Study of histopathological spectrum of ovarian lesions

Ovarian pathology ranges from innocuous non-neoplastic lesions to malignant neoplastic entities. The incidence, clinical appearance and the behaviour of the different types of ovarian tumour is extremely variable. In order to have a better understanding of frequency and histomorphological patterns of different ovarian lesions study was encountered in our tertiary care hospital.To study the histopathology of ovarian non-neoplastic and neoplastic lesions and to study the distribution of ovarian lesions with respect to various parameters like age, bilaterality, gross and microscopic features.This is a prospective study of 125 ovarian specimens received in department of pathology, G.K. General Hospital, Bhuj during August 1, 2018 to July 31, 2020. Total 125 cases of ovarian specimens were studied, amongst them 58 were non-neoplastic and remaining 67 were neoplastic. The most common non-neoplastic lesion seen was follicular cysts 12 cases (21%), followed by endometriosis 9 cases (16%). Among 67 neoplastic ovarian lesions 58(87%) cases were benign, 3(4%) cases were borderline and 6 (9%) cases were malignant. In benign ovarian neoplasm, most commonly seen lesions were serous cystadenoma 24 cases (36%) followed by 13 cases (20%) of mature cystic teratoma. In malignant cases, maximum was of high-grade serous cystadenocarcinoma.Ovarian epithelial tumours are the most common type, while serous cystadenocarcinoma was the most common malignancy. Histological examination is gold standard and in certain difficult cases require immunohistochemistry.Ovary is an important reproductive organ with involvement in production of progeny.Ovarian pathology ranges from innocuous non-neoplastic lesions to malignant neoplastic entities. Ovarian neoplasms have become increasingly important not only because of the wide range of neoplasms, but also because they have gradually increased the mortality rate. The incidence, clinical appearance and the behaviour of the different types of ovarian tumour is extremely variable.

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5-year experience with vulval lesions in a tertiary care hospital: series of 115 cases

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20205237 ◽

2020 ◽

Vol 9 (12) ◽

pp. 5001

Author(s):

Ritu Bhat ◽

Sachin Kolte

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Tertiary Care ◽

Care Hospital ◽

Labia Minora ◽

Number Of Patients ◽

Rare Tumours ◽

Wide Range ◽

Neoplastic Lesions

Background: Wide range of vulval lesions have been described with similar modes of presentation. Benign and inflammatory lesions form the major chunk. Squamous cell carcinoma is the most reported malignant entity. Aim was to review the vulval lesions received in our departmentMethods: We studied the data from the archives of the Department of Pathology for a period of 5 years from January 2014 to December 2018 for vulval biopsies and specimens sent for histopathological examination. The final diagnoses were divided into non-neoplastic, neoplastic and non- specific.Results: Age of women ranged from 22 to 86 years (mean 54.3±3.6) with the maximum number of patients between 50 to 60 years of age. Most common form of clinical presentation was an itchy white elevated lesion on the vulva (72 cases, 62.6%). The most common site for the lesions was labia minora (90 cases, 78.2%). Non neoplastic lesions were seen in 53 cases and neoplastic lesions were seen in 52 cases. There were 28 (53.8%) benign lesions while 24 cases (46.1%) were malignant. Squamous cell carcinoma was the most frequently diagnosed form accounting for 20 cases (83.3%). Rare tumours like Malignant melanoma, Merkel cell carcinoma and Neuroendocrine carcinoma formed 16.6% (n=4). Seven cases were premalignant. Two cases had non-specific histologic diagnosis showing mild chronic inflammation.Conclusions: Previous studies have reported that non-neoplastic lesions form around 70% of cases. However, in our study we found that the non-neoplastic and neoplastic lesions form equal number of cases (46%) which may be attributed to increased awareness or geographical variation.

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A RETROSPECTIVE ANALYSIS OF HISTOPATHOLOGICAL SPECTRUM OF LESIONS IN NEPHRECTOMY SPECIMENS IN A TERTIARY CARE CENTRE

10.36106/ijsr/1625859 ◽

2020 ◽

pp. 1-3

Author(s):

K. Sitharamaiah ◽

K. Anusha ◽

G.Raja Sekhar ◽

A. Bhagavan ◽

G. Baleswari

Keyword(s):

Tertiary Care ◽

Chronic Pyelonephritis ◽

Care Hospital ◽

Geographical Differences ◽

Tertiary Care Centre ◽

Common Procedure ◽

Neoplastic Lesion ◽

Radiological Data ◽

High Incidence ◽

Neoplastic Lesions

Background: Kidneys can be involved in various pathological processes. Nephrectomy is a common procedure in urological practice. Indications for nephrectomy can display geographical differences in different countries around the world with different urological causes. The aim of the study was to analyse the various lesions in nephrectomy specimens in a tertiary care hospital in Kurnool, Andhra Pradesh, South India and also to know the frequency of lesions according to the age, gender and histology. Materials and Methods: It is a retrospective study, done over a period of 13 years from June 2007 to March 2020 which included 132 nephrectomy cases. Patient information such as age, gender, clinical diagnosis, radiological data such as USG and CT results, gross morphology and microscopic data were recorded from the available data. Results: Of 132 nephrectomy specimens, 55 (41.66%) were males and 77 (58.34%) were females. The mean age was 40.46 years. 99 (75%) nephrectomy specimens showed ‑ non‑neoplastic lesions and 33 (25%) showed neoplastic lesions. The most common non‑neoplastic lesions were chronic pyelonephritis in 62 (46.96%) patients, followed by tuberculous pyelonephritis in 20 (15.15%) patients. RCC (n = 27) was the most common neoplastic lesion. Conclusion: Chronic pyelonephritis remains the most common non-neoplastic cause of nephrectomy. RCC is the most common neoplastic cause of nephrectomy. Tuberculosis has a high incidence in developing countries. Awareness of renal TB is required for the physicians, to suspect this disease in patients with unexplained urinary tract abnormalities, particularly in those with any immunosuppression and those coming from TB-endemic areas.

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Clinicopathological profile of sinonasal masses-a tertiary care centre study in rural India

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20204182 ◽

2020 ◽

Vol 6 (10) ◽

pp. 1821

Author(s):

Vidya Rokade ◽

Kiran J. Shinde ◽

Girishkumar R. More

Keyword(s):

Histopathological Examination ◽

Tertiary Care ◽

Rural India ◽

Histopathological Diagnosis ◽

Care Hospital ◽

Tertiary Care Centre ◽

Radiological Investigation ◽

Male Predominance ◽

Neoplastic Lesion ◽

Neoplastic Lesions

Background: A variety of mass lesions occur within the paranasal sinus (PNS) and nasal cavity and thus it becomes mandatory for otorhinolaryngologist to elicit detailed history and thorough examination before reaching a final diagnosis. This is retrospective study of all sinonasal masses who were undergone surgical management in the institute of rural India and so in the environment.Methods: This is a retrospective observational study of 70 patients with sinonasal masses treated at a rural tertiary care hospital in rural western Maharashtra from period of Jan 2016 to May 2018. History, clinical assessment and histopathological examination (HPE) was done in all cases as per hospital record supplemented by radiological investigation as per requirement. The patients were grouped as per their histopathological diagnosis as non-neoplastic/inflammatory and neoplastic.Results: A total of 70 patients were analysed age ranging (11-70 years). Majority of the patients were in the age groups 21-40 years (47%). There were 43 (61%) male and 27 (39%) female with M:F ratio 1.6:1. On HPE, 50 (71%) cases were non neoplastic/inflammatory and 20 (29%) cases were neoplastic lesions. HPE revealed that 50 (71%) cases were non neoplastic and 20 (29%) cases were neoplastic lesions.Conclusions: Sinonasal masses have various differential diagnoses. They are fairly common with male predominance. Benign conditions show a peak during 2nd to 4th decade of life while malignancy increasing with the age after 4th decade. In non-neoplastic lesion, Allergic nasal polyp is the commonest histological pattern seen while in malignant lesions squamous cell carcinoma is noted with 100% male predominance.

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Histopathological Study of Ovarian Lesions at a Tertiary Health Care Institute

MVP Journal of Medical Sciences ◽

10.18311/mvpjms/0/v0/i0/724 ◽

2017 ◽

Vol 4 (1) ◽

pp. 26 ◽

Cited By ~ 1

Author(s):

Amod Sawant ◽

Suresh Mahajan

Keyword(s):

Health Care ◽

Hospital Admissions ◽

Tertiary Care ◽

Cystic Teratoma ◽

Serous Cystadenoma ◽

Histopathological Study ◽

Care Hospital ◽

Health Care Centre ◽

Neoplastic Lesion ◽

Benign Cystic Teratoma

Background: Ovary is the commonest site of neoplastic and nonneoplastic lesion, can present in childhood to postmenopausal age group and accounts for the most prevalent cause of hospital admissions. Aim: This study was done to analyse the frequency of ovarian lesions their histological features in a tertiary health care centre. Materials and Methods: This is a prospective study of 143 ovarian lesions at tertiary care hospital over a period of 3yr. All the relevant data of patients analysed from hospital record file. Results: The total number of ovarian lesions studied during study period was 143 cases, amongst them 110 were non-neoplastic and remaining 33 were neoplastic. The most common non-neoplastic lesion seen was solitary follicular cysts i.e. 77 cases (70%), followed by corpus luteal cysts 14 cases (12.7%). Among the 33 neoplastic ovarian lesions 25(75.7%) cases were benign, 2(6.1%) case was at borderline and 6 (18.2%) cases were malignant. In benign ovarian neoplasm, most commonly seen lesion were serous cystadenoma followed by benign cystic teratoma. In malignant cases, maximum were of serous cystadenocarcinoma, followed by endometrioid carcinoma and 2 cases of sex-cord stromal tumours (fibromas) were observed metastatic tumours. Conclusion: Ovarian lesion possess wide gamut of histology. Specific diagnoses are made on routine gross and histological examination.

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Study of histomorphological pattern of ovarian neoplastic and non-neoplastic lesions

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20171849 ◽

2017 ◽

Vol 5 (5) ◽

pp. 2095 ◽

Cited By ~ 1

Author(s):

Rasheed Fatima ◽

Sandhya M. ◽

Sowmya T. S.

Keyword(s):

Malignant Tumors ◽

Tertiary Care ◽

Secondary Malignancy ◽

Care Hospital ◽

Age Group ◽

Cyst Adenoma ◽

Neoplastic Lesion ◽

Neoplastic Lesions ◽

Mucinous Cyst ◽

Serous Cyst Adenoma

Background: The ovary is a striking exception to the Virchow’s dictum that organs that are frequently the site of primary cancer are rarely involved in secondary malignancy, and vice versa. Both primary and secondary carcinomas of the ovary are relatively frequent and show an astounding variety of pathologic patterns. The objectives were to study the histomorphological diversity of various neoplasms and non neoplastic lesions of ovary. To provide a specific diagnosis based upon the histomorphological study which is of paramount clinical significance in further management of the patient.Methods: The present study is based on histomorphological evaluation of 100 cases of ovarian neoplastic and non neoplastic lesions received at the department of Pathology, tertiary care hospital from June 2008 to Aug 2010.Results: A wide variation of age was noted. Among neoplastic lesions, majority of the cases were seen in age group of 20-39 years i.e., 50.6%. Non neoplastic lesion occurred in all age group, but majority of the incidences were seen in the age group of 20 to 40 years of age, accounting for 60% of total occurrence. the commonest ovarian tumor was serous cyst adenoma constituting 54.1% (46 cases) of all ovarian neoplasm. Mucinous cyst adenoma was the second most common tumor. There were 72 cases (85%) of benign, 2 cases (2%) of borderline and 11 cases (13%) of malignant tumors in the present study.Conclusions: The diversity of neoplasms makes it mandatory to classify the tumors accurately by histopathological features following universally accepted classification.

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Histopathological study of ovarian lesions in a tertiary care center in Hyderabad, India: a retrospective five-year study

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20172265 ◽

2017 ◽

Vol 4 (3) ◽

pp. 745 ◽

Cited By ~ 2

Author(s):

Akina Prakash ◽

Sravan Chinthakindi ◽

Ramanan Duraiswami ◽

Indira V.

Keyword(s):

Care Center ◽

Tertiary Care ◽

Age Distribution ◽

Tertiary Hospital ◽

Serous Cystadenoma ◽

Histopathological Study ◽

Care Hospital ◽

Neoplastic Lesion ◽

Histopathological Evaluation ◽

Neoplastic Lesions

Background: The aim of the study was to identify the pattern of pathologies involving ovarian mass lesions which were received for histopathological evaluation at a tertiary hospital in Hyderabad, Telangana, India during the period January 2012 to December 2016.Methods: The data pertaining to samples of ovarian lesions received for histopathological evaluation at the laboratory of a tertiary care hospital in Hyderabad from January 2012 to December 2016, were analyzed to determine the pattern of pathologies diagnosed during such evaluation and the age distribution of all lesions.Results: Non-neoplastic lesions of the ovary constituted 44.0% of all cases received; follicular cysts constituted 45.5% of these lesions. Malignant lesions constituted only 2.0% of all pathologies. Serous cystadenoma of the ovary constituted the predominant neoplastic lesion diagnosed (62.5% of all neoplastic lesions). 53.2% of patients whose samples were received belonged to the age group of 20-39 years. 90.8% of the lesions were unilateralConclusions: The majority of ovarian lesions received for evaluation were benign and unilateral. Most patients were in the third to sixth decades of life.

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Study of histomorphological spectrum of lesions in nephrectomy specimen in a tertiary care hospital in South Gujarat

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20201914 ◽

2020 ◽

Vol 8 (5) ◽

pp. 1706

Author(s):

Himani Bajaj ◽

Rasik Hathila

Keyword(s):

Chronic Infection ◽

Surgical Intervention ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Care Hospital ◽

Age Group ◽

Common Indication ◽

Current State ◽

Neoplastic Lesion ◽

Neoplastic Lesions

Background: Nephrectomy is a standard surgical procedure in urology indicated in patients with organ confined renal malignancies and irreversible kidney damage resulting from chronic infection, trauma, obstruction and congenital malformation. This study aims to study the histomorphological features of lesions in nephrectomy specimens in a tertiary care hospital, to analyse the neoplastic and non-neoplastic lesions of kidney according to age, gender and site and observe any variation from the conventional pattern.Methods: The present study was conducted in department of pathology, Tertiary care hospital over a period of 5 years and 7 months (1 Jan 2013 to July 31, 2018). This included 4 years retrospective and 1 year 7 months prospective. A total of 73 cases of were studied.Results: Males constituted 65.73% and females constituted 35.27% of all nephrectomy cases. Right kidney was more commonly affected. Highest percentage of patients belonged to 41-50 years age group. 45 cases were of non-neoplastic lesions and 28 cases were of neoplastic lesions. Among neoplastic lesions, one case was benign while remaining 27 cases were malignant. Chronic Pyelonephritis was the most common indication overall and also amongst non-neoplastic lesions with stone identified in 55% cases. Most common neoplastic lesion in nephrectomy specimen was Renal Cell carcinoma (71.4.1%) followed by Wilms tumour (14%).Conclusions: This study gives a fair insight of the current state of incidence of neoplastic and non-neoplastic lesions of kidney requiring surgical intervention.

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Prevalence of Histopathologically Diagnosed Ophthalmic Neoplastic Lesion Among Ophthalmic Biopsies in a Pathology Laboratory of Tertiary Hospital of Nepal

Journal of Nepal Medical Association ◽

10.31729/jnma.4635 ◽

2020 ◽

Vol 57 (219) ◽

Author(s):

Santosh Upadhyaya Kafle ◽

Mrinalini Singh ◽

Prerna Arjyal Kafle ◽

BalKumar KC ◽

Sanjeeb Kumar Yadav ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Binary Data ◽

Tertiary Care ◽

Care Hospital ◽

Pathology Laboratory ◽

Medical College ◽

Neoplastic Lesion ◽

Neoplastic Lesions

Introduction: Many vision threatening or life threatening neoplastic conditions often mimic less aggressive neoplastic or non-neoplastic inflammatory variants. This study aims to comprehensively analyze the histopathological spectrum of ophthalmic neoplastic lesions tumors in a pathology laboratory in a tertiary care hospital. Methods: A descriptive cross-sectional study was conducted in the Department of Pathology at Birat Medical College and Teaching Hospital, Morang, Nepal over a period from November 2016 to October 2018. Ethical clearance was taken from Institutional Review Committee of Birat Medical College. Sample size was calculated and convenience sampling was done. Data was collected in excel and analyzed in Statistical Package for Social Sciences version 16. Point estimate at 95% Confidence Interval was calculated and frequency and percentage was calculated for binary data. Subgroup analysis was done based on age, sex, nature of lesions and site of lesions. Results: Prevalence of ophthalmic neoplastic lesion was 139 (55.37%), of which 74 (53.24%) were benign and 65 (46.76%) were malignant. Benign was mostly seen in females and of second decade and malignant was common in males and seventh decade of life respectively. Nevus in 18 (24.3%) and squamous cell carcinoma in 30 (17.6%) was found to be the most common benign and malignant lesions among the specimens. Conjunctiva and cornea in 52 (37.41%) was the most common location for those neoplastic lesions. Conclusions: The most common ophthalmic neoplastic lesion was benign. Nevus is common in females and second decade and squamous cell carcinoma is common in males and seventh decade of life.

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Histopathological Study of Cystoscopic Bladder Biopsies in a Tertiary Care Center

Birat Journal of Health Sciences ◽

10.3126/bjhs.v6i1.37565 ◽

2021 ◽

Vol 6 (1) ◽

pp. 1310-1314

Author(s):

Rachana Dhakal ◽

Hem Nath Joshi ◽

Ramesh Makaju ◽

Shailendra Sigdel

Keyword(s):

Urinary Bladder ◽

Urothelial Carcinoma ◽

Pathological Condition ◽

Care Center ◽

Tertiary Care ◽

University Hospital ◽

World Health ◽

Histopathological Study ◽

Neoplastic Lesion ◽

Neoplastic Lesions

Introduction: Non-neoplastic urinary bladder lesions are not life threatening, but are an important source to cause clinical symptoms and signs. However, neoplasms of the bladder are a source of morbidity, mortality, and exhibit more clinical challenges. Cystoscopy provides overall information about an anatomical/pathological condition of the urinary bladder which will be helpful for patients' management. A cystoscopic biopsy is a primary diagnostic tool for diagnosing urinary bladder cancer. Objectives: The objective of the study was to find the frequency and histomorphological characteristics of urinary bladder lesions in Dhulikhel Hospital, to find the clinical presentation of urinary bladder lesions and to grade the urothelial tumors based on the World Health Organization (WHO)/ International Society of Urological Pathology (ISUP) classification 2004. Methodology: This was a retrospective, cross-sectional, observational study carried out in the Department of Pathology, Dhulikhel Hospital-Kathmandu University Hospital. Convenient sampling was done. All cystoscopy biopsies received from January 2014 to December 2018 were studied. All tissue blocks were retrieved, cut, and stained with Hematoxylin and Eosin. The stained slides were examined under a light microscope by the primary investigator. Result: A total of 70 cystoscopic biopsies were analyzed. The majority of patients 20 (28.6%) were in the age group between 60 and 69 years and males were predominant 43 (61.4%). The neoplastic lesions constituted 40 (57.1%) of all bladder lesions, among them urothelial carcinoma accounted for 38 (54.2%). Similarly, chronic cystitis 27(38.6%) was the most common non-neoplastic lesion. Conclusion: The study found that the neoplastic lesions were commonly encountered in urinary bladder lesions. Among them, lowgrade urothelial carcinoma was the most common bladder tumor. However, most of the non-neoplastic lesions were inflammatory in origin. Cystoscopy combined with histomorphological examination helps in the early detection of bladder lesions.

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ANTIBIOTIC SUSCEPTIBILITY PATTERN OF STAPHYLOCOCCOUS AUREUS ISOLATED FROM VARIOUS CLINICAL SPECIMENS OF TERTIARY CARE HOSPITAL IN TIRUPATI.

10.36106/ijsr/2117632 ◽

2021 ◽

pp. 14-15

Author(s):

Indira Ananthapadmanab asamy ◽

V. Pavani Sai Mounika ◽

K. Vijayakumar ◽

C.H. Srinivasa Rao

Keyword(s):

Antimicrobial Susceptibility ◽

Tertiary Care ◽

Care Hospital ◽

Susceptibility Pattern ◽

Clinical Specimens ◽

Antimicrobial Susceptibility Pattern ◽

Wide Range ◽

Life Threatening ◽

Mrsa Infection ◽

Systemic Infections

INTRODUCTION: Staphylococcus aureus causes a wide range of infections including skin and soft tissue infections to life-threatening systemic infections like sepsis, endocarditis. This study ais to evaluate the antimicrobial susceptibility pattern of S.aurues among various clinical specimens. METHODS: The study included 326 S.aurues, isolated from various clinical specimens which were subjected to antimicrobial susceptibility testing as per CLSI guidelines. RESULTS: Among the 326 isolates, the highest were from pus specimens (47.85%), and was from Orthopaedics department (28.53%). Among the isolates, 219 (67.17%) were Methicilin resistant. All isolates were sensitive to Vancomycin, and all urine isolates were sensitive to Nitrofurantoin. The highest resistance was towards Penicillin (87.42%), Erythromycin (85.28), and Ciprooxacin (83.13%). CONCLUSION: The most effective way to prevent MRSA infection in every hospital is by performing continuous surveillance of antibiotic resistance and by following an effetive antibiotic policy.

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