scholarly journals Assessment of oral hypoglycaemic activity of water soluble extract of aloe vera and its interaction with glipizide in alloxan induced diabetic Wistar Rats

2017 ◽  
Vol 6 (8) ◽  
pp. 1917
Author(s):  
Vikalp Tiwari ◽  
Gopal Gudsurkar
Keyword(s):  
Aloe Vera ◽  
Standard Condition ◽  
Test Group ◽  
Water Soluble ◽  
Control Group ◽  
Standard Group ◽  
Distilled Water ◽  
Soluble Extract ◽  
Hypoglycaemic Activity ◽  
Water Soluble Extract

Background: Assessment of oral hypoglycaemic activity of water soluble extract of Aloe vera and its interaction with Glipizide in Alloxan induced diabetic Wistar rats.Methods: Under standard condition of testing, alloxan induced diabetic rats were kept in fasting state of 8 hours and then glucose in dose of 1gm/kg was given PO by feeding tube. There after water soluble extract of aloe vera in dose of 200mg/kg BW dissolves in 1ml of Distilled water (DW) to test group 1, Glipizide in dose of 2.5mg/kg BW dissolved in 1ml DW was given to standard group. Test group 2 received combination of Aloe vera 200mg/kg BW and Glipizide in dose of 2.5mg/kg BW dissolved in 1ml Dw. Control group received 1ml of Distilled water. Blood sugars levels of all Rats in each group were checked with Glucometer.Results: Clinically and statistically significant glucose lowering effect was observed in groups administered with Aloe vera and better results were observed in group receiving Aloe vera and Glipizide combination.Conclusions: Water soluble extract of aloe vera has significant hypoglycaemic activity and the results showed that co-administration of Aloe vera and Glipizide has superior hypoglycaemic activity compared to Aloe vera and Glipizide given Individually.

scholarly journals Spectrophotometric assessment of effect of aqueous extract of Aloe vera on rabbit erythrocytes in varying concentrations of saline

2018 ◽  
Vol 7 (4) ◽  
pp. 608
Author(s):  
Vikalp Tiwari ◽  
Ashutosh Tiwari ◽  
Pooja Solanki Mishra ◽  
Vatsala Maheshwari
Keyword(s):  
Aqueous Extract ◽  
Normal Saline ◽  
Aloe Vera ◽  
Test Group ◽  
Water Soluble ◽  
Control Group ◽  
Acute Administration ◽  
Hypotonic Solution ◽  
Soluble Extract ◽  
Water Soluble Extract

Background: Hemolytic disorders are one of the prime reasons for frequent blood transfusions which involves lots of costs and sufferings to the patient. This study was undertaken to determine the effect of water soluble extract of Aloe vera on rabbit erythrocytes in varying concentrations of NaCl from 0.9% (isotonic) to 0.15% (hypotonic).Methods: Aqueous extract of Aloe vera (AVE) 200mg/kg was orally administered to rabbits in the test group while control group was given 1ml of distilled water (DW). Blood was withdrawn from rabbits, centrifuged and suspension in 1ml of normal saline was made. 20 microliter of red blood cells suspension from both control and test groups was added to normal saline of varying concentrations from 0.9% to 0.15% NaCl which were quantitatively analysed for hemolysis by UV spectrophotometer. Data was analysed by unpaired t test and P <0.05 was considered statistically significant.Results: The difference in percentage of hemolysis in both test and control groups was not statistically significant. Therefore, acute administration of water soluble extract of Aloe vera (200mg/kg) did not have protective effect on rabbit erythrocytes against hypotonic solution of normal saline.Conclusions: Aloe vera might be useful for the treatment of oxidative stress-related human disorders by virtue of its antioxidant activity and may have a role in prevention of hemolysis which needs to be explored by further studies.

scholarly journals FORMULASI SEDIAAN KRIM ANTI LUKA BAKAR DARI EKSTRAK AIR DAGING DAUN ALOE VERA

Jurnal Kimia ◽  
2020 ◽  
pp. 37
Author(s):  
P. O. Samirana ◽  
N. W. Satriani ◽  
P. R. Harfa ◽  
S. P. P. Dewi ◽  
C. I. S. Arisanti
Keyword(s):  
Aloe Vera ◽  
Water Extract ◽  
Ash Content ◽  
Water Soluble ◽  
Soluble Extract ◽  
Meat Extract ◽  
Chemical Screening ◽  
Extract Content ◽  
Water Soluble Extract

Aloe vera (Aloe vera) is a plant that is empirically often used to heal burns. Aloe vera leaf meat water extract contains saponins and flavonoids, in addition it also contains tannins and polyphenols. This research was conducted to determine whether the extracted water of Aloe vera leaf meat had met the parameters of extract quality standards so that it could be used in formulations. The steps taken are the extraction of aloe vera leaf meat with the method of infundation maceration, standardization of Aloe vera meat water extraction including testing the determination of drying shrinkage, total ash content, determination of ash content which is insoluble in acid, determination of the essence of water soluble extract, determination of the extract soluble in ethanol and chemical screening, identification with FT-IR, preparation of cream preparations, evaluation of cream preparations. Aloe vera leaf meat extract was obtained by infudation technique. Tests for drying drying extract produced 26.33%, total ash content of 1.3%, water soluble extract content of 11.9% and ethanol soluble extract content of 12.01%, total flavonoid content of 2.9%.   Keywords: Aloe Vera, Formulation, Cream, Burns.

scholarly journals Experimental Study on Anti Scorpion Venom potential of Paravatadi Agada of Ayurveda in Indian Red Scorpion Venom (Mesobuthus tamulus)

2020 ◽  
Vol 11 (3) ◽  
pp. 456-465
Author(s):  
Sunil Deshmukh ◽  
Sonali Chalakh ◽  
Dhirajsing Rajput
Keyword(s):  
Lethal Dose ◽  
Treated Group ◽  
Scorpion Venom ◽  
Water Soluble ◽  
Control Group ◽  
Soluble Extract ◽  
Percentage Survival ◽  
Soxhlet Apparatus ◽  
Frequent Event ◽  
Water Soluble Extract

Background: Scorpion sting is a frequent event in tropical and subtropical countries. The objective of this study is to evaluate Efficacy of Paravatadi Agada on Indian Red Scorpion Venom (Mesobuthus Tamulus). Materials and Methods: PA was prepared as per textual reference. Water soluble extract of PA was obtained using Soxhlet apparatus. Swiss albino mice of 20-30gm were used. Lypholised venom sample of Mesobuthus tamales and Lyophilized monovalent enzymerefined immunoglobuline anti scorpion venom serum (ASV) was used.  Using lethal dose of scorpion venom (25.12 μg/g), venom neutralising property of PA extract (300mg/kg), ASV(1mg) intra-peritoneally  and PA(31mg/mice) orally. The parameter used were Mean survival time, protection fold and percentage survival of animals over the period of 24 hrs. Histopathological examinations of all mice were done. Result: Maximum protection fold is seen in ASV treated group which is 10.03 with 83.33 % survival but water soluble extract of PA also showed some protective effect against scorpion venom 7.68 with 50 % survival rate. Histopathological examination showed that PA extract, ASV and PA treated group showed less effect of scorpion venom on Heart, Liver and Kidney compared to control group in which sever histopathological manifestations are detected. Conclusion : The protection fold and survival percentage of extract of PA was  better than Powder form of PA but less than ASV but  enough significant in view of availability, safety, ease in method of preparation and cost effectiveness compared to ASV.

scholarly journals The Antidepressant Effects of (Arcangelisia flava (l.) Merr) Water-Soluble Extract in Balb-C Mice Reviewed from Immobility Time by Forced

2015 ◽  
Vol 3 (2) ◽  
pp. 65 ◽  
Author(s):  
Tiara A ◽  
Arief R H ◽  
Sudarsono Sudarsono
Keyword(s):  
Forced Swim Test ◽  
White Male ◽  
Water Soluble ◽  
Test Method ◽  
Laboratory Animals ◽  
Control Group ◽  
Soluble Extract ◽  
Antidepressant Effects ◽  
Immobility Time ◽  
Water Soluble Extract

<p class="Normal1">This study was conducted to examine / determine the antidepressant effects of (<em>Arcangelisiaflava</em> L.) on immobility time of the white male mice strain Balb-c by the forced swim test method. The method of research using laboratory animals such as 25 micewas divided into 5 groups. As a negative control group was only given distilled water ad libitum. Amitryptiline was used as the positive control group; the experiment group was a water-soluble extract of A.flava by  multiple doses. The results showed that the best antidepressant effects were312 mg/kgBW ; it had a minimum of immobility time compared with the other groups.</p>

scholarly journals Larvicidal Activity of A Mixture of Cashew Nut Shell Liquid and Water-Soluble Extract of Soap Nut Fruit (Sapindus rarak DC.) Against 3rd Instar Larvae of Aedes aegypti

2015 ◽  
Vol 3 (2) ◽  
pp. 53 ◽  
Author(s):  
Glory Resia Raraswati ◽  
Sudarsono Sudarsono ◽  
Budi Mulyaningsih
Keyword(s):  
Treatment Group ◽  
Aedes Aegypti ◽  
Tap Water ◽  
Water Soluble ◽  
Control Group ◽  
Soluble Extract ◽  
Cashew Nut Shell Liquid ◽  
Cashew Nut ◽  
Water Soluble Extract ◽  
Cashew Nut Shell

<p>Cashew Nut Shell Liquid (CNSL) which has been known as a waste of processing cashew fruits which is contain phenolic compounds have activity as larvicides. Cashew nut shell liquid is not soluble in the water where the larvae grow. Cashew nut shell liquid mixed with water-soluble extract of soapnut fruit which serves as a natural surfactant that can emulsify oil in water. The test subjects were larvae of <em>Aedes aegypti </em>third instar. Test subjects were divided into treatment group and control group. In the treatment group, test subjects were  the mixture of CNSL and Ethylacetat Soluble Extract (ESE) in tap water. The Larvae mortality observations were done 24 hours after the treatment. LC<sub>50</sub> and LC<sub>90 </sub>as final test data were analyzed using probit analysis. Extract constituents   of CNSL and Water Soluble Extract of SoapNut fruit (WSEoSN) were  investigated using Thin Layer Chromatography (TLC) method. The effect of CNSL as larvicides against third instar larvae of <em>Ae. aegypti </em>with were LC<sub>50</sub> of 14,12 ppm, while the LC<sub>90</sub> of 24,85 ppm.</p>

scholarly journals Physical Stability of Hair Tonic Contain Ethanol Extract Galangal (Alpinia galanga L.) Rhizome and Aloe Vera Leaf Filtrate (Aloe vera L.)

2020 ◽  
Vol 6 (2) ◽  
pp. 67
Author(s):  
Nur illiyin Akib ◽  
Andi Nafisah Tendri Adjeng ◽  
Rahiswari Pramudita Lakasa ◽  
Suryani Suryani ◽  
Ari Sartinah ◽  
...  
Keyword(s):  
Aloe Vera ◽  
Ethanol Extract ◽  
Ash Content ◽  
Water Soluble ◽  
Stability Testing ◽  
Soluble Extract ◽  
Alpinia Galanga ◽  
Cycling Test ◽  
Before And After ◽  
Water Soluble Extract

AbstractFormulation and stability testing of hair tonic contain galangal rhizome (Alpinia galanga L.) ethanol extract and Aloe vera L. filtrate has been done as alternative for dandruff removal and hair growth. This study aimed to produce stable hair tonic. Galangal rhizome extract obtained by maceration method using ethanol and aloe leaf filtrate obtained by filtering. Extracts and filtrates characterized include water and ethanol soluble content, water and ash content. Hair tonic was formulated by mechanical mixing method with variations of galangal rhizome ethanol extract and aloe vera leaf filtrate which were 4% and 12.5%; 5% and 25%; 6% and 37.5%. Hair tonic prepared were tested for stability by cycling test method including organoleptic, homogeneity, pH, and viscosity. The characteristics of the galangal rhizome ethanol extract were 12% water soluble extract, 12% ethanol soluble extract, 3% water content, and 2% ash content. The characteristics of Aloe vera leaf filtrate were 10% ethanol soluble extract, 1.6% water soluble extract, and 1% ash content. Stability testing shows that hair tonic preparations are organoleptically stable and homogeneous. The pH values before and after cycling test for formulas A, B, and C were 5.27 to 5.34, respectively; 5.00 to 5.15; and 4.87 to 5.05. Viscosity before and after the cycling test for formulas A, B, and C were 1.178 to 1.676 cPs respectively; 1,306 to 1,883 cPs; and 2,148 to 2,296 cPs. It is concluded that hair tonic prepared are stable based on the requirements of Indonesian National Standard (SNI).

Prebiotic frozen dessert processed with water‐soluble extract of rice byproduct: Vegan and nonvegan consumers perception using preferred attribute elicitation methodology and acceptance

2021 ◽  
Vol 86 (2) ◽  
pp. 523-530
Author(s):  
Jiuliane Martins da Silva ◽  
Carlos Eduardo Barão ◽  
Erick Almeida Esmerino ◽  
Adriano Gomes Cruz ◽  
Tatiana Colombo Pimentel
Keyword(s):  
Water Soluble ◽  
Soluble Extract ◽  
Frozen Dessert ◽  
Water Soluble Extract

Activation of Selective Transcription Factors and Cytokines by Water-Soluble Extract from Lentinus lepideus

2003 ◽  
Vol 228 (6) ◽  
pp. 749-758 ◽  
Author(s):  
Mirim Jin ◽  
Hyung Jin Jung ◽  
Jeong June Choi ◽  
Hyang Jeon ◽  
Jin Hwan Oh ◽  
...  
Keyword(s):  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Post Treatment ◽  
Water Soluble ◽  
Dependent Manner ◽  
Soluble Extract ◽  
Transient Transfection Assay ◽  
Gm Csf ◽  
Tnf Α ◽  
Water Soluble Extract

We isolated a water-soluble extract, PG101, from cultured mycelia of Lentinus lepideus. Treatment of human peripheral blood mononuclear cells (PBMCs) with PG101 increased levels of TNF-α, IL-1β, IL-10, and IL-12 by 100- to 1000-fold, whereas GM-CSF and IL-18 were activated by an order of magnitude. On the contrary, IFN-γ and IL-4 were not affected. The response to PG101 occurred in a dose- and time-dependent manner. From the human PBMCs treated with PG101, TNF-α was a first cytokine to be activated, detectable at 2 hr post-treatment followed by IL-1β at 6 hr post-treatment. IL-12 and IL-10 were the next to follow. GM-CSF and IL-18 both showed significant increases 24 hr after treatment. When PBMCs were sorted into various cell types, monocyte/macrophages, but not T and B cells, were the major target cell type responsive to PG101. Consistent with this result, the profile of cytokine expression upon PG101 treatment was comparable between PBMCs and a human promonocytic cell line (U937), whereas cell lines of T cell and myeloid origins did not respond to PG101. Data from a transient transfection assay involving specific reporter plasmids indicated that cellular transcription factor such as NF-κB, but not AP-1, was highly activated by PG101. Results from a gel retardation assay and the experiment involving a specific NF-κB inhibitor confirmed the involvement of NF-κB. Despite its significant biological effect on various cytokines, PG101 remained nontoxic in both rats and PBMCs even at a biological concentration approximately 20 times greater. PG101 demonstrates great potential as a therapeutic immune modulator.

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