scholarly journals Study of histomorphological pattern of ovarian neoplastic and non-neoplastic lesions

2017 ◽  
Vol 5 (5) ◽  
pp. 2095 ◽  
Author(s):  
Rasheed Fatima ◽  
Sandhya M. ◽  
Sowmya T. S.
Keyword(s):  
Malignant Tumors ◽  
Tertiary Care ◽  
Secondary Malignancy ◽  
Care Hospital ◽  
Age Group ◽  
Cyst Adenoma ◽  
Neoplastic Lesion ◽  
Neoplastic Lesions ◽  
Mucinous Cyst ◽  
Serous Cyst Adenoma

Background: The ovary is a striking exception to the Virchow’s dictum that organs that are frequently the site of primary cancer are rarely involved in secondary malignancy, and vice versa. Both primary and secondary carcinomas of the ovary are relatively frequent and show an astounding variety of pathologic patterns. The objectives were to study the histomorphological diversity of various neoplasms and non neoplastic lesions of ovary. To provide a specific diagnosis based upon the histomorphological study which is of paramount clinical significance in further management of the patient.Methods: The present study is based on histomorphological evaluation of 100 cases of ovarian neoplastic and non neoplastic lesions received at the department of Pathology, tertiary care hospital from June 2008 to Aug 2010.Results: A wide variation of age was noted. Among neoplastic lesions, majority of the cases were seen in age group of 20-39 years i.e., 50.6%. Non neoplastic lesion occurred in all age group, but majority of the incidences were seen in the age group of 20 to 40 years of age, accounting for 60% of total occurrence. the commonest ovarian tumor was serous cyst adenoma constituting 54.1% (46 cases) of all ovarian neoplasm. Mucinous cyst adenoma was the second most common tumor. There were 72 cases (85%) of benign, 2 cases (2%) of borderline and 11 cases (13%) of malignant tumors in the present study.Conclusions: The diversity of neoplasms makes it mandatory to classify the tumors accurately by histopathological features following universally accepted classification.

scholarly journals Study of histomorphological spectrum of lesions in nephrectomy specimen in a tertiary care hospital in South Gujarat

2020 ◽  
Vol 8 (5) ◽  
pp. 1706
Author(s):  
Himani Bajaj ◽  
Rasik Hathila
Keyword(s):  
Chronic Infection ◽  
Surgical Intervention ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Age Group ◽  
Common Indication ◽  
Current State ◽  
Neoplastic Lesion ◽  
Neoplastic Lesions

Background: Nephrectomy is a standard surgical procedure in urology indicated in patients with organ confined renal malignancies and irreversible kidney damage resulting from chronic infection, trauma, obstruction and congenital malformation. This study aims to study the histomorphological features of lesions in nephrectomy specimens in a tertiary care hospital, to analyse the neoplastic and non-neoplastic lesions of kidney according to age, gender and site and observe any variation from the conventional pattern.Methods: The present study was conducted in department of pathology, Tertiary care hospital over a period of 5 years and 7 months (1 Jan 2013 to July 31, 2018). This included 4 years retrospective and 1 year 7 months prospective.  A total of 73 cases of were studied.Results: Males constituted 65.73% and females constituted 35.27%  of all nephrectomy cases. Right kidney was more commonly affected. Highest percentage of patients belonged to 41-50 years age group. 45 cases were of non-neoplastic lesions and 28 cases were of neoplastic lesions. Among neoplastic lesions, one case was benign while remaining 27 cases were malignant. Chronic Pyelonephritis was the most common indication overall and also amongst non-neoplastic lesions with stone identified in 55% cases. Most common neoplastic lesion in nephrectomy specimen was Renal Cell carcinoma (71.4.1%) followed by Wilms tumour (14%).Conclusions: This study gives a fair insight of the current state of incidence of neoplastic and non-neoplastic lesions of kidney requiring surgical intervention.

scholarly journals A RETROSPECTIVE ANALYSIS OF HISTOPATHOLOGICAL SPECTRUM OF LESIONS IN NEPHRECTOMY SPECIMENS IN A TERTIARY CARE CENTRE

2020 ◽  
pp. 1-3
Author(s):  
K. Sitharamaiah ◽  
K. Anusha ◽  
G.Raja Sekhar ◽  
A. Bhagavan ◽  
G. Baleswari
Keyword(s):  
Tertiary Care ◽  
Chronic Pyelonephritis ◽  
Care Hospital ◽  
Geographical Differences ◽  
Tertiary Care Centre ◽  
Common Procedure ◽  
Neoplastic Lesion ◽  
Radiological Data ◽  
High Incidence ◽  
Neoplastic Lesions

Background: Kidneys can be involved in various pathological processes. Nephrectomy is a common procedure in urological practice. Indications for nephrectomy can display geographical differences in different countries around the world with different urological causes. The aim of the study was to analyse the various lesions in nephrectomy specimens in a tertiary care hospital in Kurnool, Andhra Pradesh, South India and also to know the frequency of lesions according to the age, gender and histology. Materials and Methods: It is a retrospective study, done over a period of 13 years from June 2007 to March 2020 which included 132 nephrectomy cases. Patient information such as age, gender, clinical diagnosis, radiological data such as USG and CT results, gross morphology and microscopic data were recorded from the available data. Results: Of 132 nephrectomy specimens, 55 (41.66%) were males and 77 (58.34%) were females. The mean age was 40.46 years. 99 (75%) nephrectomy specimens showed ‑ non‑neoplastic lesions and 33 (25%) showed neoplastic lesions. The most common non‑neoplastic lesions were chronic pyelonephritis in 62 (46.96%) patients, followed by tuberculous pyelonephritis in 20 (15.15%) patients. RCC (n = 27) was the most common neoplastic lesion. Conclusion: Chronic pyelonephritis remains the most common non-neoplastic cause of nephrectomy. RCC is the most common neoplastic cause of nephrectomy. Tuberculosis has a high incidence in developing countries. Awareness of renal TB is required for the physicians, to suspect this disease in patients with unexplained urinary tract abnormalities, particularly in those with any immunosuppression and those coming from TB-endemic areas.

scholarly journals Intraspinal Space-Occupying Lesions in Children: Clinical Features, Neuroimaging and Surgical Outcomes of 27 Cases

2021 ◽  
Author(s):  
Haigang Chang ◽  
Jingkuo Yan ◽  
Yaxiao Wang ◽  
Lei Hui ◽  
Yan Li ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Clinical Symptoms ◽  
Malignant Tumors ◽  
Treatment Options ◽  
Tertiary Care ◽  
Primary Treatment ◽  
Care Hospital ◽  
Age Group ◽  
Delayed Treatment ◽  
Non Hodgkin Lymphoma

Abstract Background: Pediatric intraspinal space-occupying lesions are relatively uncommon. However, these lesions can result in neurological disabilities due to misdiagnosis and delayed treatment. The main goal of the present study is to evaluate the clinical and radiological features and treatment options of pediatric intraspinal space-occupying lesions in order to improve the clinical recognition and management. Methods: Clinical data of 27 children with intraspinal space-occupying lesions who underwent surgery treatment in a tertiary-care hospital between 2010 and 2018 were retrospectively reviewed and analyzed. Results: Of these 27 patients, 14 (51.85%) were girls and 13 (48.15%) were boys. The most common age group affected was 10~14 years (62.96%, 9 girls and 8 boys in this age group). The mean age was 10.11 years old. Pain and weakness were the most common clinical symptoms. Preoperative magnetic resonance imaging (MRI) identified intramedullary (10 cases, 37.04%), intradural extramedullary (10 cases, 37.04%) and extradural (7 cases, 25.92%) lesions, respectively. The majority of the lesions were intraspinal tumors (23 cases, 85.19%). The histological diagnosis of tumors included embryonic residual tumors (6 cases, 22.22%), ependymoma (5 cases, 18.52%), primitive neuroectodermal tumors (PNET) (3 cases, 11.11%), schwannomas (2 cases, 7.4%), ganglioneuroma (1 case, 3.7%), Ewing’s sarc (1 case, 3.7%), B-cell non Hodgkin lymphoma (1 case, 3.7%), Hodgkin lymphoma (1 case, 3.7%), chondrosarcoma (1 case, 3.7%), ganglioglioma (1 case, 3.7%), and glioma (1 case, 3.7%). Conclusions: The incidence of pediatric intraspinal space-occupying lesions is low, and the clinical manifestation is lack of specificity. The prognosis for children with malignant tumors is poor and surgical resection is still the primary treatment option.

scholarly journals Clinicopathological profile of sinonasal masses-a tertiary care centre study in rural India

2020 ◽  
Vol 6 (10) ◽  
pp. 1821
Author(s):  
Vidya Rokade ◽  
Kiran J. Shinde ◽  
Girishkumar R. More
Keyword(s):  
Histopathological Examination ◽  
Tertiary Care ◽  
Rural India ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Tertiary Care Centre ◽  
Radiological Investigation ◽  
Male Predominance ◽  
Neoplastic Lesion ◽  
Neoplastic Lesions

<p><strong>Background:</strong> A variety of mass lesions occur within the paranasal sinus (PNS) and nasal cavity and thus it becomes mandatory for otorhinolaryngologist to elicit detailed history and thorough examination before reaching a final diagnosis. This is retrospective study of all sinonasal masses who were undergone surgical management in the institute of rural India and so in the environment.</p><p><strong>Methods:</strong> This is a retrospective observational study of 70 patients with sinonasal masses treated at a rural tertiary care hospital in rural western Maharashtra from period of Jan 2016 to May 2018. History, clinical assessment and histopathological examination (HPE) was done in all cases as per hospital record supplemented by radiological investigation as per requirement. The patients were grouped as per their histopathological diagnosis as non-neoplastic/inflammatory and neoplastic.</p><p><strong>Results:</strong> A total of 70 patients were analysed age ranging (11-70 years). Majority of the patients were in the age groups 21-40 years (47%). There were 43 (61%) male and 27 (39%) female with M:F ratio 1.6:1. On HPE, 50 (71%) cases were non neoplastic/inflammatory and 20 (29%) cases were neoplastic lesions. HPE revealed that 50 (71%) cases were non neoplastic and 20 (29%) cases were neoplastic lesions.</p><p><strong>Conclusions:</strong> Sinonasal masses have various differential diagnoses. They are fairly common with male predominance. Benign conditions show a peak during 2<sup>nd</sup> to 4<sup>th</sup> decade of life while malignancy increasing with the age after 4th decade. In non-neoplastic lesion, Allergic nasal polyp is the commonest histological pattern seen while in malignant lesions squamous cell carcinoma is noted with 100% male predominance.</p><p> </p>

scholarly journals Histopathological study of ovarian lesions in a tertiary care center in Hyderabad, India: a retrospective five-year study

2017 ◽  
Vol 4 (3) ◽  
pp. 745 ◽  
Author(s):  
Akina Prakash ◽  
Sravan Chinthakindi ◽  
Ramanan Duraiswami ◽  
Indira V.
Keyword(s):  
Care Center ◽  
Tertiary Care ◽  
Age Distribution ◽  
Tertiary Hospital ◽  
Serous Cystadenoma ◽  
Histopathological Study ◽  
Care Hospital ◽  
Neoplastic Lesion ◽  
Histopathological Evaluation ◽  
Neoplastic Lesions

Background: The aim of the study was to identify the pattern of pathologies involving ovarian mass lesions which were received for histopathological evaluation at a tertiary hospital in Hyderabad, Telangana, India during the period January 2012 to December 2016.Methods: The data pertaining to samples of ovarian lesions received for histopathological evaluation at the laboratory of a tertiary care hospital in Hyderabad from January 2012 to December 2016, were analyzed to determine the pattern of pathologies diagnosed during such evaluation and the age distribution of all lesions.Results: Non-neoplastic lesions of the ovary constituted 44.0% of all cases received; follicular cysts constituted 45.5% of these lesions. Malignant lesions constituted only 2.0% of all pathologies. Serous cystadenoma of the ovary constituted the predominant neoplastic lesion diagnosed (62.5% of all neoplastic lesions). 53.2% of patients whose samples were received belonged to the age group of 20-39 years. 90.8% of the lesions were unilateralConclusions: The majority of ovarian lesions received for evaluation were benign and unilateral. Most patients were in the third to sixth decades of life.

scholarly journals HISTOMORPHOLOGICAL SPECTRUM OF PROSTATIC LESIONS IN TERTIARY CARE HOSPITAL

2020 ◽  
pp. 1-3
Author(s):  
P. Patro
Keyword(s):  
Chronic Inflammation ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Prostate Gland ◽  
Tertiary Hospital ◽  
Morbidity And Mortality ◽  
Care Hospital ◽  
Age Group ◽  
Neoplastic Lesion ◽  
Elderly Males

Introduction: Prostate gland is crucial source of morbidity and mortality in elderly males. The spectrum of lesions includes Inflammation, BPH and Malignancy. Histomorphological diagnosis and its grading in malignancy plays cardinal role in management of prostatic lesions. Current study aims at analyzing histomorphological spectrum of lesions in prostate. Materials and Methods: Current study is done in Department Of Pathology of Tertiary Hospital from May 2018- 19. Total 98 samples were received during this period. The received biopsy was grossed, processed and Haematoxylin and Eosin slides were prepared for reporting. Results:Total 98 cases with ageranged from 30 to 82 years.74 cases were non-neoplastic and 24 neoplastic. Conclusion:As per current study, 51 – 80 years is the commonly affected age group. BPH is the most common lesion. Of which BPH with chronic inflammation is most common non-neoplastic lesion .All malignant cases are of Adenocarcinoma

Surgico-pathological analysis of testicular lesions

2021 ◽  
Vol 6 (4) ◽  
pp. 250-254
Author(s):  
Surabhi Arun Vidhale ◽  
Pragati Upasham
Keyword(s):  
Histopathological Examination ◽  
Picric Acid ◽  
Tertiary Care ◽  
Primary Objective ◽  
Histopathological Analysis ◽  
Care Hospital ◽  
Age Group ◽  
Presenting Symptoms ◽  
Neoplastic Lesions ◽  
Testicular Lesions

The primary objective of our study was to identify the different types of histopathological lesions of testes and epididymis occurring in patients admitted in a tertiary care hospital, the objective was also to analyze the spectrum of testicular lesions, our aim was to evaluate the prevalence of testicular malignancies and characterize the tumor based on their histo-morphological features. This was a prospective study of 2 years (October 2018 to October 2020) aggregating a total of 52 cases. The surgical specimens were referred to the pathology department for histopathological analysis. Adetailed preoperative history of every case with regards to age, presenting symptoms, and signs along with personal history were obtained.Also, relevant investigations like serum tumor markers and Ultrasonography findings were analyzed. Postoperatively, the tissue was sent to the histopathology department was studied by proper fixation, gross examination, adequate sampling, and paraffin sections of the same.10% formalin was used to fix the specimen. Some resources suggest the use of Bouin solution for the fixation of testis biopsy specimens. However, the picric acid in the Bouin solution presents challenges for safe handling and disposal due to its explosive potential.Hence, given the available resources in our laboratory setting, formalin was the preferred choice of fixative. We ensured that the specimens came in adequate amount of formalin from the OT with correct labeling.We excluded the autolyzed specimens. The data was noted and quantitative analysis was done.The study was further compared with other previously reported studies. 52 cases were studied and majority of the cases were reported in the age group of 31-40yrs. 65.4% cases were non neoplastic, with testicular torsion being the commonest lesion. Amongthe 23.1% neoplastic cases that were reported, mixed germ cell tumor was the commonest (75%). Non neoplastic lesions are more common than neoplastic lesions. Torsion testis was the commonest indication for orchidectomy in younger age group. Despite newer techniques in imaging and tumor marker assays the diagnosis of testicular lesions is primarily dependent upon histopathological examination.

Histomorphologic and Immunohistochemical Study of Lymph-Node Biopsies in Generalised Lymphadenopathy

2021 ◽  
Vol 8 (07) ◽  
pp. 364-368
Author(s):  
Shayfa Palliyalil ◽  
Mini B
Keyword(s):  
Lymph Node ◽  
Hodgkin Lymphoma ◽  
Tertiary Care ◽  
Final Diagnosis ◽  
Cross Sectional Study ◽  
Age Group ◽  
Cross Sectional ◽  
Neoplastic Lesion ◽  
Neoplastic Lesions ◽  
Granulomatous Lymphadenitis

BACKGROUND “Lymphadenopathy’’ refers to nodes that are abnormal in size, consistency, or number. It is designated as generalised’’ if lymph-nodes are enlarged in two or more non-contiguous areas. Approximately three fourths of patients presenting with unexplained lymph-node enlargement have localised lymphadenopathy, whereas one fourth have generalised lymphadenopathy. In the present study an attempt is made to identify and categorise various neoplastic versus nonneoplastic lesions in patients presenting with generalised lymphadenopathy in a tertiary care centre.METHODS A cross sectional study of 100 lymph-node biopsies was conducted. After adequate fixation in 10 % formalin, tissues were routinely processed and stained with haematoxylin and eosin (H & E). Special stains like Ziehl-Neelsen and reticulin were employed whenever indicated. Immunohistochemistry (IHC) was performed for all neoplastic lesions and for some cases of non-neoplastic lesions. RESULTS Amongst 100 cases of lymph node biopsies analysed in this study, 71 cases were non-neoplastic and 29 were neoplastic. The most common non-neoplastic lesion observed was granulomatous lymphadenitis (32 cases), followed by reactive lymphadenitis (20). 25 cases of non-Hodgkin lymphoma (NHL) and 4 cases of Hodgkin lymphoma were observed in the neoplastic group. In the age range of 4.5 to 77 years included in the study, major bulk of cases was found in the age group of 11 - 20 years; out of this, 78.9 % were non neoplastic and 21.1 % were neoplastic. It was observed that 100 % of cases in the age group below 10 years were non-neoplastic, whereas in the age group above 70 years, all cases were neoplastic. CONCLUSIONS Granulomatous lymphadenitis was the most common lesion observed, probably because of high incidence of tuberculosis in this part of state. Morphological evaluation by light microscopy supplemented by special stains and IHC are necessary for establishing final diagnosis of generalised lymphadenopathy. KEYWORDS Generalised Lymphadenopathy, Haematoxylin and Eosin, IHC, Granulomatous Lymphadenitis, Kikuchi Fujimoto Lymphadenopathy, Hodgkin Lymphoma, NonHodgkin Lymphoma

scholarly journals Histomorphological Spectrum of Splenectomy Specimens in a Tertiary Teaching Hospital:A Seven Year Study

2017 ◽  
Vol 6 (2) ◽  
pp. 1488
Author(s):  
Alpana Banerjee ◽  
Abhijit Datta ◽  
Shikha Das
Keyword(s):  
Tertiary Care ◽  
Secondary Malignancy ◽  
Traumatic Rupture ◽  
Care Hospital ◽  
Age Group ◽  
Metabolic Disturbances ◽  
Tertiary Teaching ◽  
Hematopoietic Disorders ◽  
Age Range ◽  
Microscopic Findings

<p><strong>Background:</strong> Spleen is the largest organ of the mononuclear phagocytic system and is involved in all systemic inflammations, generalized hematopoietic disorders, and many metabolic disturbances. Splenectomy is frequently indicated where diagnosis is already established and the purpose of surgery being largely therapeutic in nature.</p><p><strong>Objectives:</strong> The study aims to highlight the histomorphological patterns in the surgically resected splenectomy specimens received in our centre and to correlate with the clinical indications.</p><p><strong>Materials and Methods:</strong> This was a seven year study of all splenectomy specimens received at histopathology section of Department of Pathology in a tertiary care hospital. All the histopathology slides were reviewed by the authors and the microscopic findings were studied and correlated with clinical data.</p><p><strong>Results:</strong> Twenty two (22) spleen samples were received during the study period with a M:F=1: 1.2 . The age range was 2 years to 60 years. The highest number of splenectomy cases was in the age group of 11-20 years followed by 0-10 years age group. The majority of the cases of splenectomy were indicated for thalassemia (14 cases, i.e. 63.64% of all cases), followed by traumatic rupture and secondary malignancy with 2 cases each (9.09% cases each), one case each for splenic infarct, myelofibrosis, ITP and splenic tuberculosis.</p><p><strong>Conclusion:</strong> Thalassemia was proved to be the commonest indication of splenectomy, followed by traumatic rupture and secondary malignancy in the spleen. Larger studies are needed for better understanding of this important organ and unnecessary splenectomies may thus be avoided.</p>

scholarly journals Study of histopathological spectrum of ovarian lesions

2021 ◽  
Vol 6 (4) ◽  
pp. 230-236
Author(s):  
Keval A Patel ◽  
Riddhi A Parmar ◽  
Jaimin M Patel ◽  
Bhawana S Sharma ◽  
Bimal Patel ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Cystic Teratoma ◽  
Ovarian Tumour ◽  
Care Hospital ◽  
Clinical Appearance ◽  
Serous Cystadenocarcinoma ◽  
Neoplastic Lesion ◽  
Wide Range ◽  
Neoplastic Lesions ◽  
Different Types

Ovarian pathology ranges from innocuous non-neoplastic lesions to malignant neoplastic entities. The incidence, clinical appearance and the behaviour of the different types of ovarian tumour is extremely variable. In order to have a better understanding of frequency and histomorphological patterns of different ovarian lesions study was encountered in our tertiary care hospital.To study the histopathology of ovarian non-neoplastic and neoplastic lesions and to study the distribution of ovarian lesions with respect to various parameters like age, bilaterality, gross and microscopic features.This is a prospective study of 125 ovarian specimens received in department of pathology, G.K. General Hospital, Bhuj during August 1, 2018 to July 31, 2020. Total 125 cases of ovarian specimens were studied, amongst them 58 were non-neoplastic and remaining 67 were neoplastic. The most common non-neoplastic lesion seen was follicular cysts 12 cases (21%), followed by endometriosis 9 cases (16%). Among 67 neoplastic ovarian lesions 58(87%) cases were benign, 3(4%) cases were borderline and 6 (9%) cases were malignant. In benign ovarian neoplasm, most commonly seen lesions were serous cystadenoma 24 cases (36%) followed by 13 cases (20%) of mature cystic teratoma. In malignant cases, maximum was of high-grade serous cystadenocarcinoma.Ovarian epithelial tumours are the most common type, while serous cystadenocarcinoma was the most common malignancy. Histological examination is gold standard and in certain difficult cases require immunohistochemistry.Ovary is an important reproductive organ with involvement in production of progeny.Ovarian pathology ranges from innocuous non-neoplastic lesions to malignant neoplastic entities. Ovarian neoplasms have become increasingly important not only because of the wide range of neoplasms, but also because they have gradually increased the mortality rate. The incidence, clinical appearance and the behaviour of the different types of ovarian tumour is extremely variable.

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