scholarly journals Effects of thrombocytopenia in pregnancy

2018 ◽  
Vol 7 (3) ◽  
pp. 1044 ◽  
Author(s):  
Shital N. Kapadia ◽  
Harsh S. Patel ◽  
Kartikey G. Parmar
Keyword(s):  
Platelet Count ◽  
Retrospective Study ◽  
Gestational Age ◽  
Antenatal Visit ◽  
Civil Hospital ◽  
Multiple Factors ◽  
Gestational Thrombocytopenia ◽  
Common Etiology ◽  
One Year ◽  
In Pregnancy

Background: Thrombocytopenia defined as platelet count of less than 1,50,000/cu.mm. Thrombocytopenia is divided according to severity into mild moderate and severe types. Multiple factors are responsible.Methods: This is a retrospective study of one-year period including 120 pregnant patients irrespective of their gestational age at civil hospital Ahmedabad. Etiology of this condition are identified and analyzed.Results: Gestational Thrombocytopenia is the most common etiology. This condition is self-limiting usually.Conclusions: Platelet count estimation should be a routine at first antenatal visit for timely diagnosis and to achieve favorable fetomaternal outcome. 

scholarly journals Thrombocytopenia during pregnancy: an institutional based prospective study of one year

2017 ◽  
Vol 5 (8) ◽  
pp. 3502
Author(s):  
Anubha Pandey ◽  
Roma Singh
Keyword(s):  
Critical Role ◽  
Blood Platelet ◽  
Moderate Degree ◽  
Blood Disorders ◽  
Gynecology And Obstetrics ◽  
Gestational Thrombocytopenia ◽  
Number Of Patients ◽  
Common Etiology ◽  
One Year ◽  
In Pregnancy

Background: Platelets are non-nucleated cellular fragments of megakaryocytes, they play a critical role in haemostasis. Thrombocytopenia, defined as blood platelet count below 150.000/μL is the second leading cause of blood disorders in pregnancy after anemia. It complicates 7 to 10% of all pregnancies. Gestational thrombocytopenia explains 70-80% of all cases of thrombocytopenia in pregnancy. Hypertensive disorders account for approximately 20% and immune thrombocytopenic purpura for about 3-4%. Other etiologies are considered rare in pregnancy.Methods: The study was conducted in the tertiary institute over a period of one year, from January 2016 to December 2016. The samples of blood were collected from the Antenatal out-patient department and from indoor patients of the department of gynecology and obstetrics of the J.K. Hospital, Bhopal, Madhya Pradesh India.Results: Maximum number of patients had moderate degree of anemia around 58%. Most of the cases presented during 30-34 weeks of gestation. The most common etiology was gestational thrombocytopenia.Conclusions: Thrombocytopenia in pregnancy may occur secondary to a variety of causes. Most of these cases occur during specific periods of gestation. Management of pregnant women with platelet disorders requires a multidisciplinary approach and close collaboration between obstetric and hepatologist.

scholarly journals Study of thrombocytopenia in pregnancy: clinical presentation and outcome at tertiary care rural institute

2020 ◽  
Vol 9 (4) ◽  
pp. 1622
Author(s):  
Jigyasa Singh ◽  
Kalpana Kumari ◽  
Vandana Verma
Keyword(s):  
Platelet Count ◽  
Prospective Observational Study ◽  
Clinical Presentation ◽  
Tertiary Care ◽  
Late Pregnancy ◽  
Normal Platelet ◽  
Gestational Thrombocytopenia ◽  
Underlying Causes ◽  
In Pregnancy ◽  
Rule Out

Background: Platelet count below 1.5 lakh/cumm is called as thrombocytopenia. After anaemia it is the second most common haematological disorder in pregnancy. It affects nearly 6 to 15%; on an average 10% of all pregnancies. Gestational thrombocytopenia is a clinically benign thrombocytopenic disorder usually occurring in late pregnancy. It resolves spontaneously after delivery.Methods: It is a hospital based prospective observational study over a period of 1 year. All pregnant women who attended OPD at the department of obstetrics and gynecology, UPUMS, Saifai for antenatal checkup were included for the study and blood sample was withdrawn.Results: Out of 263 cases enrolled for study, 90 women were found to have thrombocytopenia, and 173 had normal platelet count. Thus, incidence of thrombocytopenia was 34%. Gestational thrombocytopenia accounted for majority of cases of thrombocytopenia in pregnancy (50%) followed by hypertensive disorders (22.4%). It was further followed by ITP (11.11%) and dengue (5.5%).Conclusions: Gestational thrombocytopenia is the most common cause of thrombocytopenia during pregnancy (50%), but other underlying causes must be considered as well. A thorough history and physical examination will rule out most causes.

scholarly journals Analysis of fetomaternal outcome of COVID-19 antenatal mothers-initial experience

2021 ◽  
Vol 10 (2) ◽  
pp. 723
Author(s):  
Priyanka Bhadana ◽  
Ashok Kumar ◽  
Indu Chawla ◽  
Bani Sarkar
Keyword(s):  
Infectious Disease ◽  
Retrospective Study ◽  
Small Group ◽  
Gestational Age ◽  
Rna Virus ◽  
Maternal Outcome ◽  
Initial Experience ◽  
Rt Pcr ◽  
Oral Swab ◽  
In Pregnancy

COVID-19 is an infectious disease caused by newly discovered single stranded RNA virus of Coronaviridae family. A retrospective study conducted in ABVIMS and RML hospital, Delhi in antenatal patients with COVID-19 infection detected by RT-PCR in nasopharyngeal and oral swab. It was found that patients with mean age of 27.2 years and mean gestational age of 39 weeks, mostly asymptomatic. Three patients undergone c section for obstetrical indications, while rest delivered vaginally. COVID-19 in pregnancy in small group of cases had good feto-maternal outcome but warrants further study.

“MATERNAL OUTCOME IN PREGNANCY WITH THROMBOCYTOPENIA”

2021 ◽  
pp. 12-15
Author(s):  
Uma Jain ◽  
Preeti Gupta ◽  
Deepali Jain
Keyword(s):  
Platelet Count ◽  
Platelet Transfusion ◽  
Normal Pregnancy ◽  
Maternity Hospital ◽  
Severe Thrombocytopenia ◽  
Fetal Outcomes ◽  
Puerperal Sepsis ◽  
Frequent Monitoring ◽  
Gestational Thrombocytopenia ◽  
In Pregnancy

INTRODUCTIONThrombocytopenia is diagnosed when the platelet count is less than 1,50,000 per microliter of blood It is a common hematological disorder Thrombocytopenia is divided into 3 types according to severity: mild (100,000 to 150,000), moderate (50,000to100,000) and severe (less than 50,000) thrombocytopenia. MATERIALAND METHODObjective- To study the incidence of thrombocytopenia in normal pregnancy. to study the maternal and fetal outcomes in pregnant patients with thrombocytopenia This is a retrospective study in which a total of 1202 patients delivered in a maternity hospital of Gwalior from 1 January 2018 to 30 June 2019 were studied. 72 patients with a platelet count below 1.5 lakhs were included in the study. RESULTSA total of 1202 patients were delivered during the study period out of the 72 patient had thrombocytopenia thus the prevalence was found to be 5.99%. rd In our study majority of the patients were multigravida 63.88% in the 3 trimester 54.16% majority by between age of 25-30 years 58.33%. In our study 61.11% of women had mild, 27.77 had moderate and 11.11% had severe thrombocytopenia. In this study, gestational thrombocytopenia was the most common etiological factor with 29.16% of cases. In our study, 70.83% of patients were delivered vaginally and 29.16% of patients were delivered by LSCS. No complication was reported in 48.61% of patients. The bleeding during CS was found in 4.16% cases, maternal hemorrhage was found in 5.55%, pulmonary edema in 5.55%, ARF in 5.55%, DIC 4.16%, and Puerperal sepsis in 2.77%. Blood transfusion was needed in 15.27% of patients, platelet transfusion in 4.16% of patients. Obstetric hysterectomy was done in 1 patient. During the study, 2 maternal death were reported due to the HELLPsyndrome and associated complications. CONCLUSIONGestational thrombocytopenia is the most common cause of thrombocytopenia during pregnancy. We conclude that early diagnosis of thrombocytopenia in pregnancy is essential for better maternal and fetal outcomes. It is important to determine the exact etiological cause of thrombocytopenia so that timely management can be provided to the pregnant patients to decrease the complication rate thus, timely diagnosis, frequent monitoring, and treatment is must achieve a better outcome.

Thrombocytopenia in Pregnancy: Approach to Diagnosis and Management

2020 ◽  
Vol 46 (03) ◽  
pp. 256-263
Author(s):  
Annemarie E. Fogerty
Keyword(s):  
Platelet Count ◽  
Immune Thrombocytopenia ◽  
Thrombocytopenic Purpura ◽  
Gestational Thrombocytopenia ◽  
Life Threatening ◽  
Immune Thrombocytopenia Purpura ◽  
The Impact ◽  
Underlying Pathophysiology ◽  
In Pregnancy ◽  
Management Issues

AbstractThe impact of thrombocytopenia varies widely depending on the underlying pathophysiology driving it. The biggest challenge in managing thrombocytopenia in pregnancy is accurately identifying the responsible pathophysiology—a task made difficult given the tremendous overlap in clinical and laboratory abnormalities associated with different thrombocytopenia processes. The most common etiologies of thrombocytopenia in pregnancy range from physiology deemed benign to those that are life-threatening to the mother and fetus. Even in cases in which the responsible etiology is deemed benign, such as gestational thrombocytopenia, there are still implications for the management of labor and delivery, a time where hemostatic challenges may prove life-threatening. In most institutions, a minimum platelet count will be mandated for epidural anesthesia to be deemed a safe option. The causes of thrombocytopenia can also include diagnoses that are pregnancy-specific (such as preeclampsia or gestational thrombocytopenia), potentially triggered by pregnancy (such as thrombotic thrombocytopenic purpura), or unrelated to or predating the pregnancy (such as liver disease, infections, or immune thrombocytopenia purpura). It is imperative that the source of thrombocytopenia is identified accurately and expeditiously, as intervention can range from observation alone to urgent fetal delivery. In this review, the approach to diagnosis and the pathophysiological mechanisms of the most common etiologies of thrombocytopenia in pregnancy and associated management issues are presented.

scholarly journals Low platelet counts in pregnancy: an alarm signal for abruption!

2018 ◽  
Vol 7 (3) ◽  
pp. 1191 ◽  
Author(s):  
Anjali Mundkur ◽  
K. P. Murali Krishnan Nambiar ◽  
Lavanya Rai
Keyword(s):  
Platelet Count ◽  
Pregnant Women ◽  
Connective Tissue Disorder ◽  
Severe Thrombocytopenia ◽  
Related Condition ◽  
Alarm Signal ◽  
Hematologic Disorder ◽  
Gestational Thrombocytopenia ◽  
In Pregnancy ◽  
Do So

Background: Thrombocytopenia, defined as a platelet count less than 150 million/mm3, affects 6% to 10% of all pregnant women and other than anemia is the most common hematologic disorder in pregnancy.Methods: We studied all patients with thrombocytopenia in pregnancy from June 2012 to May 2013. There were 86 patients recruited into the study. Pregnant women with preeclampsia and suspected connective tissue disorder were also screened for thrombocytopenia. All women with platelet count of <1.50,000/µl during the study period were included.Results: Patients were grouped in to mild thrombocytopenia (platelet 100,000-149,999/µl), moderate thrombocytopenia (platelet 50,000-99,999/µl) and severe thrombocytopenia (platelet <49,999/µl. Pregnancy specific cause of thrombocytopenia was in 63 (73.2%) women and non-pregnancy specific were in 23(26.7%) patients.Conclusions: Preeclampsia and HELLP syndrome is more common cause of thrombocytopenia in pregnancy. Abruption can occur in patients with severe thrombocytopenia. Though platelet count is not routinely done in pregnancy it is advisable to do so as it may help in detecting gestational thrombocytopenia or other immune related condition.

A retrospective 11-year analysis of obstetric patients with idiopathic thrombocytopenic purpura

Blood ◽  
2003 ◽  
Vol 102 (13) ◽  
pp. 4306-4311 ◽  
Author(s):  
Kathryn E. Webert ◽  
Richa Mittal ◽  
Christopher Sigouin ◽  
Nancy M. Heddle ◽  
John G. Kelton
Keyword(s):  
Platelet Count ◽  
Retrospective Study ◽  
Epidural Analgesia ◽  
Idiopathic Thrombocytopenic Purpura ◽  
Vaginal Bleeding ◽  
Severe Bleeding ◽  
Thrombocytopenic Purpura ◽  
Platelet Counts ◽  
Itp In Pregnancy ◽  
In Pregnancy

AbstractNumerous studies have examined the outcomes of infants born to mothers with idiopathic thrombocytopenic purpura (ITP). Fewer studies have discussed the morbidity of obstetric patients with ITP. We describe a retrospective study of 92 women with ITP during 119 pregnancies over an 11-year period. Most women had thrombocytopenia during pregnancy. At delivery, women in 98 pregnancies (89%) had platelet counts lower than 150 × 109/L; most had mild to moderate thrombocytopenia. For many, the pregnancy was uneventful; however, women had moderate to severe bleeding in 25 pregnancies (21.5%). Women in 37 pregnancies (31.1%) required treatment to increase platelet counts. During delivery, 44 women (37.3%) received epidural analgesia without complications, with most having a platelet count between 50 and 149 × 109/L. Most deliveries (82.4%) were vaginal. Bleeding was uncommon at delivery. Infant platelet counts at birth ranged from 12 to 436 × 109/L; 25.2% of infants had platelet counts lower than 150 × 109/L, and 9% had platelet counts lower than 50 × 109/L. Eighteen infants (14.6%) required treatment for hemostatic impairment. Two fetal deaths occurred. One was caused by hemorrhage. ITP in pregnancy carries a low risk, but mothers and infants may require therapy to raise their platelet counts. (Blood. 2003;102:4306-4311)

scholarly journals Pregnancy emerged thrombocytopenia: maternal and fetal outcome

2020 ◽  
Vol 8 (10) ◽  
pp. 3554
Author(s):  
Fasiha Tasneem ◽  
Vinutha M. Sharma
Keyword(s):  
Platelet Count ◽  
Incidental Finding ◽  
Multiorgan Failure ◽  
Tertiary Care ◽  
Fetal Outcome ◽  
Gestational Thrombocytopenia ◽  
Elevated Liver Enzymes ◽  
Low Platelet Count ◽  
Ceserean Section ◽  
In Pregnancy

Background: A low platelet count is often an incidental finding in pregnancy. It can be an indicator of a severe systemic disorder requiring emergent maternal and fetal care or can just be unique to pregnancy with no harm to mother or fetus. Physiological decrease in platelet count is seen in pregnancy due to hemodilution and hypercoagulating state, though the exact pathophysiology is still unclear.Methods: It is a prospective observational study done in a tertiary care centre.Results: In about 11,258 cases screened 46 patients had thrombocytopenia (0.4%). The commonest etiology is found to be gestational thrombocytopenia (n=21, 45.6%) followed by preeclampsia/ eclampsia/ HELLP (haemolysis, elevated liver enzymes, low platelet count) syndrome (n=19, 41.3%). Only one patient had immune thrombocytopenic purpura (ITP) and 7 (15.3%) were associated with amplified fragment length polymorphism (AFLP). Maximum of them (n=19, 41.3%) underwent spontaneous vaginal delivery. 4 patients (8.6%) had postpartum haemorrhage, 6 (13.04%) had ceserean section wound infection, 4 (8.6%) had disseminated intravascular coagulation (DIC) and 4 (8.6%) had multiorgan failure. 13 patients (28.3%) had platelet count between 40 to 60 thousand per cumm, 11 (23.9%) had between 60 to 80 thousand per cumm, 10 (21.7%) had between 80,000 to 1 lakh and none had their platelet count less than 20,000 per cumm.Conclusions: Gestational thrombocytopenia is not a preventable condition. It is an incidental finding in pregnancy. With strict vigilance during intrapartum and postpartum period, even without any treatment proper for the same, the maternal and fetal outcome is found to be good.

scholarly journals Fertility outcomes following myomectomy in infertile patients at our centre: a retrospective analysis

2020 ◽  
Vol 9 (6) ◽  
pp. 2249
Author(s):  
Nidhi Goyal ◽  
K. Jayakrishnan
Keyword(s):  
Retrospective Study ◽  
Retrospective Analysis ◽  
Young Patients ◽  
Pregnancy Rates ◽  
Active Management ◽  
Multiple Factors ◽  
One Year ◽  
Infertile Patients

Background: Fibroids have been known to cause infertility due to multiple factors. However, the role of myomectomy in patients with intramural and subserosal fibroids has been a topic of debate. This study evaluates outcomes following myomectomy in patients seeking treatment for infertility at study centre.Methods: This was hospital based retrospective study which evaluated 92 infertile patients who took treatment for infertility.Results: A total 41.3% patients conceived within one year of myomectomy. Pregnancy rates were better in patients with intramural combined with submucous fibroids, age between 30 and 35 years, size of largest fibroid between 3 and 6 cm and when number of fibroids were between 3 and 6 and conception was maximum after ovulation induction.Conclusions: Pregnancy rates after myomectomy are better in young patients with large fibroids. Active management for infertility needs to be done after myomectomy.

scholarly journals Corticosteroids compared with intravenous immunoglobulin for the treatment of immune thrombocytopenia in pregnancy

Blood ◽  
2016 ◽  
Vol 128 (10) ◽  
pp. 1329-1335 ◽  
Author(s):  
Dongmei Sun ◽  
Nadine Shehata ◽  
Xiang Y. Ye ◽  
Sandra Gregorovich ◽  
Bryon De France ◽  
...  
Keyword(s):  
Platelet Count ◽  
Retrospective Study ◽  
Pregnant Women ◽  
Intravenous Immunoglobulin ◽  
Immune Thrombocytopenia ◽  
Neonatal Outcomes ◽  
Key Points ◽  
Count Response ◽  
In Pregnancy

Key Points Maternal platelet count response was not different for IVIg and corticosteroids in this retrospective study of pregnant women with ITP. Neonatal outcomes were overall favorable and similar after treatment of maternal ITP with IVIg or corticosteroids.

Sign in / Sign up

Export Citation Format

Share Document