Chemotherapy of intradermal infection of rabbits with pneumococcus. Action of optoquine and other quinine derivatives

1935 ◽  
Vol 31 (8-9) ◽  
pp. 1116-1116
Author(s):  
I. А. Кolmer ◽  
А. М. Rule
Keyword(s):  
Body Weight ◽  
The Third

The main optoquin was administered to rabbits per os at 0.01 g per 1 kg of body weight immediately after infection and then within 3 days, every 6 hours. In another series of animals, optoquin was injected every 6 hours four times during infection and the same number after infection. In the third series of rabbits, optoquine was injected intramuscularly.

scholarly journals Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat

1999 ◽  
Vol 276 (5) ◽  
pp. R1425-R1433 ◽  
Author(s):  
Gertjan van Dijk ◽  
Randy J. Seeley ◽  
Todd E. Thiele ◽  
Mark I. Friedman ◽  
Hong Ji ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Body Weight ◽  
Energy Expenditure ◽  
Neuropeptide Y ◽  
Caloric Restriction ◽  
Resting Energy Expenditure ◽  
Corticotropin Releasing Hormone ◽  
Plasma Fatty Acids ◽  
The Third ◽  
Ad Libitum

To investigate whether brain leptin involves neuropeptidergic pathways influencing ingestion, metabolism, and gastrointestinal functioning, leptin (3.5 μg) was infused daily into the third cerebral ventricular of rats for 3 days. To distinguish between direct leptin effects and those secondary to leptin-induced anorexia, we studied vehicle-infused rats with food available ad libitum and those that were pair-fed to leptin-treated animals. Although body weight was comparably reduced (−8%) and plasma glycerol was comparably increased (142 and 17%, respectively) in leptin-treated and pair-fed animals relative to controls, increases in plasma fatty acids and ketones were only detected (132 and 234%, respectively) in pair-fed rats. Resting energy expenditure (−15%) and gastrointestinal fill (−50%) were reduced by pair-feeding relative to the ad libitum group, but they were not reduced by leptin treatment. Relative to controls, leptin increased hypothalamic mRNA for corticotropin-releasing hormone (CRH; 61%) and for proopiomelanocortin (POMC; 31%) but did not reduce mRNA for neuropeptide Y. These results suggest that CNS leptin prevents metabolic/gastrointestinal responses to caloric restriction by activating hypothalamic CRH- and POMC-containing pathways and raise the possibility that these peripheral responses to CNS leptin administration contribute to leptin’s anorexigenic action.

Healthwise: Part 1. Maintaining a healthy body weight

2021 ◽  
Vol 15 (4) ◽  
pp. 169-173
Author(s):  
Linda Nazarko
Keyword(s):  
Body Weight ◽  
Death Rate ◽  
Healthcare Workers ◽  
Poor Health ◽  
The Third ◽  
Lifestyle Choices ◽  
The World ◽  
Healthy Body Weight ◽  
The Uk ◽  
Healthy Body

Coronavirus (COVID-19) has claimed the lives of over 150 000 people in the UK ( UK Government, 2021 ). The UK has the third highest death rate in the world and the fourth highest obesity rate ( Lobstein, 2021 ). Although the UK is a developed nation, many people in the UK experience poor health, as a result of being overweight and inactive. Healthcare workers are not immune from these issues. This article, the first in a series, explores how readers can remain healthy and well by making lifestyle choices that promote health.

scholarly journals Nitrate and nitrite poisoning in sheep and goats caused by ingestion of Portulaca oleracea

2018 ◽  
Vol 38 (8) ◽  
pp. 1549-1553
Author(s):  
João G. Simões ◽  
Rosane Maria T. Medeiros ◽  
Márcia A. Medeiros ◽  
Robério G. Olinda ◽  
Antônio Flávio M. Dantas ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Body Weight ◽  
Clinical Signs ◽  
Portulaca Oleracea ◽  
Sheep And Goats ◽  
Ruminal Ph ◽  
The Third ◽  
Mucous Membranes ◽  
Nitrate And Nitrite ◽  
Positive Results

ABSTRACT: Three outbreaks of poisoning by Portulaca oleracea were reported in sheep and goats in Northeast Brazil. In the first outbreak, 8 out of 20 sheep were affected and later died. In the second outbreak, three goats and one sheep died out of a flock of 30 animals that included both species. In the third outbreak, two out of 19 sheep were affected, and they recovered after a treatment of 2% methylene blue at a dose of 4 mg/kg body weight. In the first and second outbreaks, the animals ingested P. oleracea after it was cut and offered in feeders. In the third outbreak, the flock was grazing in an area that had been invaded by the plant. To determine the toxicity, P. oleracea was administered experimentally at a dose of 80g/kg of body weight to seven sheep, weighing 19-30 kg. One control sheep received green grass. One to four hours after P. oleracea ingestion, the animals showed clinical signs of poisoning characterized by cyanotic mucous membranes, bloat, ruminal pH of 8-9, pollakiuria, aerophagia, involuntary movements of the upper lip, apathy, tachypnea and tachycardia. Five animals recovered, including one that was treated with 1% methylene blue, and two animals died. During necropsy, the mucous membranes were brownish, and the blood was dark brown. Diphenylamine tests of the plant and of rumen contents were positive for nitrates. Positive results for nitrates were also found in 24 samples of P. oleracea that were collected in different places in the states of Pernambuco and Paraíba. We conclude that P. oleracea accumulates nitrates at toxic levels and may cause poisoning in sheep and goats.

scholarly journals PERTUMBUHAN LARVA DAN PRODUKSI BENIH IKAN KERAPU BEBEK Cromileptes altivelis Valenciennes, 1828 HASIL BUDIDAYA TURUNAN KE-3

2018 ◽  
Vol 10 (3) ◽  
pp. 589-600
Author(s):  
Regina Melianawati ◽  
Ni Wayan Widya Astuti ◽  
. Tridjoko
Keyword(s):  
Body Weight ◽  
Survival Rate ◽  
Seed Production ◽  
Larval Growth ◽  
The Body ◽  
Third Generation ◽  
Larval Body ◽  
Spine Length ◽  
The Third ◽  
Total Length

ABSTRAKKetersediaan induk dalam suatu usaha pembenihan memiliki peran yang sangat penting. Namun demikian, ketersediaan induk yang berasal dari alam sangat terbatas jumlahnya, sehingga perlu dilakukan penyediaan calon induk yang berasal dari hasil budidaya. Ikan kerapu bebek Cromileptes altivelis Valenciennes, 1828 turunan pertama (F-1) dan turunan kedua (F-2) sudah dapat diproduksi dari hasil budidaya, namun benih turunan ketiga (F-3) belum dapat diperoleh. Penelitian ini bertujuan untuk mendapatkan karakteristik morfologis dan pertumbuhan larva ikan kerapu bebek F-3 sebagai calon induk F-3, serta tingkat keberhasilan produksi benihnya. Pemeliharaan larva dilakukan dalam hatchery hingga larva menjadi benih. Parameter yang diamati meliputi panjang total dan panjang duri sirip larva, berat tubuh larva serta sintasan dan jumlah produksi benih. Hasil penelitian menunjukkan bahwa panjang total larva umur 5, 15, 25 dan 35 hari, masing-masing adalah 3,20±0,07; 4,42±1,11; 8,35±1,12 dan 12,51±3,23 mm. Duri sirip mulai terukur pada larva umur 15 hari. Berat larva umur 30 hari adalah 0,11±0,04 g. Pola pertumbuhan panjang total dan berat tubuh larva adalah eksponensial, sedangkan pola pertumbuhan duri siripnya adalah linier. Masa pemeliharaan larva hingga menjadi benih adalah ± 40 hari. Jumlah benih ikan kerapu bebek F-3 yang diproduksi dalam satu kali siklus pemeliharaan berkisar 440 hingga 2.300 ekor dari 50 ekor induk dan 3 kali siklus pemijahan dengan tingkat kelangsungan hidup 1,30% hingga 8,80%. Hasil penelitian ini mengindikasikan bahwa ikan kerapu bebek F-3 dapat diproduksi dari hasil budidaya seperti halnya pada F-1 dan F-2. ABSTRACTBroodstocks are the most important part of humpback grouper culture, but their availability in nature are limited. Therefore, it is necessary to produce broodstock candidates from culture. The first (F-1) and the second (F-2) generation of humpback grouper have already been produced but the third generation (F-3) production is still on the way. This study was conducted to find out morphological characteristic of the third generation (F-3) of humpback grouper larvae as the candidate of the third generation of broodstock, larval growth and the success rate of seed production. Larvae rearing was done in hatchery until larvae metamorphosed to be seeds. Observed variables including larval total length and spine length, larval body weight, survival rate and the juvenile productions. The study result showed the total length of 5, 15, 25 and 35 days old larvae were 3.20±0.07; 4.42±1.11; 8.35±1.12 and 12.51±3.23 mm, respectively. The spine began measured on 15 days old larvae. The body weight of 30 days old larvae was 0.11±0.04 g. The growth pattern of larval total length and body weight were exponential, while the growth of spine was linear. Rearing period from larvae to juveniles was 40 days. Number of F-3 seed production of humpback grouper produced from once rearing cycle range between 440 and 2,300 fish and the survival rate range from 1.30% up to 8.80%. Therefore, this study could indicate that seed of F-3 humpback grouper can be produced as those of F-1 and F-2.

Effect of long term water deprivation on body weight and water intake of breeding ewes under semi-arid conditions

1978 ◽  
Vol 90 (2) ◽  
pp. 435-439 ◽  
Author(s):  
T. More ◽  
K. L. Sahni
Keyword(s):  
Body Weight ◽  
Water Intake ◽  
Body Weight Loss ◽  
Summer Season ◽  
Breeding Cycle ◽  
The Third ◽  
Arid Conditions ◽  
Body Weights ◽  
First Time

SummaryThirty-nine adult ewes of identical body size and age were randomly taken from the Chokla breed. They were divided into four groups which were allowed water once in 24, 48, 72 and 96 h. Seven ewes from each of the first, third and fourth groups were mated for the first time in the spring and for a second time in winter, so that they lambed in the monsoon and summer season respectively. All the ewes were maintained on uncultivated pasture. Watering once in 72 and 96 h caused body weight loss up to 26%, compared with those watered daily. The ewes which failed to maintain pregnancy lost more than 30% of their body weights due to watering only once in 96 h and there were about 43 and 100% lambing in the first and second breeding cycle of the same ewes. The remaining groups displayed 100% lambing. The water-intake increased significantly in the third month of pregnancy in the group allowed water daily and water consumption was found to be about 13% of body weight, whereas the values for those watered once in 72 and 96 h were 9 and 8% respectively. The water-deprived animals were able to drink up to 32 % of their body weights within 2–3 min. It is concluded that breeding ewes could be watered once in 72 h without any loss of lambing during summer.

Glucagon-like peptid-1 in obese and diabetic patients after bariatric interventions

2021 ◽  
Vol 23 (1) ◽  
pp. 89-94
Author(s):  
Anna R. Volkova ◽  
Galina V. Semikova ◽  
Valentina S. Mozgunova ◽  
Margarita N. Maltseva ◽  
Vladimir L. Bondarenko ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Weight Gain ◽  
Diabetic Patients ◽  
Obese Patients ◽  
Weight Retention ◽  
Plateau Phase ◽  
The Third ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

The relationship between the level of glucagon-like peptide-1 and repeated weight gain was evaluated in 31 patients suffering from grade IIIII obesity and type 2 diabetes mellitus after bariatric interventions for 3 years. It was found that the level of stimulated glucagon-like peptide-1 significantly increased by the third day after sleeve gastroplasty and gastroschunt compared to the initial parameters (p = 0.001 for obese patients; p = 0.000 for obese patients and diabetes mellitus). In the plateau phase (body weight retention) after bariatric intervention, the level of stimulated glucagon-like peptide-1 in obese patients and patients suffering from obesity in combination with diabetes mellitus did not significantly differ from the indicators of healthy individuals. There was no association between the level of glucagon-like peptide-1 and repeated weight gain. This may be due to the limited contribution of glucagon-like peptide-1 to body weight dynamics after bariatric interventions and the predominance of patient compliance. Thus, the level of stimulated glucagon-like peptide-1 at baseline, on the third day and in the plateau phase after bariatric intervention was not associated with the value of repeated weight gain.

EFFECTS OF MATERNAL NUTRITION ON THE HUMAN FETUS

PEDIATRICS ◽  
1973 ◽  
Vol 52 (4) ◽  
pp. 494-503
Author(s):  
Richard L. Naeye ◽  
William Blanc ◽  
Cheryl Paul
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Maternal Nutrition ◽  
Cellular Growth ◽  
Late Gestation ◽  
Third Trimester ◽  
Organ Growth ◽  
Maternal Undernutrition ◽  
The Third ◽  
Body Organ

In a study of 467 gestations maternal stature had little correlation with fetal growth but mother's pregravid body weight as well as weight gain and low-calorie diets during pregnancy did have such a correlation. Maternal undernutrition before the third trimester had little or no influence on fetal body, organ, and cellular growth while such effects were pronounced in late gestation. Fetal body and organ growth improved with successive pregnancies except in the most poorly nourished mothers, whose successive neonates became more growth retarded.

Brain-to-body ratios and time of maturation of the mouse brain

1963 ◽  
Vol 204 (2) ◽  
pp. 343-346 ◽  
Author(s):  
Tsukasa Kobayashi
Keyword(s):  
Body Weight ◽  
Short Duration ◽  
Mouse Brain ◽  
Abrupt Change ◽  
Brain Weight ◽  
Second Phase ◽  
The Third ◽  
Third Phase ◽  
The Brain

Studies on the relationships of brain weight to body weight during development were conducted in 218 mice, and revealed three distinct phases. During the first phase, the ratios are relatively constant. The second phase of short duration is characterized by abrupt reductions. In the third phase, which is the most enduring, the ratios again assume more constant values. The abrupt change in the ratios took place around 14 days of age. It is suggested that the abrupt change in the ratio is, in general, an indicator of the maturation of the brain, because there are several other parameters which approach mature levels around the 15th day. A review of the data on other species supports this suggestion.

Circulating insulin levels are related to bone density in normal postmenopausal women

1993 ◽  
Vol 265 (4) ◽  
pp. E655-E659 ◽  
Author(s):  
I. R. Reid ◽  
M. C. Evans ◽  
G. J. Cooper ◽  
R. W. Ames ◽  
J. Stapleton
Keyword(s):  
Body Weight ◽  
Postmenopausal Women ◽  
Multiple Regression ◽  
Vertebral Body ◽  
Fat Mass ◽  
Volumetric Density ◽  
Insulin Levels ◽  
The Third ◽  
Lumbar Vertebral Body ◽  
Total Body

We recently established that the dependence of bone mineral density (BMD) on body weight in women is mainly attributable to a close relationship between total body fat mass and BMD. The present study assesses whether this latter relationship might be contributed to by the hormones insulin or amylin, both of which may influence fat mass and calcium metabolism. Fifty-three normal postmenopausal women underwent a 75-g glucose tolerance test with measurement of plasma insulin and amylin concentrations every 30 min for 2 h. Body composition and BMD/height (to provide a quantity with the dimensions of volumetric density that is independent of body size) were measured by dual-energy X-ray absorptiometry, and volumetric density of the third lumbar vertebral body was calculated. Circulating insulin concentrations correlated with BMD/height and volumetric density of the third lumbar vertebral body (r = 0.28-0.52). They also were related to body weight (r = 0.34-0.56) and fat mass (r = 0.38-0.56) but were not independently related to lean mass on multiple regression. There were no consistent relationships between amylin levels and these variables. Multiple-regression analyses with fat mass and insulin levels as independent variables indicated that BMD/height of total body and femoral trochanter were primarily related to fat mass, whereas, in femoral neck, the significant relationship was with insulin. Volumetric density of the third lumbar vertebral body was related to insulin levels alone on this analysis.(ABSTRACT TRUNCATED AT 250 WORDS)

Effect of giving water intermittently on excretion patterns of water and certain electrolytes in Ghokla sheep during summer

1978 ◽  
Vol 91 (3) ◽  
pp. 677-680 ◽  
Author(s):  
T. More ◽  
K. L. Sahni
Keyword(s):  
Body Weight ◽  
Water Intake ◽  
Feed Intake ◽  
Water Deprivation ◽  
Urine Volume ◽  
Significant Decline ◽  
The Third ◽  
Hot Climate ◽  
External Balances ◽  
Sodium And Potassium

SummaryExternal balances of water, sodium and potassium were examined in carpet wool Chokla sheep given water once in 24, 48 and 72 h during the hot months. There was a significant decline (P < 0·01) in feed intake on the third day of dehydration. The water intake of this group approached 30% of body weight and there was also a significant (P < 0·05) decrease in urine volume after 2 days of water deprivation. There was a large balance for potassium in all treatments and most especially when the sheep were given water every 72 h. It is argued that this unusually high balance of potassium was probably a characteristic of sheep adapted to a hot climate.

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