scholarly journals Association of serum ferritin with insulin resistance in women with polycystic ovarian syndrome

2021 ◽  
Vol 10 (8) ◽  
pp. 2924
Author(s):  
Taslima Begum ◽  
Shakeela Ishra ◽  
Begum Shaira Sharifa ◽  
Shamsun Nahar ◽  
Hosne Ara Begum ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Resistance Index ◽  
Outcome Variable ◽  
Strong Positive Correlation ◽  
Model Assessment

Background: Emerging scientific evidence has disclosed unsuspected influences between iron metabolism, insulin resistance and type 2 diabetes. Even mildly elevated body iron stores are associated with statistically significant increases in glucose homeostasis indices. But till now high serum ferritin associated with type 2 diabetes is not recognized as an entity in the current clinical guidelines for the management of type 2 diabetes.Methods: This was a Cross sectional study carried out from September 2016 to March, 2017 at PCO clinic of infertility outpatient department (OPD), department of obstetrics and gynecology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. The study population consisted of all the diagnosed PCOS patients. Purposive sampling Main outcome variable: serum ferritin level and insulin resistance index (Homeostatic model assessment of insulin resistance: HOMA-IR).Results: Most of the (90.9%) patients were aged 20-30 years having BMI >25 kg/m2, mostly overweight (52.53%) or obese (25.25%). Significant increase of serum ferritin level (72.89±34.97; p=0.001) was noted in PCOS patients with insulin resistance. Marked increase in serum ferritin (82.81±31.57, p<0.001), fasting serum insulin (16.39±7.1; p<0.001), HOMA-IR (3.51±1.55; p<0.001) and more cases with insulin resistance (78.3%; p<0.001) were found in women with high ferritin level (when ≥45.5 ng/ml). Statistically significant strong positive correlation between serum ferritin level and fasting insulin level (r=0.528; p<0.001) as well as HOMA-IR (r=0.492; p<0.001) were observed.Conclusions: These results demonstrated that elevated level of serum ferritin was associated with insulin resistance in PCOS women.

scholarly journals Increased Serum Ferritin Levels in Type 2 Diabetes Mellitus Patients: A Hospital Based Cross-Sectional Study

2021 ◽  
Vol 9 (02) ◽  
pp. 56-60
Author(s):  
Rajendra Kumar Chaudhari ◽  
Apeksha Niraula ◽  
Basanta Gelal ◽  
Jouslin Kishore Baranwal ◽  
Deependra Prasad Sarraf ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Cross Sectional Study ◽  
Healthy Controls ◽  
Sectional Study ◽  
Cross Sectional ◽  
Age And Sex

INTRODUCTION: Type 2 diabetes mellitus is a metabolic disorder of multiple etiology characterized by chronic hyperglycemia with a derangement in carbohydrate, fat and protein metabolism resulting from defects in insulin secretion and action. Ferritin is a ubiquitous intracellular protein complex that reflects the iron stores of the body. Studies have shown that the increased body iron stores are associated with the development of glucose intolerance often leading to metabolic syndrome and type 2 diabetes (T2DM). The objective of the study was to find out association of serum ferritin level with T2DM and assess the correlation between serum ferritin and HbA1c. MATERIAL AND METHODS: A hospital based comparative cross-sectional study was conducted in 43 diabetic patients and 42 age and sex matched healthy controls. Fasting blood glucose (FBG), postprandial blood glucose (PBG), Glycated hemoglobin (HbA1c) and serum ferritin were estimated in cobas c311 autoanalyser using standard protocol. RESULTS: Mean age of healthy control and T2DM were found 54.83 ± 6.48 and 55.95±10.92 years respectively. Mean FBG (mg/dL) (170.41 ± 71.7 v/s 98.38 ± 9.7), PBG (mg/dL) (266.16 ± 110.09 v/s 123.20 ± 17.0), HbA1c (%) (8.17 ± 1.83 v/s 4.9 ± 0.29 and median ferritin (μg/L) 207.90 (138, 306.0) v/s 127.95 (85.75, 210.25) were significantly higher in T2DM compared to the healthy controls. Spearman’s correlation depicted that ferritin level was positively correlated with HbA1c level but the correlation was statistically insignificant. CONCLUSION: Serum ferritin level was found significantly higher in T2DM compared to healthy age and sex matched controls in our study.

Serum ferritin level in type 2 diabetes mellitus -A case control study

2016 ◽  
Vol 3 (1) ◽  
pp. 62
Author(s):  
Sangappa Virupaxappa Kashinakunti ◽  
Kavitha Hiremath ◽  
Manjula Rangappa ◽  
Gurupadappa Shantappa Kallaganada
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Case Control Study ◽  
Ferritin Level ◽  
Case Control ◽  
Control Study

scholarly journals Elevated Serum Ferritin Level Is Associated with the Incident Type 2 Diabetes in Healthy Korean Men: A 4 Year Longitudinal Study

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e75250 ◽  
Author(s):  
Chang Hee Jung ◽  
Min Jung Lee ◽  
Jenie Yoonoo Hwang ◽  
Jung Eun Jang ◽  
Jaechan Leem ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Longitudinal Study ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Elevated Serum ◽  
Incident Type ◽  
Incident Type 2 Diabetes

scholarly journals Association of Serum Ferritin and Inflammatory Biomarkers with Insulin Resistance in Chinese Type 2 Diabetes Mellitus Patients

2020 ◽  
Vol 1 (7) ◽  
pp. 363-371
Author(s):  
Pratiksha Paudel ◽  
Shitian Zhang ◽  
Bei Guo ◽  
Alisha Pannu ◽  
Gajarishiyan Rasalingam ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Serum Ferritin ◽  
Chinese Population ◽  
Inflammatory Biomarkers ◽  
Model Assessment ◽  
Tnf Α

Objective: Obesity-induced Insulin Resistance (IR) is one of the main causes of Type 2 Diabetes Mellitus (T2DM) and accompanies the progression of T2DM. Serum Ferritin has been shown to be associated with IR. Inflammation is also suggested to be involved in IR and pancreatic β-cell dysfunction. However, there is lack of enough evidence concerning the interrelationship between serum Ferritin, inflammation, and IR in the Chinese population with T2DM. In this study, the relationships between serum Ferritin and inflammatory biomarkers with IR in Chinese population were investigated. Methods: This cross-sectional study was conducted with 207 Chinese participants, aged 40-60 years in Tianjin, China. Serum Ferritin, transferrin, and folate were measured by immuno-assay analyzer. The levels of TNF-α, IL-1β, and IL-6 were detected by ELISA. IR was evaluated by Homeostasis model assessment (HOMA) of IR. Correlations were examined by regression analyses. Results: Serum Ferritin level was higher in non-diabetic obese and diabetic group than the non-diabetic lean group. The levels of TNF-α and CRP were significantly higher in the diabetic obese group than non-diabetic and diabetic lean subjects. Serum Ferritin, TNF-α, and CRP were all correlated with BMI. TNF-α correlated with IR and FPI. TNF-α, IL-6, IL-1β, and CRP were all correlated with FPG and HbA1c. Conclusion: In Chinese population, IR had a significant association with TNF-α but not with serum Ferritin. Serum Ferritin, TNF-α, and CRP were all correlated with BMI. Inflammation and glucose metabolism factors (FPG, HbA1c) showed a strong correlation with each other as well as with adiposity.

scholarly journals Characteristics of the intestinal flora in patients with peripheral neuropathy associated with type 2 diabetes

2020 ◽  
Vol 48 (9) ◽  
pp. 030006052093680
Author(s):  
Yayun Wang ◽  
Xiaolong Ye ◽  
Dafa Ding ◽  
Yibing Lu
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Peripheral Neuropathy ◽  
Intestinal Flora ◽  
Resistance Index ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Clinical Indicators ◽  
Insulin Resistance Index

Objective To study the characteristics of the intestinal flora in patients with diabetic peripheral neuropathy (DPN) and analyze the association between the intestinal flora and clinical indicators. Methods We classified 80 subjects into three groups: patients with DPN (n = 45), patients type 2 diabetes without DPN (n = 21), and healthy controls (n = 14). The intestinal flora composition was compared among the three groups, and the correlation between the intestinal flora and clinical indicators was analyzed. Results At the phylum level, the richness of Firmicutes and Actinobacteria was elevated in the DN group, and that of Bacteroidetes was decreased. At the genus level, the richness of Bacteroides and Faecalibacterium was significantly decreased in the DPN group, whereas that of Escherichia- Shigella, Lachnoclostridium, Blautia, Megasphaera, and Ruminococcus torques group was increased. The homeostasis model assessment insulin resistance index was positively correlated with Megasphaera richness. Glycine ursodeoxycholic acid was positively correlated with Ruminococcus gnavus group and Phascolarctobacterium richness. Tauroursodeoxycholic acid was positively correlated with Ruminococcus gnavus group and Parabacteroides richness. Conclusion There was obvious intestinal microbiota disorder in patients with DPN, which may be related to insulin resistance. These changes may have important roles in the development of DPN.

scholarly journals The Impact of Adiponectin Gene Polymorphisms on the Insulin Resistance Index in Patients with Diabetes and Newly Diagnosed Type 2 Diabetes

2019 ◽  
Vol 25 (3-4) ◽  
pp. 106-112
Author(s):  
Helma Karimi ◽  
Masoumeh Nezhadali ◽  
Mehdi Hedayati ◽  
Maryam Mahdavi ◽  
Sara Sheikholeslami
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Resistance Index ◽  
Enzyme Linked Immunosorbent Assay ◽  
Model Assessment ◽  
Adiponectin Gene ◽  
Positive Correlation ◽  
The Impact ◽  
Sensitive Group

<b><i>Background:</i></b> Some adipokine hormones can affect both human and animal models of insulin resistance. <b><i>Aims:</i></b> This study was conducted to assess the association between rs17300539 and rs266729 of the adiponectin gene and insulin resistance and anthropometric and metabolic characteristics in impaired fasting glucose (IFG)/type 2 diabetes mellitus (T2DM) and nondiabetic participants. <b><i>Methods:</i></b> DNA was extracted from 80 participants with fasting blood sugar (FBS) &#x3c;100 mg/dL in nondiabetics and 80 participants with FBS ≥100 mg/dL in the IFG/T2DM group. Genotyping was performed using a polymerase chain reaction-restriction fragment length polymorphism assay. Statistical analysis was performed using SPSS software version 20. Insulin and adiponectin hormone were measured using enzyme-linked immunosorbent assay and other biochemical variables were determined using the standard methods. <b><i>Results:</i></b> The levels of homeostatic model assessment of insulin resistance (HOMA-IR) between the IFG/T2DM and the nondiabetic group were significantly different (IFG/T2DM = 3.27, nondiabetic = 1.71; <i>p</i> &#x3c; 0.001). The frequency of the GA genotype of rs17300539 was higher in the insulin-resistant (HOMA-IR ≥2.6, 29.7%) than in the insulin-sensitive group (HOMA-IR &#x3c;2.6, 18.4%) and the GG genotype were more frequent in the insulin-sensitive group (81.6%); however, it had a marginal association (<i>p</i> = 0.07). This association was not statistically significant for rs266729. HOMA-IR had a positive correlation with triglyceride (TG) and total cholesterol (TC) and was negatively correlated with adiponectin level. <b><i>Conclusion:</i></b> IFG/T2DM patients have a higher level of HOMA-IR in comparison with nondiabetics. The genotype of GA in rs17300539 increases the risk of HOMA-IR. HOMA-IR has a positive correlation with TC and TG. Moreover, HOMA-IR increases the risk of T2DM.

scholarly journals Increased Serum Ferritin Levels in Type 2 Diabetes Mellitus Patients: A Hospital Based Cross-Sectional Study

2021 ◽  
Author(s):  
Rajendra Chaudhari ◽  
Apeksha Niraula ◽  
Basanta Gelal ◽  
Jouslin Baranwal ◽  
Deependra Sarraf ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Cross Sectional Study ◽  
Healthy Controls ◽  
Sectional Study ◽  
Cross Sectional ◽  
Age And Sex

Abstract Background: Type 2 diabetes mellitus is a metabolic disorder of multiple etiology characterized by chronic hyperglycemia with a derangement in carbohydrate, fat and protein metabolism resulting from defects in insulin secretion and action. Ferritin is a ubiquitous intracellular protein complex that reflects the iron stores of the body. Studies have shown that the increased body iron stores are associated with the development of glucose intolerance often leading to metabolic syndrome and type 2 diabetes (T2DM). The objective of the study was to find out association of serum ferritin level with T2DM and assess the correlation between serum ferritin and HbA1c. Methods: A hospital based comparative cross-sectional study was conducted in 43 diabetic patients and 42 age and sex matched healthy controls. Fasting blood glucose (FBG), postprandial blood glucose (PBG), Glycated hemoglobin (HbA1c) and serum ferritin were estimated in cobas c311 autoanalyser using standard protocol. Results: Mean age of healthy control and T2DM were found 54.83 ± 6.48 and 55.95±10.92 years respectively. Mean FPG (mg/dl) (170.41 ± 71.7 v/s 98.38 ± 9.7), PBG (mg/dl) (266.16 ± 110.09 v/s 123.20 ± 17.0), HbA1c (%) (8.17 ± 1.83 v/s 4.9 ± 0.29 and median ferritin (μg/L) 207.90 (138, 306.0) v/s 127.95 (85.75, 210.25) were significantly higher in T2DM compared to the healthy controls. Spearman’s correlation depicted that ferritin level was positively correlated with HbA1c level but the correlation was statistically insignificant. Conclusion: Serum ferritin level was found significantly increased in T2DM compared to healthy age and sex matched controls in our study.

scholarly journals Acanthosis nigricans and insulin resistance in obese children

2010 ◽  
Vol 50 (5) ◽  
pp. 274 ◽  
Author(s):  
Kristellina Sangirta Tirtamulia ◽  
Adrian Umboh ◽  
Sarah Maria Warouw ◽  
Vivekenanda Pateda ◽  
Frecillia Regina
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Acanthosis Nigricans ◽  
Resistance Index ◽  
Skin Condition ◽  
Cross Sectional Study ◽  
Model Assessment ◽  
Obese Children ◽  
Cross Sectional

Background Acanthosis nigricans (AN) is a skin condition characterized by darkening and thickening of skin. AN has been reported to be linked to insulin resistance (IR), that associated with type 2 diabetes, in obese children in many country.Objective To determine the relation between acanthosis nigricans and insulin resistance in obese children.Methods We conducted a cross sectional study in Wenang District, Manado, from October 2009 until January 2010. We examined 54 obese children aged 10-14  years for insulin resistance using Homeostasis Model Assessment of Insulin Resistance Index (HOMA-IR). We analyzed the results byT-test and phi coefficient correlation. The value of P<O.05 was significant in statistical analysis.Results Acanthosis nigricans was positive in 33 children. Insulin resistance was found in 34 from 54 subjects, 28 of them has AN and 6has no AN. Obese children with AN had higher HOMA-IR than children without AN. Presence of AN was associated with IR (P<O.OOl, r=0.57).Conclusions There is a weak correlation between AN and IR in obese children. It is important to identify obese children with IR for early intervention and prevention of type  2 diabetes, but AN could not be a reliable marker of IR.

scholarly journals Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patients

2008 ◽  
Vol 295 (6) ◽  
pp. E1401-E1408 ◽  
Author(s):  
Gilberto Paz-Filho ◽  
Karin Esposito ◽  
Barry Hurwitz ◽  
Anil Sharma ◽  
Chuanhui Dong ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Mixed Model ◽  
Resistance Index ◽  
Oral Glucose ◽  
Model Assessment ◽  
Rapid Weight Gain ◽  
Hypoglycemic Reaction ◽  
Homeostatic Model Assessment

Leptin replacement rescues the phenotype of morbid obesity and hypogonadism in leptin-deficient adults. However, leptin's effects on insulin resistance are not well understood. Our objective was to evaluate the effects of leptin on insulin resistance. Three leptin-deficient adults (male, 32 yr old, BMI 23.5 kg/m2; female, 42 yr old, BMI 25.1 kg/m2; female, 46 yr old, BMI 31.7 kg/m2) with a missense mutation of the leptin gene were evaluated during treatment with recombinant methionyl human leptin (r-metHuLeptin). Insulin resistance was determined by euglycemic hyperinsulinemic clamps and by oral glucose tolerance tests (OGTTs), whereas patients were on r-metHuLeptin and after treatment was interrupted for 2–4 wk in the 4th, 5th, and 6th years of treatment. At baseline, all patients had normal insulin levels, C-peptide, and homeostatic model assessment of insulin resistance index, except for one female diagnosed with type 2 diabetes. The glucose infusion rate was significantly lower with r-metHuLeptin (12.03 ± 3.27 vs. 8.16 ± 2.77 mg·kg−1·min−1, P = 0.0016) but did not differ in the 4th, 5th, and 6th years of treatment when all results were analyzed by a mixed model [ F( 1 , 4 ) = 0.57 and P = 0.5951]. The female patient with type 2 diabetes became euglycemic after treatment with r-metHuLeptin and subsequent weight loss. The OGTT suggested that two patients showed decreased insulin resistance while off treatment. During an off-leptin OGTT, one of the patients developed a moderate hypoglycemic reaction attributed to increased posthepatic insulin delivery and sensitivity. We conclude that, in leptin-deficient adults, the interruption of r-metHuLeptin decreases insulin resistance in the context of rapid weight gain. Our results suggest that hyperleptinemia may contribute to mediate the increased insulin resistance of obesity.

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