THE RELATIONSHIP BETWEEN THE ONSET OF SEVERE PREECLAMPSIA AND PERINATAL COMPLICATIONS AT RUMKITAL Dr. RAMELAN IN SURABAYA

2021 ◽  
Vol 5 (2) ◽  
pp. 139
Author(s):  
Widya Retno ◽  
Ivon Diah Wittiarika ◽  
Muhammad Aldika Akbar
Keyword(s):  
Preterm Delivery ◽  
Early Onset ◽  
Late Onset ◽  
Previous History ◽  
Severe Preeclampsia ◽  
P Value ◽  
Chronic Hypertension ◽  
Perinatal Complications ◽  
Exact Test ◽  
The Relationship

 Abstract Background: Preeclampsia is one of the biggest causes of maternal-fetal morbidity and mortality. Based on the prognosis, the classification of Preeclampsia is early onset (<34 weeks) and late onset (> 34 weeks). Purpose: to investigate the relationship between the onset of severe Preeclampsia and perinatal complications. Method: This research is a quantitative study with a retrospective observational analytic study type and collected medical record data. The study population was severe Preeclampsia  patients who gave birth at RUMKITAL Dr. Ramelan Surabaya for the period January 2018 - June 2020 and has no previous history of chronic hypertension. The research sample was 79 subjects with 44 subjects early onset, and 35 subjects late onset. Perinatal complications  examined are preterm delivery, asphyxia, LBW, IUGR, stillbirth. The chi-square test or Fisher’s Exact Test was used to analyze relationships. Result: From the results of the study, the comparison of the percentage from early onset and late onset that experienced complications was 93.2% vs 48.6%, p-value = 0.000, OR = 14.5, CI = 3,764–55,635.  At preterm delivery, it was found that 75% vs 28.6%, p-value = 0.000,  OR = 7.5, CI = 2,754-20,422. . In asphyxia, it was found 41.7% vs 31.4%, p-value = 0.46. At LBW, it was found 72.7% vs 17.1%, p-value = 0,000, OR = 12.9, CI = 4,285-38,771. In IUGR, it was found that 15.9% vs 2.9%, p-value = 0.000. In stillbirth, it was found 18.2% vs 0% and p-value = 0.008. Conclusion: the onset of severe Preeclampsia is related with perinatal complications. Complications associated with the onset severe Preeclampsia are preterm, LBW, stillbirth. Meanwhile, complications that are not related with the onset severe Preeclampsia are asphyxia and IUGR  

Epidemiological Profile and Postpartum Outcome for Severe Preeclamptic Patients

2021 ◽  
pp. 45-50
Author(s):  
Suher Dafaus ◽  
Amel Morgham ◽  
Nasreen Osman
Keyword(s):  
Caesarean Section ◽  
Positive Family History ◽  
Previous History ◽  
Severe Preeclampsia ◽  
Intrauterine Fetal Death ◽  
Chronic Hypertension ◽  
Hypertensive Disorder ◽  
Adequate Treatment ◽  
History Of ◽  
The Mean

Background and objective. Preeclampsia is a multisystemic disorder, which involves the placenta, liver, blood, neurological and cardiovascular systems. It is one of the leading causes of maternal and fetal morbidity and mortality. This study aimed at describing the characteristic features for mothers who had severe preeclampsia and to know the complications during puerperium. Methods. A prospective study conducted over a period from February 2009 up to November 2009 involving 100 pre-eclampsia patients admitted and delivered in Aljalaa Maternity Hospital, Tripoli, Libya. Results. The patients mean age was 33.3 +5.9 years. The mean gestational age at admission time was 36.8+3.2 weeks and 64% of them were term. 58% of the patients with severe preeclampsia had a positive family history of chronic hypertension whereas 42% of patients had a previous history of preeclampsia. 40% of patients were primigravida. The mean systolic blood pressure at admission was 164+15.4 mmHg and the mean diastolic pressure was 113+6 mmHg. The common symptoms were headache, abdominal pain, and blurred vision (54%, 37%, and 31% respectively), whereas 9% of the patients presented with the eclamptic fit. The pregnancy in 66% patients ended by caesarean section, 78% of them were emergency caesarean section. The birth weight of 13% of new-borns was less than 1500 grams. Furthermore, 10% diagnosed with intrauterine fetal death (IUFD) antenatally and 9% died after admission to nursery intensive care unit post-delivery. Conclusion. the effects of hypertensive disorder associated with pregnancy could be prevented by close antenatal care particularly for whose had previous history of preeclampsia. In addition; early recognition and adequate treatment, and timely delivery can prevent preeclampsia and will improve maternal and neonatal outcomes.

O3-10-01: DIFFERENT EFFECTS OF APOE ε4 ALLELE ON THE RELATIONSHIP BETWEEN TAU AND β-AMYLOID IN EARLY-ONSET AND LATE-ONSET ALZHEIMER DISEASE

2006 ◽  
Vol 14 (7S_Part_19) ◽  
pp. P1039-P1040
Author(s):  
Young Noh ◽  
Tae Sung Lim ◽  
Sang-Yoon Lee ◽  
Kee Hyung Park ◽  
Dong Jin Shin ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Early Onset ◽  
Late Onset ◽  
Apoe Ε4 ◽  
Ε4 Allele ◽  
Β Amyloid ◽  
The Relationship

scholarly journals Early-onset social anxiety disorder in adults: clinical and therapeutic features

2005 ◽  
Vol 27 (1) ◽  
pp. 32-36 ◽  
Author(s):  
Gabriela Bezerra de Menezes ◽  
Leonardo F. Fontenelle ◽  
Márcio Versiani
Keyword(s):  
Anxiety Disorder ◽  
Social Anxiety ◽  
Social Phobia ◽  
Social Anxiety Disorder ◽  
Early Onset ◽  
Late Onset ◽  
Exact Test ◽  
Dsm Iv ◽  
Student’S T ◽  
Psychiatric Complications

OBJECTIVE: To investigate possible differences in clinical and treatment response in patients suffering from early-onset (< 18 years) and late-onset (>18 years) social anxiety disorder. METHODS: Patients diagnosed with social anxiety disorder of early-onset (n = 47; 75.8%) were compared to those diagnosed with late-onset social anxiety disorder (n = 15; 24.2%) in terms of age, mode of onset, subtype, psychiatric comorbidities (according to the Structured Clinical Interview for DSM-IV), symptom severity and response (assessed according to the Clinical Global Impression scale) after at least ten weeks of drug treatment. The statistical analyses included chi² tests with Yates correction or Fisher's exact test, as well as Student's t-test or Mann-Whitney test. The level of statistic significance adopted was 5%. RESULTS: Patients presenting early-onset phobic symptoms more frequently: were inactive (chi² = 4.28; df = 1; p = 0.04); suffered from the generalized subtype of social phobia (chi² = 6.53; df = 1; p = 0.01); and presented psychiatric comorbidity (chi² = 6.71; df = 1; p = 0.01). No differences were observed between the groups in severity of symptoms and therapeutic response. CONCLUSION: The findings suggest the existence of a possible social anxiety disorder subtype characterized by early onset of symptoms, higher rates of absenteeism, a wider range of social phobia symptoms and psychiatric complications.

The relationship of angiogenic factors to maternal and neonatal manifestations of early-onset and late-onset preeclampsia

2014 ◽  
Vol 34 (11) ◽  
pp. 1084-1092 ◽  
Author(s):  
Cilene Carlos Pinheiro ◽  
Patricia Rayol ◽  
Luiz Gozzani ◽  
Luciene Machado dos Reis ◽  
Gianfranco Zampieri ◽  
...  
Keyword(s):  
Early Onset ◽  
Late Onset ◽  
Angiogenic Factors ◽  
Relationship Of ◽  
The Relationship

scholarly journals Maternal Serum Angiogenic Factor sFlt-1 to PlGF Ratio in Preeclampsia: A Useful Marker for Differential Diagnosis and Prognosis Evaluation in Chinese Women

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Wei-zhen Lou ◽  
Fang Jiang ◽  
Jing Hu ◽  
Xiao-xu Chen ◽  
Ying-na Song ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Early Onset ◽  
Late Onset ◽  
Gestational Hypertension ◽  
Angiogenic Factor ◽  
Chronic Hypertension ◽  
Control Groups ◽  
Roc Curve Analysis ◽  
And Control ◽  
Plgf Ratio

The ratio of soluble fms-like tyrosine kinase-1 to placental growth factor (sFlt-1/PlGF) is elevated and proved to be useful in preeclampsia (PE) diagnosis. Its value in differential diagnosis with other pregnancy complications and prediction of pregnancy duration has yet to be clarified in Chinese population. We retrospectively analyzed 118 singleton pregnancies with suspected or diagnosed PE at the Peking Union Medical College Hospital (PUMCH) in China. Among these, 62 pregnancies were diagnosed as PE (48 early onsets and 14 late onsets, with 39 and 5 severe PE, respectively), 12 gestational hypertension (GH), 15 chronic hypertension (chrHTN), 16 autoimmune diseases, and 13 pregnancies with uncomplicated proteinuria. And 76 normal pregnancies were included as control. The results showed (1) the sFlt-1/PlGF ratio in early onset PE subgroup was significantly higher than that in GH, chrHTN, and control groups; the sFlt-1/PlGF ratio in late onset PE subgroup was significantly higher than that in chrHTN and control groups, but similar as GH group; the sFlt-1/PlGF ratio was similar among GH, chrHTN, and control groups. (2) The sFlt-1/PlGF ratio was significantly increased in the PE group compared with autoimmune disease and uncomplicated proteinuria pregnancies. (3) By ROC curve analysis, the cutoff value of the sFlt-1/PlGF ratio was less than 21.5 to rule out PE and higher than 97.2 to confirm the diagnosis of PE. (4) The sFlt-1/PlGF ratio was higher in PE pregnancies delivering within 7 days than those more than 7 days, either in early onset PE or severe PE. In conclusion, we show that maternal sFlt-1/PlGF ratio is an efficient biomarker in the diagnosis and differential diagnosis of PE. This ratio can be used to predict the timing of delivery for PE pregnancies.

scholarly journals HUBUNGAN ANTARA PARITAS, RIWAYAT KEHAMILAN,DAN ASUPAN KALSIUM DENGAN KEJADIAN PRE EKLAMPSIA BERAT

2019 ◽  
Vol 10 (2) ◽  
pp. 358
Author(s):  
Diah Andriani ◽  
Rusnoto Rusnoto
Keyword(s):  
Pregnant Women ◽  
Calcium Intake ◽  
Severe Preeclampsia ◽  
Influential Factor ◽  
Bivariate Analysis ◽  
P Value ◽  
Pregnancy History ◽  
History Of ◽  
Relationship Of ◽  
The Relationship

Latar Belakang: Preeklampsia/eklampsia merupakan salah satu penyebab utama morbiditas dan mortalitas perinatal di Indonesia. Sampai sekarang penyakit preeklamsia/eklamsia masih merupakan masalah kebidanan yang belum dapat erpecahkan secara tuntas. Preeklampsia merupakan penyakit yang angka kejadiannya di setiap negara berbeda-beda.Tujuan : Mengetahui hubungan paritas, riwayat kehamilan,dan asupan kalsium dengan kejadian pre eklampsia berat di UPT Puskesmas Jepang.Metode: Dalam penelitian ini yang menjadi populasi adalah semua ibu hamil yang melakukan ANC di Puskesmas Jepang Kecamatan Mejobo Kabupaten Kudus pada bulan Agustus 2017 sebanyak 30 ibu hamil.Sampel dalam penelitian ini adalah ibu hamil yang melakukan kunjungan ANC di Puskesmas Jepang Kecamatan Mejobo Kabupaten Kudus  pada bulan Agustus 2017 sebanyak 30 orang. Analisis data menggunakan analisis univariat dan bivariat. Hasil penelitian Mayoritas responden memiliki paritas multipara sebanyak 18 orang (60%), dan yang primipara sebanyak 12 orang (40%). Mayoritas responden memiliki riwayat tidak pernah pre eklampsia berat sebanyak 16 orang (53,3%) dan yang pernah pre eklampsia berat sebanyak 14 orang (46,7%). Mayoritas responden memiliki asupan kalsium cukup sebanyak 18 orang (60%) dan yang asupan kalsium tidak cukup sebanyak 12 orang (40%). Mayoritas responden tidak pre eklampsia berat sebanyak 18 orang (60%) dan yang pre eklampsia berat sebanyak 12 orang (40%). Ada  hubungan paritas dengan kejadian pre eklampsia berat di upt puskesmas jepang (p value = 0,001). Ada  hubungan riwayat kehamilan dengan kejadian pre eklampsia berat di upt puskesmas jepang (p value = 0,001). Ada  hubungan asupan kalsium dengan kejadian pre eklampsia berat di upt puskesmas jepang (p value = 0,009). Berdasarkan analisis regresi faktor yang paling berpengaruh dengan kejadian pre eklampsia berat adalah asupan kalsium (koefisien = 0,477). Kesimpulan Ada  hubungan paritas, riwayat kehamilan dan asupan kalsium dengan kejadian pre eklampsia berat di UPT Puskesmas Jepang..Kata Kunci      : Preeklampsia berat, paritas, riwayat kehamilan, asupan kalsiu ABSTRACT Background: Preeclampsia / eclampsia is one of the major causes of perinatal morbidity and mortality in Indonesia. Until now the disease of preeclampsia / eclampsia is still a matter of obstetrics that can not be eradicated completely. Preeclampsia is a disease whose number of events in each country is different. Objective: To determine the relationship of parity, pregnancy history, and calcium intake with the incidence of severe pre eclampsia Method: In this study the population is all pregnant women who do the ANC at the Health Center of Jepang District Mejobo Kudus Regency in August 2017 as many as 30 pregnant women. Samples in this study were pregnant women who visited the ANC at the Puskesmas Jepang District Mejobo Kudus District on in August 2017 as many as 30 people. Data analysis used univariate and bivariate analysis. Result of research Majority of respondents have multiparity parity as many as 18 people (60%), and primipara 12 (40%). The majority of respondents have a history of never preeclampsia  as many as 16 people (53.3%) and who ever peb as many as 14 people (46.7%). The majority of respondents have enough intake of calcium as many as 18 people (60%) and who intake of calcium is not enough as many as 12 people (40%). The majority of respondents are not preeclampsia as many as 18 people (60%) and who preeclampsia  as many as 12 people (40%). There is a parity relationship with the incidence of severe eclampsia in Puskesmas Jepang upt (p value = 0.001). There was a correlation of pregnancy history with severe pre eclampsia incidence at upt Puskesmas jepang  (p value = 0,001). There is a correlation of calcium intake with severe pre eclampsia occurrence at UPT Puskesmas jepang  (p value = 0,009). Based on regression analysis the most influential factor with severe pre eclampsia incidence was calcium intake (coefficient = 0.477). Conclusion There was a parity relationship, a history of pregnancy and calcium intake with severe preeclampsia events at the UPT Puskesmas Jepang. . Keywords: severe preeclampsia, parity, pregnancy history, calcium supplements  

scholarly journals The Relationship between Duration of Benzene Exposure with Liver Enzymes in Car Painting Workshop Workers

2021 ◽  
Vol 10 (3) ◽  
pp. 361
Author(s):  
Fitri Yatulaini ◽  
Abdul Rohim Tualeka ◽  
Juliana Jalaludin ◽  
Syamsiar S Russeng
Keyword(s):  
The Body ◽  
Observational Research ◽  
P Value ◽  
Test Results ◽  
Cross Sectional ◽  
Exact Test ◽  
Benzene Exposure ◽  
Measurement Results ◽  
Basic Parameters ◽  
The Relationship

Introduction: Benzene is a carcinogenic compound that can be found in a car painting workshop in Surabaya. The source of benzene in the car painting workshop comes from thinners. Inhalation is the main route for benzene to enter the body. The duration of benzene exposure can affect the accumulation of benzene concentrations. If work safety is not considered, the benzene compound can cause the liver disease. Furthermore, SGOT and SGPT are basic parameters of liver function. The study aims to determine the relationship between the duration of benzene exposure with SGOT and SGPT levels in car painting workshop workers. Method: observational research with a cross-sectional approach was applied as the method of this study. The research was conducted in a car painting workshop in 2019 with 20 workers. The variables were the duration of benzene exposure (hours/day) and levels of SGOT and SGPT. Data analysis used the Fisher's Exact Test and Coefficient Contingency test. Results: Workers worked with a duration of benzene exposure ≤ 8 hours/day by 70% and > 8 hours/day by 30%. The measurement results exceeded the normal limit with the value of SGOT of 15% and the SGPT of 30%. Furthermore, the Sstatistical test show p-values between the duration of benzene exposure and SGOT (0.202) and SGPT (0.303), body weight with SGOT (1.000) and SGPT (1.000), education with SGOT (0.199) and SGPT (0.182) and alcohol consumption with SGOT (1.000) and SGPT (1.000). Conclusion: There was no relationship between the duration of benzene exposure with SGOT and SGPT levels in car painting workshop workers in Surabaya with a p-value >0.05.Keywords: car painting workers, duration of benzene exposure, SGOT, SGPT 

scholarly journals Correlation of Ship Sanitation with Cockroach Density in Kendari Port Area

2021 ◽  
Vol 4 (1) ◽  
pp. 102-112
Author(s):  
Sriwani Supardin
Keyword(s):  
High Risk ◽  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
Exact Test ◽  
Fisher's Exact Test ◽  
Port Area ◽  
Fisher’S Exact Test ◽  
The Relationship

Ship sanitation is an indicator of vessel cleanliness, vector control in 2017 no high-risk vessels were found, in 2018 there were 7 high-risk vessels and in 2019 there were 15 high-risk vessels. This study aims to determine the relationship between kitchen sanitation, food raft space and warehouse with cockroach density on ships in the Kendari port area. This type of research is an observational, Cross-Sectional Study design. The population is all ships berthed in the Kendari port area as many as 41 ships and a sample of 37 vessels taken by purposive sampling. Data analysis used fisher's exact test. The results showed that of the 37 ships, the highest density of cockroaches met the requirements (75.7%), the rest did not meet the requirements (24.3%). The kitchen sanitation met the requirements (75.7%), the rest did not meet the requirements (24.3%), then the food raft room sanitation met the requirements (83.8%) and did not meet the requirements (16.2%). Furthermore, warehouse sanitation fulfills the requirements (62.2%) and does not meet the requirements (37.8%). The results of Fisher's exact test obtained p value (0,000). The conclusion of this study is that there is a relationship between kitchen sanitation, food raft space and warehouse with cockroach density on ships in the Kendari port area. Suggestions for the KKP to establish policies to prevent cockroach development.

scholarly journals Pengetahuan Masyarakat Penghuni Gunung Kemukus Tentang Pencegahan HIV-AIDS Di Kabupaten Sragen

2016 ◽  
Vol 5 (1) ◽  
Author(s):  
Dwi Sulistyowati
Keyword(s):  
Sex Workers ◽  
Aids Prevention ◽  
P Value ◽  
Commercial Sex ◽  
Chi Square ◽  
Cross Sectional ◽  
Commercial Sex Workers ◽  
Exact Test ◽  
The Relationship ◽  
Hiv Aids

Abstract: Commercial Sex Workers, Knowledge, HIV-AIDS Prevention Efforts. The number of HIV-AIDS sufferers in Indonesia continues to increase and most productive attacking a young age. Health care workers interview results in Hospital SoeratnoGemolong in October 2014, there were 25 HIV-positive AIDS, largely affected by HIV-AIDS is not a native districts Miri Sragen. To analyze the mountain commercial sex workers kemukus knowledge about HIV-AIDS on HIV-AIDS prevention. The study design was observational analytic, using a cross-sectional approach in which to make observations and measurements only once when the measurement variables were analyzed with the model Kai squared test (Chi-Square) to analyze the relationship between one or more independent variables with the dependent variable category. The result of statistical test analysis Fisher's exact Test the relationship between knowledge of HIV-AIDS prevention efforts gained value P-Value: 0.005> 0.001. HIV-AIDS prevention at the commercial sex workers in Mount Kemukus significant associated with HIV-AIDS knowledge

scholarly journals Perbedaan Rerata Kadar Soluble Fms-Like Tyrosine Kinase-1 (Sflt-1) Serum pada Penderita Early Onset, Late Onset Preeklampsia Berat / Eklampsia dan Kehamilan Normal

2016 ◽  
Vol 5 (1) ◽  
Author(s):  
Laila Rahmi ◽  
Rahmatina B. Herman ◽  
Yusrawati Yusrawati
Keyword(s):  
Growth Factor ◽  
Tyrosine Kinase ◽  
Early Onset ◽  
Late Onset ◽  
Serum Levels ◽  
Normal Pregnancy ◽  
Severe Preeclampsia ◽  
Cross Sectional ◽  
Post Hoc ◽  
Endothelial Growth Factor

AbstrakPreeklampsia merupakan sumber utama morbiditas dan mortalitas ibu di seluruh dunia. Kegagalan pengaturan dan ketidakseimbangan agen vasoaktif proangiogenik dan antiangiogenik plasenta, soluble fms-like tyrosine kinase-1 (sFlt-1), vascular endothelial growth factor (VEGF) dan placental growth factor (PlGF) memainkan peran penting dalam patogenesis preeklampsia. Tujuan penelitian ini adalah menentukan perbedaan rerata kadar sFlt-1 serum pada penderita early onset, late onset preeklampsia berat/ eklampsia dan kehamilan normal. Penelitian dilakukan di RSUP Dr. M. Djamil, RS TK. III dr. Reksodiwiryo dan Laboratorium Biologi Molekuler Fakultas Kedokteran Universitas Andalas Padang dari Februari sampai  Desember 2014 dengan desain cross sectional. Subjek berjumlah 84 orang, terdiri dari tiga kelompok, yaitu kelompok early onset preeklampsia berat/ eklampsia, late onset preeklampsia berat/ eklampsia, dan kehamilan normal sebagai kelompok kontrol yang diambil dengan teknik consecutive sampling. Darah dikumpulkan dari subjek penelitian dengan cara intravena kemudian diukur dengan metode ELISA. Rerata kadar sFlt-1 pada kelompok early onset, late onset preeklampsia berat/ eklampsia dan kehamilan normal secara berturut-turut adalah 4,69±0,96 ng/ml, 2,39±0,57 ng/ml, dan 1,23±0,42 ng/ml. Perbedaan ini sangat signifikan dengan uji statistik ANOVA (p<0,05) dan uji Post Hoc Test Multiple Comparisons. Kesimpulan penelitian adalah terdapat perbedaan yang sangat signifikan antara kadar sFlt-1 serum pada kelompok early onset preeklampsia berat/ eklampsia, late onset preeklampsia berat/ eklampsia dan kehamilan normal.Kata kunci: sFlt-1, antiangiogenik, preeklampsia berat/ eklampsia, kehamilan normal AbstractPreeclampsia is a major cause maternal morbidity and mortality in the world. Failure regulation and imbalance of vasoactive agents and antiangiogenic proangiogenik placenta, soluble fms-like tyrosine kinase-1 (sFlt-1), vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) have an important role in the pathogenesis of preeclampsia. The objective of this study was to determine the differences between the mean serum levels of sFlt-1 in patients with early onset, late onset severe preeclampsia/eclampsia and normal pregnancy. This study was conducted in Dr. M. Djamil hospital, dr. Reksodiwiryo TK. III hospital and Biology Moleculer Laboratory Medicine Faculty of Andalas University Padang from February until December 2014 with a cross sectional design. The total subjects were 84 persons, consist of three groups, there was early onset severe preeclampsia/ eclampsia, late onset severe preeclampsia/ eclampsia and normal pregnancy as control group. The subjects were selected by consecutive sampling technique. The blood was collected by intravenous,  then sFlt-1 serum measured by ELISA. The mean levels of sFlt-1 in the early onset group, late onset severe preeclampsia/ eclampsia group and normal pregnancy group were 4.69±0.96 ng/ml, 2.39±0.57 ng/ml and 1.23±0.42 ng/ml. This difference very significant by ANOVA statisctical test (p<0,05) and Multiple Comparisons Post Hoc Test. The conclusion of this study is very significant differences between serum levels of sFlt-1 in early onset severe preeclampsia/ eclampsia group, late onset severe preeclampsia/ eclampsia on  normal pregnancy.Keywords: sFlt-1, antiangiogenic, severe preeclampsia/ eclampsia, normal pregnancy

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