scholarly journals Knowledge of Cancer cervix and its causative agents among HIV-infected and HIV-uninfected adolescent women in rural Medical College in Maharashtra, India

2019 ◽  
Vol 8 (6) ◽  
pp. 2342
Author(s):  
Ravi M. Raval ◽  
Vaibhav B. Patil ◽  
Pradnya P. Thaware
Keyword(s):  
Cervical Cancer ◽  
Large Scale ◽  
Papilloma Virus ◽  
Hpv Knowledge ◽  
Medical College ◽  
Adolescent Women ◽  
Knowledge Based ◽  
Significant Difference ◽  
Causative Agents ◽  
Knowledge Of Cancer

Background: The aim of this study is to examine the knowledge of human papilloma virus (HPV) and cervical cancer among HIV-infected and HIV-uninfected female adolescents attending Antenatal OPD in Department of Obstetrics and Gynecology, Government Medical College, Miraj, Maharashtra, India.Methods: Subjects were recruited randomly from OPD attending patients.  A total of 30 subjects, 15 HIV-infected and 15 HIV-uninfected were selected via randomization and completed a measure of HPV knowledge, based on a previously validated instrument. The study took place in December 2017.Results: The overall mean score on the measure for all subjects was 43.3% (S.D. 10.9). There was no significant difference in HPV knowledge between the HIV-infected and HIV-uninfected groups. Based on results from a previous large-scale study using the same validated measure, this sample scored significantly worse on general HPV knowledge than samples from the other studies.Conclusions: Given the limited knowledge of HPV in this sample, there is greater need for education about the prevention of cervical cancer, specifically among high-risk adolescent women.

scholarly journals Breakthroughs and Issues in HPV Genital Infections in relation to Cervical Cancer

2012 ◽  
Vol 1 (2) ◽  
pp. 27-30
Author(s):  
Farhat Hussain ◽  
Khairun Nahar ◽  
Kaniz Fatema ◽  
Mahbuba Khan
Keyword(s):  
Cervical Cancer ◽  
Pap Smear ◽  
Pap Test ◽  
Cervical Cancer Prevention ◽  
Cervical Lesions ◽  
Related Condition ◽  
Papilloma Virus ◽  
Medical College ◽  
Hpv Test ◽  
Neoplastic Process

The field of cervical cancer prevention is rapidly evolving because of identification of the cause of disease. Human Papilloma Virus (HPV) has been recognized as a necessary cause of cervical cancer, and the association applies equally to both squamous cell and adenocarcinoma and is consistent worldwide. HPV 16 and 18 together attribute 70% of world's cervical cancer. HPV is highly prevalent among sexually active women and traceable in its natural history with technology that can detect HPV DMA at all stages of infection and neoplastic process. HPV DMA testing represents the scientifically obvious next step after Pap test for secondary prevention. A clinically validated and FDA approved HPV test has proven a substantial gain in sensitivity with a limited loss in speciality as compared to the standard Pap smear. We are now in the fortunate position of having two highly promising HPV vaccines in the pipeline. These vaccines today represent new hope for protection against cervical cancer, pre-cancerous cervical lesions and other HPV related condition for the current generation of adolescents, for the young and middle aged women as well as for the future generations. DOI: http://dx.doi.org/10.3329/jssmc.v1i2.12163 Journal of Shaheed Suhrawardy Medical College Vol.1, No.2, December 2009 p.27-30

scholarly journals Awareness about human papilloma virus vaccine among medical students

2016 ◽  
Vol 7 (4) ◽  
pp. 64-67 ◽  
Author(s):  
Snigdha Kamini ◽  
Devi Madhavi Bhimarasetty
Keyword(s):  
Health Care ◽  
Cervical Cancer ◽  
Medical Students ◽  
Human Papilloma Virus ◽  
Health Care Providers ◽  
Hpv Vaccination ◽  
Human Papilloma Virus Vaccine ◽  
Care Providers ◽  
Papilloma Virus ◽  
Medical College

Background: Human papilloma virus is a causative agent of cervical cancer. Hence,vaccination against HPV is an important mode of primary prevention against cervical cancer. Two vaccines against HPV have been approved and recommended for use in India. However the availability of these vaccines is hardly known and seldom utilised even among the medical fraternity.Aims and Objectives: This study aims to find out the awareness about HPV vaccination among medical students of Andhra Medical College, India. Results of this study will help in assessing the need for awareness programs among health care professionals regarding this important public health issue. Materials and Methods: An observational descriptive study was conducted to know the awareness of HPV infection and vaccination among medical students of a government medical college at Visakhapatnam in Andhra Pradesh. A pretested questionnaire was administered to students of final MBBS Part 1 and final MBBS part 2. Results were analyzed in MS excel and the statistical significance of difference in knowledge between males and females was assessed. Results: Overall, the level of awareness reported was 54.5%. Females had slightly better knowledge than males. Students of final year Part 2 had better knowledge the Final year part 1. The most commonly cited source of information was medical education and the most important factor that deterred subjects from receiving/advising HPV vaccination was lack of knowledge. Conclusion: There exists a large gap in knowledge regarding HPV vaccination. Addressing this gap is necessary if we want to decrease the burden of cervical cancer in India. Medical students, health care providers should be sensitized first and then we should reach out to the public.Asian Journal of Medical Sciences Vol.7(4) 2016 64-67

The Application of DNA Ploidy Analysis in Large-Scale Population Screening for Cervical Cancer

2021 ◽  
pp. 1-8
Author(s):  
Yulin Guo ◽  
Qiuzi Peng ◽  
Ying Wang ◽  
Lu Li ◽  
Xiaoyun Yi ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Predictive Value ◽  
Large Scale ◽  
Dna Ploidy ◽  
Population Screening ◽  
Opportunistic Screening ◽  
Ploidy Analysis ◽  
Significant Difference ◽  
Scale Population

<b><i>Objective:</i></b> The objective of this study was to evaluate the application of DNA ploidy analysis in large-scale population screening for cervical cancer. <b><i>Methods:</i></b> From March 2016 to March 2019, eligible subjects were enrolled and recommended to undergo DNA ploidy analysis, the ThinPrep cytology test (TCT), and high-risk human papillomavirus (hrHPV) detection concurrently. Patients with positive results were recommended for colposcopy, and biopsy diagnosis was regarded as the “gold standard.” We compared the test efficiencies of the 3 methods and compared the efficiency and accuracy of the TCT in our hospital and the “2-cancer screening” project in Hubei Province during the same period. <b><i>Results:</i></b> Among 20,574 women, the positive rates of DNA ploidy analysis, cytology, and hrHPV testing were 4.01%, 4.71%, and 16.28%, respectively. The sensitivities of these methods for screening for grade 2+ cervical intraepithelial neoplasia were 0.70, 0.68, and 0.96, and their specificities were 0.79, 0.82, and 0.45, respectively. On comparing DNA ploidy analysis with the TCT, there was no significant difference in the sensitivity, specificity, positive predictive value, negative predictive value, and missed diagnosis rate. In opportunistic screening and the 2-cancer screening project, the positive rates of cytology were 4.71% and 2.87%, respectively. And the efficiency and accuracy of the TCT in opportunistic screening were higher than in the 2-cancer screening project. <b><i>Conclusion:</i></b> Therefore, DNA ploidy analysis, which is of low-cost and does not depend on cytopathologists, can replace cytology and be applied in large-scale population screening for cervical cancer.

scholarly journals Lab-on-Chip assay of tumour markers and Human Papilloma Virus for cervical cancer detection at point-of-care

2021 ◽  
Author(s):  
Benjamin W. Wormald ◽  
Nicolas Moser ◽  
Nandita M. deSouza ◽  
Katerina-Theresa Mantikas ◽  
Kenny Malpartida-Cardenas ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papilloma Virus ◽  
Large Scale ◽  
Htert Mrna ◽  
Human Telomerase Reverse Transcriptase ◽  
Tissue Samples ◽  
Papilloma Virus ◽  
Lab On Chip ◽  
Hpv Dna ◽  
On Chip

Abstract Cervical cancer affects over half a million people worldwide each year, the majority of whom are in resource-limited settingswhere cytology screening is not available. As persistent human papilloma virus (HPV) infections are a key causative factor,detection of HPV strains now complements cytology where screening services exist. This work demonstrates the efficacy of ahandheld Lab-on-Chip (LoC) device in detecting cervical cancer from biopsy samples. The device is based on Ion-SensitiveField-Effect Transistor (ISFET) sensors used in combination with loop-mediated isothermal amplification (LAMP) assays, toamplify HPV DNA and human telomerase reverse transcriptase (hTERT) mRNA. These markers were selected because of theirhigh levels of expression in cervical cancer cells, but low to nil expression in normal cervical tissue. The achieved analyticalsensitivity for the molecular targets resolved down to a single copy per reaction for the mRNA markers, achieving a limit ofdetection of 102for hTERT. In the tissue samples, HPV-16 DNA was present in 4/5 malignant and 2/5 benign tissues, withHPV-18 DNA being present in 1/5 malignant and 1/5 benign tissues. hTERT mRNA was detected in all malignant and nobenign tissues, with the demonstrated pilot data to indicate the potential for using the LoC in cervical cancer screening inresource-limited settings on a large scale

A new perspective of different schemes of neoadjuvant chemotherapy followed by concurrent chemotherapy and radiotherapy for locally advanced cervical cancer.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e18011-e18011
Author(s):  
Xue Tian ◽  
Fenghu Li ◽  
Ran Li ◽  
Feiyue Yang ◽  
Jianying Chang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Large Scale ◽  
Locally Advanced ◽  
Survival Rates ◽  
Concurrent Chemotherapy ◽  
External Beam Radiation ◽  
Intracavitary Brachytherapy ◽  
Beam Radiation ◽  
Significant Difference

e18011 Background: To observe the clinical effect, survival time and toxicity and side effects in unoperated cervical cancer patients treated with different schemes of neoadjuvant chemotherapy (NACT) followed by concurrent chemotherapy and radiotherapy (CCRT). Methods: A retrospective analysis was performed in 120 patients who were followed up until they died or being followed up at least 5 years. The treatment schedules consisted of 2 cycles of intravenous paclitaxel 135-175 mg/m2 plus cisplatin 60-80mg/m2 (TP group, 62 patients) or lobaplatin 30mg/m2 (TL group, 58 patients) every 21 days. Patients were then submitted to CCRT. Chemotherapy regimen of CCRT was cisplatin 40 mg/m2 (TP group) or lobaplatin 30mg/m2 (TL group) weekly. External beam radiation therapy (total 50.4-56.35Gy, 28 fractions, 180-215cGy per fraction daily) was administered using the3D-CRT or IMRT followed by intracavitary brachytherapy (5Gy per fractions, mostly 5 fractions, Ir192 based). Results: The proportion who had a complete/partial response was 81.7% after NACT, and 99.2% after all treatment. In all patients, the one-year, three-year and five-year survival rates were 99.2%, 81.7% and 69.2% respectively. In TP group vs. TL group, the 3-yr and 5-yr survival rates were 85.5% vs.77.6% (χ2= 1.248, p = 0.264) and 75.8% vs. 63.8% (χ2= 2.059, p = 0.151) with no significant difference. In mass size ≥ 5cm group vs. <5cm group, 3-yr survival rates were 88.0% vs.77.1% with no significant difference (χ2= 2.296, p = 0.130), but 5-yr survival rates were 82.0% vs.61.4% (χ2= 5.878, p = 0.015) with significant difference. The 3-yr and 5-yr OS rates between stage IIB and stage IIIB were not significantly different, respectively 83.1% vs. 70.6% (χ2= 2.083, p = 0.149) and 67.7% vs. 64.7% (χ2= 0.090, p = 0.765) . In TP group, grade 3 or 4 digestive reaction was obviously more frequent than TL group, respectively 54.3% vs. 1.8%(p = 0.000). Neutropenia and thrombocytopenia are more common in TL group than TP group, respectively 48.3% vs. 30.6%(p = 0.0.048) and 44.8% vs. 1.6%(p = 0.000). Conclusions: For patients with severe digestive system reaction or contraindications of cisplatin, lobaplatin was might be used as an alternative drug. A prospective research is undergoing in our hospital. NACT may improve the prognosis of patients with large-scale mass. A undergoing prospective study protocol was approved by the Ethics Committee of hospital number 2017-02 and was registered in ClinicalTrial.gov as ChiCTR-IIR-17011559.

HPV VACCINE AND CERVICAL CANCER

2011 ◽  
pp. 108-115
Author(s):  
Vu Quoc Huy Nguyen
Keyword(s):  
Cervical Cancer ◽  
Relative Risk ◽  
Hpv Vaccine ◽  
Hpv Vaccination ◽  
Preventive Strategy ◽  
Protective Effects ◽  
Papilloma Virus ◽  
Vaccine Trials ◽  
Close Relationship ◽  
The Relationship

Persistent infection with high-risk Human Papilloma Virus (HPV) has been identified as the causal factor of cervical cancer, with relative risk up to 300-400 folds. This very close relationship leads to the preventive strategy of vaccination against HPV infections and HPV-related lesions. The article describes molecular and immunologic characteristics of HPV, currently available HPV vaccines and its protective effects; the relationship between HPV vaccination and cervical cancer screening, and an introduction to therapeutic HPV vaccine trials.

A Synopsis on the Role of Human Papilloma Virus Infection in Cervical Cancer

2018 ◽  
Vol 19 (9) ◽  
pp. 798-805 ◽  
Author(s):  
Mohd Saeed ◽  
Fawaz D. Alshammari ◽  
Md. Jahoor Alam ◽  
Khan Mohd Sarim ◽  
Khurshid Ahmad ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Virus Infection ◽  
Human Papilloma Virus ◽  
Human Papilloma Virus Infection ◽  
Papilloma Virus

scholarly journals A comparative evaluation of post placental intrauterine contraceptive device (IUCD) insertion between normal delivery and caesarean section

2018 ◽  
Vol 7 (9) ◽  
pp. 3826
Author(s):  
Sharmistha Sarkar ◽  
Dhruba Prasad Paul ◽  
Jayanta Ray
Keyword(s):  
Caesarean Section ◽  
Vaginal Delivery ◽  
Comparative Evaluation ◽  
P Value ◽  
Contraceptive Device ◽  
Government Medical College ◽  
Expulsion Rate ◽  
Medical College ◽  
Significant Difference ◽  
Post Placental

Background: Adverse maternal and perinatal outcomes are related to pregnancies spaced too closely together. Objective of present study was to compare the expulsion rate and complications between post placental IUCD insertion between caesarean section and vaginal delivery.Methods: This study was a prospective comparative study conducted in the department of Obstetrics and Gynecology, at Agartala Government Medical College over 1.5 Years (January 2016-June2017) All cases at term pregnancy delivering by caesarean section and vaginal delivery were divided into two different groups. Sample size of 105 in each group. Subjects recruited from-obstetrics OPD and casualty of Agartala Government Medical College (AGMC) and GB Pant Hospital expulsion rate and complications. Comparative evaluation of Expulsion rate and complications following post placental IUCD insertion between caesarean section and vaginal delivery at the end of six months, one year and one and half year.Results: There was no significant difference in either complications between the two groups (P value-.913) or outcomes (p value-.035). Expulsion rate 18.2% following vaginal delivery compared to those with intracaesarean insertion i.e 3.8%.Conclusions: The complications associated with postplacental Intrauterine device insertion is insignificant, still the awareness, acceptance and continuation are very low. Therefore Information, education Communication activity by the field workers must be enhanced to overcome this knowledge gap.

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