scholarly journals PHARMACEUTICAL POTENTIAL OF LABORATORY GROWN CULTURES OF BLUE-GREEN ALGAE: A COMPREHENSIVE REVIEW AND FUTURE POSSIBILITIES

2021 ◽  
Vol 9 (5) ◽  
pp. 543-571
Author(s):  
Ritu Chauhan ◽  
◽  
Abhishek Chauhan ◽  
Ashutosh Tripathi ◽  
Anuj Ranjan ◽  
...  
Keyword(s):  
Green Algae ◽  
Bioactive Compounds ◽  
Current Knowledge ◽  
Biological Activities ◽  
Biologically Active ◽  
Primary And Secondary Metabolites ◽  
Blue Green Algae ◽  
Green Algal ◽  
Algal Group ◽  
Diverse Application

COVID-19 pandemic has taught the world researchers the urgent need for new sources and novel pharmaceuticals not only for existing diseases but also for both seasonal epidemics and future pandemics. Pharmaceutical drug discoveries for the past fifty years depended deeply on the procedure of empirical transmission of a huge number of pure bioactive compounds to provide new leads. The screening of extracts or isolating compounds is a common way to discover novel biologically active molecules. Most of the valuable Blue-Green algal metabolites are concentrated in their biomass. For existence in nature, Blue-Green algae (BGA) secrete and contain various organic substances like proteins, fatty acids, vitamins, pigments, primary and secondary metabolites, and these compounds are explored for potential biological activities such as antibacterial, antifungal, antiviral (including the anti-SARS-CoV-2 virus that causes COVID-19), anticancer, antioxidant, antidiabetic, protease inhibitory activity, anti-inflammatory activity, etc. Due to their diverse application, pharmaceutical companies have shown commercial interest in the Blue-green algal group for the discovery and development of novel molecules to combat deadly diseases for the benefit of society and mankind. The current review paper highlights and discusses the diverse pharmaceutical potential of laboratory-grown cultures of BGA along with comprehensive and current knowledge on bioactive compounds discovered by researchers globally.

Volatile Compounds of the Cyanophyceae – A Review

1983 ◽  
Vol 15 (6-7) ◽  
pp. 181-190 ◽  
Author(s):  
George P Slater ◽  
Vivian C Blok
Keyword(s):  
Fatty Acids ◽  
Volatile Compounds ◽  
Organic Compounds ◽  
Green Algae ◽  
Aquatic Organisms ◽  
Blue Green Algae ◽  
Green Algal

A relationship between blue-green algae and off-flavours in water was reported as early as 1883. Continuing research has shown that two metabolites, geosmin and methylisoborneol are major contributors to unpalatable flavours in water and aquatic organisms. Many instances of the co-occurrence of these two compounds and dense blooms of blue-green algae have been recorded. Cultures of Anabaena, Lyngbya, Osciiiatoria, and Sympioca species have been shown to produce geosmin or methylisoborneol while blooms of Aphanizomenon, Anabaena, Microcystis, Oscillatoria, and Gomphosphaeria have been found in water containing geosmin or the odour of this compound. Actinomycetes have also been shown to produce these two compounds. In addition to geosmin and methylisoborneol, there is evidence that several other blue-green algal metabolites contribute to aquatic taste and odour problems. Among them is β-cyclocitral which has a distinctive tobacco flavour. Blue-green algae produce a variety of organic compounds including hydrocarbons, fatty acids, aromatics, ketones, terpenoids, amines and Sulfides which could contribute to the over-all flavour of water and aquatic organisms.

Ubiquitin fragments: their known biological activities and putative roles

2010 ◽  
Vol 1 (1) ◽  
pp. 67-83 ◽  
Author(s):  
Paweł Pasikowski ◽  
Marzena Cydzik ◽  
Alicja Kluczyk ◽  
Piotr Stefanowicz ◽  
Zbigniew Szewczuk
Keyword(s):  
Immune Responses ◽  
Cell Biology ◽  
Current Knowledge ◽  
Biological Activities ◽  
Biologically Active ◽  
Humoral Immune ◽  
Cellular Processes ◽  
Humoral Immune Responses ◽  
Protein Molecules ◽  
Antibacterial And Antifungal

AbstractUbiquitin (Ub) is involved in many key processes of cell biology. Identification of compounds that could interfere in the ubiquitination process is of importance. It could be expected that peptides derived from the Ub-binding regions might be able to interact with Ub receptors themselves and modify an ability of the Ub receptors interactions. This review summarizes current knowledge about known Ub-derived peptides and discusses putative activity of unexplored Ub fragments. Among identified biologically active Ub-derived peptides, its decapeptide fragment of the LEDGRTLSDY sequence was found to exhibit strong immunosuppressive effects on the cellular and humoral immune responses, comparable to that of cyclosporine. Some of the Ub fragments possess strong antibacterial and antifungal potency. In the search for new peptides that could interfere in the interaction of Ub with other proteins, we investigated the pentapeptide Ub sequences present in non-ubiquitin proteins. Based on examination of the Swiss-Prot database, we postulated that sequences of some Ub fragments often exist in other protein molecules. However, some of those motives are represented more frequently than others and could be involved in regulation of cellular processes related to Ub.

Blue-green Algal Ammonia Uptake in Hypertrophic Prairie Lakes

1981 ◽  
Vol 38 (9) ◽  
pp. 1040-1044 ◽  
Author(s):  
T. P. Murphy ◽  
B. G. Brownlee
Keyword(s):  
Microcystis Aeruginosa ◽  
Green Algae ◽  
Nitrogen Cycle ◽  
Nitrogen Limitation ◽  
Kinetic Studies ◽  
Blue Green Algae ◽  
Ammonia Uptake ◽  
Green Algal ◽  
Prairie Lakes ◽  
Menten Kinetic

Within 24 h of an increase in lake [Formula: see text] concentration, [Formula: see text] uptake by Aphanizomenon flos-aquae and Microcystis aeruginosa increases much beyond the capacity predicted by Michaelis–Menten kinetic studies. In hypertrophic lakes this response enables these blue-green algae to optimize ammonia uptake during large oscillations of [Formula: see text] concentration, to aid them in competing with other algae, and to conserve [Formula: see text] within the ecosystem. Nitrogen limitation in the hypertrophic prairie lakes is a rare event.Key words: ammonia uptake, prairie lakes, nitrogen limitation, nitrogen cycle

Differential temperature sensitivity of two cladoceran species to resource variation during a blue-green algal bloom

1986 ◽  
Vol 64 (8) ◽  
pp. 1739-1744 ◽  
Author(s):  
Stephen T. Threlkeld
Keyword(s):  
Growth Rate ◽  
Population Growth ◽  
Green Algae ◽  
Growth Rates ◽  
Algal Bloom ◽  
Zooplankton Community Structure ◽  
Lake Texoma ◽  
Blue Green Algae ◽  
Green Algal ◽  
First Reproduction

The sensitivity of life-table parameters of two cladoceran zooplankton to slight, natural variations in temperature was determined during the onset of a midsummer blue-green algal bloom in a large turbid reservoir (Lake Texoma, Oklahoma, Texas). Prior to the onset of blue-green algae, cohorts of Ceriodaphnia lacustris incubated at ambient epilimnion temperatures (27–30 °C) had higher individual somatic and population growth rates, an earlier age at first reproduction, and shorter life-spans than cohorts incubated at a constant 25 °C. As blue-green algae became abundant, Ceriodaphnia growth rates were reduced more dramatically at ambient temperatures than at 25 °C, suggesting that a temperature–resource interaction was important to determination of somatic growth rate, age of first reproduction, and population growth rate. Ceriodaphnia populations declined in Lake Texoma as blue-green algae became abundant. Diaphanosoma leuchtenbergianum, which was abundant throughout the period of blue-green algal dominance, did not show the temperature–resource interaction found for Ceriodaphnia. Temperature–resource interactions have been hypothesized to determine seasonal change in zooplankton community structure; this study provides experimental evidence of demographic consequences in natural populations of one kind of common temperature–resource interaction.

Cyanobacterial management manual - a practical guide to applying the state of the art

2009 ◽  
Vol 4 (4) ◽  
Author(s):  
MD Burch ◽  
G. Newcombe ◽  
L. Ho
Keyword(s):  
Green Algae ◽  
Current Knowledge ◽  
Management Strategies ◽  
Practical Experience ◽  
Water Industry ◽  
Research Knowledge ◽  
Blue Green Algae ◽  
Practical Guide ◽  
Water Treatment Process ◽  
Toxic Cyanobacteria

This paper introduces a practical guide developed for use by the water industry for the management of toxic cyanobacteria. The guide entitled ‘Management Strategies for Cyanobacteria (Blue-Green Algae) and their Toxins: A Guide for Water Utilities’ (Ho et al., 2009) is a comprehensive guide/manual, which summarises current knowledge on the management of blue-green algae (cyanobacteria) and their toxins. The manual covers management strategies for source waters and all stages of the water treatment process. This guide is a consolidated collection of both practical experience and research knowledge developed over the last 20 years within the Australian and international water industry.

Light and Nutrient Effects on the Relative Biomass of Blue-Green Algae in Lake Phytoplankton

1986 ◽  
Vol 43 (1) ◽  
pp. 148-153 ◽  
Author(s):  
Val H. Smith
Keyword(s):  
Green Algae ◽  
Current Knowledge ◽  
Light Availability ◽  
Light Level ◽  
Algal Community ◽  
Regression Analyses ◽  
Secchi Disc ◽  
Blue Green Algae ◽  
Nutrient Effects ◽  
Using Data

The factors determining the relative biomass of blue-green algae during the growing season were studied using data from 22 lakes worldwide. Multiple linear regression analyses suggest that total nitrogen (TN), total phosphorus (TP), and light (as estimated from Secchi disc transparency and the depth of the mixed layer) interact to determine the relative biomass of planktonic blue-green algae. At a fixed TN: TP ratio, blue-green relative biomass increases as light availability decreases. At a fixed light level, blue-green relative biomass also increases as the TN: TP ratio decreases. Both effects are consistent with current knowledge of algal physiology, and with a recently proposed theoretical framework for algal community structure.

A Comparison of the Use of Azolla and Blue-green Algal Bio-fertilizers with Green Manuring, Organic Manuring and Urea in Transplanted and Direct-seeded Rice

1989 ◽  
Vol 25 (4) ◽  
pp. 485-491 ◽  
Author(s):  
A. L. Singh ◽  
P. K. Singh
Keyword(s):  
Green Algae ◽  
Nitrogen Uptake ◽  
Rice Field ◽  
Nitrogen Sources ◽  
Poor Response ◽  
Rice Crop ◽  
Green Manuring ◽  
Blue Green Algae ◽  
Green Algal ◽  
Direct Seeded

SUMMARYAzolla and blue-green algae (BGA) inoculated in a rice field produced a higher biomass and fixed more nitrogen in transplanted than in direct-seeded rice. Application of Azolla, BGA, composts of Eichhomia and Azolla and green manuring with Sesbania increased tiller numbers, height, grain and straw yields, and nitrogen uptake by rice in both the transplanted and the direct-seeded crop. The growing and incorporating of three Azolla crops with the rice crop produced more grain than the use of other nitrogen sources but the rice crops showed a poor response to inoculation with BGA. The yield of rice following green manuring with Sesbania or the use of two crops of Azolla after transplanting was similar to that of a crop receiving 60 kg N ha−1 as urea, but smaller yields resulted from the use of composts of Azolla and Eichhornia.

Blue-green algae of a developing salt marsh

1963 ◽  
Vol 43 (2) ◽  
pp. 309-317 ◽  
Author(s):  
W. D. P. Stewart ◽  
G. J. F. Pugh
Keyword(s):  
Salt Marsh ◽  
Green Algae ◽  
Salt Marshes ◽  
Personal Communication ◽  
Soil Samples ◽  
Algal Flora ◽  
Present Communication ◽  
Blue Green Algae ◽  
The Past ◽  
Green Algal

In the past few years considerable attention has been paid to the distribution of the microflora of the salt marshes at Gibraltar Point, Lincolnshire (National Grid reference TF 555576). During these studies it was observed (Turner, personal communication) that blue-green algae (Myxophyceae) were of frequent occurrence in soil samples from the region, but no analyses of the algal flora were carried out. It is well established, however, that blue-green algae are generally present in salt marsh regions (Chapman, 1960 a). Previous studies on the blue-green algae of British salt marshes are few, although detailed investigations have been carried out at Canvey and Ynyslas (Carter, 1932, 1933 a, b) and Scolt Head Island (Chapman, 1939). Some difficulty is experienced, however, in attempting to correlate these results with present day studies, mainly because of the widespread colonization of salt marsh regions within recent years by Spartina townsendii H. & J. Groves, and by the fact that few quantitative data are available. It is hoped that the present communication which is concerned with the blue-green algal flora of the New Marsh at Gibraltar Point, a region dominated by Spartina townsendii, will allow an assessment to be made of the flora prevailing in a developing salt marsh under present-day conditions.

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