scholarly journals Changes in the morphological composition of the blood during congestion

2020 ◽  
Vol 22 (2) ◽  
pp. 167-176
Author(s):  
M. G. Kurlov
Keyword(s):  
Morphological Changes ◽  
Cardiac Activity ◽  
Cardiac Patients ◽  
Pathological Conditions ◽  
Morphological Composition ◽  
Work Abroad ◽  
Small Work

One of the main works of my late teacher, Professor V.A.Manassein, relates to the study of changes in blood during experimental fever. The data of this work are still cited in monographs on this issue. Vyacheslav Avksentievich, one of the first Russian doctors, worked on the study of morphological changes in blood in various pathological conditions and, sending me to work abroad, he strongly recommended that I pay special attention to this department of pathology and the clinic. Wishing to mark the memory of my teacher in some way, I allow myself in this small work to report the results of my clinic's research on the morphology of blood in cardiac patients during the period of disturbance of the compensation of cardiac activity.

scholarly journals A Potential Involvement of Anandamide in the Modulation of HO/NOS Systems: Women, Menopause, and “Medical Cannabinoids”

2020 ◽  
Vol 21 (22) ◽  
pp. 8801
Author(s):  
Renáta Szabó ◽  
Denise Börzsei ◽  
Zsuzsanna Szabó ◽  
Alexandra Hoffmann ◽  
István Zupkó ◽  
...  
Keyword(s):  
Therapeutic Strategy ◽  
Cardiac Activity ◽  
Pathological Conditions ◽  
Ovx Rats ◽  
Calcitonin Gene ◽  
Combined Administration ◽  
Estrogen Withdrawal ◽  
Female Wistar Rats ◽  
Oxide Synthase ◽  
Surgically Induced

Endocannabinoids and their receptors are present in the cardiovascular system; however, their actions under different pathological conditions remain controversial. The aim of our study was to examine the effects of anandamide (AEA) on heme oxygenase (HO) and nitric oxide synthase (NOS) systems in an estrogen-depleted rat model. Sham-operated (SO) and surgically induced estrogen-deficient (OVX) female Wistar rats were used. During a two-week period, a group of OVX rats received 0.1 mg/kg estrogen (E2) per os, while AEA-induced alterations were analyzed after two weeks of AEA treatment at the dose of 1.0 mg/kg. At the end of the experiment, cardiac activity and expression of HO and NOS enzymes, content of cannabinoid 1 receptor, as well as concentrations of transient potential vanilloid 1 (TRPV1) and calcitonin gene-related peptide (CGRP) were measured. Our results show that estrogen withdrawal caused a significant decrease in both NOS and HO systems, and a similar tendency was observed regarding the TRPV1/CGRP pathway. Two weeks of either AEA or E2 treatment restored the adverse changes; however, the combined administration of these two molecules did not result in a further improvement. In light of the potential relationship between AEA and HO/NOS systems, AEA-induced upregulation of HO/NOS enzymes may be a therapeutic strategy in estrogen-deficient conditions.

scholarly journals Cerebral Endothelial Function Determined by Cerebrovascular Reactivity to L-Arginine

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Janja Pretnar-Oblak
Keyword(s):  
Endothelial Function ◽  
Morphological Changes ◽  
Transcranial Doppler Sonography ◽  
Intima Media Thickness ◽  
Cerebrovascular Reactivity ◽  
Cerebral Endothelium ◽  
Enhanced Production ◽  
Pathological Conditions ◽  
Flow Mediated Dilatation ◽  
Potential Improvement

Endothelium forms the inner cellular lining of blood vessels and plays an important role in many physiological functions including the control of vasomotor tone. Cerebral endothelium is probably one of the most specific types but until recently it was impossible to determine its function. In this review, the role of cerebrovascular reactivity to L-arginine (CVR-L-Arg) for assessment of cerebral endothelial function is discussed. L-Arginine induces vasodilatation through enhanced production of nitric oxide (NO) in the cerebral endothelium. Transcranial Doppler sonography is used for evaluation of cerebral blood flow changes. The method is noninvasive, inexpensive, and enables reproducible measurements. CVR-L-Arg has been compared to flow-mediated dilatation as a gold standard for systemic endothelial function and intima-media thickness as a marker for morphological changes. However, it seems to show specific cerebral endothelial function. So far CVR-L-Arg has been used to study cerebral endothelial function in many pathological conditions such as stroke, migraine, etc. In addition CVR-L-Arg has also proven its usefulness in order to show potential improvement after pharmacological interventions. In conclusion CVR-L-Arg is a promising noninvasive research method that could provide means for evaluation of cerebral endothelial function in physiological and pathological conditions.

scholarly journals Participation of WNT andβ-Catenin in Physiological and Pathological Endometrial Changes: Association with Angiogenesis

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Jolanta Kiewisz ◽  
Tomasz Wasniewski ◽  
Zbigniew Kmiec
Keyword(s):  
Current Knowledge ◽  
Morphological Changes ◽  
Female Reproductive System ◽  
Therapeutic Approaches ◽  
Cell Recruitment ◽  
Wnt Proteins ◽  
Pathological Conditions ◽  
Proliferation And Differentiation ◽  
Endometrial Proliferation

WNT proteins are involved in embryonic development, sex determination, stem cell recruitment, angiogenesis, and cancer. They take part in morphological changes in the endometrium during development, regulate processes of endometrial proliferation and differentiation. This review presents current knowledge about implication of WNT proteins andβ-catenin in physiological endometrial functions as well as their involvement in uterine carcinogenesis. Influence of WNT proteins on the formation of blood vessel, taking place both under healthy and pathological conditions, is also considered. Participation of WNT proteins,β-catenin, and inhibitors and inducers of WNT signaling in the process of endometrial angiogenesis is largely unknown. Thus, confirmation of their local and systemic participation in the process of endometrial angiogenesis may in the long term help to establish new diagnostic and therapeutic approaches in conditions associated with the pathology of the female reproductive system.

On the clinical significance of the study of the morphological composition of the cantharidin bladder in allergic conditions

1937 ◽  
Vol 33 (5) ◽  
pp. 554-561
Author(s):  
K. E. Myasnikov
Keyword(s):  
Clinical Significance ◽  
Experimental Work ◽  
Morphological Changes ◽  
Important Conclusion ◽  
Morphological Composition ◽  
Inflammatory Processes ◽  
Morphological Processes ◽  
To Come

Ressle's experimental work on the study of inflammatory processes in allergies and the connection of morphological changes with the phenomena of immunity gave him the opportunity to come to an important conclusion that "morphological processes in the foci of inflammation are one of the most subtle indicators of the onset of allergies, even the mildest degrees of it."

Trophoblast development of normal primate placenta: A morphometric study

1987 ◽  
Vol 45 ◽  
pp. 822-823
Author(s):  
A. Weberg ◽  
R. C. Kaufmann ◽  
S. Verhulst ◽  
K. S. Amankwah
Keyword(s):  
Gestational Age ◽  
Morphological Changes ◽  
Quantitative Measure ◽  
Developmental Changes ◽  
Ultrastructural Changes ◽  
Morphometric Study ◽  
Morphological Development ◽  
Early Gestation ◽  
Pathological Conditions ◽  
Fetal Vessels

Histological and ultrastructural changes in the morphological development of placentae at various gestational ages have been descriptive and qualitative. A few studies have applied morphometric techniques to quantify the developmental changes in the trophoblast layer and stromal constituents, including fetal vessels. The data from these studies are primarily based on light microscopic observations and were derived from midterm to older placentae. However, no distinction was made between vasculosyncytial membrane and other syncytial areas. The vasculosyncytial region of the developing placenta serves as a valuable indicator of some pathological conditions; therefore, a quantitative measure of the changes in these regions during development would be beneficial. Using placentae from early gestation to term and distinguishing between vasculosyncytial areas, the trophoblast layer was measured with morphometric techniques, and observed morphological changes were correlated with gestational age.

Morphological Changes in the Rat Granulosa Cell Surface During Differentiation Induced by Estradiol and Gonadotropins

1977 ◽  
Vol 35 ◽  
pp. 484-485
Author(s):  
P. Bagavandoss ◽  
JoAnne S. Richards ◽  
A. Rees Midgley
Keyword(s):  
Cell Surface ◽  
Granulosa Cell ◽  
Morphological Changes ◽  
Follicular Development ◽  
Female Rats ◽  
Functional Changes ◽  
Group 4 ◽  
Group 3 ◽  
Group 5 ◽  
Group 2

During follicular development in the mammalian ovary, several functional changes occur in the granulosa cells in response to steroid hormones and gonadotropins (1,2). In particular, marked changes in the content of membrane-associated receptors for the gonadotropins have been observed (1).We report here scanning electron microscope observations of morphological changes that occur on the granulosa cell surface in response to the administration of estradiol, human follicle stimulating hormone (hFSH), and human chorionic gonadotropin (hCG).Immature female rats that were hypophysectcmized on day 24 of age were treated in the following manner. Group 1: control groups were injected once a day with 0.1 ml phosphate buffered saline (PBS) for 3 days; group 2: estradiol (1.5 mg/0.2 ml propylene glycol) once a day for 3 days; group 3: estradiol for 3 days followed by 2 days of hFSH (1 μg/0.1 ml) twice daily, group 4: same as in group 3; group 5: same as in group 3 with a final injection of hCG (5 IU/0.1 ml) on the fifth day.

Morphological and elemental analysis of isolated incubated frog retina-choroid

1984 ◽  
Vol 42 ◽  
pp. 298-299
Author(s):  
B. J. Panessa-Warren ◽  
J. B. Warren ◽  
H. W. Kraner
Keyword(s):  
Elemental Analysis ◽  
Pigment Epithelium ◽  
Human Retina ◽  
Healthy Individuals ◽  
Anterior Portion ◽  
Pathological Conditions ◽  
Frog Retina ◽  
Isolated Retina ◽  
Vertebrate Eye ◽  
Retina Pigment Epithelium

Our previous studies have demonstrated that abnormally high amounts of calcium (Ca) and zinc (Zn) can be accumulated in human retina-choroid under pathological conditions and that barium (Ba), which was not detected in the eyes of healthy individuals, is deposited in the retina pigment epithelium (RPE), and to a lesser extent in the sensory retina and iris. In an attempt to understand how these cations can be accumulated in the vertebrate eye, a morphological and microanalytical study of the uptake and loss of specific cations (K, Ca,Ba,Zn) was undertaken with incubated Rana catesbiana isolated retina and RPE preparations. Large frogs (650-800 gms) were dark adapted, guillotined and their eyes enucleated in deep ruby light. The eyes were hemisected behind the ora serrata and the anterior portion of the eye removed. The eyecup was bisected along the plane of the optic disc and the two segments of retina peeled away from the RPE and incubated.

Effect of verapamil on cytoplasmic distribution of granules and microfilaments in amphibian urinary bladder

1988 ◽  
Vol 46 ◽  
pp. 324-325
Author(s):  
A.J. Mia ◽  
L.X. Oakford ◽  
T. Yorio
Keyword(s):  
Urinary Bladder ◽  
Water Flow ◽  
Morphological Changes ◽  
Granular Cell ◽  
Cytosolic Calcium ◽  
Calcium Storage ◽  
Amphibian Urinary Bladder ◽  
Vesicular Membrane ◽  
High Concentrations ◽  
Cytoskeletal System

The amphibian urinary bladder has been used as a ‘model’ system for studies of the mechanism of action of antidiuretic hormone (ADH) in stimulating transepithelial water flow. The increase in water permeability is accompanied by morphological changes that include the stimulation of apical microvilli, mobilization of microtubules and microfilaments and vesicular membrane fusion events . It has been shown that alterations in the cytosolic calcium concentrations can inhibit ADH transmembrane water flow and induce alterations in the epithelial cell cytomorphology, including the cytoskeletal system . Recently, the subapical granules of the granular cell in the amphibian urinary bladder have been shown to contain high concentrations of calcium, and it was suggested that these cytoplasmic constituents may act as calcium storage sites for intracellular calcium homeostasis. The present study utilizes the calcium antagonist, verapamil, to examine the effect of calcium deprivation on the cytomorphological features of epithelial cells from amphibian urinary bladder, with particular emphasis on subapical granule and microfilament distribution.

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