mineral density (BMD) was 42%, in which osteoporosis was detected in 11.8% and osteopenia in 30.6% of the patients. Osteoporosis rate was higher at the young age group (18-45) and this difference was statistically significant (p=0.018). There was no significant difference between male and female sexes according to osteoporosis and osteopenia rates. Patients receiving polytherapy had higher osteoporosis rate and lower BMD compared to patients receiving monotherapy. Comparison of separate drug groups according to osteoporosis rate revealed that osteoporosis rate was highest in patient groups using VPA+ carbamazepine (CBZ) (29.4%) and VPA polytherapy (19.4%). Total of osteopenia and osteoporosis, or low BMD, was highest in VPA polytherapy (VPA+ non-enzyme-inducing AED [NEID]) and CBZ polytherapy (CBZ+NEID) groups, with rates of 58.3% and 55.1%, respectively. In addition, there was no significant difference between drug groups according to bone metabolism markers, vitamin D levels, and osteopenia-osteoporosis rates. Assuming bone health will be affected at an early age in epilepsy patients, providing lifestyle and diet recommendations, avoiding polytherapy including VPA and CBZ when possible, and evaluating bone metabolism at regular intervals are actions that should be applied in routine practice.

PROVISION OF VITAMIN D FOR CHILDREN AND ADOLESCENTS IN THE CITY OF ULAN-UDE

2021 ◽  
Vol 100 (3) ◽  
pp. 295-300
Author(s):  
N.B. Gomboeva ◽  
◽  
E.I. Grigoryeva ◽  
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Respiratory Infections ◽  
Sharp Decrease ◽  
The Body ◽  
Severe Deficiency ◽  
Significant Difference ◽  
25 Oh Vitamin D ◽  
The City

The proven relationship between the frequency of influenza and acute respiratory infections in children with vitamin D deficiency and the data on the relationship between a high mortality rate from SARS-CoV-2 in patients with low levels of vitamin D in the body under conditions of a forced sharp decrease in the level of insolation in the period from March 11, 2020 dictated the relevance assessing the vitamin D supply of children and adolescents in educational organizations of the city of Ulan-Ude. Purpose of the study: to assess the vitamin D supply of children and adolescents living in the city of Ulan-Ude. Methods: in a non-randomized, single-center, transverse (one-stage) uncontrolled comparative study, the concentration of 25(OH) vitamin D – 25(OH)D – in the blood serum of children and adolescents in Ulan-Ude was studied from May 22 to May 24, 2020. Moderate vitamin D deficiency (deficiency) was determined when the content of 25(OH)D was in the range of 20–30 ng/ml, the deficiency was within the limits, and the severe deficiency was <10 ng/ml. Results: assessment of vitamin D provision was carried out in 60 children aged 10 to 17 years (15 [11; 16] years), of which 19 boys, 41 girls. Children were divided into 2 groups depending on age: 10–11 years old (grade 5) (n=27) and 15–17 years old (grades 9–11) (n=33). Deficiency of vitamin D was found in 4 (15%), 11 (33%); deficit – in 19 (70%), 18 (55%); severe deficiency – in 2 (7%), 4 (12%), respectively. Along with low indicators of the provision of children and adolescents in the city of Ulan-Ude, an even lower provision of children and adolescents of Buryats was noted. The concentration of vitamin D in Buryat children and adolescents below normal (less than 30 ng/ml) was found in 35 (100%) children and adolescents, deficiency – in 8 (23%) children, vitamin D deficiency – in 21 (60%) children and severe deficiency – in 6 (17%). A statistically significant difference in the content of 25(OH)D between children and adolescents of Russian nationality and Buryats was revealed (p=0,0056). Evaluation of the diet showed that the frequency of consumption of fish as a source of vitamin D by children and adolescents is low. Conclusion: there is a high incidence of vitamin D deficiency and deficiency, which amounted to 97% in the examined children and adolescents living in the city of Ulan-Ude, more pronounced in Buryat children and adolescents, which requires organizational measures to replenish the vitamin D deficiency.

THE EFFECT OF 'CONCERN FOR OSTEOPOROSIS' AND SELF-PERCEIVED 'RISK OF OSTEOPOROSIS AND FRACTURE' ON ANTI-OSTEOPOROSIS BEHAVIOR OF POST MENOPAUSAL WOMEN- A CROSS-SECTIONAL STUDY.

2021 ◽  
pp. 28-31
Author(s):  
Deepali Srivastava ◽  
Sandeepa Srivastava ◽  
Ashish Kumar ◽  
Sanjiv Kumar
Keyword(s):  
Vitamin D ◽  
Risk Perception ◽  
Perceived Risk ◽  
Vitamin D Supplementation ◽  
Medical Advice ◽  
Vitamin Supplementation ◽  
Cross Sectional ◽  
Increased Risk ◽  
Bmd Testing ◽  
One Year

Introduction: Osteoporosis is more prevalent in women, especially following menopause. The total affected population would have been around 35 to 40 million. Morbidity due to disease includes decreased mobility, decreased quality of life, and increased risk of mortality following an osteoporotic fracture. The morbidity due to the disease may be decreased through diet, exercise, supplementation, and medication. The objective of this study is to determine the effect of 'concern for osteoporosis' and self-perceived 'risk of osteoporosis and fracture' on antiosteoporosis behaviour such as (1) calcium and vitamin D supplementation, (2) seeking medical advice, (3) undergoing bone mineral (BMD) testing, and (4) taking antiosteoporosis medication (AOM). Material And Method:The study was conducted on women attending outpatient clinic of the Obstretics and Gynaecology and Orthopaedics department. Patients were required to ll up the Global Longitudinal Osteoporosis in Women Questionnaire. Enrolled patients were contacted after one year by means of telephone calls, hospital visits and home visits and data was collected for self-reported use of supplements, self-reported seeking of medical advice regarding osteoporosis, self-reported BMD testing, and self-reported use of antiosteoporosis medications etc. Results:Total of 1562 women were enrolled for the study out of which data of only 1000 women was analyzed at end of one year. At the end of one year period 360 women reported use of Calcium and or Vitamin D. Table 4 depicts the association between the use of vitamin supplementation and concern and risk perception. Concern (P=0.61), risk perception to osteoporosis (P=0.13), and risk perception to fracture (P=0.29) were not signicantly associated with use of vitamin supplementation in the next 12 months (i.e., calcium and/or vitamin D). Concern (p= <0.001), risk perception to osteoporosis (p=<0.001), and risk perception to fracture (p=<0.001) were signicantly associated with women seeking medical care during the next one year. Concern (p=0.35) was not signicantly associated with undergoing BMD examination. Risk perception to osteoporosis (p=0.03) and risk perception to fracture (p=0.03) were signicantly associated with women undergoing BMD medical examination in one year. Concern about osteoporosis (p=0.64) was not signicantly associated with treatment with anti-osteoporotic medication. Risk perception to osteoporosis (p=0.06) and risk perception to fracture (p=0.002) were signicantly associated with women. Conclusion: Concern for osteoporosis is associated with likelihood of seeking medical advice. Perception of risk for Osteoporosis and fractures is positively associated with seeking medical advice, BMD examination and AOM treatment

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