Evaluation strength of the supporting apparatus of the lens at combination of age-related cataract with involutional changes in connective tissue

AIM: The clinical evaluation of zonules condition in patients with age-related cataracts without weak zonular support signs against the background of connective tissue somatic involutional changes. MATERIALS AND METHODS: The main group consisted of 70 patients (70 eyes) with connective tissue involutional somatic pathology without concomitant eye pathology, eye injuries, and decompensated systemic diseases; the control group included 60 people (60 eyes) with age-related cataracts without connective tissue involutional pathology. Using ocular echography (Aviso S, Quantel Medical, France) with high resolution (50 MHz) sensor, we estimated the ciliary processes to lens equator distance symmetry in 2 main meridians (of 6 and 12 hours). Its equal value in 2 opposite meridians or difference less than 0.3 mm between them was considered as the sign of symmetry; the difference of 0.3 mm and more was a sign of asymmetry. RESULTS: The presence of ciliary processes to lens equator distance asymmetry between the meridians was revealed in 28 eyes in the main group (40%); in 14 of the eyes with asymmetry ranging from 0.4 and more, a 1st degree lens subluxation was revealed intraoperatively. CONCLUSIONS: The presence of ciliary processes to lens equator distance asymmetry indicates subclinical involutional changes in the lens ligament apparatus, which has a prognostic value for choosing a model of an intraocular lens to be implanted.

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Ultrastructure changes and expression of NLRP3 inflammasome in lens anterior capsule of patient with cataracts associated with uveitis

10.21203/rs.2.16181/v1 ◽

2019 ◽

Author(s):

Chu Zhang ◽

Chong-Hui Ying ◽

siqin Sun ◽

yuechun Wen ◽

Zicheng Zhu

Keyword(s):

Epithelial Cells ◽

Ultrastructural Changes ◽

Lens Epithelial Cells ◽

Control Group ◽

Anterior Capsule ◽

Caspase 1 ◽

Pyrin Domain ◽

Age Related ◽

The Difference ◽

Domain 3

Abstract ● AIM : T o investigate the expression of nod-like receptor pyrin domain 3 (NLRP3) in lens anterior capsule of Uveitis associated with cataract and observe the ultrastructural changes of them . ● Methods: 17(22 eyes) cases of uveitis associated with cataract were selected a s experimental group and 1 0 (18 eyes) cases of age-related cataract were selected a s contro l group. The expressions of NLRP3, apoptosis-related speckle protein （ASC） and caspase-1 protein were tested by immunohistochemical and the ultrastructural changes of anterior capsul e was observed under electron microscope. ● Results: The expression of NLRP3 、 caspase-1 and ASC in the anterior capsu le of cataracts associated with uveitis was significantly higher than that of the control group, the difference was statistically significant (p ＜ 0.05). The apoptotic changes of lens epithelial cells in uveitis associated with cataract were obvious, and the apoptotic changes of lens epithelial cells were mild in age-related cataract patients. ● Conclusion: Strongly postive expressed NLRP3 inflamma some and obvious apoptotic changes are founded in the lens epithelial cells of patients with uveitis associat ed with cataract, suggesting that NLRP3 inflamma some and the apoptosis of lens epithelial cells may play a role in the progress of uveitis associat ed with cataract.

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Вплив поліморфізму генів PTHR1 та COL1A1 на розвиток захворювань тканин пародонта у людей молодого віку

CLINICAL DENTISTRY ◽

10.11603/2311-9624.2017.2.7936 ◽

2017 ◽

Author(s):

M. A. Luchynskyi ◽

Y. V. Boliuk ◽

V. M. Luchynskyi

Keyword(s):

Young People ◽

Periodontal Diseases ◽

Main Group ◽

Control Group ◽

Type I ◽

Periodontal Tissue ◽

Endogenous Factors ◽

Stage Of Development ◽

The Difference ◽

Collagen Chain

At the present stage of development of dentistry, the leading Ukrainian and foreign scientists devote a considerable part of the research to a deeper study of the etiology and pathogenetic mechanisms of periodontal tissue diseases and the influence of various exogenous and endogenous factors on their course.The aim of the study – to learn the ability and methods of forecasting and early diagnosis of the periodontal tissue lesions in young people. Materials and Methods. During our research we examined 24 young people with periodontal tissue diseases, who were included to the main group, and 15 healthy people, who formed the control group. The complex clinical examination was performed in each research group. It was studied the distribution of polymorphous variants of the type I parathormone receptor and the α1-chain of collagen gene with a help of polymerase chain reaction by restrictase cleavage of DNA fragments and electrophoresis in polyacrylamide gel (AA/BA 29:1). Results and Discussion. The distribution of genotypes by PTHR1 gene in control group was similar to those in main group (p>0.05). Also we didn’t find the difference between frequencies of the separate alleles in people with periodontal tissue pathology and without it (p>0.05). Yes, the repetitions of the allele 5 encoding normal type I parathormone receptor were found more often, comparing with the allele 6 that is responsible for the formation of unfunctional PTHR1 (р<0.001) in both main and control groups. The dominance of the genotype TT, which corresponds to the pathology, was found in young people with the periodontal tissue lesions – (38.46 ± 4.79) %, while among the control group the genotype of norm GG was met the most often – (68.24±5.08) %. Also, the frequency of repetitions of the allele T encoding the imperfect collagen chain was (57.60±3.79) % in young people with periodontal diseases, and in the control group this figure was (13.27±2.81) %, p<0.001. Conclusions. According to our results the presence of allele T and genotype TT that correspond the imperfect collagen chain may be one of the causes of periodontal tissue pathology.

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Psychodiagnostics of suicide

Likarska sprava ◽

10.31640/jvd.1-2.2019(1) ◽

2019 ◽

pp. 3-9

Author(s):

G. K. Dzub ◽

V. A. Protzyc ◽

V. A. Protzyc

Keyword(s):

Depressive Disorders ◽

Self Esteem ◽

Psychological Research ◽

Main Group ◽

Control Group ◽

Self Assessment ◽

Suicidal Attempts ◽

The Difference ◽

High Level ◽

And Control

An original hypothesis for the detection of suicidal readiness has been proposed: the dissociation between low self-esteem of personal qualitiesand high level of claims in behavior exists in all types of suicides. The main point is that suicide occurs in a situation where environmental conditions are appear to be completely incompatible with a person’s self-esteem; preserving the personality then the protective adaptive response of the personality is accomplished in the most radical way – self-destruction. Therefore, to detect readiness for suicide, you can use the methods of experimental psychological (psychodiagnostic) research. These are methods of self-assessment of a situation, that is, a tests assessing one's own merits and determining the level of claims in behavior. Discrepancies in the performance of these tests will reflect the degree of readiness for suicide. Confirmation has been obtained through clinical and experimental psychological research. On the material of 240 subjects, the modified methods of Dembo – Rubinstein and Hoppe were used. The main group consisted of 160 persons who committed suicidal attempts, of which 98 women and 62 men, average age (41.0 ± 9.7) years, including 86 with depressive disorders, 46 with neurotic disorders and 28 mentally healthy. In the control group there were 80 healthy individuals who did not commit suicidal attempts, with identical gender balance, average age and social status. The modification of the methods was that the results were presented in quantitative terms in points. In the main group, the dissociation indicators between the high level of claims and low self-esteem according to the methods of Dembo – Rubinstein and F. Hoppe were 46.8 ± 4.6, and in the control group – 27.00 ± 5.24 (P < 0,001). The difference between dissociation in the main and control groups is very significant (P < 0,0005), a score of 40–45 points indicates a suicidal risk, and 50–55 and more confidently point to the upcoming suicide attempt. As a result, the hypothesis is confirmed and a valid method of predicting suicide or assessing the degree of its risk arises; the method is suitable for practical use.

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STUDY OF THE MESOTHERAPY EFFECT WITH EPIPHYSIS PEPTIDES ON THE MOISTURE AND ELASTICITY OF THE SKIN

Russian Journal of Skin and Venereal Diseases ◽

10.18821/1560-9588-2017-20-5-305-310 ◽

2017 ◽

Vol 20 (5) ◽

pp. 305-310

Author(s):

Tatiyana N. Korolkova ◽

S. E Goma

Keyword(s):

Moisture Content ◽

Main Group ◽

Control Group ◽

Isotonic Solution ◽

Metabolic Processes ◽

Skin Changes ◽

Age Related ◽

Intradermal Administration ◽

Group 12 ◽

Before And After

Introduction. Mesotherapy is a widely used method of preventing external signs of aging in cosmetology. However, drugs that have proven effectiveness are not enough, therefore epiphyseal peptides are of great interest. Purpose: is to study the effect of intradermal administration of peptide epiphysis on the functional para-meters of the skin. Material and methods. There were 38 women in the research devided into 2 comparable groups. The main group (26 persons) was treated by mesotherapy with epiphyseal peptides. Face, neck and decollete zones were treated by the method of “deep nappage” once a week, 5 procedures per course. Isotonic solution of NaCl was similarly injected into the neck and decollete areas of the control group (12 people). The moisture content (Corneometer CM 825, “Courage & Khazaka”, Germany) and the elasticity (Cutometer MPA 580, “Courage & Khazaka”, Germany) of the skin were determined. Functional skin parameters were evaluated before and after treatment (in both groups) and also on the 1st and 6th months after mesotherapy in the main group. Results. Under the influence of epiphysis peptides the moisture content of the skin increases by 10% after treatment (in the control group without changes) and after 1 month, then decreases by 5% in 6 months below the initial values. In the main group R0 and R8 parameters increase immediately after treatment by 21% and 20% (in the control group R0 and R8 decrease by 4-6%), then decrease by 6-7% and by 28%. The R4 parameter increases immediately after treatment by 20-25% (in the control group it decreases by 13%), then decreases by 12% and 24%; F0 and F1 parameteres increase immediately after treatment by 17% and 22% (in the control group they decrease by 4% and 3%), then decrease by 11% and 9%, by 25% and 28%. Conclusion. The revealed dynamics of skin functional indexes may support the stimulating effect of peptide epiphysis on the cellular elements of the dermis (activation of metabolic processes after treatment and improvement of elasticity parameters by 25-28% after 6 months). Mesotherapy with epiphyseal peptides can be recommended as a method of prevention and correction of age-related skin changes.

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Blood antioxidant capacity change in patients with the «dry» form of age-related macular degeneration treated with polarized polychromatic non-coherent light and dynamic electromyostimulation

Kazan medical journal ◽

10.17816/kmj2129 ◽

2012 ◽

Vol 93 (6) ◽

pp. 994-996

Author(s):

F R Saifullina ◽

R Z Sharafieva ◽

V I Pogorel’tsev ◽

F M Fayzrahmanova ◽

E A Abdulaeva

Keyword(s):

Visual Acuity ◽

Antioxidant Capacity ◽

Macular Degeneration ◽

Combined Treatment ◽

Mean Value ◽

Main Group ◽

Age Related Macular Degeneration ◽

Control Group ◽

Coherent Light ◽

Age Related

Aim. To assess the antioxidant capacity in patients with the «dry» form of age-related macular degeneration before and after combined treatment with polarized polychromatic non-coherent light and dynamic electromyostimulation. Methods. Two groups of patients with the «dry» form of age-related macular degeneration were examined. 40 patients (80 eyes) from the main group were treated using combined treatment and 39 patients (78 eyes) in the group of control who were treated conventionally. The integral blood antioxidant capacity was measured by galvanometry. Results. Blood antioxidant capacity in healthy subjects is 26.0 kC/l. In patients of the main group blood antioxidant capacity before the treatment was equal to 22.81±0.27 kC/l, compared to 22.17±0.20 kC/l in control group (total mean value 22.49±0.27 kC/l). There was a relevant elevation of the blood antioxidant capacity at the late stages after the treatment - up to 12 months, compared to only 2 months in the control group. Visual acuity in patients of the main group before the treatment was 0.87±0.02, after the treatment was finished - 0.96±0,01 (p 0.001), 2 months after the treatment - 0.95±0.01 (p 0.001), 6 months after the treatment - 0.96±0.01 (p 0.001), 12 months after the treatment - 0.95±0.01 (p 0.001). Visual acuity in patients of the control group before the treatment was 0.91±0.02, after the treatment was finished - 0.95±0.02 (p 0.05), 2 months after the treatment - 0.94±0.02 (p 0.05), 6 months after the treatment - 0.92±0.02 (p 0.05). 12 months after the treatment the visual acuity deteriorated compared to the treatment start and was measured as 0.89±0.02. Conclusion. There is a decrease of blood antioxidant capacity (22.49±0.27 kC/l) in patients with the «dry» form of age-related macular degeneration; a relevant increase of blood antioxidant capacity and visual acuity can be observed up to 12 months after the treatment with polarized polychromatic non-coherent light and dynamic electromyostimulation.

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Psychotherapeutic care in the system of comprehensive rehabilitation of persons with limb amputation

Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH) ◽

10.20340/vmi-rvz.2021.3.psy.1 ◽

2021 ◽

Author(s):

L. I. Mostovaya ◽

E. P. Krivoschekov ◽

E. B. Elshin ◽

V. E. Romanov ◽

M. Y. Khoroshilov

Keyword(s):

Depression Scale ◽

Vascular Diseases ◽

Main Group ◽

Psychological Help ◽

Limb Amputation ◽

Control Group ◽

Hamilton Depression Scale ◽

The Difference ◽

To Receive ◽

Psychotherapeutic Care

Purpose. Study of the influence of psychotherapeutic assistance on the rehabilitation of persons who have undergone limb amputation.Materials and methods. A study of the psychological characteristics of 48 patients who underwent amputation of the lower extremity was carried out on the basis of the departments of vascular surgery and traumatology of the Samara Seredavin Regional Clinical Hospital. The control group included 25 people (16 men, 9 women), aged 45 to 70 years. Amputations of the extremities were performed by him in connection with the developed gangrene due to obliterating vascular diseases. The main group consisted of 23 people (14 men, 9 women) aged 35 to 60 years with a stable and prosperous social status, who received an acute sudden injury that ended in amputation of one or both lower extremities. The examination was carried out on the 3-5th day of the postoperative period, depending on the patient's condition. For the study, the following psychodiagnostic methods and techniques were used: 1) clinical conversation; 2) coping test by R. Lazarus, S. Folkman; 3) methodology for diagnosing the type of attitude to the disease; 4) Hamilton Depression Scale; 5) S. Rosenzweig's test of drawing frustration.Results. The difference between the group of patients and the control group was statistically confirmed in terms of “seeking social support” (higher in the control group), “confrontation” and “flight – avoidance” (higher in the group of patients) (p < 0.05). In the control group, depression is absent in 85% of the subjects, in 15% of patients there is a mild depressive state (p < 0.05). According to S. Rosenzweig's method, the predominance of extrapunitive reactions was revealed in both groups (E = 59.6 in the main group of patients and 44.1 in the control group) due to reactions of the ego-protective type (ED = 56.2 in the main group of patients and 46.3 – in the control group).Conclusion. Patients who underwent surgery for limb amputation and who took a conscious and active part in individual and group psychotherapy by the time of discharge from the hospital showed a decrease in anxiety and depressive manifestations, a decrease in the manifestations of outward aggression, the construction of optimistic prospects) than in patients who categorically refuse to receive psychological help and support. The provision of psychotherapeutic assistance to persons after amputation of limbs should begin in the first days after the operation.

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The state of microcirculation and identification of microcirculatory predictors of chronic pain in younger patients with functional disorders of the masticatory system affected by connective tissue dysplasia

Periodontology ◽

10.33925/1683-3759-2020-25-4-308-316 ◽

2020 ◽

Vol 25 (4) ◽

pp. 308-316

Author(s):

E. Е. Statovskaya

Keyword(s):

Chronic Pain ◽

Blood Flow ◽

Connective Tissue ◽

Pain Syndrome ◽

High Amplitude ◽

Masticatory Muscles ◽

Main Group ◽

Control Group ◽

Doppler Flowmetry ◽

Connective Tissue Dysplasia

Relevance. Occlusal splints, made for the patients with temporomandibular disorders (TMD), influence proprioceptive sensitivity, sensory characteristics of pain, parameters of microcirculation of the pulp and periodontium of the healthy teeth. Condition of the pulp and periodontium of the healthy teeth should be assessed in patients with TMD associated with connective tissue dysplasia (CTD).Materials and methods. The study examined 36 TMD patients aged 26.3 ± 1.3 лет (М ± m) with CTD (n = 20, main group) and without CTD (n = 16, control group); with natural teeth, without complaints of TMD, masticatory muscles and periodontal condition. Laser doppler flowmetry (LDF) helped to analyze blood flow parameters in the periodontium and pulp of the healthy teeth. Received results were statistically analyzed.Results. Wavelet analysis revealed different microcirculatory flowmotion: high-amplitude irregular type was in patients of the main group, low-amplitude regular type was in controls. In the main group, perfusion is supported by high values of flux and vasomotion, ergotropic sympathetic effects (controlled by catecholamines) prevail, myogenic tone is reduced, elevated microvascular tone reflects possible changes in rheologic blood properties, microcirculatory signs of pain syndrome and relatively elevated ischemic index in pulp microcirculation of healthy teeth.Conclusion. Sensory and regulatory mechanisms, reflected by the condition of periodontium and pulp blood flow, can be regarded as early signs of inflammation and chronic pain in the diagnosis of TMD in patients without complaints.

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Postreceptoral adaptation abnormalities in early age-related maculopathy

Visual Neuroscience ◽

10.1017/s0952523806230190 ◽

2006 ◽

Vol 23 (6) ◽

pp. 863-870 ◽

Cited By ~ 5

Author(s):

B. FEIGL ◽

B. BROWN ◽

J. LOVIE-KITCHIN ◽

P. SWANN

Keyword(s):

Treatment Options ◽

Multifocal Electroretinogram ◽

Bipolar Cells ◽

Western World ◽

Control Group ◽

Age Related ◽

Novel Approach ◽

Local Functional ◽

The Difference ◽

Fast Adaptation

Age-related maculopathy (ARM) has become the major cause of blindness in the Western World. Currently its pathogenesis and primary site of functional damage is not fully understood but ischemia is believed to play a major role. Early detection and precise monitoring of progression of ARM are main goals of current research due to lack of sufficient treatment options, especially in the dry, atrophic form of this disease. We applied the multifocal electroretinogram (mfERG) that can detect any local functional deficit objectively in the central retina. We recorded two paradigms in early ARM patients, the fast flicker and the slow flash paradigm which both represent fast adaptation processes of the proximal retina but under differing photopic conditions and stimulation rates. By subtracting the waveform responses we extracted a late component in the difference waveform that was significantly reduced in the early ARM group compared to a healthy control group (p ≤ 0.05). We propose that this multifocal nonlinear analysis permits the detection of adaptative deficits and provides topographic mapping of retinal dysfunction in early ARM. The difference waveform component we extracted with this novel approach might indicate early functional loss in ARM caused by ischemia in postreceptoral layers such as bipolar cells and inner plexiform regions.

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AB0954 IS CONNECTIVE TISSUE MASSAGE EFFECTIVE IN INDIVIDUALS WITH FIBROMYALGIA?

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.6316 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 1774.1-1775

Author(s):

A. Keskin ◽

B. Basakci Calik ◽

E. Gur Kabul ◽

V. Cobankara

Keyword(s):

Quality Of Life ◽

Connective Tissue ◽

Treatment Method ◽

Control Group ◽

Treatment Results ◽

Sf 36 ◽

The Difference ◽

Pre Treatment ◽

Connective Tissue Massage

Background:Fibromyalgia (FM) is a systemic rheumatic disease characterized by diffuse pain in the body, tenderness, fatigue and many more symptoms. Exercise is effective and safe method in individuals with FM. Connective tissue massage, another treatment method, is a reflex therapy where shear force is applied in a certain order at the connective tissue interfaces of the skin. In the literature, there is limited study releted compared with clinical pilates exercises and connective tissue massage in individuals with FM.Objectives:The aim of the study was to examine the effectiveness of clinical pilates exercises and connective tissue massage in Individuals with Fibromyalgia on disease activity, number of painful regions, anxiety, biopsychosocial status and quality of life.Methods:32 women (age mean=52.43±8.32) diagnosed with FM according to American College of Rheumatology (ACR) criteria were included in this study. Participants were randomly divided into two groups as interventional group (n=15, mean age=48.80±7.48) and control group (n=17, mean age=55.64±7.87). While the connective tissue massage and clinical pilates exercises were applied to the treatment group, only clinical pilates exercises were applied to the control group. After the demographic characteristics and disease related data of the individuals were recorded; number of painful regions were assessed with Pain Location Inventory (PLI), disease impact with Fibromyalgia Impact Questionnare (FIQ), functional status with Health Assessment Questionnare (HAQ), anxiety with Beck Anxiety Inventory (BAI), quality of life with Short Form-36 (SF-36) and biopsychosocial status with Cognitive Exercise Therapy Approach (BETY) Scale were evaluated. All evaluations were made before and after treatment. All interventions were applied 3 days per week for 6 weeks by the same experienced physical therapist. One session for clinical pilates exercises consisted of 60 minutes (10 minutes warm up, 40 minutes clinical pilates exercises, 10 minutes cool-down). Connective tissue massage was started from lumbosacral region and continued lower thoracic, scapular, interscapular, and cervical regions, respectively. The Kolmogorov-Smirnov Test was used to determine whether the continuous variables were normal distributions.Results:When the pre-treatment and post-treatment results are analyzed; the results were significant in the intervention group of PLI (p = 0.007), SF 36 physical component (p = 0.025) and mental component (p = 0.017) and FIQ (p = 0.004), while in the control group the difference in SF 36 physical component (p = 0.008) and mental component (p = 0.024), FIQ (p = 0.001) and BAI (p = 0.043) was significant. Delta values were calculated by subtracting post-treatment results from pre-treatment results. When the delta values of the groups are compared, it was determined that the difference only in the PLI (p = 0.023) were significant in favor of the treatment group.Conclusion:According to our results, connective tissue massage has been shown to be effective in reducing the number of painful areas in addition to the positive effects of clinical pilates exercises in individuals with FM. In order to increase the effectiveness of treatment in individuals with FM, we recommend the use of connective tissue massage as an additional treatment method.References:[1]Busch, Angela J., et al. Exercise therapy for fibromyalgia. Current pain and headache reports 2011;15: 358.[2]Burckhardt CS. Nonpharmacologic management strategies in fibromyalgia. Rheumatic diseases clinics of North America, 2002, 28(2),291-304.Disclosure of Interests:None declared

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Radiofrequency Ablation Effect on Histo- and Fibroarchitectonics of Plantar Aponeurosis in Dogs with Fasciopathy Simulated by Alprostadil

Journal of Anatomy and Histopathology ◽

10.18499/2225-7357-2020-9-1-56-63 ◽

2020 ◽

Vol 9 (1) ◽

pp. 56-63

Author(s):

M. V. Markelova ◽

L. B. Reznik ◽

A. V. Kononov ◽

G. G. Dzyuba ◽

V. N. Silant'ev ◽

...

Keyword(s):

Radiofrequency Ablation ◽

Connective Tissue ◽

Comparison Group ◽

Group Processes ◽

Collagen Fibers ◽

Main Group ◽

Energy Conditions ◽

Control Group ◽

Single Exposure ◽

Plantar Aponeurosis

The aim of the study was to investigate radiofrequency ablation (RFA) effect on histo- and fibroarchitectonics of plantar aponeurosis in dogs with fasciopathy simulated by alprostan.Material and methods. Methods of light microscopy (Van Gieson, Weigert–Van Gieson and picro-allory staining with alcian and toluidine blue) and morphometry were used in the study. The study involved sections of plantar aponeurosis in animals of the control group (without fasciopathy, n=8), the main group (with RFA, n=8) and the comparison group (without RFA, n=8).Results. The study demonstrated that a single exposure to RFA after simulated alprostane fasciopathy (four-time injection of the medication during 35 days) did not cause an increase or occurrence of additional pathological changes in the injection area after 7 days. Edema, microbleeding, infiltration by lymphocytes, plasmocytes and leukocytes, dystrophy in the form of mucoid swelling, collapse and rupture of collagen fibers were revealed in animals of the main group, as well as in animals of the comparison group. Processes of adaptation and regeneration of the connective tissue in both groups were manifested in the form of a large number of activated fibrocytes, fibroblasts, microvessels, and the formation of collagen fibers. All these together resulted in the same type of heterochronous and heteromorphic spatial histotopographic changes in the aponeurosis – its structure became more cellular, but less ordered in space. Foci of the chaotic distribution of damaged and newly formed collagen fibers appeared. However, exposure to RFA under moderate power (energy) conditions destroyed cells, thin and damaged collagen fibers, and prevented the development of irreversible fibrinoid swelling and granulation tissue around the foci of dystrophy. Together, all these changes reduced the possibility of gross cicatricial rearrangements in the foci of pathologically altered collagen networks.Conclusion. A single exposure to RFA prevented the development of irreversible stromal-vascular dysproteinoses, inflammatory processes and gross cicatricial changes in the connective tissue of the plantar aponeurosis in dogs. These changes can be determined as reasons for the positive clinical effect of RFA on the foci of pathologically altered collagen networks in fasciopathies.

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