A RETROSPECTIVE ANALYSIS OF HISTOPATHOLOGICAL SPECTRUM OF LESIONS IN NEPHRECTOMY SPECIMENS IN A TERTIARY CARE CENTRE

Background: Kidneys can be involved in various pathological processes. Nephrectomy is a common procedure in urological practice. Indications for nephrectomy can display geographical differences in different countries around the world with different urological causes. The aim of the study was to analyse the various lesions in nephrectomy specimens in a tertiary care hospital in Kurnool, Andhra Pradesh, South India and also to know the frequency of lesions according to the age, gender and histology. Materials and Methods: It is a retrospective study, done over a period of 13 years from June 2007 to March 2020 which included 132 nephrectomy cases. Patient information such as age, gender, clinical diagnosis, radiological data such as USG and CT results, gross morphology and microscopic data were recorded from the available data. Results: Of 132 nephrectomy specimens, 55 (41.66%) were males and 77 (58.34%) were females. The mean age was 40.46 years. 99 (75%) nephrectomy specimens showed ‑ non‑neoplastic lesions and 33 (25%) showed neoplastic lesions. The most common non‑neoplastic lesions were chronic pyelonephritis in 62 (46.96%) patients, followed by tuberculous pyelonephritis in 20 (15.15%) patients. RCC (n = 27) was the most common neoplastic lesion. Conclusion: Chronic pyelonephritis remains the most common non-neoplastic cause of nephrectomy. RCC is the most common neoplastic cause of nephrectomy. Tuberculosis has a high incidence in developing countries. Awareness of renal TB is required for the physicians, to suspect this disease in patients with unexplained urinary tract abnormalities, particularly in those with any immunosuppression and those coming from TB-endemic areas.

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Clinicopathological profile of sinonasal masses-a tertiary care centre study in rural India

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20204182 ◽

2020 ◽

Vol 6 (10) ◽

pp. 1821

Author(s):

Vidya Rokade ◽

Kiran J. Shinde ◽

Girishkumar R. More

Keyword(s):

Histopathological Examination ◽

Tertiary Care ◽

Rural India ◽

Histopathological Diagnosis ◽

Care Hospital ◽

Tertiary Care Centre ◽

Radiological Investigation ◽

Male Predominance ◽

Neoplastic Lesion ◽

Neoplastic Lesions

Background: A variety of mass lesions occur within the paranasal sinus (PNS) and nasal cavity and thus it becomes mandatory for otorhinolaryngologist to elicit detailed history and thorough examination before reaching a final diagnosis. This is retrospective study of all sinonasal masses who were undergone surgical management in the institute of rural India and so in the environment.Methods: This is a retrospective observational study of 70 patients with sinonasal masses treated at a rural tertiary care hospital in rural western Maharashtra from period of Jan 2016 to May 2018. History, clinical assessment and histopathological examination (HPE) was done in all cases as per hospital record supplemented by radiological investigation as per requirement. The patients were grouped as per their histopathological diagnosis as non-neoplastic/inflammatory and neoplastic.Results: A total of 70 patients were analysed age ranging (11-70 years). Majority of the patients were in the age groups 21-40 years (47%). There were 43 (61%) male and 27 (39%) female with M:F ratio 1.6:1. On HPE, 50 (71%) cases were non neoplastic/inflammatory and 20 (29%) cases were neoplastic lesions. HPE revealed that 50 (71%) cases were non neoplastic and 20 (29%) cases were neoplastic lesions.Conclusions: Sinonasal masses have various differential diagnoses. They are fairly common with male predominance. Benign conditions show a peak during 2nd to 4th decade of life while malignancy increasing with the age after 4th decade. In non-neoplastic lesion, Allergic nasal polyp is the commonest histological pattern seen while in malignant lesions squamous cell carcinoma is noted with 100% male predominance.

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A study of etiology and outcome of preterm birth at a tertiary care centre

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20174429 ◽

2017 ◽

Vol 6 (10) ◽

pp. 4488

Author(s):

Shaveta Garg ◽

Tajinder Kaur ◽

Ajayveer Singh Saran ◽

Monu Yadav

Keyword(s):

Preterm Birth ◽

Tertiary Care ◽

Preterm Births ◽

Active Phase ◽

Care Hospital ◽

Tertiary Care Centre ◽

Mortality And Morbidity ◽

High Incidence ◽

History Of ◽

Tract Infections

Background: Preterm births are still the leading cause of perinatal mortality and morbidity. It is a major challenge in the obstetrical health care.Methods: This study was conducted over a period of eight months from September 2016 till April 2017 at a tertiary care hospital. All patients who delivered a live baby before 37 weeks of gestation were included in the study.Results: Present study was conducted on 100 eligible women out of which 7 delivered before 30 weeks but majority of them (55%) delivered after 34 weeks of gestation. In our study, most of the patients (66%) presented in active phase of labor which resulted in preterm birth of baby. The most common risk factor of preterm labor was genitourinary tract infections (34%) followed by Preterm Premature rupture of membranes (22%). Past obstetric history of preterm delivery and abortions also had a significant impact on the present pregnancy outcome.Conclusions: Preterm labour and birth still have a high incidence causing significant neonatal mortality and morbidity as well as economic burden on family and hospital. The causes of preterm birth are multifactorial and modifiable. This incidence can be reduced by early identification of established risk factors, as revisited and reemphasized in our study, with the help of universal and proper antenatal care.

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HISTOPATHOLOGICAL SPECTRUM OF LESIONS OF CERVIX IN A TERTIARY CARE HOSPITAL: A RETROSPECTIVE STUDY

10.36106/ijsr/9234987 ◽

2020 ◽

pp. 1-3

Author(s):

Sujeeva Swapna R ◽

Siva Sankar Naik V ◽

Neeraja M ◽

Bhavani C ◽

Jhansi Rani C

Keyword(s):

Retrospective Study ◽

Large Scale ◽

Tertiary Care ◽

Easy Access ◽

Care Hospital ◽

Cervical Lesions ◽

Tertiary Care Centre ◽

Medical College ◽

Neoplastic Lesion ◽

Histological Variants

INTRODUCTION: Majority of the specimens which reach the histopathology laboratory are from gynecology department. The accessibility of the cervix to direct examination makes it the object of intensive and large scale study. Various inflammatory as well as infectious lesions are common in uterine cervix due to vulnerability to sexual trauma and being an easy access to various infections. Cervical cancer is one of the most frequently seen cancer in women in India. AIM: The present study is aimed to find out the most common types of the cervical lesions, incidence and histological variants of malignancies in women so as to understand the distribution of various diseases. MATERIAL AND METHODS: This is a retrospective study done in Government Medical College , Ananthapuram , a Tertiary Care Centre, for a period of 2 years, from January 2017 to December 2018. RESULTS: A total of 448 cases were retrieved from histopathology department and evaluated. The age group of the patients was between 20-80years. There was about 388 (86.6%) cases were non –neoplastic and 60 (13.39%) cases were neoplastic. CONCLUSION: The most common of non neoplastic lesions was chronic non-specific cervicitis. Most common neoplastic lesion was squamous cell carcinoma.

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Study of histomorphological pattern of ovarian neoplastic and non-neoplastic lesions

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20171849 ◽

2017 ◽

Vol 5 (5) ◽

pp. 2095 ◽

Cited By ~ 1

Author(s):

Rasheed Fatima ◽

Sandhya M. ◽

Sowmya T. S.

Keyword(s):

Malignant Tumors ◽

Tertiary Care ◽

Secondary Malignancy ◽

Care Hospital ◽

Age Group ◽

Cyst Adenoma ◽

Neoplastic Lesion ◽

Neoplastic Lesions ◽

Mucinous Cyst ◽

Serous Cyst Adenoma

Background: The ovary is a striking exception to the Virchow’s dictum that organs that are frequently the site of primary cancer are rarely involved in secondary malignancy, and vice versa. Both primary and secondary carcinomas of the ovary are relatively frequent and show an astounding variety of pathologic patterns. The objectives were to study the histomorphological diversity of various neoplasms and non neoplastic lesions of ovary. To provide a specific diagnosis based upon the histomorphological study which is of paramount clinical significance in further management of the patient.Methods: The present study is based on histomorphological evaluation of 100 cases of ovarian neoplastic and non neoplastic lesions received at the department of Pathology, tertiary care hospital from June 2008 to Aug 2010.Results: A wide variation of age was noted. Among neoplastic lesions, majority of the cases were seen in age group of 20-39 years i.e., 50.6%. Non neoplastic lesion occurred in all age group, but majority of the incidences were seen in the age group of 20 to 40 years of age, accounting for 60% of total occurrence. the commonest ovarian tumor was serous cyst adenoma constituting 54.1% (46 cases) of all ovarian neoplasm. Mucinous cyst adenoma was the second most common tumor. There were 72 cases (85%) of benign, 2 cases (2%) of borderline and 11 cases (13%) of malignant tumors in the present study.Conclusions: The diversity of neoplasms makes it mandatory to classify the tumors accurately by histopathological features following universally accepted classification.

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Histopathological study of ovarian lesions in a tertiary care center in Hyderabad, India: a retrospective five-year study

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20172265 ◽

2017 ◽

Vol 4 (3) ◽

pp. 745 ◽

Cited By ~ 2

Author(s):

Akina Prakash ◽

Sravan Chinthakindi ◽

Ramanan Duraiswami ◽

Indira V.

Keyword(s):

Care Center ◽

Tertiary Care ◽

Age Distribution ◽

Tertiary Hospital ◽

Serous Cystadenoma ◽

Histopathological Study ◽

Care Hospital ◽

Neoplastic Lesion ◽

Histopathological Evaluation ◽

Neoplastic Lesions

Background: The aim of the study was to identify the pattern of pathologies involving ovarian mass lesions which were received for histopathological evaluation at a tertiary hospital in Hyderabad, Telangana, India during the period January 2012 to December 2016.Methods: The data pertaining to samples of ovarian lesions received for histopathological evaluation at the laboratory of a tertiary care hospital in Hyderabad from January 2012 to December 2016, were analyzed to determine the pattern of pathologies diagnosed during such evaluation and the age distribution of all lesions.Results: Non-neoplastic lesions of the ovary constituted 44.0% of all cases received; follicular cysts constituted 45.5% of these lesions. Malignant lesions constituted only 2.0% of all pathologies. Serous cystadenoma of the ovary constituted the predominant neoplastic lesion diagnosed (62.5% of all neoplastic lesions). 53.2% of patients whose samples were received belonged to the age group of 20-39 years. 90.8% of the lesions were unilateralConclusions: The majority of ovarian lesions received for evaluation were benign and unilateral. Most patients were in the third to sixth decades of life.

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Study of histomorphological spectrum of lesions in nephrectomy specimen in a tertiary care hospital in South Gujarat

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20201914 ◽

2020 ◽

Vol 8 (5) ◽

pp. 1706

Author(s):

Himani Bajaj ◽

Rasik Hathila

Keyword(s):

Chronic Infection ◽

Surgical Intervention ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Care Hospital ◽

Age Group ◽

Common Indication ◽

Current State ◽

Neoplastic Lesion ◽

Neoplastic Lesions

Background: Nephrectomy is a standard surgical procedure in urology indicated in patients with organ confined renal malignancies and irreversible kidney damage resulting from chronic infection, trauma, obstruction and congenital malformation. This study aims to study the histomorphological features of lesions in nephrectomy specimens in a tertiary care hospital, to analyse the neoplastic and non-neoplastic lesions of kidney according to age, gender and site and observe any variation from the conventional pattern.Methods: The present study was conducted in department of pathology, Tertiary care hospital over a period of 5 years and 7 months (1 Jan 2013 to July 31, 2018). This included 4 years retrospective and 1 year 7 months prospective. A total of 73 cases of were studied.Results: Males constituted 65.73% and females constituted 35.27% of all nephrectomy cases. Right kidney was more commonly affected. Highest percentage of patients belonged to 41-50 years age group. 45 cases were of non-neoplastic lesions and 28 cases were of neoplastic lesions. Among neoplastic lesions, one case was benign while remaining 27 cases were malignant. Chronic Pyelonephritis was the most common indication overall and also amongst non-neoplastic lesions with stone identified in 55% cases. Most common neoplastic lesion in nephrectomy specimen was Renal Cell carcinoma (71.4.1%) followed by Wilms tumour (14%).Conclusions: This study gives a fair insight of the current state of incidence of neoplastic and non-neoplastic lesions of kidney requiring surgical intervention.

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Pattern of neoplastic and non-neoplastic lesions of ovary: a five-year study in a tertiary care centre of rural india

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20182828 ◽

2018 ◽

Vol 6 (7) ◽

pp. 2418

Author(s):

Geeta Maurya ◽

Sanjeev Kumar Singh ◽

Pinki Pandey ◽

Vineet Chaturvedi

Keyword(s):

Tertiary Care ◽

Female Genital Tract ◽

Mucinous Cystadenoma ◽

Histopathological Study ◽

Care Centre ◽

Tertiary Care Centre ◽

Serous Adenocarcinoma ◽

Follicular Cyst ◽

Neoplastic Lesion ◽

Neoplastic Lesions

Background: Most common ovarian lesions include benign non-neoplastic lesions including functional cysts and neoplastic lesions. While among cancers of female genital tract, the incidence of ovarian cancer ranks below only carcinoma of cervix and endometrium. The aim of this study was to observe and evaluate the frequency and morphological pattern of different ovarian pathologies encountered in this tertiary care centre of rural India.Methods: This was a retrospective five years observational study (2012-16) and conducted at Department of Pathology of UPUMS, Saifai. The study material included 264 histopathology specimens received in our department.Results: Total 264 cases of ovarian pathologies were studied, in which 147 cases were non-neoplastic while remaining 117 cases were neoplastic. The most common non-neoplastic lesion was follicular cyst (51.7%), followed by corpus luteal cyst (30.61%), endometriosis (15.64%). Among 117 neoplastic cases, 87 cases (74.35%) were benign, 5 cases (4.27%) were borderline tumours and 25 cases (21.36%) were diagnosed malignant. Serous cystadenoma was most common benign tumour with 53 cases (45.29%) followed by 20 cases (17.09%) of dermoid cyst and 12 cases (10.25%) of mucinous cystadenoma. While in malignant tumours, serous adenocarcinoma were most common (4.27%) followed by mucinous adenocarcinoma (2.56%).Conclusions: In our study, non-neoplastic ovarian lesions were more commonly seen than neoplastic lesions. Surface epithelial tumours were most common histologic type in all age groups. While serous adenocarcinoma was most common ovarian malignancy seen. Both non-neoplastic as well as neoplastic lesions of ovary often present with similar clinical and radiological features. So histopathological study is essential to diagnose ovarian tumours.

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Study of histopathological spectrum of ovarian lesions

IP Archives of Cytology and Histopathology Research ◽

10.18231/j.achr.2021.052 ◽

2021 ◽

Vol 6 (4) ◽

pp. 230-236

Author(s):

Keval A Patel ◽

Riddhi A Parmar ◽

Jaimin M Patel ◽

Bhawana S Sharma ◽

Bimal Patel ◽

...

Keyword(s):

Tertiary Care ◽

Cystic Teratoma ◽

Ovarian Tumour ◽

Care Hospital ◽

Clinical Appearance ◽

Serous Cystadenocarcinoma ◽

Neoplastic Lesion ◽

Wide Range ◽

Neoplastic Lesions ◽

Different Types

Ovarian pathology ranges from innocuous non-neoplastic lesions to malignant neoplastic entities. The incidence, clinical appearance and the behaviour of the different types of ovarian tumour is extremely variable. In order to have a better understanding of frequency and histomorphological patterns of different ovarian lesions study was encountered in our tertiary care hospital.To study the histopathology of ovarian non-neoplastic and neoplastic lesions and to study the distribution of ovarian lesions with respect to various parameters like age, bilaterality, gross and microscopic features.This is a prospective study of 125 ovarian specimens received in department of pathology, G.K. General Hospital, Bhuj during August 1, 2018 to July 31, 2020. Total 125 cases of ovarian specimens were studied, amongst them 58 were non-neoplastic and remaining 67 were neoplastic. The most common non-neoplastic lesion seen was follicular cysts 12 cases (21%), followed by endometriosis 9 cases (16%). Among 67 neoplastic ovarian lesions 58(87%) cases were benign, 3(4%) cases were borderline and 6 (9%) cases were malignant. In benign ovarian neoplasm, most commonly seen lesions were serous cystadenoma 24 cases (36%) followed by 13 cases (20%) of mature cystic teratoma. In malignant cases, maximum was of high-grade serous cystadenocarcinoma.Ovarian epithelial tumours are the most common type, while serous cystadenocarcinoma was the most common malignancy. Histological examination is gold standard and in certain difficult cases require immunohistochemistry.Ovary is an important reproductive organ with involvement in production of progeny.Ovarian pathology ranges from innocuous non-neoplastic lesions to malignant neoplastic entities. Ovarian neoplasms have become increasingly important not only because of the wide range of neoplasms, but also because they have gradually increased the mortality rate. The incidence, clinical appearance and the behaviour of the different types of ovarian tumour is extremely variable.

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Prevalence of Histopathologically Diagnosed Ophthalmic Neoplastic Lesion Among Ophthalmic Biopsies in a Pathology Laboratory of Tertiary Hospital of Nepal

Journal of Nepal Medical Association ◽

10.31729/jnma.4635 ◽

2020 ◽

Vol 57 (219) ◽

Author(s):

Santosh Upadhyaya Kafle ◽

Mrinalini Singh ◽

Prerna Arjyal Kafle ◽

BalKumar KC ◽

Sanjeeb Kumar Yadav ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Binary Data ◽

Tertiary Care ◽

Care Hospital ◽

Pathology Laboratory ◽

Medical College ◽

Neoplastic Lesion ◽

Neoplastic Lesions

Introduction: Many vision threatening or life threatening neoplastic conditions often mimic less aggressive neoplastic or non-neoplastic inflammatory variants. This study aims to comprehensively analyze the histopathological spectrum of ophthalmic neoplastic lesions tumors in a pathology laboratory in a tertiary care hospital. Methods: A descriptive cross-sectional study was conducted in the Department of Pathology at Birat Medical College and Teaching Hospital, Morang, Nepal over a period from November 2016 to October 2018. Ethical clearance was taken from Institutional Review Committee of Birat Medical College. Sample size was calculated and convenience sampling was done. Data was collected in excel and analyzed in Statistical Package for Social Sciences version 16. Point estimate at 95% Confidence Interval was calculated and frequency and percentage was calculated for binary data. Subgroup analysis was done based on age, sex, nature of lesions and site of lesions. Results: Prevalence of ophthalmic neoplastic lesion was 139 (55.37%), of which 74 (53.24%) were benign and 65 (46.76%) were malignant. Benign was mostly seen in females and of second decade and malignant was common in males and seventh decade of life respectively. Nevus in 18 (24.3%) and squamous cell carcinoma in 30 (17.6%) was found to be the most common benign and malignant lesions among the specimens. Conjunctiva and cornea in 52 (37.41%) was the most common location for those neoplastic lesions. Conclusions: The most common ophthalmic neoplastic lesion was benign. Nevus is common in females and second decade and squamous cell carcinoma is common in males and seventh decade of life.

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Histopathological Study of Cystoscopic Bladder Biopsies in a Tertiary Care Center

Birat Journal of Health Sciences ◽

10.3126/bjhs.v6i1.37565 ◽

2021 ◽

Vol 6 (1) ◽

pp. 1310-1314

Author(s):

Rachana Dhakal ◽

Hem Nath Joshi ◽

Ramesh Makaju ◽

Shailendra Sigdel

Keyword(s):

Urinary Bladder ◽

Urothelial Carcinoma ◽

Pathological Condition ◽

Care Center ◽

Tertiary Care ◽

University Hospital ◽

World Health ◽

Histopathological Study ◽

Neoplastic Lesion ◽

Neoplastic Lesions

Introduction: Non-neoplastic urinary bladder lesions are not life threatening, but are an important source to cause clinical symptoms and signs. However, neoplasms of the bladder are a source of morbidity, mortality, and exhibit more clinical challenges. Cystoscopy provides overall information about an anatomical/pathological condition of the urinary bladder which will be helpful for patients' management. A cystoscopic biopsy is a primary diagnostic tool for diagnosing urinary bladder cancer. Objectives: The objective of the study was to find the frequency and histomorphological characteristics of urinary bladder lesions in Dhulikhel Hospital, to find the clinical presentation of urinary bladder lesions and to grade the urothelial tumors based on the World Health Organization (WHO)/ International Society of Urological Pathology (ISUP) classification 2004. Methodology: This was a retrospective, cross-sectional, observational study carried out in the Department of Pathology, Dhulikhel Hospital-Kathmandu University Hospital. Convenient sampling was done. All cystoscopy biopsies received from January 2014 to December 2018 were studied. All tissue blocks were retrieved, cut, and stained with Hematoxylin and Eosin. The stained slides were examined under a light microscope by the primary investigator. Result: A total of 70 cystoscopic biopsies were analyzed. The majority of patients 20 (28.6%) were in the age group between 60 and 69 years and males were predominant 43 (61.4%). The neoplastic lesions constituted 40 (57.1%) of all bladder lesions, among them urothelial carcinoma accounted for 38 (54.2%). Similarly, chronic cystitis 27(38.6%) was the most common non-neoplastic lesion. Conclusion: The study found that the neoplastic lesions were commonly encountered in urinary bladder lesions. Among them, lowgrade urothelial carcinoma was the most common bladder tumor. However, most of the non-neoplastic lesions were inflammatory in origin. Cystoscopy combined with histomorphological examination helps in the early detection of bladder lesions.

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