scholarly journals Features of Diagnosis and Treatment of the Drug-Induced Glaucoma Clinical Case

2019 ◽  
Vol 16 (3) ◽  
pp. 399-407 ◽  
Author(s):  
I. L. Simakova ◽  
A. N. Kulikov ◽  
I. A. Tikhonovskay ◽  
M. V. Sukhinin ◽  
R. D. Berezin ◽  
...  
Keyword(s):  
Clinical Case ◽  
Systemic Disease ◽  
Drug Induced ◽  
The Past ◽  
Medical Institutions ◽  
Key Points ◽  
Corticosteroid Drugs ◽  
Chronic Blepharitis

Purpose: To describe the interesting and fairly rare due to its features clinical case of secondary glaucoma caused by prolonged use of corticosteroids in the composition of ocular drops and ointments for the treatment of chronic blepharitis. Key points: The features of this case are the young age of the patient, as well as late diagnosis of steroid glaucoma and concomitant systemic disease in the form of psoriatic spondylitis, despite regular examinations of the patient by ophthalmologists from various medical institutions over the past two years in connection with the treatment of chronic blepharitis with frequent exacerbations in both eyes. The abolition of corticosteroid drugs, complex treatment in combination with immunocorrection, systemic therapy of psoriatic spondylitis and surgical treatment of glaucoma in both eyes led to long-term remission of chronic blepharitis, stabilization of the glaucomatous process and improvement of the patient’s quality of life. Conclusion: Ophthalmologists should monitor the level of intraocular pressure in all patients who are treated with drugs containing corticosteroids

scholarly journals Trends and Developments in Bioinformatics in 2010: Prospects and Perspectives

2011 ◽  
Vol 20 (01) ◽  
pp. 146-155
Author(s):  
A. V. Alekseyenko ◽  
Y. Aphinyanaphongs ◽  
S. Brown ◽  
D. Fenyo ◽  
L. Fu ◽  
...  
Keyword(s):  
Best Practices ◽  
Open Problems ◽  
The Past ◽  
New Methods ◽  
Methods Development ◽  
Long Term Trends ◽  
To Come ◽  
Generation Sequencing

SummaryTo survey major developments and trends in the field of Bioinformatics in 2010 and their relationships to those of previous years, with emphasis on long-term trends, on best practices, on quality of the science of informatics, and on quality of science as a function of informatics.A critical review of articles in the literature of Bioinformatics over the past year.Our main results suggest that Bioinformatics continues to be a major catalyst for progress in Biology and Translational Medicine, as a consequence of new assaying technologies, most predominantly Next Generation Sequencing, which are changing the landscape of modern biological and medical research. These assays critically depend on bioinformatics and have led to quick growth of corresponding informatics methods development. Clinical-grade molecular signatures are proliferating at a rapid rate. However, a highly publicized incident at a prominent university showed that deficiencies in informatics methods can lead to catastrophic consequences for important scientific projects. Developing evidence-driven protocols and best practices is greatly needed given how serious are the implications for the quality of translational and basic science.Several exciting new methods have appeared over the past 18 months, that open new roads for progress in bioinformatics methods and their impact in biomedicine. At the same time, the range of open problems of great significance is extensive, ensuring the vitality of the field for many years to come.

scholarly journals Late Effects and Survivorship Issues in Patients with Neuroblastoma

Children ◽  
2018 ◽  
Vol 5 (8) ◽  
pp. 107 ◽  
Author(s):  
Danielle Friedman ◽  
Tara Henderson
Keyword(s):  
Late Effects ◽  
Survival Rates ◽  
Premature Mortality ◽  
The Past ◽  
Excess Morbidity ◽  
Related Risk ◽  
Impaired Quality ◽  
Made In

Over the past two decades, marked progress has been made in understanding the biology of neuroblastoma; this has led to refined risk stratification and treatment modifications with resultant increasing 5-year survival rates for children with neuroblastoma. Survivors, however, remain at risk for a wide variety of potential treatment-related complications, or “late effects”, which may lead to excess morbidity and premature mortality in this cohort. This review summarizes the existing survivorship literature on long-term health outcomes for survivors of neuroblastoma, focusing specifically on potential injury to the endocrine, sensory, cardiovascular, pulmonary, and renal systems, as well as survivors’ treatment-related risk for subsequent neoplasms and impaired quality of life. Additional work is needed to assess the potential late effects of newer multimodality therapies with the aim of optimizing long-term medical and psychosocial outcomes for all survivors of neuroblastoma.

Quality of life following surgery for congenital cardiac malformations in neonates and infants

2005 ◽  
Vol 15 (S1) ◽  
pp. 174-178 ◽  
Author(s):  
Kathleen Mussatto ◽  
James Tweddell
Keyword(s):  
Quality Of Life ◽  
Future Research ◽  
Cardiac Malformations ◽  
The Past ◽  
Congenital Cardiac Disease ◽  
Major Shift ◽  
Neonates And Infants ◽  
The Impact

The past two decades have witnessed a major shift towards repair of most congenital cardiac malformations during the neonatal or infant periods of life.1 Early anatomic correction or palliation, dramatic improvements in survival, and reduced morbidity due to improvements in perioperative and long-term medical management, have resulted in new populations of children that have reaped the benefits of the best care currently available for treatment of congenital cardiac disease. The impact of the congenital cardiac malformations, however, extends far beyond the walls of the hospital or clinic where we diagnose, treat, and follow our patients. The breakthrough of achieving predictable results with repair or palliation of most lesions during the neonatal and infant periods mandates us to look beyond survival, and to examine the lives our patients lead when they are outside of our care. Our purpose in this review is to discuss the measures of psychosocial outcome that are appropriate for exploration in those neonates and infants who survive cardiac surgery, to explore what is known about the psychosocial outcomes and quality of life for these patients, and what needs exist for future research.

Clinical Features of PTSD and Adjustment Disorders in Refugees from the Zone ATO

2017 ◽  
Vol 41 (S1) ◽  
pp. S725-S725
Author(s):  
H. Kozhyna ◽  
V. Korostiy ◽  
V. Mykhaylov
Keyword(s):  
Emotional Disorders ◽  
Clinical Features ◽  
Trait Anxiety ◽  
Adjustment Disorders ◽  
Test Results ◽  
Medical Institutions ◽  
Reactive Anxiety ◽  
Competing Interest

AimTo study clinical features of PTSD and adjustment disorders in refugees from the zone ATO.MethodsWe have a complex psychopathological and psychodiagnostic research 156 refugees in volunteer center in Kharkiv.ResultsAmong the IDPs observed, 75.9% have violations of adaptation: long-term depressive reaction and predominant disturbance of other emotions. The men reactive alarm indicators (average – 37.7 ± 3.0), were higher than trait anxiety (average – 32.6 ± 2.9). On the contrary, women figures trait anxiety (average – 38.6 ± 2.9) were higher than reactive anxiety (average – 34.7 ± 3.0). Severity of depressive symptoms also slightly prevailed in women. The mean score on the Hamilton scale for men was 17.0 ± 2.3 points, women – 18.0 ± 2.3 points.Test results on a scale of quality of life showed no significant differences between men and women. We have developed a medical and psychological support system to correct the neurotic disorders in refugees.ConclusionsThe majority of people who left the ATO zone have psycho-emotional disorders of different severity and require a further correction in the specialized medical institutions.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Modern clinical and physiological bases of super microsurgery. The view of a physiologist and surgeons

2021 ◽  
Vol 24 (2) ◽  
pp. 48-56
Author(s):  
N. A. Bubnova ◽  
L. Ya. Kanina ◽  
N. P. Erofeev ◽  
R. P. Borisova
Keyword(s):  
Lower Extremities ◽  
Pharmacological Agents ◽  
Critical Studies ◽  
The Past ◽  
Vasoactive Substances ◽  
Biopsy Specimens ◽  
Medical Institutions ◽  
Functional Mechanisms ◽  
First Time

This paper is a retrospective analysis of the long-term work of a large group of Russian scientists representing various Medical Institutions of St. Petersburg (in the past years of Leningrad) in the period from the 70s of the XX century to the present in the field of theoretical clinical lymphology. We aimed to discuss critical studies of a group of anatomists, in the sphere of the structure of lymphangions and lymph nodes in health and lymphedema of the lower extremities in humans. Experimental data of physiologists are presented, which made it possible for the first time to substantiate the functional mechanisms of active lymph transport in health and in lymphedema of the lower extremities. In addition, there are some results of testing biopsy specimens with various pharmacological agents and vasoactive substances. At last, there is an example of the clinical use of theoretical knowledge in the tactics of choice and expediency of surgical treatment of lymph drainage disorders in patients is given.

Medical Management Considerations for Patients With Lung Transplantation

2001 ◽  
Vol 14 (4) ◽  
pp. 258-276 ◽  
Author(s):  
Robert E. Dupuis ◽  
David J. Taber ◽  
Amy L. Fann ◽  
Kevin P. Lumbert
Keyword(s):  
Lung Transplantation ◽  
Immunosuppressive Agents ◽  
Chronic Obstructive ◽  
Drug Induced ◽  
Obstructive Pulmonary Disease ◽  
Drug Regimens ◽  
Short And Long Term ◽  
End Stage

Lung transplantation has become an accepted modality for the treatment of end-stage lung disease. Adult and pediatric patients with a variety of lung diseases, including cystic fibrosis, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis are candidates for lung transplantation. Lung transplantation can extend survival and improve quality of life for these patients. With the introduction of new immunosuppressive agents and enhanced surgical and medical care, both short- and long-term morbidity and mortality in these populations, although not as good as other transplant types, are improving. After lung transplantation, recipients continue to face a number of obstacles including post-operative complications, complex drug regimens, drug-induced toxicities, infection, and rejection. An understanding of the management and monitoring issues after lung transplantation is the focus of this review.

Development of sulfasalazine-associated drug-induced lupus erythematosus in patient with rheumatoid arthritis (clinical case)

2021 ◽  
pp. 26-29
Author(s):  
A. N. Kovshik ◽  
E. P. Kiseleva ◽  
N. G. Klyukvina ◽  
G. V. Lukina
Keyword(s):  
Rheumatoid Arthritis ◽  
Lupus Erythematosus ◽  
Clinical Case ◽  
Clinical Manifestations ◽  
New Drugs ◽  
Drug Induced ◽  
Reliable Diagnosis ◽  
Term Administration ◽  
Lupus Syndrome

Drug-induced lupus syndrome (DLS) is a rare adverse event with a variety of drugs. More than a hundred of drugs are known that can cause the development of DLS, and this list is growing as new drugs appear. Physicians of any specialty can face such complications of therapy and should be aware of this pathology. The article presents an analysis of a clinical case of DLS development against the background of long-term administration of sulfasalazine in a patient with a reliable diagnosis of rheumatoid arthritis, as well as a literature review, which includes data on the prevalence, drug groups, clinical manifestations, diagnosis and treatment of this pathology.

Technical Fixes, Technological Solutions

1997 ◽  
Author(s):  
Robert Pool
Keyword(s):  
Water Pollution ◽  
Global Warming ◽  
Hazardous Wastes ◽  
Technological Disaster ◽  
The Public ◽  
The Past ◽  
The World ◽  
Underlying Theme

The past couple of decades have been a confusing, frustrating period for engineers. With their creations making the world an ever richer, healthier, more comfortable place, it should have been a time of triumph and congratulation for them. Instead, it has been an era of discontent. Even as people have come to rely on technology more and more, they have liked it less. They distrust the machines that are supposedly their servants. Sometimes they fear them. And they worry about the sort of world they are leaving to their children. Engineers, too, have begun to wonder if something is wrong. It is not simply that the public doesn’t love them. They can live with that. But some of the long-term costs of technology have been higher than anyone expected: air and water pollution, hazardous wastes, the threat to the Earth’s ozone layer, the possibility of global warming. And the drumbeat of sudden technological disaster over the past twenty years is enough to give anyone pause: Three Mile Island, Bhopal, the Challenger, Chernobyl, the Exxon Valdez, the downing of a commercial airliner by a missile from the U.S.S. Vincennes. Is it time to rethink our approach to technology? Some engineers believe that it is. In one specialty after another, a few prophets have emerged who argue for doing things in a fundamentally new way. And surprisingly, although these visionaries have focused on problems and concerns unique to their own particular areas of engineering, a single underlying theme appears in their messages again and again: Engineers should pay more attention to the larger world in which their devices will function, and they should consciously take that world into account in their designs. Although this may sound like a simple, even a self-evident, bit of advice, it is actually quite a revolutionary one for engineering. Traditionally, engineers have aimed at perfecting their machines as machines. This can be seen in the traditional measures of machines: how fast they are, how much they can produce, the quality of their output, how easy they are to use, how much they cost, how long they last.

Can implant-retained overdenture components cause damage to the opposing natural dentition?

Dental Update ◽  
2021 ◽  
Vol 48 (7) ◽  
pp. 571-578
Author(s):  
Nahal Razaghi ◽  
Mike Hughes ◽  
Mital Patel
Keyword(s):  
Quality Of Life ◽  
Clinical Relevance ◽  
Clinical Case ◽  
Case Series ◽  
Patient Assessment ◽  
Careful Patient ◽  
Potential Problems ◽  
Natural Dentition

This clinical case series highlights an under-reported and often unidentified complication of implant-retained overdentures that may leave patients with a risk of long-term discomfort and preventable damage to the opposing dentition. A variety of cases is discussed to demonstrate potential problems and symptoms that can flag up signs of parafunctional habits in implant patients, and how these can be managed successfully. CPD/Clinical Relevance: Implant-retained overdentures provide a significant improvement in quality of life; however, careful patient assessment and management is essential to ensure the components do not cause damage to the opposing dentition.

scholarly journals Biomaterials for Pelvic Floor Reconstructive Surgery: How Can We Do Better?

2015 ◽  
Vol 2015 ◽  
pp. 1-20 ◽  
Author(s):  
Giulia Gigliobianco ◽  
Sabiniano Roman Regueros ◽  
Nadir I. Osman ◽  
Julio Bissoli ◽  
Anthony J. Bullock ◽  
...  
Keyword(s):  
Immune Responses ◽  
Surgical Repair ◽  
Physical And Mechanical Properties ◽  
Pelvic Organ ◽  
Host Responses ◽  
Health Issues ◽  
Major Health ◽  
The Past

Stress urinary incontinence (SUI) and pelvic organ prolapse (POP) are major health issues that detrimentally impact the quality of life of millions of women worldwide. Surgical repair is an effective and durable treatment for both conditions. Over the past two decades there has been a trend to enforce or reinforce repairs with synthetic and biological materials. The determinants of surgical outcome are many, encompassing the physical and mechanical properties of the material used, and individual immune responses, as well surgical and constitutional factors. Of the current biomaterials in use none represents an ideal. Biomaterials that induce limited inflammatory response followed by constructive remodelling appear to have more long term success than biomaterials that induce chronic inflammation, fibrosis and encapsulation. In this review we draw upon published animal and human studies to characterize the changes biomaterials undergo after implantation and the typical host responses, placing these in the context of clinical outcomes.

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