scholarly journals Comparison between Vinorelbine–Carboplatin and Vinorelbine–Cisplatin in Stage III–IV EGFR Mutations-Negative NSCLC

2021 ◽  
Author(s):  
Laksmi Wulandari ◽  
Gatot Soegiarto ◽  
Anna Febriani ◽  
Farah Fatmawati ◽  
Wirya Sastra Amran
Keyword(s):  
Lung Cancer ◽  
Body Weight ◽  
Evaluation Criteria ◽  
Growth Factor Receptor ◽  
The Body ◽  
Stage Iii ◽  
Egfr Mutations ◽  
Group I ◽  
Significant Difference ◽  
Group Ii

Abstract Introduction There are a substantial number of lung cancer patients with negative mutations in Indonesia. This type of cancer is deemed to be the major contributor of lung cancer patient’s death. However, reseaerch related to therapy using vinorelbine combined with platinum-based compounds is still scarce in Indonesia. The aim of this study was to compare the efficacy and tolerability between vinorelbine and carboplatin with vinorelbin and cisplatin in stage III-IV epidermal growth factor receptor (EGFR) mutations-negative non-small cell lung cancer (NSCLC). Methods The participants were divided into two groups—group I(vinorelbine–carboplatin) and group II (vinorelbine–cisplatin). The participants were assessed based on several measurement criteria. Not only Eq-5D was performed, but the body weight and response evaluation criteria for solid tumors (RECIST) were also examined. The participants received chemotherapy for four cycles (1 cycle = 21 days). Results The quality of life was considered stable in 60% of group I and 60% of group II (p=0.255). In both groups, 46.67% of participants had an increased body weight, while the other 20.00% was stable (p = 1.000). In terms of RECIST evaluation after the second cycle, 80.00% of group I and 86.67% of group II were considered to have a stable disease, with 20% of group I and none of group II had partial response (p = 0.027). However, after the fourth cycle, there were no significant difference between the groups (p = 0.734). Conclusion In EGFR mutation-negative NSCLC patients, the combination of vinorelbine and carboplatin showed comparable outcomes to vinorelbine and cisplatin chemotherapy with no significant differences.

scholarly journals The Influence On Bodyweight In Male Mice (Mus Musculus) Induced By Monosodium Glutamate (Msg)

2018 ◽  
Vol 1 (1) ◽  
pp. 01-03
Author(s):  
Yunita Sari Pane
Keyword(s):  
Body Weight ◽  
Monosodium Glutamate ◽  
Group Iv ◽  
Post Treatment ◽  
The Body ◽  
Male Mice ◽  
Group Iii ◽  
Group I ◽  
Significant Difference ◽  
Group Ii

The used of monosodium glutamate (MSG) oftenly found in almost every food that we consumed everyday. It suggested that MSG can increase appetite, can caused intake much foods, and increased the bodyweight. The aim of study is to prove the changes that occur in male mice by induce of MSG. The experimental study used 24 male mice, 30-45 gram, 12-14 weeks divided into 4 groups, ie group-I (negative control/placebo given aquadest 0.2 cc/20gBW mice); group-II, MSG with the dose of 5 mg/gBW mice); group-III, MSG with the dose of 10 mg/gBW mice and group-IV, MSG with the dose of 20 mg/gBW mice. All of these treatments were administered orally for 14 days. Permanent cervical fracture execution was performed at the end of the study. The body weight measured in pre and post treatment. The significant difference of data between different groups was compared by ANOVA followed by Tukey test. The compared of between pre –post treatment used paired test to analyze the changes of bodyweight This study proved that the comparison of mean values ± SEM of body weight between groups were not significantly different; group I (39,83±3,26), group II (39,33±2,04), group III (38,00±1,39) and group IV (38,33±1,76) (p = 0.930) and the changes of bodyweight pre and post treatmen also not significantly different, whereas p > 0.05. The study concluded that no changes in the body weight between groups and pasca induced by MSG. In the future studies, we consider to examining the effects MSG with longer of duration and more variations doses in MSG.

scholarly journals Investigation of the Protective Effects of Taurine against Alloxan-Induced Diabetic Retinal Changes via Electroretinogram and Retinal Histology with New Zealand White Rabbits

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Samuel Tung-Hsing Chiang ◽  
Shang-Min Yeh ◽  
Yi-Chen Chen ◽  
Shiun-Long Lin ◽  
Jung-Kai Tseng
Keyword(s):  
Body Weight ◽  
Protective Role ◽  
The Body ◽  
Antidiabetic Activity ◽  
Protective Effects ◽  
Group Iii ◽  
Glucose Levels ◽  
Diabetic Retina ◽  
Group I ◽  
Group Ii

The purpose of this study was to investigate the protective role of orally administered taurine against diabetic retinal changes via electroretinogram (ERG) and retinal histology on rabbits. Rabbits were randomly assigned into groups: Group I (vehicle administration only); Group II (diabetes: induced by 100 mg/kg alloxan injection); Group III (diabetes and fed with 200 mg/kg taurine); and Group IV (diabetes and fed with 400 mg/kg taurine). The body weight and blood glucose levels of the rabbits were monitored weekly. The ERG was measured on weeks 5 and 15. Retinal histology was analyzed in the end of the experiment. Results revealed that a taurine supplement significantly ameliorates the alloxan-induced hyperglycemia and protects the retina from electrophysiological changes. Group II showed a significant(P<0.05)change in the mean scotopic b-wave amplitude when compared to that of Group I, whereas the diabetic rabbits treated with taurine (Group III and IV) were analogous to Group I. Histologically, the amount of Bipolar and Müller cells showed no difference(P>0.05)between all groups and when compared with those of Group I. Our study provides solid evidences that taurine possesses an antidiabetic activity, reduced loss of body weight, and less electrophysiological changes of the diabetic retina.

scholarly journals Continued gefitinib retreatment beyond progression in patients with advanced non-small cell lung cancer harboring sensitive EGFR mutations

2020 ◽  
Vol 48 (10) ◽  
pp. 030006052095503
Author(s):  
Xuhong Jiang ◽  
Xiaoqing Li ◽  
Lingli Tu ◽  
Jin Cai ◽  
Man Wei ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Disease Progression ◽  
Cell Lung Cancer ◽  
Evaluation Criteria ◽  
Growth Factor Receptor ◽  
Progression Free Survival ◽  
Small Cell ◽  
Egfr Mutations ◽  
Small Cell Lung

Purpose To evaluate the effectiveness and safety of gefitinib retreatment beyond disease progression in patients with advanced non-small cell lung cancer (NSCLC) with sensitive epidermal growth factor receptor ( EGFR) mutations. Methods Data from patients with stage III/IV NSCLC were analyzed retrospectively. Patients with sensitive EGFR mutations received first-line treatment with gefitinib followed by retreatment with gefitinib after disease progression. Progression-free survival (PFS) after the first treatment (PFS-1) was defined as the time to progression or death using the Response Evaluation Criteria in Solid Tumors criteria (RECIST) v1.1 criteria. The second PFS (PFS-2) was defined as the interval between the first and second progressions, at the investigator’s discretion. Toxicities were recorded in accordance with the National Cancer Institute (NCI)-Common Terminology Criteria (CTC) version 4.0. Results Sixteen patients aged 53 to 80 years (median 66 years) were included in the analysis. The median PFS-1 and PFS-2 were 10.0 months and 14.0 months, respectively. The median overall survival (OS) was 36.0 months. No toxicity of grade 3 or worse was observed. Conclusions Our findings suggest that gefitinib retreatment beyond disease progression may be an effective and tolerable approach for NSCLC patients with sensitive EGFR mutations.

Comparison of stress distribution in a three unit cement retained implant supported prosthesis with different implant abutment connections: A photoelastic analysis

2020 ◽  
Vol 12 (1) ◽  
pp. 35-43
Author(s):  
Dr Poojya R ◽  
Dr Darakshan Nazir ◽  
Dr Shruthi C S
Keyword(s):  
Stress Distribution ◽  
Axial Loading ◽  
The Body ◽  
Partial Denture ◽  
Fixed Partial Denture ◽  
Group I ◽  
Significant Difference ◽  
Implant Abutment ◽  
Oblique Loading ◽  
Group Ii

Aim: With the emphasis on success of implant supported prosthesis, and health of the surrounding tissues that are related to accuracy, and fit between the implant components, stability at implant abutment interface is of prime importance. The aim of this study is to evaluate and compare the stress distribution in three unit cement retained implant supported fixed partial denture with different implant abutment connections through photo elasticity. Materials and methods: Two photo elastic resin models were fabricated of standard dimensions (44mmx22mmx10mm). Group I sample: Three unit cement retained implant supported fixed partial denture with Internal implant abutment connection (Internal hexagonal connection) (Paltop Advanced, Keystone Dental Company, US)Group II sample: Three unit cement retained implant supported fixed partial denture with conical Morse taper connection (1.5 degree Morse taper) (Paltop Conical Active, Keystone Dental Company, US). Three unit cement retained implant supported fixed partial denture simulated missing mandibular first molar. Axial and oblique loads of 100N were placed on each implant and pontic area for 10 sec. Ten tests were done for each group. The stress values around the implants were derived from the colored fringe patterns obtained through polariscope, which were photographed after load applications from which values were derived. Results: Under axial loading, there was statistically significant difference between internal hexagonal connection and Morse taper connection in three unit implant supported prosthesis. Stresses were more in Group II sample with Morse taper connection. Under oblique loading, there was no statistically significant difference between Group I and Group II samples. Conclusion: Within the limitations of this in vitro study, it can be concluded that Internal hexagonal connection showed less stresses as compared to Morse taper connection in a three unit cement retained implant supported prosthesis. Stresses were concentrated more in apical area under axial loading; while under oblique loading stresses were seen on the side of application of force on the body of the implant and on the apical region. However, stresses were uniformly distributed in both groups I and group II samples. In both groups stresses under oblique loading were more than axial loading, but that was not statistically significant.

scholarly journals Effect of WW Domain-Containing Oxidoreductase Gene Polymorphism on Clinicopathological Characteristics of Patients with EGFR Mutant Lung Adenocarcinoma in Taiwan

2021 ◽  
Vol 18 (24) ◽  
pp. 13136
Author(s):  
Ju-Pi Li ◽  
Jinghua Tsai Chang ◽  
Po-Chung Ju ◽  
Ming-Hong Hsieh ◽  
Yu-Hua Chao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lung Adenocarcinoma ◽  
Growth Factor Receptor ◽  
Egfr Mutations ◽  
Genotype Distribution ◽  
Nucleotide Polymorphisms ◽  
Primary Tumors ◽  
Ww Domain ◽  
Significant Difference ◽  
Egfr Mutant

Lung adenocarcinoma is the most common histological type of non-small cell lung cancer, which accounts for the majority of lung cancers. Previous studies have showed that dysregulation of WW domain-containing oxidoreductase (WWOX) participates in the generation of several cancer types, including lung cancer. However, whether these WWOX polymorphisms are related to the clinical risk of epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma is worthy of investigation. The present study examined the relationship between the WWOX single-nucleotide polymorphisms (SNPs; rs11545028, rs12918952, rs3764340, rs73569323, and rs383362) and the clinicopathological factors in lung adenocarcinoma patients with or without EGFR mutations. We found that there was no significant difference in the genotype distribution of WWOX polymorphism between EGFR wild-type and EGFR mutant in patients with lung adenocarcinoma. Our results demonstrated that the presence of at least one G genotype (CG and GG) allele on WWOX rs3764340 was associated with a significantly higher risk of nearby lymph node involvement in those patients harboring EGFR mutations (odds ratio (OR) = 3.881, p = 0.010) compared with the CC genotype. Furthermore, in the subgroup of lung adenocarcinoma patients with the EGFR-L858R mutation, both WWOX rs3764340 C/G (OR = 5.209, p = 0.023) and rs73569323 C/T polymorphisms (OR = 3.886, p = 0.039) exhibited significant associations with the size of primary tumors and the invasion of adjacent tissues. In conclusion, these data indicate that WWOX SNPs may help predict tumor growth and invasion in patients with EGFR mutant lung adenocarcinoma, especially those with the EGFR-L858R mutant in Taiwan.

scholarly journals Assessment of Effect of Exercise on Body Composition in Obese and Overweight

2022 ◽  
Vol 8 (1) ◽  
pp. 1-6
Author(s):  
Reshma Shireesha ◽  
Obulesu Obulesu
Keyword(s):  
Body Composition ◽  
Body Fat ◽  
Health Benefit ◽  
The Body ◽  
Control Group ◽  
Fat Percentage ◽  
Group I ◽  
Significant Difference ◽  
The Mean ◽  
Group Ii

Background: Aim: To assess the effect of exercise on body composition in obese and overweight. Methods: A total of seventy- two overweight subjects of either gender were enrolled for the study. Two groups were prepared. One group was experimental group (n=36) and the second group was control group (n=36). Parameter such as age, height and weight was recorded. On the basis of variables body mass Index and body fat percentage of every subject was determined. The experiment group were put on aerobic exercises spread over duration of four weeks. Results: The mean height in group I was 163.7 cm and 165.4 cm in group II. Weight was 65.2 kg and 63.5 kgs in group II, BMI (Kg/m2) was 29.4 and 29.1, body fat was 29.3% and 29.6% in group I and II respectively. A significant difference was observed (P< 0.05). The mean pre- test BMI was 29.6 and 38.5 and post- test value was 26.4 and 38.9 in group I and II respectively. A significant difference was observed (P< 0.05). Conclusions: Regular physical activity appears to confer a health benefit to the people. There was a positive relationship between aerobic exercises and overweight women in order to reduce the value of fat in the body.

scholarly journals Therapeutic efficacy of isometamidium chloride in the treatment of Trypanosoma congolense infection in Sokoto Red bucks

2020 ◽  
pp. 40-43
Keyword(s):  
Body Weight ◽  
Therapeutic Efficacy ◽  
Clinical Signs ◽  
Treated Group ◽  
Trypanosoma Congolense ◽  
Post Treatment ◽  
The Body ◽  
Group I ◽  
Drug Concentrations ◽  
Group Ii

Introduction: Treatment of animal trypanosomiasis using isometamidium chloride (ISM) is largely done with 1% solution however, 2% solution has been found to be more effective. In this study, therapeutic efficacy of ISM drug concentrations was studied in Trypanosoma congolense infected Sokoto Red Bucks (SRB). The aim of the study was to determine the efficacy of the curative (1%) and prophylactic (2%) concentrations of ISM in the treatment of experimentally infected SRB with Trypanosoma congolense. Methods: Twelve SRB were divided into three groups of four animals each: Group I (1% ISM treated), Group II (2% ISM treated) at the dose rate of 0.5 mg/kg body weight intramuscularly and Group III (uninfected and untreated-Control). Groups I and II bucks were each inoculated intravenously with approximately 1x106 T. congolense. Clinical signs, rectal temperature, body weight, packed cell volume (PCV), total white blood cell count (TWBCC) were monitored. Wet-mount and micro haematocrit centrifugation technique (HCT) were used to monitor the parasitaemia post-infection and post-treatment. Seven days post-treatment the blood from the treated groups were sub-inoculated into mice. Results: Group I had relapse of the infection two weeks post-treatment while no relapse of the infection was observed in the Group II till five weeks post-treatment. Significant (p < 0.05) changes in the PCV, WBCC and body weight were properly recorded as well as the clinical signs and the body weight. Significance: The 2% ISM confers better and longer cure than the 1% ISM in treating trypanosomosis in goat.

scholarly journals The effect of meniran herbs extract (Phyllantus niruri) to triglycerides blood level in wistar rats

2012 ◽  
Vol 10 (1) ◽  
pp. 23-27
Author(s):  
JUDO YUSTANTO KAHONO ◽  
KISRINI KISRINI ◽  
YUL MARIYAH
Keyword(s):  
Body Weight ◽  
Wistar Rats ◽  
Negative Control ◽  
Control Group ◽  
Control Group Design ◽  
Total Period ◽  
Group I ◽  
Significant Difference ◽  
Post Test ◽  
Group Ii

Kahono JY, Kisrini, Mariyah Y. 2012. The effect of meniran herbs (Phyllantus niruri) extract to blood triglyceride level in rats. Biofarmasi 10: 23-27. The aim of this experiment was to determine the effect of meniran herbs (Phyllantus niruri L.) extract to blood triglycerides level in Wistar rats (Rattus norvegicus). This experiment was a laboratory experiment with pre and post-test with a control group design. The samples were 30 male Wistar rats with ±200 gram of body weight and ±2 months old. The samples were divided into five groups by using a purposive random sampling technique and each group consisted of six rats. Group I as a negative control, group II as a positive control, and groups III, IV and V as meniran herbs extract groups with first dose, second dose, and third dose. All rats were simultaneously given with hyperlipemic feed. Group II was simultaneously administered with Cholvastin 0.5 mg/200 grams body weight/day. Groups III, IV and V were simultaneously treated with meniran herbs extract at dose of 25 mg, 50 mg and 100 mg/200 grams body weight/day. The total period of this experiment was 21 days. At the day 1st and 21st, blood was collected from rat orbital venous plexus. Serum was analyzed for their pre and post-test blood triglycerides. Statistical analysis was performed by one-way analysis of variance (ANOVA) followed by a post-hoc test. The value of p=0.002 (p<0.05) showed there was a significant difference between pre-test and post-test in delta means of blood triglycerides level among groups. Meniran herbs extract had a significant triglycerides lowering effect against blood triglycerides level of Wistar rats. The most potential of meniran herbs extract dose was 100 mg/200 gram body weight/day.

The occurrence of abnormal body weight values and selected eating habits and physical activity of nurses

2019 ◽  
Vol 87 (4) ◽  
pp. 179-187
Author(s):  
Wioletta Waksmańska ◽  
Halina Woś ◽  
Rafał Bobiński
Keyword(s):  
Physical Activity ◽  
Body Weight ◽  
Nursing Students ◽  
Eating Habits ◽  
The Body ◽  
Daily Consumption ◽  
Group Iii ◽  
Group I ◽  
Excessive Body Weight ◽  
Group Ii

Aim. The aim of the research was to analyze the incidence of abnormal body weight values and to assess eating habits and physical activity of nurses.Material and Methods. The studies involved all first‑year nursing students of the second degree daily studies, working as a nurse. The women’s eating habits were analyzed based the diet. The questionnaire allowed the researchers to determine daily consumption of each particular dietary component (proteins, carbohydrates, fats, fatty acids, vitamins) as well as the women’s calorie consumption.Results. The analysis showed that the group of underweight participants was comprised of 5 students (group I), the group of participants with normal body weight — of 43 students (group II), and the group of participants with excessive body weight — of 10 students (group III). Group II students spent the longest time on (moderate and intense) physical activity (on average 378 minutes/week), whereas group III students — the shortest (on average 203 minutes/week). While analyzing the average protein intake, it was found that all groups exceeded its daily requirement. The intake of sodium and cholesterol was exceeded more than twice of the recommended amount. A very low intake of vitamin D — covering from 40 to 48% of the daily requirement — was observed in all groups.Conclusions. Despite the fact that the nurses’ diet includes all nutrients necessary for the body, it is not properly balanced which obliges to raising awareness of types of consumed food.

Hyperfractionated radiation therapy with or without concurrent low-dose daily carboplatin/etoposide for stage III non-small-cell lung cancer: a randomized study.

1996 ◽  
Vol 14 (4) ◽  
pp. 1065-1070 ◽  
Author(s):  
B Jeremic ◽  
Y Shibamoto ◽  
L Acimovic ◽  
S Milisavljevic
Keyword(s):  
Lung Cancer ◽  
Low Dose ◽  
Small Cell ◽  
Stage Iii ◽  
Small Cell Lung ◽  
Free Survival ◽  
Group I ◽  
Hyperfractionated Radiation Therapy ◽  
Stage Iii Nsclc ◽  
Group Ii

PURPOSE To investigate the efficacy of concurrent hyperfractionated radiation therapy (HFX RT) and low-dose daily chemotherapy (CHT) in stage III non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS Between January 1990 and December 1991, 131 patients with histologically or cytologically confirmed stage III NSCLC, Karnofsky performance status (KPS) > or = 50, and no previous therapy were randomly treated as follows: group I, HFX RT with 1.2 Gy twice daily to a total dose of 69.6 Gy (n = 66); and group II, same HFX RT with CHT consisting of 50 mg of carboplatin (CBDCA) and 50 mg of etoposide (VP-16) given on each RT day (n = 65). RESULTS Group II patients had a significantly longer survival time than group I patients, with a median survival of 22 versus 14 months and 4-year survival rates of 23% versus 9% (P = .021). The median time to local recurrence and 4-year local recurrence-free survival rate were also significantly higher in group II than in group I (25 v 20 months and 42% v 19% respectively, P = .015). In contrast, the distant metastasis-free survival rate did not significantly differ in the two groups (P = .33). The two groups showed similar incidence of acute and late high-grade toxicity (P = .44 and .75, respectively). No treatment-related toxicity was observed. CONCLUSION The combination of HFX RT and low-dose daily CBDCA plus VP-16 was tolerable and improved the survival of patients with stage III NSCLC as a result of improved local control.

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