The stomach as the target organ of celiac disease

The aim of this study was to observe the features of chronic gastritis in children with celiac disease (СD). Materials and methods. 176 children with chronic gastritis (CG) aged from 3 to 16 years were examined. Group I consisted 58 child ren with CG and newly diagnosed CD not adherent to the gluten-free diet (GFD), group II consisted 49 children with CG and CD, adherent to the GFD. In the group III of comparisons were 69 children with CG and excluded CD. The exa mination included serological, morphological methods to confirm or exclude CD. The histological examination of the biopsy specimens of the gastric mucosa, the determination of antiparietal antibodies by the method of iIFR and ELISA (antibodies to Castle’s intrinsic factor and Anti-H+/K+ ATPase antibodies) were carried out. Results. Helicobacter pylori infection was diagnosed in vast majority of patients in all groups. Autoantibodies to the gastric mucosa were found in every tenth patient in groups I and III, and did not occur in group II. In group II statistically significant the etiology of gastritis remained not determined. Endoscopically the gastric mucosa in groups I and II often remained intact. Accor ding to the morphological study in groups I and II, the pathological process was more often localized in the body of the stomach, and in group III in the antrum. Autoimmune gastritis is presented in groups without a statistically significant difference. Conclusion. Chronic gastritis is a frequent co-morbid pathology in СD, and it is also not uncommon in these patients. Data of endoscopy in children, regardless of diet, does not reflect the complete picture of CG. All children with CD, regardless of compliance with GFD, are recommended to take biopsy specimens of the gastric mucosa for histological examination in order to exclude CG, and in case of detecting atrophic changes in the gastric mucosa to define the antiparietal antibodies.

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The Influence On Bodyweight In Male Mice (Mus Musculus) Induced By Monosodium Glutamate (Msg)

General medicine and Clinical Practice ◽

10.31579/2639-4162/005 ◽

2018 ◽

Vol 1 (1) ◽

pp. 01-03

Author(s):

Yunita Sari Pane

Keyword(s):

Body Weight ◽

Monosodium Glutamate ◽

Group Iv ◽

Post Treatment ◽

The Body ◽

Male Mice ◽

Group Iii ◽

Group I ◽

Significant Difference ◽

Group Ii

The used of monosodium glutamate (MSG) oftenly found in almost every food that we consumed everyday. It suggested that MSG can increase appetite, can caused intake much foods, and increased the bodyweight. The aim of study is to prove the changes that occur in male mice by induce of MSG. The experimental study used 24 male mice, 30-45 gram, 12-14 weeks divided into 4 groups, ie group-I (negative control/placebo given aquadest 0.2 cc/20gBW mice); group-II, MSG with the dose of 5 mg/gBW mice); group-III, MSG with the dose of 10 mg/gBW mice and group-IV, MSG with the dose of 20 mg/gBW mice. All of these treatments were administered orally for 14 days. Permanent cervical fracture execution was performed at the end of the study. The body weight measured in pre and post treatment. The significant difference of data between different groups was compared by ANOVA followed by Tukey test. The compared of between pre –post treatment used paired test to analyze the changes of bodyweight This study proved that the comparison of mean values ± SEM of body weight between groups were not significantly different; group I (39,83±3,26), group II (39,33±2,04), group III (38,00±1,39) and group IV (38,33±1,76) (p = 0.930) and the changes of bodyweight pre and post treatmen also not significantly different, whereas p > 0.05. The study concluded that no changes in the body weight between groups and pasca induced by MSG. In the future studies, we consider to examining the effects MSG with longer of duration and more variations doses in MSG.

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Role of Cord Blood Carboxyhemoglobin in Detecting Significant Hyperbilirubinemia in Term Neonates with ABO Alloimmunization

American Journal of Perinatology ◽

10.1055/s-0040-1722328 ◽

2021 ◽

Author(s):

Mahir Tıraş ◽

Emrah Can ◽

Şahin Hamilçıkan

Keyword(s):

Cord Blood ◽

Total Serum ◽

Healthy Controls ◽

Term Neonates ◽

Group Iii ◽

Group I ◽

Significant Difference ◽

Group Ii ◽

Positive Direct ◽

Severe Hyperbilirubinemia

Objective This study aimed to assess whether cord blood carboxyhemoglobin (COHb) levels in jaundiced term neonates with and without a positive direct Coombs test (DCT) and in healthy controls could be used as a predictor of severe hyperbilirubinemia. The percentage of cord blood COHb should be higher among neonates with Coombs-positive ABO hemolytic disease than among those with Coombs-negative ABO incompatibility and higher than that of ABO-compatible control neonates. Study Design This cross-sectional descriptive study of 198 term neonates comprised three subgroups: group I featured 68 DCT-positive ABO-incompatible neonates (ABO + DCT), group II featured 60 DCT-negative ABO-incompatible neonates with hyperbilirubinemia (ABO–DCT), and group III featured 70 healthy controls. COHb was determined by an OSM3 hemoximeter. Results Group I differed from groups II and III for cord blood bilirubin, cord blood hemoglobin, and cord blood hematocrit. Groups I and II had higher mean total serum bilirubin (TSB) levels than group III, while there was no difference in the mean TSB levels between groups I and II. There was no significant difference between the COHb group means for groups I, II, and III (p = 0.98). The area under the receiver operating characteristic curve calculated for group I/group III and group II/group III were found to be 0.62 and 0.54, respectively. Conclusion COHb levels did not prove to be superior to the DCT for predicting the risk of developing severe hyperbilirubinemia in term neonates. Key Points

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Comparative Analysis of Acid-base Status Parameters in Newborn with Congenital Surgical Malformations During Perioperative Care Based on Types of Anesthesia

Journal of Internal Medicine: Science & Art ◽

10.36013/jimsa.v2i1.50 ◽

2021 ◽

Vol 2 ◽

pp. 14-22

Author(s):

Oleksii Vlasov

Keyword(s):

Regional Anesthesia ◽

Oxygen Mixture ◽

Acid Base ◽

Group Iii ◽

Group I ◽

Anesthesia Group ◽

Significant Difference ◽

Combined Anesthesia ◽

Acid Base Status ◽

Group Ii

Introduction: Congenital malformations (CM) are most common in newborns and infants in the first year of life and require surgical correction in the first hours, days, months of life. Surgical interventions in severely ill babies with malformations can lead to catabolic stress, circulatory and respiratory disorders, metabolism shifts, water-electrolyte, protein, and acid-base status disorders. This study aimed to compare acid-base status in newborns and infants with congenital surgical pathology under different types of combined anesthesia. Materials and methods: This retrospective study included 150 newborns and infants with CM who required surgery. The patients were divided into three groups based on types of provided anesthesia: inhalation by Sevoran (sevoflurane) and regional anesthesia (group I); inhalation of Sevoran and intravenous anesthesia by Fentanyl (group II); and intravenous combination of Fentanyl and 20% Sodium Oxybutyrate (group III). The analysis included: acid-base status, peripheral oximetry, and the need for an oxygen mixture inhaled by the patient. Results In group I, there was a significant reduction in partial tension of CO2 and increased pH from the pre-surgical status, at the time of induction of anesthesia, during the most painful, traumatic stage, and after surgery compared to group II and III. Peripheral O2 saturation was not critically reduced at all stages of observation except in babies of group I compared to group III at the stage of induction of anesthesia (97.79 ± 2.45 vs. 98.79 ± 1.63, p = 0.0194) and at the most painful period of surgery (96.29 ± 3.47 vs. 98.10 ± 2.47, p = 0.0368). In group I, newborns and infants required higher oxygen concentrations in the inhalation mixture. There was a significant difference in FiO2 between groups I and III during the most painful stage of surgery (0.47 ± 0.29 and 0.33 ± 0.2, p = 0.0071), and immediately after surgery (0.34 ± 0, 19 and 0.26 ± 0.13, p = 0.0246). Conclusion: Among the newborns and infants with CM requiring surgical intervention and combined anesthesia, the most substantial acid-base status changes were observed in the group where anesthesia was provided by Sevoran (sevoflurane) and regional anesthesia (Group I).

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Comparison between Vinorelbine–Carboplatin and Vinorelbine–Cisplatin in Stage III–IV EGFR Mutations-Negative NSCLC

Asian Journal of Oncology ◽

10.1055/s-0041-1730255 ◽

2021 ◽

Author(s):

Laksmi Wulandari ◽

Gatot Soegiarto ◽

Anna Febriani ◽

Farah Fatmawati ◽

Wirya Sastra Amran

Keyword(s):

Lung Cancer ◽

Body Weight ◽

Evaluation Criteria ◽

Growth Factor Receptor ◽

The Body ◽

Stage Iii ◽

Egfr Mutations ◽

Group I ◽

Significant Difference ◽

Group Ii

Abstract Introduction There are a substantial number of lung cancer patients with negative mutations in Indonesia. This type of cancer is deemed to be the major contributor of lung cancer patient’s death. However, reseaerch related to therapy using vinorelbine combined with platinum-based compounds is still scarce in Indonesia. The aim of this study was to compare the efficacy and tolerability between vinorelbine and carboplatin with vinorelbin and cisplatin in stage III-IV epidermal growth factor receptor (EGFR) mutations-negative non-small cell lung cancer (NSCLC). Methods The participants were divided into two groups—group I(vinorelbine–carboplatin) and group II (vinorelbine–cisplatin). The participants were assessed based on several measurement criteria. Not only Eq-5D was performed, but the body weight and response evaluation criteria for solid tumors (RECIST) were also examined. The participants received chemotherapy for four cycles (1 cycle = 21 days). Results The quality of life was considered stable in 60% of group I and 60% of group II (p=0.255). In both groups, 46.67% of participants had an increased body weight, while the other 20.00% was stable (p = 1.000). In terms of RECIST evaluation after the second cycle, 80.00% of group I and 86.67% of group II were considered to have a stable disease, with 20% of group I and none of group II had partial response (p = 0.027). However, after the fourth cycle, there were no significant difference between the groups (p = 0.734). Conclusion In EGFR mutation-negative NSCLC patients, the combination of vinorelbine and carboplatin showed comparable outcomes to vinorelbine and cisplatin chemotherapy with no significant differences.

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Assessment of Outcome of Intrathecal Analgesia in Multiparous Women Undergoing Vaginal Delivery

Academia Anesthesiologica International ◽

10.21276/aan.2020.5.1.31 ◽

2020 ◽

Vol 5 (1) ◽

pp. 153-155

Author(s):

Sanjay Melville Masih ◽

Rakesh Kumar Gupta

Keyword(s):

Vaginal Delivery ◽

Group Iv ◽

Normal Vaginal Delivery ◽

Secondary Outcome ◽

Group Iii ◽

Group I ◽

Significant Difference ◽

Multiparous Women ◽

Group Ii ◽

Intrathecal Analgesia

Background: The present study was conducted to assess the outcome of intrathecal analgesia in multiparous women undergoing vaginal delivery. Subjects and Methods: The present study was conducted among 80 multiparous women ages ranged 18- 40 years. All patients received 0.5 ml of intrathecal injection of 2.5 mg bupivacaine 0.5% and 1 ml dexamethasone 4 mg plus a 0.5 ml adjuvant. The adjuvants in group I patients were 100 μg morphine, 25 μg fentanyl in group II, 5 μg dexmedetomidine in group III and normal saline in group IV (control group). The primary and secondary outcome was the duration of pain relief, the analgesia onset time, the maximum level of sensory block, the visual analogue scale (VAS) was recorded. Results: The mean duration of analgesia in group I was 182.4 minutes, in group II was 170.5 minutes, in group III was 200.4 minutes and in group, IV was 140.2 minutes. The onset of analgesia was 3.9 minutes, 2.8 minutes, 2.7 minutes and 4.5 minutes in group I, II, III and IV respectively. S1 sensory regression time (minutes) was 181.4, 157.4, 185.3 and 130.6 in group I, II, III and IV respectively. Modified Bromage scale 5 minutes, 15 minutes and 30 minutes after IT in all groups was 0.0. VAS was 1.3, 1.6, 1.6 and 3.1 with significant differences in all groups (P< 0.05). There was non- significant difference in mean age, weight, height and gestational age between all groups (P> 0.05). There was a non- significant difference in APGAR 1, 5, umbilical pH immediately after delivery, neonatal HR after 5minute, 15 minutes and 30 minutes in all groups (P> 0.05). Conclusion: The authors found that dexmedetomidine is a safe and effective adjuvant to intrathecal bupivacaine-dexamethasone in multiparous women undergoing normal vaginal delivery.

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Is there a difference in prevalence of anxiety and depression symptoms among patients with different stages of hypertension?

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.358 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S414-S414 ◽

Cited By ~ 1

Author(s):

A. Mermerelis ◽

S.M. Kyvelou ◽

V. Akke ◽

C. Papageorgiou ◽

C. Stefanadis ◽

...

Keyword(s):

Depression Scale ◽

Group Iv ◽

Anxiety And Depression ◽

Depression Symptoms ◽

Study Cohort ◽

Hypertensive Patients ◽

Group Iii ◽

Group I ◽

Significant Difference ◽

Group Ii

IntroductionWhether anxiety and depression are associated with hypertension and to what extent is not clear.AimsThe aim of the present study was to assess any differences in the prevalence of anxiety and depression among different groups of hypertensive patients.MethodsThe study cohort comprised of 127 patients (75 male, mean age 54 ± 14) who underwent assessment of their blood pressure levels and were divided in four groups: group I (normotensives, n = 34), group II (stage 1 HTN, n = 33), group III (stage 2 HTN, n = 30) and group IV (stage 3 HTN, n = 30). The evaluation of anxiety disorder was made by means of Hospital Anxiety Depression Scale (HADS), while the evaluation of depression was made with the Beck Depression Inventory (BDI). Statistical analysis was done with SPSS for windows. P-value was set at 0.05 for differences to be considered significant.ResultsComparing the four groups of patients there was a significant difference both in BDI (8.6 ± 7.0 vs. 11.6 ± 10.4 vs. 27.1 ± 5.8 vs. 32.4 ± 3.9, P < 0.0001) and HADS (10.2 ± 7.2 vs. 9.7 ± 7.0 vs. 16 ± 4.7 vs. 27 ± 5.1, P < 0.0001). We proceeded to comparison among the 4 groups and there was a significant rise in the BDI and HADS in three of the four groups group II > group III > group IV, P < 0.0001.ConclusionThese data suggest that there is a clear burden of anxiety and depression as the levels of BP increase. This finding is of important clinical significance as it could contribute to a different approach of hypertensive patients. A larger cohort study could enlightened the mechanisms involved.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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The Role of sFas in the Immune Escape Mechanism and Progression of Cancer Larynx

Clinical medicine Ear nose and throat ◽

10.4137/cment.s2565 ◽

2009 ◽

Vol 2 ◽

pp. CMENT.S2565

Author(s):

Amr A El Badry ◽

Ismail Elmofty ◽

Amira Helmy

Keyword(s):

Serum Level ◽

Buffy Coat ◽

Control Group ◽

Group Iii ◽

Soluble Fas ◽

Group I ◽

Significant Difference ◽

Cancer Larynx ◽

The Mean ◽

Group Ii

This work assess serum levels of soluble Fas form (sFas) in patients with different stages of laryngeal squamous cell carcinoma(LSCC) to investigate its prognostic significance. We correlate its levels with the morphological changes of peripheral blood cells via buffy coat examinatin. The study population included 70 patients clinically diagnosed and pathohistologically confirmed LSCC in addition to 20 healthy controls. According to TNM classification 33(47.1%) patients were in stage I (group I) and 24(34.3%) in stage II (group II), 13(18.5%) in stage III (group III). The results revealed that the mean serum level of sFas (pg/ml) in the control group was 51.2, in group I was 66.33, in group II was 81.33 and in group III was 112.45. Statistical analysis of the mean of sFas by ELISA test in the patients' groups in comparison to the control revealed a significant increase of both group II and III in comparison to the control group (P < 0.01) but there was no significant difference (P > 0.05) between group I in comparison to either the control or group II. There was a significant difference (P < 0.05) between group I in comparison to group III. LM examination revealed massive extent of the apoptotic cells in group III when compared to both group I and group II. EM examination of the buffy coat revealed apoptotic changes, mainly in the peripheral blood mononuclear cells (PBMNCs), represented by surface membrane ruffles and blebs with clumped nuclear chromatin and vacuolated cytoplasm. In conclusion, this study may help us to better understand one of the escape mechanisms in cancer larynx. This mechanism is represented by the significant increase in both the serum level of sFas and the morphological apoptotic changes that detected in PBMNCs. Soluble Fas may contribute to the progression of laryngeal cancer. It can be used as an attractive target for anticancer therapy and may be considered as a marker of disease progression and poor prognosis in laryngeal cancer.

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A note on the effect of weaning age on lamb production

Animal Science ◽

10.1017/s0003356100028610 ◽

1969 ◽

Vol 11 (4) ◽

pp. 569-572

Author(s):

M. A. Sharafeldin ◽

I. A. Ramadan

Keyword(s):

Mortality Rates ◽

The Body ◽

The Other ◽

Suckling Period ◽

Group Iii ◽

Group I ◽

Body Weights ◽

Weaning Age ◽

Group Ii ◽

Better Than

SUMMARYAt birth, the Barki lambs used in this experiment were randomly allocated to three groups which numbered 133, 126 and 154 lambs of both sexes weaned at the ages of 10 weeks (Group I), 12 weeks (Group II) and 16 weeks (Group III) respectively.The most pronounced differences between the three groups of lambs in their body weights took place at the age from 4 to 6 months. Group II lambs performed as well as or even slightly better than the other two groups, which leads to the conclusion that as far as the body weight of lambs is concerned there is no need to extend their suckling period more than 12 weeks.The three groups of lambs varied little in their mortality rates from 2·5 to 12 months of age.

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Different Bleeding Patterns with the Use of Levonorgestrel Intrauterine System: Are They Associated with Changes in Uterine Artery Blood Flow?

BioMed Research International ◽

10.1155/2014/815127 ◽

2014 ◽

Vol 2014 ◽

pp. 1-6 ◽

Cited By ~ 5

Author(s):

Carlo Bastianelli ◽

Manuela Farris ◽

Stefania Rapiti ◽

Roberta Bruno Vecchio ◽

Giuseppe Benagiano

Keyword(s):

Blood Flow ◽

Uterine Artery ◽

Endometrial Thickness ◽

Power Doppler ◽

Artery Blood Flow ◽

Group Iii ◽

Group I ◽

Significant Difference ◽

Before And After ◽

Group Ii

Objective. Evaluate if different bleeding patterns associated with the use of the levonorgestrel intrauterine system (LNG-IUS) are associated with different uterine and endometrial vascularization patterns, as evidenced by ultrasound power Doppler analysis.Methodology. A longitudinal study, with each subject acting as its own control was conducted between January 2010 and December 2012. Healthy volunteers with a history of heavy but cyclic and regular menstrual cycles were enrolled in the study. Ultrasonographic examination was performed before and after six months of LNG-IUS placement: uterine volume, endometrial thickness, and subendometrial and myometrial Doppler blood flow patterns have been evaluated.Results. A total of 32 women were enrolled out of 186 initially screened. At six months of follow-up, all subjects showed a reduction in menstrual blood loss; for analysis, they were retrospectively divided into 3 groups: normal cycling women (Group I), amenorrheic women (Group II), and women with prolonged bleedings (Group III). Intergroup analysis documented a statistically significant difference in endometrial thickness among the three groups; in addition, mean pulsatility index (PI) and resistance index (RI) in the spiral arteries were significantly lower in Group I and Group III compared to Group II. This difference persisted also when comparing—within subjects of Group III—mean PI and RI mean values before and after insertion.Conclusions. The LNG-IUS not only altered endometrial thickness, but—in women with prolonged bleedings—also significantly changed uterine artery blood flow. Further studies are needed to confirm these results and enable gynecologists to properly counsel women, improving initial continuation rates.

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Effects of different bleaching methods on shear bond strengths of orthodontic brackets

The Angle Orthodontist ◽

10.2319/071812-586.1 ◽

2012 ◽

Vol 83 (4) ◽

pp. 686-690 ◽

Cited By ~ 11

Author(s):

Ahmet Yalcin Gungor ◽

Erhan Ozcan ◽

Huseyin Alkis ◽

Hakan Turkkahraman

Keyword(s):

Shear Bond Strength ◽

Testing Machine ◽

Orthodontic Brackets ◽

Group Iii ◽

Group I ◽

Human Enamel ◽

Significant Difference ◽

Bond Strengths ◽

Group Ii ◽

Method Group

ABSTRACT Objective: To evaluate the effects of different bleaching methods on the shear bond strength (SBS) of orthodontic brackets. Materials and Methods: Forty-five freshly extracted premolars were randomly divided into three groups (n = 15 per group). In group I, bleaching was performed with the office bleaching method. In group II, bleaching was performed with the home bleaching method. Group III served as the control. Orthodontic brackets were bonded with a light cure composite resin and cured with an LED light. After bonding, the SBS of the brackets were tested with a Universal testing machine. Results: Analysis of variance indicated a significant difference between groups (P < .001). The highest values for SBS were measured in group III (20.99 ± 2.32 MPa). The SBS was significantly lower in groups I and II than in group III (P < .001). The lowest values for SBS were measured in group II (6.42 ± 0.81 MPa). SBS was significantly higher in group I than in group II (P < .001). Conclusions: Both of the bleaching methods significantly affected the SBS of orthodontic brackets on human enamel. Bleaching with the home bleaching method affected SBS more adversely than did bleaching with the office bleaching method.

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