scholarly journals Operative delivery in pregnant women with asthma

2019 ◽  
Vol 68 (4) ◽  
pp. 19-26
Author(s):  
Olga V. Lavrova ◽  
Elena A. Shapovalova ◽  
Yulia R. Dymarskaya ◽  
Dmitry S. Sudakov ◽  
Anna V. Paliychuk
Keyword(s):  
Cesarean Section ◽  
Pregnant Women ◽  
Allergic Diseases ◽  
First Trimester ◽  
Control Group ◽  
Operative Delivery ◽  
Common Chronic Disease ◽  
Pregnancy And Childbirth ◽  
Asthma Patients ◽  
And Control

Hypothesis/aims of study. Asthma is the most common chronic disease of the respiratory system in women during pregnancy. Numerous studies show an increased frequency of all complications of pregnancy and delivery by cesarean section in women with asthma. Such delivery is reported to be observed more often in patients with severe asthma and asthma exacerbations during gestation. There are conflicting data showing that the use of asthma medication increases the risk of complications of pregnancy and childbirth. This study aimed at analyzing the frequency of cesarean section in patients with asthma, depending on the severity, course, and control of the disease. Study design, materials and methods. This retrospective study involved data of 170 patients with varying severity and control of asthma, who were under the supervision of a pulmonologist from the first trimester of pregnancy. According to the severity of asthma, patients were divided into subgroups with mild intermittent, mild persistent, and moderate and severe course of the disease. The control group was represented by 30 patients who did not suffer from any pulmonary and allergic diseases. Results. The cesarean delivery rate in patients with asthma in the whole group was significantly higher than in patients of the control group. Exacerbation of asthma during pregnancy significantly increases the frequency of abdominal operative delivery, and the use of modern drugs to achieve control of asthma during pregnancy has a positive effect and is associated with a lower birth rate by cesarean section. Conclusion. The active simultaneous management of pulmonary problems in pregnant women allows timely and adequate therapeutic measures aimed to achieve control of asthma during pregnancy, thereby reducing obstetric and perinatal risks, including those associated with the method of delivery.

scholarly journals The Effect of Inhaled Corticosteroid Therapy on Periodontal Status in Patients with Asthma

2021 ◽  
Vol 12 (1) ◽  
pp. 240
Author(s):  
Elżbieta Dembowska ◽  
Aleksandra Jaroń ◽  
Karolina Skoczek-Szlosser ◽  
Ewa Gabrysz-Trybek ◽  
Joanna Bladowska ◽  
...  
Keyword(s):  
Oral Health ◽  
Allergic Diseases ◽  
Study Groups ◽  
Oral Health Status ◽  
Control Group ◽  
Periodontal Status ◽  
Common Chronic Disease ◽  
Group Iii ◽  
Dmf Index ◽  
Asthma Patients

Asthma belongs to a broad group of allergic diseases and is the most common chronic disease found in children and adults up to four decades of age. Already published studies suggest that the use of inhaled anti-asthmatic medications affects both general health and oral health. The study included 120 adult patients aged 18 to 71 divided into three groups: I “PERIO-ASTHMA”—with asthma and periodontitis, II “ASTHMA”—with asthma without periodontitis, and control group III “CONTROL”—without asthma and periodontitis. The patients were monitored for oral health status for six months. Oral health was assessed by dental indices: DMF index, PI, BoP, PD, and CAL at interproximal sites. Significantly deeper pockets in the lateral segments of the dentition were observed in all study groups. In addition, the bronchial-only group had significantly deeper pockets in the lateral sextants than the control group at all time points. There was no significant worsening of periodontal status by CAL and PD in asthma patients treated with inhalation, irrespective of baseline periodontal status. Depending on the severity of asthma, an increase in BOP was observed in the central sextant in patients without periodontitis. The history of asthma and the use of ICS has an impact on the periodontal status of patients.

Influence of the category of urgency of the caesarean section on the adaptive capabilities of pregnant and parturient women

2017 ◽  
pp. 10-15
Author(s):  
I.A. Usevych ◽  
◽  
V.L. Kolesnik ◽  
Keyword(s):  
Caesarean Section ◽  
Cesarean Section ◽  
Pregnant Women ◽  
Maximum Level ◽  
Psychological Problems ◽  
Control Group ◽  
Pregnancy And Childbirth ◽  
Adaptive Capabilities ◽  
Section Operation ◽  
History Of

Psychological problems during pregnancy and childbirth for today is a little studied subject of modern obstetrics. The possibilities for solving psychological problems that arise in cases of emergency obstetric situations are almost not used by Ukrainian specialists through the marriage of knowledge and skills to provide crisis psychological help to obstetric patients. The objective: to determine the level of psychoemotional load in pregnant and parturient women, depending on the category of urgency of cesarean section. Material and methods. The main group of the study was presented: 1 group - pregnant women, who had planned a cesarean section operation according to the ІV category of urgency and who had already had a caesarean section in the anamnesis; ІІ group – pregnant women who planned an operation according to the IV category of urgency and who had no previous caesarean section in their history; ІІІ group – pregnant and parturient women who underwent surgery, respectively, in the I–III category of urgency; Control group – 30 pregnant women in the period of 37–41 weeks of pregnancy. A survey was conducted using the questionnaires of J.Teylor, Ch.Spielberger and SAN-test. Results. On the eve of labor in pregnant women there is an increase in the psychoemotional load, which can be determined using the above questionnaires. There is a direct dependence on the category of urgency of cesarean section and the level of psychoemotional load. Also revealed the correlation dependence of the voltage of the adaptation reserves of the pregnant woman on the presence of a history of caesarean section. Conclusion. Almost 50 percent of pregnant women, in cases of cesarean section, respectively, 1–3 categories of urgency in the preoperative period have the maximum level of psychoemotional load according to the questionnaires used. Pregnant women who have undergone a caesarean section in anamnesis are more adapted and have less psycho-emotional stress than women who have a cesarean section for the first time. Key words: cesarean section, psychoemotional state, pregnancy, childbirth, scale J. Teylor, scale Ch. Spielberger, SAN-test.

scholarly journals The efficiency of treatment of vaginal infections in women with a history of miscarriage

2019 ◽  
Vol 68 (5) ◽  
pp. 63-74
Author(s):  
Anna A. Siniakova ◽  
Elena V. Shipitsyna ◽  
Olga V. Budilovskaya ◽  
Vyacheslav M. Bolotskikh ◽  
Alevtina M. Savicheva
Keyword(s):  
Bacterial Vaginosis ◽  
Pregnant Women ◽  
First Trimester ◽  
Main Group ◽  
Control Group ◽  
Vaginal Infections ◽  
Pregnancy And Childbirth ◽  
Vaginal Microflora ◽  
History Of ◽  
Threatened Abortion

Hypothesis/aims of study. The problem of vaginal infections during pregnancy is of high importance in obstetric practice. To predict the risks and reduce the frequency of pregnancy and childbirth complications, it is necessary to dynamically assess the vaginal microflora and treat its disorders. The aim of the study was to investigate the vaginal microflora and evaluate the effectiveness of treating vaginal infections in pregnant women with a history of miscarriage. Study design, materials and methods. The study included 153 pregnant women in the first trimester. The main group (group I) consisted of 99 women with a history of miscarriage, 35 of whom had signs of threatened abortion (subgroup IA) and 64 did not (subgroup IB). The control group (group II) comprised 54 women without a history of miscarriage and signs of threatened abortion. The vaginal microflora was examined using microscopic, bacteriological and quantitative real-time PCR methods. All patients with an established vaginal infection (bacterial vaginosis, aerobic vaginitis, and vulvovaginal candidiasis) received etiotropic therapy, depending on the microorganisms identified and their sensitivity to antimicrobial drugs. After treatment, in order to assess the effectiveness of the therapy, the vaginal microflora was examined in the second trimester and the outcomes and complications of present pregnancy were evaluated. Results. In women of subgroup IA, vulvovaginitis and bacterial vaginosis were detected 3.5 times more often compared to the control group, and 1.6 times more often compared to subgroup IB (66% and 19%, respectively, p 0.001; 66% and 42%, respectively, p 0.05). Aerobic vaginitis was the most frequent vaginal infection in the first trimester of pregnancy in women of the main group (p 0.05). After treatment, the frequency of the vaginal infections in the second trimester in women of the main group significantly decreased: by 1.9 times in subgroup IA and by 1.5 times in subgroup IB (p 0.05). There were no significant differences in the frequency of adverse pregnancy outcomes in women with bacterial vaginosis or vulvovaginitis as compared to women with normal vaginal microflora. Nevertheless, pregnancy and childbirth complications were diagnosed 4 times more frequently in the main group (23% and 6%, respectively, p 0.05), with the complications occurring significantly more often in the cases of vulvovaginitis or bacterial vaginosis and signs of threatened abortion in the first trimester (p 0.05). Conclusion. Etiotropic therapy of vaginal infections diagnosed in the first trimester of pregnancy in women with a history of miscarriage was highly effective. In 40% of women, vaginal microbiocenosis normalized, and the clinical symptoms of vaginosis/vaginitis disappeared. Differences in the frequency of adverse pregnancy outcomes in women with vulvovaginitis or bacterial vaginosis in the first trimester and in women with normal vaginal microbiocenosis were not significant. However, the treatment of vaginal infections in the group of pregnant women with a history of miscarriage did not significantly affect the frequency of pregnancy and childbirth complications.

scholarly journals Evaluation of some trace elements in sera of asthma patients: a case control study.

Folia Medica ◽  
2021 ◽  
Vol 63 (5) ◽  
pp. 797-804
Author(s):  
Falah S. Al-Fartusie ◽  
Manal J. Abood ◽  
Hassanain K. Al-Bairmani ◽  
Ahmed S. Mohammed
Keyword(s):  
Trace Elements ◽  
Allergic Diseases ◽  
Control Group ◽  
Asthmatic Patients ◽  
Atomic Absorption Technique ◽  
Asthma Patients ◽  
Low Levels ◽  
And Control ◽  
Control Study ◽  
Absorption Technique

Introduction: Asthma is a chronic in&#64258;ammatory disease of the airways characterized by recurrent respiratory symptoms of dyspnea, wheezing, chest tightness, and cough. Aim: This study aims to investigate the concentrations of Cu, Zn, Mg, Mn, Fe, Cr, Ni, and Al in the serum of asthmatic patients. Materials and methods: An atomic absorption technique was used to determine the levels of trace elements. The study included sixty asthmatic patients and ninety healthy individuals as control group their ages ranging from 20 to 45 years. Results: We found a significant increase of the levels of copper, iron, and aluminum by 20%, 54%, and 47% (p<0.01), respectively, in the asthmatic patients as compared with the controls. On the other hand, in comparison with the controls, the levels of zinc, magnesium, manganese, and nickel were found to be significantly decreased (p<0.01) by 24%, 16%, 53%, and 81%, respectively, in the asthmatic patient group. Moreover, chromium level showed non-significant differences (p>0.05) between patients and control group. Conclusions: The increased level of Cu and Fe may reflect their potential role in the pathogenesis of asthma. Furthermore, the serum iron levels tend to be increased as a result of the inflammatory process that occurs in asthma. Low levels of Zn, Mg, and Mn may contribute to allergic diseases due to their role in the synthesis of certain antioxidants or to their effect on the immune system.

Obstetric and perinatal outcomes in women with threatened interruption of pregnancy, living in the armed conflict zone

2020 ◽  
pp. 21-24
Author(s):  
I.Yu. Romanenko ◽  
Keyword(s):  
Pregnant Women ◽  
Inflammatory Diseases ◽  
Perinatal Outcomes ◽  
Control Group ◽  
Operative Delivery ◽  
Pregnancy And Childbirth ◽  
Group I ◽  
History Of ◽  
Complicated Course ◽  
Female Genital

The objective: was to evaluate the course of pregnancy, childbirth and perinatal outcomes of delivery of women with threatened interruption of pregnancy (TIP), living in the Lugansk region, to improve treatment and preventive measures and prevent obstetric and perinatal complications in such women. Materials and methods. A prospective clinical and statistical analysis of the course of pregnancy and childbirth of 86 pregnant women in first and second trimesters of pregnancy were hospitalized regarding TIP in the hospitals located in the Luhansk region was performed (group I). The control group consisted of 64 pregnant women with non-complicated obstetric anamnesis and physiological course of pregnancy with similar gestational period of pregnancy and place of residence (group II). Results. In women of group I, a history of female genital inflammatory diseases was significantly more frequent, and a complicated course of pregnancy and childbirth was registered. The number of cases of acute respiratory viral infection (ARVI) was in 4, isthmic-cervical insufficiency (ICI) was in 3 times more often than in healthy pregnant women, asymptomatic bacteriuria, recurring TIP, gestational pyelonephritis and ureaplasma infection were found only in pregnant women of group I, the number of cases of anemia there was no significant difference. 13 (15.12%) of women of group I and 3 (4.69%) of group II (p=0.041) had spontaneous preterm birth at 33–37 weeks of gestation; operative delivery was registered in 23 (26.74%) and 8 (12.50%) cases, respectively (p=0.033). It was established that recurrent TIP, ARVI during this pregnancy, ICI, gestational pyelonephritis are statistically significant risk factors for preterm delivery and operative delivery. Premature rupture of the membranes was found in 1.58, weakness of labor – in 2.2, premature detachment of a normally located placenta – in 6, fetal distress – in 1.9 times more often in women of group I, central placenta previa was noted only in group I. Conclusions. The complicated course of the first and second trimesters of pregnancy, in particular, recurrent TIP, ARVI during this pregnancy, ICI, gestational pyelonephritis, had a direct effect on frequency increase of premature termination of pregnancy and operative delivery in patients of the main group compared with women of the control group. The presence of a history of chronic female genital inflammatory diseases, sexually transmitted infections, ARVI during this pregnancy, TIP in the first and second trimesters, allows pregnant women to be at high risk of developing gestational complications in order to conduct timely treatment. Key words: pregnancy, the threat of abortion, childbirth, the condition of newborns.

scholarly journals The Reactivity Levels of Progesterone, Nitric Oxide and Nuclear Factor Kappa-B on the Serum of Term and Post-Term Pregnancy, Clinical Study in Padang, West Sumatera, Indonesia

2019 ◽  
Vol 7 (11) ◽  
pp. 1729-1732
Author(s):  
Defrin Defrin ◽  
Eti Yerizel ◽  
Donel Suhaimi ◽  
Afriwardi Afriwardi
Keyword(s):  
Cesarean Section ◽  
Premature Birth ◽  
Mode Of Delivery ◽  
First Trimester ◽  
Target Group ◽  
Control Group ◽  
First Trimester Screening ◽  
Trimester Screening ◽  
The Difference ◽  
And Control

BACKGROUND: A variety of recent evidence exists about the clinical implication of low level of Pregnancy-associated plasma protein A (PAPP-A) in pregnancy. This glycoprotein is a protease, which releases the Insulin-like growth factor from IGFBP 4. Its role is a trophoblastic invasion of decidua, stimulation of cell mitosis and differentiation. It has an immunosuppressive effect in the placenta, inhibition of coagulation and complex role for integration of all these processes in the placenta. Level of PAPP-A (under 0.4 MoM-Multiple of Medians) in first-trimester screening in chromosomally and morphologically normal fetuses, could influence fetal weight, preeclampsia, premature birth and stillbirth. As a result of the complications as mentioned earlier, there is implication on timing, mode of delivery and condition of the newborn.AIM: The study aims to evaluate the influence of low PAPP-A, measured in the first trimester on the outcome of pregnancy, with accent disorders, which are the result of placental insufficiency. Also, gestational week, mode of delivery and condition of newborn secondary underlying conditions will be evaluated.MATERIAL AND METHODS: After given information and consultation about the expectation from the screening, pregnant women with a singleton pregnancy were tested for First Trimester Screening to estimate the risk for Trisomy 21, 13, 18- the most frequent chromosomopathies. After exclusion of chromosomopathies and congenital malformations, one hundred and fourteen patients enrolled in the study. The target group (n = 64) with PAPP-A below 0.4 MoM and control group (n = 50) with PAPP-A equal and above 0.4 MoM. An assessment of mode and time of delivery and presence of small for gestational age newborns, preeclampsia, premature birth and newborn condition at delivery was made.RESULTS: The percentage of the patients delivered in term was similar between the target group (n = 64) and the control group (n = 50), 82.81% vs 82.0% respectively. The rate of cesarean section was 29.7 % in the target group vs 32% in the control group. A significant difference was found about elective vs urgent cesarean section in favour of the target group. The difference was present about the complication in pregnancy before delivery, 56% vs 22%, p = 0.023, which were the main indication for cesarean section. The difference in newborn outcome was not significant.CONCLUSION: There is a difference in frequency of complications, in the cases with PAPP-A under 0.4 MoM, such as premature birth, preeclampsia compound with SGA fetuses versus the control group. The difference for SGA newborn and premature birth among the groups has statistical significance. The patients delivered with cesarean section were with the main indications SGA or elevated blood pressure, often occurred combined with prematurity. Apgar score and birth weight were similar in target and control group, but the newborns with a birth weight under 2500 g. were more frequent in the target group. Because these results did not show another significance among two groups, probably lower cut-off is needed, combining with another test (Doppler of uterine arteries in the first trimester, biochemical test). Presence of other diseases which could hurt placental function should be emphasised.

Fetal-Maternal Hemorrhage in First-Trimester Intrauterine Hematoma

2021 ◽  
Vol 48 (3) ◽  
pp. 227-234
Author(s):  
Thaisa A.R.M. Narciso ◽  
Mara S Hoshida ◽  
Priscilla R Costa ◽  
Andrea Niquirilo ◽  
Sckarlet E Biancolin ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Pregnant Women ◽  
Fetal Hemoglobin ◽  
First Trimester ◽  
Maternal Blood ◽  
Control Group ◽  
Asymptomatic Patients ◽  
Ultrasound Findings ◽  
Moderate Negative Correlation ◽  
And Control

<b><i>Objective:</i></b> The objective of this study was to compare the frequency and percentage of fetal hemoglobin (HbF%) by flow cytometry of (1) first-trimester asymptomatic patients with intrauterine hematoma (IUH), (2) first-trimester pregnant patients with vaginal bleeding (VB), and (3) first-trimester asymptomatic pregnant women without hematoma. <b><i>Methods:</i></b> Prospective study involving pregnant women in the first trimester of pregnancy. Patients with ultrasound findings of asymptomatic hematoma and with VB were paired with asymptomatic pregnant women of same gestational age without hematoma (control group [CG]). Maternal blood HbF% was evaluated by flow cytometry. The groups were compared in terms of circulating fetal hemoglobin and HbF%. <b><i>Results:</i></b> Sixty-six patients were selected, 22 with hematoma, 17 with bleeding, and 27 in the CG. Fetal hemoglobin was detected in 15 patients with hematoma (68.2%) and 13 with bleeding (76.5%) and in 20 of the control (74.1%) (<i>p</i> = 0.830). The mean HbF% of each group was 0.054, 0.012, and 0.042 for hematoma, bleeding, and control, respectively, and differences were not significant (<i>p</i> = 0.141). There was a moderate negative correlation between the volume of hematoma and HbF% (<i>r</i><sub>Spearman</sub> = −0.527; <i>p</i> = 0.012). <b><i>Conclusions:</i></b> The fetal-maternal hemorrhage expressed by Hbf% in first-trimester pregnancies did not seem to differ between patients with and without ultrasound findings of IUH.

scholarly journals Perbedaan Mual dan Muntah Ibu Hamil Trimester I yang Diberikan Ekstrak Jahe dan Ekstrak Daun Mint

2018 ◽  
Vol 9 (2) ◽  
pp. 253
Author(s):  
Anita Anita ◽  
Aprina Aprina ◽  
Ratna Aryani
Keyword(s):  
Pregnant Women ◽  
Vitamin B6 ◽  
Alternative Therapy ◽  
First Trimester ◽  
Health Centers ◽  
Nausea And Vomiting ◽  
Control Group ◽  
Control Groups ◽  
Ginger Extract ◽  
And Control

<p>Study of literature with meta-analysis was obtained 7 out of 10 women around the world to experience nausea and vomiting during pregnancy, with an average incidence of 69.4% (66.5-72.3%, CI 95%). The purpose of research to find out the difference of nausea and vomiting of pregnant women through assessment scale Rhodes after administration of ginger extract and mint leaf extract in Inpatient Health Center Bandar Lampung in 2016. The target of research is the discovery of alternative therapy/food in the community to reduce nausea and vomiting of pregnant women. Type of research is quantitative research, design experimental research. The study population is the entire first-trimester pregnant women who visit health centers Inpatient Bandar Lampung, with 10 (ten) PHC hospitalization. The total sample was 102, the group treated with the extract of ginger were 34 respondents, a group treated extract of mint leaves were 34 respondents, and the group without treatment who received standard procedures health centers (Vitamin B6) were 34 respondents, with the criteria of pregnant women the first trimester without GI disease. The results of the study there were significant differences between the measurement value of nausea and vomiting before and after administration of ginger extract, extract of mint and a control group with p = 0.001 in the extract of ginger, p=0.000 in the extract mint, and p=0.001 in the control group with (standard treatment of health centers with vitamin B6). There were no differences between mean nausea and vomiting in the first trimester pregnant women who received ginger extract and mint with a p=0.548, ginger extract and control groups with p=0.807, mint extract and control groups with p=0,407 ginger and mint can be an alternative therapy to reduce vomiting and nausea of pregnant woman in trimester I. Advanced research about the composition, dosage and side effects of ginger and mint benefit to the problem of gastrointestinal disorders who experience nausea and vomiting.</p>

scholarly journals Clinical Importance of Low Level of PAPP-A in First Trimester of Pregnancy - An Obstetrical Dilemma in Chromosomally Normal Fetus

2019 ◽  
Vol 7 (9) ◽  
pp. 1475-1479 ◽  
Author(s):  
Vesna Livrinova ◽  
Igor Petrov ◽  
Igor Samardziski ◽  
Viktorija Jovanovska ◽  
Aleksandra Atanasova Boshku ◽  
...  
Keyword(s):  
Cesarean Section ◽  
Premature Birth ◽  
Mode Of Delivery ◽  
First Trimester ◽  
Target Group ◽  
Control Group ◽  
First Trimester Screening ◽  
Trimester Screening ◽  
The Difference ◽  
And Control

BACKGROUND: A variety of recent evidence exists about the clinical implication of low level of Pregnancy-associated plasma protein A (PAPP-A) in pregnancy. This glycoprotein is a protease, which releases the Insulin-like growth factor from IGFBP 4. Its role is a trophoblastic invasion of decidua, stimulation of cell mitosis and differentiation. It has an immunosuppressive effect in the placenta, inhibition of coagulation and complex role for integration of all these processes in the placenta. Level of PAPP-A (under 0.4 MoM-Multiple of Medians) in first-trimester screening in chromosomally and morphologically normal fetuses, could influence fetal weight, preeclampsia, premature birth and stillbirth. As a result of the complications mentioned above, there is implication on timing, mode of delivery and condition of the newborn. AIM: The study aims to evaluate the influence of low PAPP-A, measured in the first trimester on the outcome of pregnancy, with accent disorders which are the result of placental insufficiency. Also, gestational week, mode of delivery and condition of newborn secondary underlying conditions will be evaluated. MATERIAL AND METHODS: After given information and consultation about the expectation from the screening, pregnant women with a singleton pregnancy were tested for First Trimester Screening to estimate the risk for Trisomy 21, 13, 18- the most frequent chromosomopathies. After exclusion of chromosomopathies and congenital malformations, one hundred and fourteen patients enrolled in the study. The target group (n = 64) with PAPP-A below 0.4 MoM and control group (n = 50) with PAPP-A equal and above 0.4 MoM. An assessment of mode and time of delivery and presence of small for gestational age newborns, preeclampsia, premature birth and newborn condition at delivery was made. RESULTS: The percentage of the patients delivered in term was similar between the target group (n = 64) and the control group (n = 50), 82.81% vs 82.0% respectively. The rate of cesarean section was 29.7 % in the target group vs 32% in the control group. A significant difference was found about elective vs urgent cesarean section in favour of the target group. The difference was present about the complication in pregnancy before delivery, 56% vs 22%, p = 0.023, which were the main indication for cesarean section. The difference in newborn outcome was not significant. CONCLUSION: There is a difference in frequency of complications, in the cases with PAPP-A under 0.4 MoM, such as premature birth, preeclampsia compound with SGA fetuses versus the control group. The difference for SGA newborn and premature birth among the groups has statistical significance. The patients delivered with cesarean section were with the main indications SGA or elevated blood pressure, often occurred combined with prematurity. Apgar score and birth weight were similar in target and control group, but the newborns with a birth weight under 2500 g. were more frequent in the target group. Because these results did not show another significance among two groups, probably lower cut-off is needed, combining with another test (Doppler of uterine arteries in the first trimester, biochemical test). Presence of other diseases which could hurt placental function should be emphasised.

scholarly journals Estimating Rate of Insulin Resistance in Patients with Preeclampsia Using HOMA-IR Index and Comparison with Nonpreeclampsia Pregnant Women

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Farideh Rezaei Abhari ◽  
Maryam Ghanbari Andarieh ◽  
Asadollah Farokhfar ◽  
Soleiman Ahmady
Keyword(s):  
Insulin Resistance ◽  
Pregnant Women ◽  
Fasting Blood Glucose ◽  
First Trimester ◽  
Control Group ◽  
Case Group ◽  
Third Trimester ◽  
Significant Difference ◽  
Diagnosis Criteria ◽  
And Control

Women with preeclampsia, independent of obesity and glucose intolerance, exhibit insulin resistance during pregnancy. The purpose of the present study is to determine whether early diagnosis of insulin resistance during pregnancy can predict preeclampsia. Through a case-control study, 675 pregnant women were selected and their first trimester blood was taken. Their fasting blood glucose and insulin were also measured after diagnosis of preeclampsia by 20 weeks of pregnancy. Based on the experiments conducted on 675 women who were 20 weeks past their pregnancy, 375 cases with preeclampsia were selected and assigned to the case group. 35 other pregnant women were put in the control group. Diagnosis criteria for the participants included blood pressure above 140/90 and proteinuria above 300 mg or above +1. Both groups were matched according to age, parity, gestational age, and BMI. Homa-Irand rate of insulin resistance was calculated by HOMA-IR and patients were followed up. Homeostatic model assessments (HOMA-IR) revealed that the average insulin resistance increased during pregnancy among both the case and control groups. There was a significant difference between insulin resistance of these two groups in both first trimester and third trimester and after developing preeclampsia (P< 0.001,P= 0.021). Insulin-resistance of the group with preeclampsia was higher in first trimester prior to diagnosis as well as the third trimester after diagnosis compared to natural pregnancy under similar conditions. Measurement of insulin resistance in first trimester may be useful in predicting the risk of preeclampsia.

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