scholarly journals Medico-social aspects of invalidity and morbidity in children population with endocrine system diseases

2020 ◽  
Vol 23 (2) ◽  
pp. 8-11
Author(s):  
Olga V. Miachina ◽  
Sergei N. Puzin ◽  
Alexander N. Pashkov ◽  
Dmitry I. Esaulenko
Keyword(s):  
Children And Adolescents ◽  
Endocrine System ◽  
Social Aspects ◽  
Control Group ◽  
Disabled Children ◽  
Endocrine System Diseases ◽  
Exhaled Air ◽  
Adaptation Processes ◽  
First Time

Investigation realized in Voronezh found that the level of general disability was 11.09 0.56 per 1000 children, and the level of first-time disability was 1.38 0.18 per 1000 children, which is lower than in Russia as a whole. In the age structure of disability persons from 5 to 9 years old are dominated, and by gender trait boys. Primary morbidity level in children is higher than in adolescents: 1407.68 86.60 and 1281.33 162.25 per 1000 children, respectively. According to the primary morbidity level, 15 ranking places were allocated. Endocrine system diseases occupy 12 and 9 rank places in children and adolescents, respectively. Prevalence of endocrine system diseases was 4.32 0.78 and 14.94 2.71 per 1000 children in this age group. There is an increase in endocrine pathology by 3.5 times with age. It was investigated that children and adolescents suffering from endocrine system diseases (type 1 diabetes, AIT, obesity) are characterized by adaptation processes decrease, regulatory mechanisms imbalance and energy disorders (p 0.05 compared to the control group of healthy individuals), which is detected by bioelectrography of exhaled air condensate. The obtained data can be used in preparation of complex programs for prevention of morbidity and disability of children and medical and social rehabilitation of disabled children in Voronezh and in other territories.

Analysis of diabetes-associated autoantibodies in children and adolescents with autoimmune thyroid diseases

2019 ◽  
Vol 32 (4) ◽  
pp. 355-361 ◽  
Author(s):  
Marta Rydzewska ◽  
Justyna Michalak ◽  
Anna Bossowska ◽  
Shu Chen ◽  
Sarah Black ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Study Groups ◽  
Thyroid Diseases ◽  
Control Group ◽  
Acid Decarboxylase ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Glutamic Acid Decarboxylase Autoantibodies ◽  
Group 2

Abstract Background Zinc transporter 8 autoantibodies (ZnT8Abs) together with glutamic acid decarboxylase autoantibodies (GADAbs), insulinoma antigen 2 autoantibodies (IA-2Abs) and insulin autoantibodies (IAbs) are markers of type 1 diabetes mellitus (T1DM). We studied the prevalence of ZnT8Ab in children with autoimmune thyroid diseases (AITDs) to assess the association of AITDs and T1DM at the serological level. Methods The study groups consisted of 44 children with Graves’ disease (GD), 65 children with Hashimoto’s thyroiditis (HT), 199 children with T1DM with or without AITDs and 58 control children. ZnT8Ab, GADAb, IA-2Ab, IAb, 21-hydroxylase autoantibodies (21-OHAbs) and acetylcholine receptor autoantibodies (AChRAbs) were measured. Results ZnT8Abs were found in 4/44 (9.1%) patients with GD, and 4/44 (9.1%) patients with GD were positive for GADAb. Of the 65 HT patients, six (9.2%) were positive for ZnT8Ab, while four (6.2%) were positive for GADAb. In the T1DM group, 128/199 (64%) of the patients were positive for ZnT8Ab, 133/199 (67%) for GADAb and 109/199 (55%) for IA-2Ab. One GD patient and one HT patient were positive for all the four diabetes-associated autoantibodies. Two HT patients were positive for three diabetes autoantibodies. Two GD (4.5%) and five HT (7.7%) patients were positive for 21-OHAb only. None of the patients had AChRAb. In the control group, 2/58 (3.4%) were positive for GADAb and 2/58 (3.4%) were positive for ZnT8Ab. Conclusions Diabetes-associated autoantibodies including ZnT8Ab were found in children and adolescents with GD and HT.

scholarly journals Evaluation of Corneal Endothelium in Children and Adolescents with Type 1 Diabetes Mellitus

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Beata Urban ◽  
Dorota Raczyńska ◽  
Alina Bakunowicz-Łazarczyk ◽  
Krystyna Raczyńska ◽  
Małgorzata Krętowska
Keyword(s):  
Diabetes Mellitus ◽  
Children And Adolescents ◽  
Corneal Endothelium ◽  
Corneal Thickness ◽  
Group Versus ◽  
Control Group ◽  
Diabetic Patients ◽  
Duration Of Diabetes ◽  
The Mean

Purpose. To evaluate the systemic and local factors that contribute to the damage of endothelial cells in diabetic patients and to compare the endothelial structure of the cornea in diabetic and nondiabetic patients.Materials and Methods. The endothelial cell density (ECD) and central corneal thickness (CCT) were investigated in 123 eyes of type 1 diabetic patients and in 124 eyes of nondiabetic patients. The mean diabetic patients age was 15.34 ± 3.06 years versus 14.58 ± 2.01 years in the control group. The mean duration of diabetes was 8.02 ± 3.9 years. The corneal endothelium was imaged by the Topcon SP-2000P.Results. The mean ECD in diabetic eyes was 2435.55 ± 443.43 cells/mm2and was significantly lower than in control group (2970.75 ± 270.1 cells/mm2). The mean CCT was 0.55 ± 0.03 mm in diabetic group versus 0.53 ± 0.033 mm in control group. ECD and CCT significantly correlated only with duration of diabetes. There was no correlation between ECD and CCT and patient age, sex, HbA1C level, and plasma creatinine level.Conclusions. ECD is decreased and CCT is increased in children and adolescents with diabetes mellitus. Duration of diabetes is the factor that affects ECD and CCT.

The associations between mental health, health-related quality of life and insulin pump therapy among children and adolescents with type 1 diabetes

2018 ◽  
Vol 31 (10) ◽  
pp. 1065-1072 ◽  
Author(s):  
Brigitta Munkácsi ◽  
Gábor Papp ◽  
Enikő Felszeghy ◽  
Karolina Eszter Kovács ◽  
Beáta Erika Nagy
Keyword(s):  
Mental Health ◽  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Mental Health Problems ◽  
Well Being ◽  
Health Problems ◽  
Insulin Pump Therapy ◽  
Control Group ◽  
Subjective Well Being

Abstract Background Diabetes has previously been linked to mental health problems in children and adolescents, but more recent studies have yielded mixed findings. The aim of the current study was to compare symptoms of mental health problems in children and adolescents with and without type 1 diabetes (T1DM). Methods Life quality, subjective well-being, self-rated health, depression and somatic symptoms in children and adolescents with diabetes (n=130) were measured and compared to the results of a socio-demographically joined control group (n=177) which consists of healthy children and adolescents. Results A significant difference could be observed between the groups in well-being and depressive symptoms as according to the results, the research sample namely the children with T1DM could be described with significantly higher subjective well-being and mood, but with less physical symptoms and lower level of depression as those in the control group. Conclusions These findings suggest that T1DM is not associated with an increased risk of psychosocial problems, and confirm that even a severe disease of a child can lead to personal growth.

Salivary interleukin-8 levels in children suffering from Type 1 diabetes mellitus

2013 ◽  
Vol 37 (4) ◽  
pp. 377-380 ◽  
Author(s):  
D Dakovic ◽  
M Colic ◽  
S Cakic ◽  
I Mileusnic ◽  
Z Hajdukovic ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Statistical Significance ◽  
Control Group ◽  
Healthy Children ◽  
Study Results ◽  
Type 1 Dm

Objective: The aim of this study was to investigate the differences between the salivary levels of IL-8 in patients with Type 1 diabetes mellitus (DM) with (DM+P) or without (DM-P) concomitant periodontitis and healthy subjects. The correlations between the levels of these cytokines and clinical periodontal parameters were also established. Methods: Twenty children and adolescents with Type 1 DM (10 diagnosed with periodontitis, 10 presenting no signs of periodontitis) and a control group consisting of 20 healthy children and adolescents aged 7-18 years were recruited for this study. Results: The Salivary IL-8 level was statistically significantly (p<0.005) elevated in subjects with Type 1 DM (474.47 ± 716.76) compared to non-diabetic control group (101.99 ± 68.32). There was no difference (p≯0.05) in the salivary IL-8 level when subjects with Type 1 DM with concomitant periodontitis were compared to diabetics without periodontitis. When the salivary IL-8 level in subjects with Type 1 DM was correlated with the clinical parameters, no statistical significance was found. Conclusion: An elevated salivary IL-8 level in subjects with Type 1 DM without concomitant periodontitis plays a major role in the development of diabetic micro and macroangiopathy and pathogenesis of atherosclerosis. Consequently, this may offer a basis for the assessment of risk, prophylaxis and treatment of diabetic complications.

scholarly journals Remote monitoring and treatment of children and adolescents with type 1 diabetes

2020 ◽  
Vol 66 (4) ◽  
pp. 50-60
Author(s):  
Dmitry N. Laptev ◽  
Andrey O. Emelyanov ◽  
Yulia G. Samoilova ◽  
Elena B. Khramova ◽  
Elena E. Petriaikina ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Insulin Therapy ◽  
Children And Adolescents ◽  
Remote Monitoring ◽  
Insulin Pump ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Number Of Patients

RATIONALE: Continuous subcutaneous insulin infusion (CSII) is an effective method for optimizing glycemic control in children with type 1 diabetes mellitus (DM1). However, the use of CSII does not always result in adequate glycemic control. Telehealth can be applied as one of the methods to improve the effectiveness of treatment.AIMS: To evaluate the use of remote medical support of children and adolescents with DM1 and its influence on glycemic control, quality of life, and incidence of acute complications of DM1.MATERIALS AND METHODS: We conducted a 24-week multi-institutional prospective open-label controlled clinical trial. 180 children and adolescents were included in this study and divided into the following categories: 1) age 8–18 years; 2) DM1 at least 1 year; 3) pump insulin therapy Medtronic Paradigm (Medtronic MiniMed, USA) at least 6 months; 4) self-monitoring of glycemia at least 4 times a day and replacement of the insulin pump infusion system at least once every 3 days; 5) inadequate glycemic control of DM1: the level of glycated hemoglobin (HbA1c) 7.5% or higher. Patients were assigned to a remote consultation group (RC; n=100) or a traditional control group (TC; n=80). All patients were trained on the basic principles of DM1 and CSII, and we measured initial HbA1c, then after 12 and 24 weeks, also registered and analyzed glycemic indicators and daily doses of insulin, evaluated and corrected the treatment. Patients or their parents in the RC group sent pump data via the Internet to the pump insulin therapy center at least once every 2 weeks at home and received treatment recommendations in response.RESULTS: The total number of patients included in the study in all institutions was 180 children at 8–18 years. Patients in both groups did not differ in age, gender, duration of DM1 and CSII, and HbA1c level. The total amount of remote consultations for all institutions was 949. The decrease in the level of HbA1c by the end of the study against the initial one was statistically significantly greater in the RC group: 1.17% compared to 0.59% in the TC group (p<0.05). The proportion of patients who reached the target level of HbA1c (<7.5%) was significantly higher in the RC group (32%) compared to the TC group (12.5%, p<0.05). During the study, the incidence of DKA and severe hypoglycemia in the RC group was statistically significantly lower.CONCLUSIONS: Remote monitoring in children with DM1 resulted in significant improvements in glycemic control (HbA1c, glycemic variability, and hypoglycemic frequency). The accumulation of evidence on the effectiveness and safety of telehealth in DM should contribute to implementing this approach in practical health care.

scholarly journals High Levels of Perfluorooctane Sulfonate in Children at the Onset of Diabetes

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Barbara Predieri ◽  
Lorenzo Iughetti ◽  
Cristiana Guerranti ◽  
Patrizia Bruzzi ◽  
Guido Perra ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Linear Regression Analysis ◽  
Endocrine System ◽  
Perfluorooctane Sulfonate ◽  
Perfluorinated Compounds ◽  
Peroxisome Proliferator ◽  
Multivariate Linear Regression Analysis ◽  
Healthy Controls

Background. Impairments of endocrine system may be associated with exposure to perfluorinated compounds that are able to bind nuclear receptors, including the peroxisome proliferator-activating receptors. Aim of this study was to assess perfluorooctane sulfonate and perfluorooctanoic acid concentrations in children and adolescents at the onset of type 1 diabetes compared to healthy controls.Methods. Forty-four children and adolescents were recruited and subdivided into two groups: (A) 25 subjects with type 1 diabetes and (B) 19 healthy controls. Perfluorinated compounds were measured using high performance liquid chromatography with electrospray ionization tandem mass spectrometry. Nonparametric statistical analysis was performed.Results. Perfluorooctane sulfonate concentrations were significantly higher in patients with type 1 diabetes compared to controls (1.53 ± 1.50 versus 0.55 ± 0.15 ng/mL, resp.;p<0.001). Multivariate linear regression analysis identified lipid levels as significant predictive factors for perfluorooctane sulfonate levels.Conclusions. Our data suggests that higher serum levels of perfluorooctane sulfonate may be considered a biomarker of exposure and susceptibility to develop type 1 diabetes.

scholarly journals Prevalence of Type1 Diabetes among School Children andAdolescents in Sana’a City, Yemen

2020 ◽  
Keyword(s):  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
School Children ◽  
Plasma Glucose ◽  
Control Group ◽  
Glucose Levels ◽  
Glucose Testing ◽  
Age Range ◽  
Urine Testing

Background: Childhood diabetes was rare and rapidly fatal at the start of the 20th century but the incidence began to increase steadily by the end of the century. This study aimed at screening for diabetes among school children and adolescents in Sana’a city, Yemen. Methods: Of a total student population of 26410 from four educational district registers in Sana’a city, 2870 students were screened for diabetes by urine glucose testing. Diagnosis of diabetes was first suspected from urine testing, then confirmed by blood glucose testing.Results: Glucosuria was detected in the urine samples of 10 out of 2870 students, giving an overall crude prevalence of 0.35% among school children and adolescents investigated. Diagnosis of type 1 diabetes was confirmed for all students with glucosuria by testing plasma glucose and Cpeptide levels of the index patients and a control group. As compared to control group, students with diabetes had significantly higher mean fasting and 2hpostprandial plasma glucose levels (P< 0.0001) but significantly lower mean fasting serum Cpeptide value (P< 0.0001). The agestandardized prevalence rate for age range 519 years (Census 1994 populationadjusted rate) is 0.36% (95% CI: 0.20.5%).Conclusion: : Pediatric-onset Type 1 diabetes is relatively prevalent among school children and adolescents in Yemen, with a slightly higher frequency in those aged ≥ 15 years, but no significant sexdifference.

scholarly journals Study of Visfatin Level in Type 1 Diabetic Children and Adolescents

2017 ◽  
Vol 5 (3) ◽  
pp. 299-304 ◽  
Author(s):  
Mona H. El Samahi ◽  
Nagwa Abdallah Ismail ◽  
Randa M. Matter ◽  
Abeer Selim ◽  
Alshaymaa Ahmed Ibrahim ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Inverse Correlation ◽  
Insulin Dosage ◽  
Control Group ◽  
Diabetic Patients ◽  
Intracellular Enzyme ◽  
Nicotinamide Phosphoribosyltransferase ◽  
Diabetic Children ◽  
Visfatin Level

BACKGROUND: Visfatin is an intracellular enzyme, known as nicotinamide phosphoribosyltransferase (Nampt) and pre-B-cell colony-enhancing factor (PBEF-1). It has insulin-mimetic effects and lowers plasma glucose levels.AIM: The aim of the work was to assess serum concentration of Visfatin in type 1 diabetic children and adolescents and study its relationships with duration of diabetes, body mass index (BMI), glycemic control, insulin dosage, lipid profile and microvascular complications.MATERIAL AND METHODS: Fifty children and adolescents with type 1 diabetes mellitus were recruited with 30 ages and gender-matched healthy subjects. They were subjected to history taking; anthropometric measurements and chronic diabetic complications were recorded if present. Laboratory analysis included urinary microalbumin, serum triglycerides, HDL, LDL, cholesterol, fasting blood glucose, glycosylated Hb (HbA1c) and serum visfatin which was measured with enzyme-linked immunosorbent assay.RESULTS: Diabetic patients showed highly significant decrease in the level of visfatin compared to the control group (P = 0.0001).There was significant further decrease in visfatin level in diabetics with microalbuminuria (n = 13) compared to normoalbuminuric patients (n = 37) (P = 0.015). There was highly significant inverse correlation between visfatin level with age (r = -0.379, p = 0.007), BMI (r = -0.418, p = 0.003), waist circumference (r = -0.430, p = 0.002), hip circumference (r = -0.389, p = 0.005) and microalbuminuria (r = -0.323, p = 0.022).CONCLUSIONS: Type 1 diabetic children and adolescents had a significantly lower visfatin level compared to controls. A marked decrease in the level of visfatin was shown in patients with microalbuminuria with an inverse correlation with BMI suggesting an important role of visfatin in the pathogenesis of type 1 diabetics and type 1 diabetic nephropathy.

scholarly journals Influence of two different methods of nutrition education on the quality of life in children and adolescents with type 1 diabetes mellitus – a randomized study

2020 ◽  
pp. 197-206
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Nutrition Education ◽  
Tertiary Education ◽  
Interactive Methods ◽  
Control Group

Background. Nutrition education is one of the most important factors determining the effectiveness of treatment and maintaining an adequate quality of life (QoL) in children and adolescents with type 1 diabetes. Objective. The primary objective was to compare the influence of two methods of nutrition education on the QoL. The secondary objective was to identify other determinants of the QoL. Material and Methods. A randomized single-blind study was conducted between October 2017 and April 2019 at the Children’s Clinical Hospital in Warsaw. The study included 170 patients (aged 8-17) with at least 1-year history of type 1 diabetes, treated with insulin pumps. The participants were randomly divided into two groups: a control group (C) – traditional/ informative education methods, and an experimental group (E) – modern/interactive methods. PedsQL Diabetes Module 3.0 questionnaire was used in the assessment of the QoL. Total PedsQL score was the primary outcome. The secondary outcomes included the results obtained in five subscales of the questionnaire. The relationships between selected variables and changes in scores were also verified. Results. Data obtained from 136 patients were analyzed. In both groups no significant changes regarding total PedsQL were noted 6 months after the intervention. However, a significant reduction occurred as regards the scores of ‘Communication’ subscale in group C. Analyzing other determinants of the QoL, significant dependencies were observed between: the level of physical activity and a change in ‘Diabetes symptoms’ subscale, and the level of parents’ education and a change in ‘Treatment barriers’ subscale. Conclusions. Both methods of nutrition education exerted a comparable influence on the total QoL. However, modern methods were more effective in terms of the improvement in the aspect of communication. Additionally, moderate physical activity and parents’ tertiary education constituted valid determinants of various aspects of the QoL in children and adolescents with type 1 diabetes.

scholarly journals Vaccination against pneumococcal and influenza infections in children and adolescents with type 1 diabetes

2009 ◽  
Vol 55 (4) ◽  
pp. 6-11 ◽  
Author(s):  
T V Skochilova ◽  
V. A. Vorob'eva ◽  
M. P. Kostinov ◽  
A. A. Tarasova ◽  
T. I. Korovkina ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Clinical Laboratory ◽  
Respiratory Infections ◽  
Influenza Infection ◽  
Pneumococcal Infection ◽  
Density Lipoprotein ◽  
Control Group ◽  
The Stability

The effect of a Pneumo 23 vaccine against pneumococcal infection (n = 72; Subgroup 1) in combination with a Grippol vaccine against influenza infection (n = 28; Subgroup 2) was studied in children and adolescents with type 1 diabetes on insulin therapy. A control group consisted of 30 unvaccinated children. Unlike monovaccination, combined vaccination was ascertained to cause a significant reduction in the glycated hemoglobin following a year. The daily dose of insulin and the levels of high-density lipoprotein cholesterol, triglycerides, and b-lipoproteins were unchanged in all the groups. The level of albumins increased, by approximating to the normal values. The blood content of urea and creatinine remained to be in the normal range at all stages of the study. In Subgroup 2 children microalbuminuria was significantly decreased. Within a year after vaccination, all the children and adolescents with T1D also showed a reduction in the number of disease decompensation episodes, which being significant in Subgroup 2, resulting from the reductions in the incidence and severity of acute respiratory infections. In the vaccinated children, the number of late vascular diabetic complications remained unchanged. Vaccination against pneumococcal infection in 13 children before hospital discharge in the subcompensation phase was followed by the same changes in the biochemical parameters and the clinical course of T1D parameters as in the patients vaccinated in the phase of compensation of the disease. The dynamic abdominal ultrasonographic pattern was found to become worse in the unvaccinated patients than that in Subgroup 1 patients. Analysis of clinical, laboratory, and instrumental results indicated the stability of the course of T1D in the children and adolescents vaccinated against pneumococcal and influenza infections.

Sign in / Sign up

Export Citation Format

Share Document