Possibilities for predicting prelabor rupture of membranes

2021 ◽  
Vol 70 (2) ◽  
pp. 107-118
Author(s):  
Viktor A. Mudrov
Keyword(s):  
Preterm Labor ◽  
Distress Syndrome ◽  
Integrated Approach ◽  
Cochrane Library ◽  
Operative Delivery ◽  
Perinatal Morbidity ◽  
Labor Management ◽  
Systematic Analysis ◽  
Septic Complications ◽  
Prelabor Rupture Of Membranes

Prelabor rupture of membranes occurs in 20% of all pregnancies, while in the structure of preterm labor it occurs in 40% of cases. Particular attention to prelabor rupture of membranes is primarily due to the risk of developing septic complications being increased as the duration of the anhydrous interval increases. Currently, there are no effective methods for preventing prelabor rupture of membranes. Therefore, the timeliness of prevention of fetal respiratory distress syndrome depends on the effectiveness of the prognosis of this condition. The aim of this study was to assess the possibilities for predicting prelabor rupture of membranes. This was achieved by using an analytical method including carrying out a detailed systematic analysis of modern domestic and foreign literature on predicting prelabor rupture of membranes. The study used databases such as eLIBRARY.RU, Scopus, PubMed, MEDLINE, ScienceDirect, Cochrane Library and FIPS from the creation until December 2020. An integrated approach to assessing the likelihood of prelabor rupture of membranes will allow optimizing the tactics of pregnancy and labor management, which in the future will reduce not only the incidence of maternal and perinatal morbidity, but also the frequency of operative delivery.

scholarly journals EFFECTIVENESS AND SAFETY DIFFERENCES OF ISOXSUPRINE AND NIFEDIPINE AS TOCOLYTICS IN THE RISK OF PRETERM LABOR

2017 ◽  
Vol 53 (4) ◽  
pp. 242
Author(s):  
Nur Oktavia ◽  
Yulistiani Yulistiani ◽  
Unedo H Markus ◽  
Hendriette Irene Mamo
Keyword(s):  
Observational Study ◽  
Preterm Labor ◽  
Morbidity And Mortality ◽  
Perinatal Morbidity ◽  
Premature Labor ◽  
The Difference

Premature labor is a cause of high rates of perinatal morbidity and mortality. The use of tocolytics is one of the efforts to handle the risk of preterm labor. Tocolytics which are widely used in Indonesia is isoxsuprine and nifedipine. The purpose of this study was to identify the difference of effectiveness and safety of isoxsuprine as tocolytics in the risk of preterm labor. This was an observational study in the form of a case study that was done in detail and depth to the patients who were diagnosed as imminent preterm labor. In conclusion, there were differences in the effectiveness and safety of isoxsuprine and nifedipine as tocolytics in the risk of preterm labor.

scholarly journals Effectiveness of Glucocorticoids on acute respiratory distress syndrome: An umbrella review

2020 ◽  
Author(s):  
Semagn Mekonnen ◽  
Haile Mariam Mulugeta Kassim ◽  
Bivash Basu ◽  
Solomon Nega
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Systemic Review ◽  
Cochrane Library ◽  
Umbrella Review ◽  
Quality Of Evidence ◽  
Secondary Outcomes

Abstract Background Management of Acute Respiratory Distress Syndrome is a very challenging critical illness in ICU with high morbidity and mortality worldwide.The review was intended to provide evidence on the effectiveness of Glucocorticoid treatment for acute respiratory distress syndrome Method A comprehensive search strategy was conducted on PubMed/Medline, Cochrane Library, Science direct, LILACS, and African Online Journal. Data extraction was carried out with two independent authors with customized checklist. The quality of each systemic review was assessed by two independent authors using AMSTAR tool and the overall quality of evidence was generated with online GRADEpro GDT software for primary and secondary outcomes. Result The umbrella review included nine systemic reviews and meta-analysis and one narrative review with eight thousand four hundred ninety one participants. The methodological quality of the included studies was moderate to high quality. The overall quality of evidence and recommendation varied form high to very low. Conclusion There is high to moderate quality evidence on the initiation of early low dose prolonged glucocorticoid for reduction of mortality for ARDS. However, randomized controlled trials with large sample sizes to address ventilator-free days, the incidence of infection and other glucocorticoid associated adverse events is required as the quality of evidence with these secondary outcomes were low to very low

scholarly journals METHOD FOR PREDICTING PERINATAL HYPOXIC LESIONS OF THE CENTRAL NERVOUS SYSTEM IN NEWBORNS

2019 ◽  
Vol 64 (2) ◽  
pp. 89-93 ◽  
Author(s):  
A. . Smirnova ◽  
N. . Borzova ◽  
N. . Sotnikova ◽  
A. . Malyshkina ◽  
E. . Bojko
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pregnant Women ◽  
Preterm Labor ◽  
Venous Blood ◽  
Perinatal Morbidity ◽  
The Central Nervous System

Perinatal lesions of the Central nervous system (CNS) in newborns occupy a leading place in the structure of perinatal morbidity and subsequent disability of children. To identify the features of the content of sRAGE in pregnant women with threatening preterm labor (UPR) in the period of 22-27 weeks, who subsequently gave birth to children with perinatal CNS lesion. Serum of venous blood of pregnant women with UPR at the term of 22-27 weeks was determined by ELISA once the content of sRAGE. If the value of sRAGE in pregnant women is 659.5 PG/ml or less, perinatal hypoxic lesions of the Central nervous system in newborns are predicted with an accuracy of 75.8% (sensitivity of 82.6%, specificity of 66.7%).

scholarly journals WNT5A Correlates with Clinicopathological Characteristics in Gastric Cancer: a Meta-Analysis

2017 ◽  
Vol 41 (1) ◽  
pp. 33-40 ◽  
Author(s):  
Seungyoon Nam ◽  
Jun-Won Chung ◽  
Jun-Young Yang
Keyword(s):  
Gastric Cancer ◽  
Wnt Signaling ◽  
Meta Analysis ◽  
Clinicopathological Characteristics ◽  
Cochrane Library ◽  
Systematic Analysis ◽  
Advanced Tumor ◽  
Advanced Stages ◽  
Cancer Types ◽  
Embryonic Signaling

Background/Aims: Gastric cancer (GC), the third-leading cause of cancer death in the world, is typically diagnosed only in its advanced stages. WNT signaling has been associated with clinicopathological characteristics in diverse cancer types. But the systematic analysis of WNT5A, a member in the signaling, has not been inspected. Thus, our study used a meta-analysis to statistically associate WNT5A expression with GC clinicopathological characteristics. Methods: For a systematic literature review of GC in combination with the WNT signaling molecule WNT5A, we searched for PubMed, Cochrane Library, and Web of Science. It led to the five cohorts, in four eligible studies, consisting of 1,034 patients (617 WNT5A-positive and 417 WNT5A-negative patients). These patients were inspected by the library “meta” in R software for our meta-analysis. Results: Our meta-analysis, revealed a statistically significant associations of WNT5A-positivity with lymph node metastasis (p=0.0047), some types of Lauren diffuse subtype GCs (p<0.0001), advanced tumor depth (p<0.0001), and advanced UICC stages (p=0.0461) with no observation of bias or confounding factors. Conclusions: These results support the feasibility of targeting this embryonic signaling pathway, both for therapy, and as a biomarker to “guide” various individual interventions (i.e., “personalized medicine”).

scholarly journals Contemporary large-scale international design competitions1 in China. A case study of Baietan, Guangzhou

2013 ◽  
Vol 6 (4) ◽  
Author(s):  
Zheng Liang ◽  
Raine Mäntysalo
Keyword(s):  
Large Scale ◽  
Integrated Approach ◽  
Public Access ◽  
Systematic Analysis ◽  
Planning And Design ◽  
Trading Zones ◽  
Culture Gap ◽  
Urban Planning And Design ◽  
Competition Rules ◽  
Political Background

The importance of contemporary design competitions has been increasingly recognized in fast-growing China in the course of World Trade Organization (WTO) integration and globalization. However, scientific and systematic analysis is rare on how international design competitions are introduced, and how they interact and transplant in the Chinese context. The well-known Chinese-Western culture gap and complicated social and political background make this topic more challenging. Herein, the authors focus on how the international design competitions were “translated” into both international and local perspectives with a compara­tive analysis on development of international design competitions between the Chinese and the Finnish model. To fully exemplify the design-completion procedure and the different roles of Chinese stakeholders and their perspectives on design competitions, the authors study the Baietan case, which was chosen due to its specific relationship with the city’s strategic plan, its representativeness in using international design competitions in connection to large-scale urban projects in China and its public access to the relevant documentation. The preliminary findings suggest that Chinese-style design competitions, acting as ‘designed trading zones’, with less-defined competition rules compared to the Finnish model, may foster the settings of local transformation in adopting international urban planning and design knowledge. However, an integrated approach is required to address subsequent implementation.

scholarly journals Microbial burden and inflammasome activation in amniotic fluid of patients with preterm prelabor rupture of membranes

2020 ◽  
Vol 48 (2) ◽  
pp. 115-131 ◽  
Author(s):  
Kevin R. Theis ◽  
Roberto Romero ◽  
Kenichiro Motomura ◽  
Jose Galaz ◽  
Andrew D. Winters ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Ribosomal Rna ◽  
Preterm Labor ◽  
Rrna Gene ◽  
Inflammasome Activation ◽  
Amniotic Cavity ◽  
Valuable Complement ◽  
Polymerase Chain ◽  
Adverse Pregnancy ◽  
Prelabor Rupture Of Membranes

Abstract Background Intra-amniotic inflammation, which is associated with adverse pregnancy outcomes, can occur in the presence or absence of detectable microorganisms, and involves activation of the inflammasome. Intra-amniotic inflammasome activation has been reported in clinical chorioamnionitis at term and preterm labor with intact membranes, but it has not yet been investigated in women with preterm prelabor rupture of membranes (preterm PROM) in the presence/absence of detectable microorganisms. The aim of this study was to determine whether, among women with preterm PROM, there is an association between detectable microorganisms in amniotic fluid and intra-amniotic inflammation, and whether intra-amniotic inflammasome activation correlates with microbial burden. Methods Amniotic fluids from 59 cases of preterm PROM were examined for the presence/absence of microorganisms through culture and 16S ribosomal RNA (rRNA) gene quantitative real-time polymerase chain reaction (qPCR), and concentrations of interleukin-6 (IL-6) and ASC [apoptosis-associated spec-like protein containing a caspase recruitment domain (CARD)], an indicator of inflammasome activation, were determined. Results qPCR identified more microbe-positive amniotic fluids than culture. Greater than 50% of patients with a negative culture and high IL-6 concentration in amniotic fluid yielded a positive qPCR signal. ASC concentrations were greatest in patients with high qPCR signals and elevated IL-6 concentrations in amniotic fluid (i.e. intra-amniotic infection). ASC concentrations tended to increase in patients without detectable microorganisms but yet with elevated IL-6 concentrations (i.e. sterile intra-amniotic inflammation) compared to those without intra-amniotic inflammation. Conclusion qPCR is a valuable complement to microbiological culture for the detection of microorganisms in the amniotic cavity in women with preterm PROM, and microbial burden is associated with the severity of intra-amniotic inflammatory response, including inflammasome activation.

Web based Analysis of Critical Medical Care Technology

2020 ◽  
pp. 66-73
Author(s):  
Karthikeyan K ◽  
Prakash E.P
Keyword(s):  
Professional Education ◽  
Medical Information ◽  
Critical Role ◽  
Cochrane Library ◽  
Financial Analyst ◽  
Systematic Analysis ◽  
Medical Practitioners ◽  
Service Training ◽  
Training Methodologies ◽  
Care Technology

The In-service Training Web-centred Delivery (ITWD) of medical data is a fundamental investment option for financial analyst that plays a critical role in supporting the competencies of medical practitioners. In this paper, a critical analysis of the training and education aspect of medical information was conducted in the process of identifying fundamental training methodologies for medical practitioners as Continued Professional Education (CPE). The paper also evaluates the possible evidences and results retrieved from CPE. This paper includes a literature review from many databases such as Cumulative Index, Cochrane Library and PubMed library for medical practitioners which includes the information published from 2011. The articles under review, selected in this research were used to retrieve quality reviews based on systematic analysis, programme analysis and randomized controlled trials for peer-reviewed articles published from 2011. In this paper, the research questions concentrate on the evidence that effectively support the educational frequency, media, setting and techniques meant to deliver the medical instructions for the CPE.

scholarly journals SUSTAINABLE SOCIAL DEVELOPMENT, ECONOMIC GROWTH AND TECHNOLOGICAL BREAKTHROUGHS: CREATIVITY AND CREATIVE CHANGE

2019 ◽  
Vol 12 (2) ◽  
pp. 301-314 ◽  
Author(s):  
Borisas Melnikas
Keyword(s):  
Economic Growth ◽  
Social Development ◽  
Complex Analysis ◽  
Technological Development ◽  
Holistic Approach ◽  
Integrated Approach ◽  
Economic Life ◽  
Development Economic ◽  
Systematic Analysis ◽  
Development Processes

This theoretical article is intended for complex analysis of complicated phenomena and processes of the promotion of creativity and creative changes in the main areas of the contemporary social and economic life, as well as for the current and most important issues of sustainability, social development, economic growth and technological breakthroughs. Purpose – to prepare, disseminate and implement the new concept of the sustainable social development, economic growth, innovations and technological breakthroughs, the essence of which is an integrated holistic approach to harmonization of various development processes and the use of specific managerial tools and instruments based on the ideas of creativity and creative changes.Research methodology – systematic analysis and synthesis of various scientific ideas and approaches, formulation and analysis of new insights. Findings – a new concept of the promotion of creativity and creative changes is prepared. This concept provides an integrated approach to the solution of the problems of social development, economic growth, innovation activities, technological progress and breakthroughs, as well as of the application of the specific managerial tools and instruments based on the ideas of creativity and creative changes. Implementation of this concept in the practice of the social and economic activities, research and academic studies creates various preconditions for anticipation and realization of new opportunities for social and economic development and technological breakthroughs under contemporary conditions of globalization, European integration and the creation of knowledge-based society. Research limitations – the proposed concept is limited to the cases of the research on general tendencies and the development processes of the society, as well as to the cases of the macroeconomic analysis and preparation of the strategic decisions for social, economic, political and technological development. Originality/Value – the new insights and perspective ideas provided for the priorities of the various social sciences and humanities, particularly – sociology, economics and management science, and of the application of the specific management tools, are described and analyzed. Orientation to these insights and ideas highlights new significant trends in the scientific research.

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