scholarly journals Magnetic Resonance Imaging of the Whole Body (DWIBS). Potentialities and Perspectives for Application in Bone Pathology

2015 ◽  
Vol 22 (2) ◽  
pp. 19-24
Author(s):  
A. K Morozov ◽  
A. N Makhson ◽  
I. N Karpov
Keyword(s):  
Magnetic Resonance ◽  
High Sensitivity ◽  
Whole Body ◽  
Whole Body Imaging ◽  
Bone Pathology ◽  
Presumptive Diagnosis ◽  
Whole Body Mri ◽  
Study Results ◽  
True Signal ◽  
Reduced Water

The purpose of the study was to determine the role and place of whole body MRI with DWIBS in diagnosis of human loco-motor system oncologic pathology. Two hundred fifty six patients with presumptive diagnosis of oncologic disease were examined. Obtained signal was evaluated by true signal intensity scale in minimal examination volume (voxel), either drawn through the volumetric lesion or in an isolated area of arbitrary shape. Study results were verified using standard MRI protocols (T1, T2, STIR), contrast enhancement, MSCT, radionuclide and morphologic examination. High sensitivity of the technique to pathologically changed tissues with reduced water diffusion coefficient was demonstrated. Magnetic resonance diffusion-weighted whole-body imaging with DWIBS may be recommended as noninvasive screening technique for the diagnosis of both primary and secondary (metastases) oncologic process.

scholarly journals Magnetic Resonance Imaging of the Whole Body (DWIBS). Potentialities and Perspectives for Application in Bone Pathology

2015 ◽  
pp. 19-24
Author(s):  
A. K. Morozov ◽  
A. N. Makhson ◽  
I. N. Karpov
Keyword(s):  
Magnetic Resonance ◽  
High Sensitivity ◽  
Whole Body ◽  
Whole Body Imaging ◽  
Bone Pathology ◽  
Presumptive Diagnosis ◽  
Whole Body Mri ◽  
Study Results ◽  
True Signal ◽  
Reduced Water

The purpose of the study was to determine the role and place of whole body MRI with DWIBS in diagnosis of human loco-motor system oncologic pathology. Two hundred fifty six patients with presumptive diagnosis of oncologic disease were examined. Obtained signal was evaluated by true signal intensity scale in minimal examination volume (voxel), either drawn through the volumetric lesion or in an isolated area of arbitrary shape. Study results were verified using standard MRI protocols (T1, T2, STIR), contrast enhancement, MSCT, radionuclide and morphologic examination. High sensitivity of the technique to pathologically changed tissues with reduced water diffusion coefficient was demonstrated. Magnetic resonance diffusion-weighted whole-body imaging with DWIBS may be recommended as noninvasive screening technique for the diagnosis of both primary and secondary (metastases) oncologic process.

scholarly journals Whole-Body Functional MRI and PET/MRI in Multiple Myeloma

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3155
Author(s):  
Sébastien Mulé ◽  
Edouard Reizine ◽  
Paul Blanc-Durand ◽  
Laurence Baranes ◽  
Pierre Zerbib ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Functional Mri ◽  
Bone Marrow Involvement ◽  
High Sensitivity ◽  
Response To Treatment ◽  
Whole Body ◽  
Response Evaluation ◽  
Whole Body Mri ◽  
Dce Mri

Bone disease is one of the major features of multiple myeloma (MM), and imaging has a pivotal role in both diagnosis and follow-up. Whole-body magnetic resonance imaging (MRI) is recognized as the gold standard for the detection of bone marrow involvement, owing to its high sensitivity. The use of functional MRI sequences further improved the performances of whole-body MRI in the setting of MM. Whole-body diffusion-weighted (DW) MRI is the most attractive functional technique and its systematic implementation in general clinical practice is now recommended by the International Myeloma Working Group. Whole-body dynamic contrast-enhanced (DCE) MRI might provide further information on lesions vascularity and help evaluate response to treatment. Whole Body PET/MRI is an emerging hybrid imaging technique that offers the opportunity to combine information on morphology, fat content of bone marrow, bone marrow cellularity and vascularization, and metabolic activity. Whole-body PET/MRI allows a one-stop-shop examination, including the most sensitive technique for detecting bone marrow involvement, and the most recognized technique for treatment response evaluation. This review aims at providing an overview on the value of whole-body MRI, including DW and DCE MRI, and combined whole-body 18F-FDG PET/MRI in diagnosis, staging, and response evaluation in patients with MM.

scholarly journals Magnetic resonance diffusion-weighted whole-body imaging (DWIBS) in the urinary bladder cancer diagnostics

2012 ◽  
Vol 1 (2) ◽  
pp. 0210
Author(s):  
Vladimir M. Popkov ◽  
M.L. Chekhonatskaya ◽  
Viktor V. Zuev ◽  
A.N. Ponukalin ◽  
Y.E. Nikolsky
Keyword(s):  
Bladder Cancer ◽  
Magnetic Resonance ◽  
Urinary Bladder ◽  
Urinary Bladder Cancer ◽  
Cancer Diagnostics ◽  
Whole Body ◽  
Whole Body Imaging ◽  
Body Imaging ◽  
Diffusion Weighted

scholarly journals In Vivo Magnetic Resonance Tracking of Magnetically Labeled Cells after Transplantation

2002 ◽  
Vol 22 (8) ◽  
pp. 899-907 ◽  
Author(s):  
Jeff W. M. Bulte ◽  
Ian D. Duncan ◽  
Joseph A. Frank
Keyword(s):  
Stem Cell ◽  
Magnetic Resonance ◽  
Mr Imaging ◽  
Superparamagnetic Iron Oxide ◽  
Whole Body ◽  
Whole Body Imaging ◽  
Body Imaging ◽  
Stem And Progenitor Cells ◽  
The Central Nervous System

During the last few years, the therapeutic use of stem and progenitor cells as a substitute for malfunctioning endogenous cell populations has received considerable attention. Unlike their current use in animal models, the introduction of therapeutic cells in patients will require techniques that can monitor their tissue biodistribution noninvasively. Among the different imaging modalities, magnetic resonance (MR) imaging offers both near-cellular (i.e., 25- to 50-μ) resolution and whole-body imaging capability. In order to be visualized, cells must be labeled with an intracellular tracer molecule that can be detected by MR imaging. Methods have now been developed that make it possible to incorporate sufficient amounts of superparamagnetic iron oxide into cells, enabling their detection in vivo using MR imaging. This is illustrated for (neural stem cell—derived) magnetically labeled oligodendroglial progenitors, transplanted in the central nervous system of dysmyelinated rats. Cells can be followed in vivo for at least 6 weeks after transplantation, with a good histopathologic correlation including the formation of myelin. Now that MR tracking of magnetically labeled cells appears feasible, it is anticipated that this technique may ultimately become an important tool for monitoring the efficacy of clinical (stem) cell transplantation protocols.

scholarly journals Radionuclide, magnetic resonance and computed tomography imaging in European round back slugs (Arionidae) and leopard slugs (Limacidae)

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nicola Beindorff ◽  
Fabian Schmitz-Peiffer ◽  
Daniel Messroghli ◽  
Winfried Brenner ◽  
Janet F. Eary
Keyword(s):  
Computed Tomography ◽  
Magnetic Resonance ◽  
Kidney Function ◽  
Single Photon ◽  
Photon Emission ◽  
Functional Anatomy ◽  
Whole Body ◽  
Emission Computed Tomography ◽  
Whole Body Imaging ◽  
Imaging Protocol

AbstractOther than in animal models of human disease, little functional imaging has been performed in most of the animal world. The aim of this study was to explore the functional anatomy of the European round back slug (Arionidae) and leopard slug (Limacidae) and to establish an imaging protocol for comparative species study. Radionuclide images with single photon emission computed tomography (SPECT) and positron emission tomography (PET) were obtained after injections of standard clinical radiopharmaceuticals 99mtechnetium dicarboxypropane diphosphonate (bone scintigraphy), 99mtechnetium mercaptoacetyltriglycine (kidney function), 99mtechnetium diethylenetriaminepentaacetic acid (kidney function), 99mtechnetium pertechnetate (mediated by the sodium-iodide symporter), 99mtechnetium sestamibi (cardiac scintigraphy) or 18F-fluoro-deoxyglucose (glucose metabolism) in combination with magnetic resonance imaging (MRI) and computed tomography (CT) for uptake anatomic definition. Images were compared with anatomic drawings for the Arionidae species. Additionally, organ uptake data was determined for a description of slug functional anatomy in comparison to human tracer biodistribution patterns identifying the heart, the open circulatory anatomy, calcified shell remnant, renal structure (nephridium), liver (digestive gland) and intestine. The results show the detailed functional anatomy of Arionidae and Limacidae, and describe an in vivo whole-body imaging procedure for invertebrate species.

scholarly journals Can Whole-body MRI Replace CT in Management of Metastatic Testicular Cancer? A Prospective, Non-inferiority Study.

2022 ◽  
Author(s):  
Solveig Kärk Abildtrup Larsen ◽  
Vibeke Løgager ◽  
Catharina Bylov ◽  
Hanne Nellemann ◽  
Mads Agerbæk ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Predictive Value ◽  
Interobserver Agreement ◽  
Whole Body ◽  
High Survival ◽  
Whole Body Imaging ◽  
Whole Body Mri ◽  
Contrast Enhanced ◽  
Lesion Level ◽  
Ct And Mri

Abstract Purpose Concerns of imaging-related radiation in young patients with high survival rates have increased the use of magnetic resonance imaging (MRI) in testicular cancer (TC) stage I. However, computed tomography (CT) is still preferred for metastatic TC. The purpose of this study was to compare whole-body MRI incl. diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) with contrast-enhanced, thoracoabdominal CT in metastatic TC.Methods A prospective, non-inferiority study of 84 consecutive patients (median age 33 years) with newly diagnosed metastatic TC (February 2018 - January 2021). Exclusion criteria were age <18 years, claustrophobia and MRI contraindications. Patients had both MRI and CT before and after treatment. Anonymised images were reviewed by experienced radiologists.Lesion malignancy was evaluated on a Likert scale (1 benign – 4 malignant). Sensitivity, specificity, positive predictive value, negative predictive value and accuracy were calculated on patient and lesion level. For non-inferiority testing, the difference in sensitivity between CT and MRI was calculated. The level of significance was set at 5%. ROC curves and interobserver agreement were calculated.Results On patient level, MRI had 98% sensitivity and 75% specificity compared to CT. On lesion level within each modality, MRI had 99% sensitivity and 78% specificity, whereas CT had 98% sensitivity and 88% specificity. MRI sensitivity was non-inferior to CT (difference 0.57% (95% CI -1.4-2.5%)). The interobserver agreement was substantial between CT and MRI. Conclusion MRI with DWIBS was non-inferior to contrast-enhanced CT in detecting metastatic TC disease. Trial registration www.clinicaltrials.gov NCT03436901, finished July 1st 2021.

scholarly journals Whole-body magnetic resonance imaging for diagnosis and treatment monitoring in multiple myeloma

2020 ◽  
Vol 65 (4) ◽  
pp. 431-443
Author(s):  
N. S. Lutsik ◽  
L. P. Mendeleeva ◽  
M. V. Solovev ◽  
S. M. Kulikov ◽  
Yu. A. Chabaeva ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Myeloma ◽  
Bone Marrow ◽  
Magnetic Resonance ◽  
Whole Body ◽  
Relative Reduction ◽  
Resonance Imaging ◽  
Whole Body Mri ◽  
Adc Values ◽  
Antitumour Response

Introduction. Whole-body diffusion-weighted magnetic resonance imaging (MRI) is an informative method for bone marrow infiltration diagnosis in patients with multiple myeloma (MM) and post-monitoring in autologous haematopoietic stem cell transplantation (auto-HSCT).Aim: to study bone marrow lesions in MM patients using whole-body MRI prior to and after chemotherapy with subsequent auto-HSCT.Materials and methods. Forty patients with MM were included in a prospective study of whole-body MRI before and after high-dose chemotherapy with auto-HSCT. All patients had whole-body MRI prior to and at +100 day of auto-HSCT. Antitumour response was assessed after induction and at +100 day. The number and volume of bone marrow lesions prior to and at +100 day of auto-HSCT were determined, along with apparent diffusion coefficient (ADC) in the lesions.Results. We observed a significant reduction of 29 % in the number of lesions, 40 % — in their volume and 33 % — in ADC. A significant correlation was revealed between relative reduction in the number and volume of foci (r = 0.52, p = 0.0017). A correlation was found between relative reduction in the foci number and ADC (r = 0.47, p = 0.016). Patients with lesions > 7 cm3 in MRI data exhibited a lesser reduction in the foci number and volume and ADC values after auto-HSCT compared to patients with lesions < 7 cm3.Conclusion. Whole-body MRI with diffusion-weighted imaging and subsequent estimation of the number and volume of lesions and their ADC values prior to and after auto-HSCT add power to assessing antitumour response in MM patients with auto-HSCT.

scholarly journals Quantitative Imaging in Muscle Diseases with Focus on Non-proton MRI and Other Advanced MRI Techniques

2020 ◽  
Vol 24 (04) ◽  
pp. 402-412
Author(s):  
Marc-André Weber ◽  
Armin M. Nagel ◽  
Hermien E. Kan ◽  
Mike P. Wattjes
Keyword(s):  
Magnetic Resonance ◽  
Diffusion Tensor ◽  
T2 Mapping ◽  
Quantitative Mri ◽  
Whole Body ◽  
Resonance Spectroscopy ◽  
Whole Body Imaging ◽  
Muscle Involvement ◽  
Muscle Diseases ◽  
Proton Mri

AbstractThe role of neuromuscular imaging in the diagnosis of inherited and acquired muscle diseases has gained clinical relevance. In particular, magnetic resonance imaging (MRI), especially whole-body applications, is increasingly being used for the diagnosis and monitoring of disease progression. In addition, they are considered as a powerful outcome measure in clinical trials. Because many muscle diseases have a distinct muscle involvement pattern, whole-body imaging can be of diagnostic value by identifying this pattern and thus narrowing the differential diagnosis and supporting the clinical diagnosis. In addition, more advanced MRI applications including non-proton MRI, diffusion tensor imaging, perfusion MRI, T2 mapping, and magnetic resonance spectroscopy provide deeper insights into muscle pathophysiology beyond the mere detection of fatty degeneration and/or muscle edema. In this review article, we present and discuss recent data on these quantitative MRI techniques in muscle diseases, with a particular focus on non-proton imaging techniques.

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