Clinico-pathological correlation of ovarian tumors and tumor like lesions with role of CA125 and HE4 as biomarkers for discrimination of benign and malignant ovarian tumors

Background: Ovarian tumors and tumor like lesions of ovary frequently form pelvic masses and are associated with hormonal manifestations. Clinically or surgically they can mimic malignancy but pathologically they could be benign tumors or tumor like lesions.Methods: The aim of present study is to do clinico-histopathological correlation of ovarian tumors and tumor like lesions of ovary and also evaluate the role of serum CA125, HE4 and calculate risk of ovarian malignancy algorithm (ROMA), for differentiation of benign and malignant ovarian tumors.233 cases of ovarian tumors and tumor like lesions were studied. Tumors were classified according to WHO classification. Clinical and histological findings were compiled on proforma and subjected to analysis.Results: In present study, out of total 233 cases, 41.2% were ovarian tumors and 58.8% tumor like lesions of ovary. Among tumor like lesions, follicular cyst was commonest lesion while among ovarian tumors, benign serous surface epithelial tumor was commonest. In patients with ovarian tumors, blood samples were collected, before and after the treatment for analysis of CA125, HE4 and ROMA.Conclusions: Serum values of CA125and HE4 as well as ROMA were highly elevated in women with malignant epithelial tumors as compared to women with benign lesions. Also, all the parameters i.e. HE4, CA125 and ROMA showed significant difference before and after surgery. Hence measuring serum HE4 and CA125 along with ROMA calculation may provide higher accuracy for detecting malignant epithelial ovarian tumor.

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SUBLINGUAL VITAMIN D3 DRUG THERAPY IN VITAMIN D DEFICIENCY PATIENTS AT PRAVARA RURAL HOSPITAL

International Journal of Clinical and Biomedical Research ◽

10.31878/ijcbr.2019.54.05 ◽

2019 ◽

pp. 18-20

Author(s):

Sanjeeva Kumar Goud T ◽

Rahul Kunkulol

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Vitamin D3 ◽

Serum Vitamin ◽

Cross Sectional ◽

Serum Vitamin D ◽

Significant Difference ◽

Before And After

The present study was aimed to study the effect of Sublingual Vitamin D3 on Serum Vitamin D level in Vitamin D deficiency patients. This was a cross-sectional and interventional study. All the Vitamin D deficiency patients of age 18-60years and either gender, willing to participate in the study were included. Patients who had greater than 20 ng/ml were excluded from the study. The total number of participants in our study was 200, out of these 111 males and 89 females, the mean age in our study was 51.07 ± 7.39Yrs. All volunteers were given sublingual vitamin D3 (60,000IU) in six doses every fifteen days of follow up for 3 months. The subject’s serum 25(OH)D levels were estimated before and after the treatment of sublingual vitamin D3. There was a statistically significant difference in serum vitamin D3 level before 16.61±6.71 ng/ml and after 35.80±7.80 ng/ml after treatment with Sublingual Vitamin D3. Six doses of 60,000IU of Vitamin D3 sublingual route having improved the role of serum 25(OH)D levels in the treatment of Vitamin D3 deficiency patients.Keywords: Vitamin D3; Sublingual route

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Role of CA 19-9 in complex ovarian tumors

10.1055/s-0039-1685299 ◽

2016 ◽

Author(s):

Dhanya S. Thomas ◽

Ajit Sebastian ◽

Vinotha Thomas ◽

Anitha Thomas ◽

Rachel Chandy ◽

...

Keyword(s):

Malignant Tumors ◽

Ovarian Tumors ◽

Benign Tumors ◽

Ovarian Mass ◽

Radiological Findings ◽

Epithelial Tumors ◽

Mucin Glycoprotein ◽

Glycoprotein Antigen ◽

Mucinous Tumours

Background: Cancer antigen 19-9 (CA 19-9) is a tumor-associated mucin glycoprotein antigen that may be elevated in healthy individuals as well as in patients with benign and malignant tumors. It is useful in the management of pancreatic and other gastrointestinal tumors. CA 19-9 is also elevated in benign and malignant ovarian tumors. Aim: To study the pattern of serum CA19-9 in complex ovarian tumors. Methods: The study design was descriptive, based on data collected from medical records. Patients with a complex ovarian mass, who were investigated with CA 19-9 and had undergone surgery, wereincluded in the study. The study duration was 2 years from January 2014 to December 2015. A total of 273 patients (119 - benign and 154 malignant) with complex ovarian mass and elevated CA 19-9 underwent surgery during the study period. Results: CA 19-9 was elevated in 55 patients (20%). Of these, 23 patients had benign tumors while 32 had malignant tumors.Among patients with benign tumors, 21 had dermoid, 23 had mucinous tumors and 75 had other types of tumors. CA 19-9 was elevated in 10 (47.6%) of the dermoids, 7 (30.4%) of the mucinous tumors and 6 (8%) of the other benign tumors. Among patients with malignant tumors, 138 were epithelial and 16 were non epithelial tumors. Of the epithelial tumors, 31 were mucinous and 107 were non mucinous types. Overall, 29 (21%) had elevated CA 19-9. Of the epithelial tumors, 22.6% of the mucinous type and 20.6% of the non mucinous type had elevated CA 19-9. Among the non-epithelial tumors, 3 (18.8%) had elevated CA19-9. Conclusion: CA 19-9 is elevated in several conditions but most likely to be raised in dermoid cysts and mucinous tumours. CA19-9 levels need to be interpreted along with clinical and radiological findings.

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Endothelium-dependent arterial wall tone elasticity modulated by blood viscosity

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.00330.2001 ◽

2002 ◽

Vol 282 (2) ◽

pp. H389-H394 ◽

Cited By ~ 39

Author(s):

Edmundo I. Cabrera Fischer ◽

Ricardo L. Armentano ◽

Franco M. Pessana ◽

Sebastián Graf ◽

Luis Romero ◽

...

Keyword(s):

Blood Viscosity ◽

Muscle Activation ◽

Arterial Wall ◽

Mock Circulation ◽

Significant Difference ◽

Before And After ◽

Strain Relationship ◽

Instantaneous Pressure

The role of blood viscosity on arterial wall elasticity before and after deendothelization (DE) was studied. Seven ovine brachiocephalic arteries were studied in vitro under physiological pulsatile flow conditions achieved by a mock circulation loop. Instantaneous pressure and diameter signals were assessed in each arterial segment. Incremental elastic modulus ( E inc) was calculated using the slope of the pure elastic stress-strain relationship. There was no significant difference between E inc values before and after DE (3.11 vs. 3.16 107 dyn/cm2) at a blood viscosity of 2.00 mPa · s. Increases in blood viscosity (2.50, 3.00, 3.50, and 4.00 mPa · s) always resulted in decreases of E inc before DE; inversely, increases in blood viscosity resulted in increases of E inc after DE. These values of E inc, for identical levels of blood viscosity, were always significantly lower ( P< 0.05) before DE than those obtained after DE. Arterial wall elasticity assessed through E inc was strongly influenced by blood viscosity, probably due to presence or absence of endothelium relaxing factors or to direct shear smooth muscle activation when endothelial cells are removed.

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Vitamin E in the neuroprotection of cisplatin induced peripheral neurotoxicity and ototoxicity

Journal of Clinical Oncology ◽

10.1200/jco.2007.25.18_suppl.9114 ◽

2007 ◽

Vol 25 (18_suppl) ◽

pp. 9114-9114 ◽

Cited By ~ 7

Author(s):

A. Pace ◽

S. Carpano ◽

E. Galiè ◽

A. Savarese ◽

M. Della Giulia ◽

...

Keyword(s):

Placebo Group ◽

Vitamin E ◽

Peripheral Neurotoxicity ◽

Double Blind ◽

Multicentric Study ◽

Phase Ii Studies ◽

Significant Difference ◽

Before And After ◽

Vitamin E Supplementation

9114 Background: Peripheral neurotoxicity is a well recognized effect of cisplatin chemotherapy that can result in severe disability and represents a major dose-limiting factor. Several phase II studies have recently investigated the role of vitamin E as neuroprotectant in the prevention of cisplatin induced peripheral neurotoxicity and ototoxicity. Methods: An Italian randomized, placebo controlled, double blind multicentric study is ongoing to confirm the role of vitamin E supplementation in the prevention of neurotoxicity and ototoxicity induced by cisplatin Patients candidates to cisplatin chemotherapy were randomised to either vitamin E supplementation (a-tocopherol 400 mg/day) or to placebo. Patients were evaluated with neurological and neurophysiological examination before and after treatment. Neurotoxicity was measured using the comprehensive clinical and neurophysiological Total Neuropathy Score (TNS). Ototoxicity was evaluated with audiometric test and acoustic evoked potential before and after treatment. Results: 81 patients have been enrolled in 3 italian oncologic centers. An interim analysis on the first 50 patients was carried out. 25 patients (11 in the vit E group and 14 in the placebo group) received a cumulative dose higher than 300 mg/mq and were evaluable for neurotoxicity. Statistical analysis showed a significant difference (p < 0.05) in median neurotoxicity score observed in vit E group (TNS=1) respect to the placebo group (TNS=5). Conclusions: This is the first randomised, placebo controlled, double blind trial exploring the efficacy of vitamin E in the neuroprotection of cisplatin neurotoxicity. The results of this study confirm the neuroprotective effect of vitamin E supplementation against cisplatin-induced neurotoxicity. No significant financial relationships to disclose.

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The Effect of Music Therapy on Self-Reported Affect in Hospitalised Paediatric Patients

10.26686/wgtn.16967416 ◽

2021 ◽

Author(s):

◽

Ruth Elizabeth Armstrong

Keyword(s):

Music Therapy ◽

Hospital Environment ◽

Future Research ◽

Psychosocial Needs ◽

Clinical Notes ◽

Significant Difference ◽

Before And After ◽

The Impact ◽

Therapy Sessions

<p>The present research examines the effect of music therapy on the affect of hospitalised children. It took place on a paediatric ward of a New Zealand public hospital. This study aimed to investigate the role of music therapy in addressing patients' psychosocial needs. Literature on the impact of hospitalisation, and on the use of music therapy in hospitals and paediatrics was reviewed. The research involved an audit of the therapist's clinical notes from music therapy sessions over the course of seven months. The clinical notes included measurements of children's mood from the beginning and end of sessions, using McGrath's (1990) Affective Facial Scale. It was hypothesised that mood measures following music therapy would be higher than pre-music therapy scores. Statistical analysis of the facial scale data did not show a significant difference between 'before' and 'after' measures. These results were discussed with regard to a ceiling effect (this is, the measurements indicated patients were at the happy end of the scale before the music therapy session, so there was little room on the scale for mood to improve following music therapy). The measurement of emotion did not prove to be straightforward. The hospital environment may have influenced the patients' responses in a number of ways. These environmental influences are discussed with reference to examples from the clinical notes. The usefulness of facial scales in this context is discussed, as well as other limitations of the research. Suggestions for future research include the use of other mood measures, and the inclusion of measurements of parental mood and how this affects the child.</p>

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The Effect of Music Therapy on Self-Reported Affect in Hospitalised Paediatric Patients

10.26686/wgtn.16967416.v1 ◽

2021 ◽

Author(s):

◽

Ruth Elizabeth Armstrong

Keyword(s):

Music Therapy ◽

Hospital Environment ◽

Future Research ◽

Psychosocial Needs ◽

Clinical Notes ◽

Significant Difference ◽

Before And After ◽

The Impact ◽

Therapy Sessions

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Clinicomorphological study of ovarian tumours: two year study

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20202585 ◽

2020 ◽

Vol 7 (7) ◽

pp. 1061

Author(s):

Sheela K. M. ◽

Priya M. G. ◽

Veena Vijayan

Keyword(s):

Wide Spectrum ◽

Serous Cystadenoma ◽

Ovarian Tumors ◽

Serous Carcinoma ◽

Benign Tumors ◽

Borderline Tumor ◽

Government Medical College ◽

Age Group ◽

Epithelial Tumor ◽

Medical College

Background: The ovarian tumors manifest a wide spectrum of clinical, morphological and histological features. The aim of the study was to study the histopathological patterns of 597 ovarian tumors received in Government Medical College, Thiruvananthapuram, Kerala for a period of 2 years and to correlate with variousclinical parameters like age, nature of presentation, laterality of tumors.Methods: This is a retrospective study of 597 ovarian tumors at Government Medical College, Thiruvananthapuram for a period of 2 years. The clinical data of the patients was obtained from their respective files.Results: Study included 597 cases removed from 570 patients. Total 543 cases were unilateral and 27 cases were bilateral. The predominant age group of ovarian tumors was 4th to 5th decade. The most common clinical presentation was pain abdomen followed by mass abdomen. In the present study, 85% cases were benign tumors, 3.34% were borderline and 11.6% were malignant. Surface epithelial tumors were the most common ovarian neoplasm (79%), followed by germ cell tumor (25%), sex cord stromal tumors (4.2%) and metastasis (0.34%). The most common benign tumor was serous cystadenoma and the most common malignant tumor was serous carcinoma. Mucinous borderline tumor was the most common borderline tumor in this study.Conclusions: Majority of ovarian tumors in this study were benign. Surface epithelial tumor was the most common ovarian tumor in the present study. Most common age group was 40-49 years.

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Pengaruh Edukasi Kesehatan Terhadap Pengetahuan Pasien Stroke dan Keluarga: Peran, Dukungan, dan Persiapan Perawatan Pasien Stroke di Rumah

Media Kesehatan Politeknik Kesehatan Makassar ◽

10.32382/medkes.v13i2.662 ◽

2018 ◽

Vol 13 (2) ◽

pp. 8

Author(s):

Cecep Eli Kosasih ◽

Tetti Solehati ◽

Chandra Isabela Purba

Keyword(s):

Health Education ◽

Test Design ◽

Stroke Patients ◽

Significant Difference ◽

The Family ◽

Before And After ◽

Post Test ◽

Level Of Knowledge ◽

At Home

AbstractStroke patients face a number of problems that include physical, social, emotional, psychological, and spiritual which can cause a decrease in their well-being. Strengthening the role of the family, family support, and preparation for care by the family at home is needed. One effort is to increase the knowledge of stroke patients and families through health education. This study aimed to determine the effect of health education on the knowledge of stroke patients and families on the role, support, and preparation of care at home. The research method used a quasi-experimental design with a one group pre-post test design. The study was conducted at Al Islam Bandung Hospital in 2018. Respondents consisted of 16 stroke patients and 16 stroke family families. The instrument uses a questionnaire. Data analysis using univariate and bivariate analysis. The results showed that before and after the intervention there were significant mean differences in the level of knowledge of patients from 7.94 to 10.38 (p = 0.002), but in the variable readiness of stroke patients there was no significant difference in average seen from the mean value of 14.25 became 15.88 (p = 0.411). In the patient's family, it was shown that before and after the intervention there was a significant of mean difference in the level of knowledge from 5.19 to 6.81 (p = 0.012). Conclusion: health education has been shown to be influential in increasing the level of knowledge of patients and their families regarding stroke, readiness, the role of family carers for stroke patients, psychological support, and preparation for the care of stroke patients at home. However,health education does not affect the level of readiness of stroke patients for transition. Suggestion: readiness to accept the transition in stroke patients is not enough only by health education alone but family participation is needed in providing support to these patients therefore it is recommended that nurses always support the family to support stroke patients. AbstrakPasien stroke menghadapi sejumlah masalah yang mencakup fisik, sosial, emosional, psikologis, dan spiritual yang dapat menyebabkan penurunan kesejateraannya. Diperlukan penguatan peran keluarga, dukungan keluarga, serta persiapan perawatan oleh keluarga di rumah. Salah satu upayanya adalah dengan meningkatkan pengetahuan pasien stroke dan keluarga melalui edukasi kesehatan. Penelitian ini bertujuan untuk mengetahui pengaruh edukasi kesehatan terhadap pengetahuan pasien stroke dan keluarga akan peran, dukungan, dan persiapan perawatan. Metode penelitian menggunakan desain quasi eksperiment dengan rancangan one group pre-post test design. Penelitian dilakukan di Rumah Sakit Al Islam Bandung pada tahun 2018. Responden terdiri dari 16 pasien stroke dan 16 keluarga pasien stroke. Instrumen menggunakan kuesioner. Analisis data menggunakan analisis univariat dan bivariat. Hasil penelitian menunjukan bahwa sebelum dan setelah intervensi terdapat perbedaan rata-rata yang signifikan tingkat pengetahuan pasien dari 7,94 menjadi 10,38 (p = 0,002), tetapi pada variabel kesiapan pasien stroke tidak terdapat perbedaan rata-rata yang signifikan terlihat dari rata-rata nilai 14,25 menjadi 15,88 (p = 0,411). Pada keluarga pasien menunjukan bahwa sebelum dan setelah intervensi terdapat perbedaan rata-rata tingkat pengetahuan yang signifikan dari 5,19 menjadi 6,81 (p = 0,012). Simpulan: edukasi kesehatan terbukti berpengaruh dalam meningkatkan tingkat pengetahuan pasien dan keluarganya mengenai stroke, kesiapan, peran keluarga pengasuh pasien stroke, dukungan psikologis, dan persiapan perawatan pasien stroke di rumah. Edukasi Kesehatan tidak berpengaruh terhadap tingkat kesiapan pasien stroke untuk transisi. Saran : kesiapan untuk menerima transisi pada pasien stroke tidak cukup dengan edukasi kesehatan saja tapi diperlukan peran serta keluarga dalam memberikan dukungan kepada pasien tersebut oleh karena itu disarankan agar perawat selalu mensupport keluarga agar melakukan dukunganpada pasien stroke.

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The role of farmer organizations and networks in the rice supply chain in Thailand

Journal of Agribusiness in Developing and Emerging Economies ◽

10.1108/jadee-01-2017-0016 ◽

2018 ◽

Vol 8 (3) ◽

pp. 554-578 ◽

Cited By ~ 7

Author(s):

Jedsadaporn Sathapatyanon ◽

John K.M. Kuwornu ◽

Ganesh Prasad Shivakoti ◽

Peeyush Soni ◽

Anil Kumar Anal ◽

...

Keyword(s):

Supply Chain ◽

Cooperative Networks ◽

Primary Data ◽

Content Type ◽

Farmer Organizations ◽

Significant Difference ◽

Before And After ◽

Rice Farmer ◽

Financial Arrangements

Purpose The purpose of this paper is to examine the development of rice supply chain in the context of the role of rice farmer organizations and cooperative networks in Thailand. Design/methodology/approach Primary data were solicited from the cooperatives and members of cooperatives for this study through questionnaire administration. The questionnaire containing a five-point Likert scale was posed to respondents to ascertain their problems before and after joining the network (for cooperative) and after joining the cooperative (for members). This study employed the independent two-sample student t-test (two-tailed) to test for significant difference in the means of scores regarding the problems of cooperatives before and after the cooperative network, and also to test for significant difference in the means of scores of the problems of members of the cooperatives before and after joining the cooperative. Findings The study revealed that key production and marketing problems such as increased transaction costs and market uncertainties confronting the cooperative organizations have been diminished as a result of the networks. Key problems of the members of the cooperatives such as exploitation and opportunistic behavior of traders to whom they sell their products have been reduced as a result of joining the cooperatives. Research limitations/implications This paper is not without caveat. The governance structures in relation to leadership, financial arrangements and bargaining power balance have not been analyzed in this study and these are avenues for further research. Originality/value To the best of the authors’ knowledge, this study is the first that examined the combined roles of farmer organizations and cooperative networks in developing the rice supply chain in Thailand.

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Blockade of neuronal nitric oxide synthase alters the baroreflex control of heart rate in the rabbit

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.1998.274.1.r181 ◽

1998 ◽

Vol 274 (1) ◽

pp. R181-R186 ◽

Cited By ~ 13

Author(s):

Hiroshi Murakami ◽

Jun-Li Liu ◽

Hirohito Yoneyama ◽

Yasuhiro Nishida ◽

Kenji Okada ◽

...

Keyword(s):

Nitric Oxide ◽

Heart Rate ◽

No Synthase ◽

Baroreflex Control ◽

Neuronal No Synthase ◽

Significant Difference ◽

Before And After ◽

Synthase Inhibitor ◽

Oxide Synthase

In previous studies we used N G-nitro-l-arginine (l-NNA) to investigate the role of nitric oxide (NO) in baroreflex control of heart rate (HR) and renal sympathetic nerve activity (RSNA).l-NNA increased resting mean arterial pressure (MAP), decreased HR, and did not change or slightly decreased RSNA. These changes complicated the assessment of the central effects of NO on the baroreflex control of HR and RSNA. Therefore, in the present study the effects of the relatively selective neuronal NO synthase inhibitor 7-nitroindazole (7-NI) on the baroreflex control of HR and RSNA were investigated in rabbits. Intraperitoneal injection of 7-NI (50 mg/kg) had no effect on resting HR, MAP, or RSNA. 7-NI significantly reduced the lower plateau of the HR-MAP baroreflex curve from 140 ± 4 to 125 ± 4 and from 177 ± 10 to 120 ± 9 beats/min in conscious and anesthetized preparations, respectively ( P < 0.05). In contrast, there was no significant difference in the RSNA-MAP curves before and after 7-NI administration in conscious or anesthetized preparations. These data suggest that blockade of neuronal NO synthase influences baroreflex control of HR but not of RSNA in rabbits.

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