scholarly journals A Study on Vitamin D Levels in Patients Attended at OPD of A Tertiary Care Hospital of Chattogram

2020 ◽  
Vol 18 (2) ◽  
pp. 37-40
Author(s):  
Shaheda Ahmed ◽  
Md Jalal Uddin ◽  
AYM Masud Reza Khan
Keyword(s):  
Vitamin D ◽  
Tertiary Care ◽  
Serum Vitamin ◽  
Hypovitaminosis D ◽  
Whole Body ◽  
Care Hospital ◽  
Mineral Density ◽  
Female Ratio ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Background: Vitamin D is a fat soluble vitamin, having important role in calcium and phosphorous metabolism. Many researches support the role of vitamin D against cancer, cardiovascular diseases, fractures and falls, cognitive disorders, Parkinsonism, auto-immune diseases, respiratory ailments and depression. Thus Vitamin D Deficiency (VDD) is an alarming public problem. Purpose of this study was to measure the frequency of hypovitaminosis D among different age and sex group of Chattogram, Bangladesh. Materials and methods: A cross sectional hospital based observational study was conducted over a period of six months from February 2018 to July 2018 at a leading diagnostic complex and hospital of Chattogram. A total of 243 patients were included in the study. Number of male and female respondents were 86 and 157 respectively. Age range was 15-85 years. Blood samples were collected aseptically after an oral informed consent. Serum vitamin D levels were estimated using standard laboratory technique (Chemiluminescent microparticle immunoassay method). Results: Among 243 respondents, male female ratio was 1:1.83, mean age was 47± 16.3 years, prevalence of hypovitaminosis was 82%, among male hypovitaminosis was found in 78% cases, whereas among female it was a bit higher with 84%. Sex difference was strongly significant with p value of < 0.01. Conclusion: The present study has limitation with estimation of only vitamin D, in absence of valuable indicators of bone health like serum calcium, bone mineral density and parathyroid hormone. Factors like, less outdoor activities, obesity or covering whole body (Abaiya or burkah) in case of Muslim women, which could be responsible for more hypovitaminosis in case of female was not noticed. But it was very much clear that 45-60 years age group was the most vulnerable with highest level of hypovitaminosis-D in both sexes. Chatt Maa Shi Hosp Med Coll J; Vol.18 (2); July 2019; Page 37-40

scholarly journals Prevalence of Hypovitaminosis D in Patients Visiting a Tertiary Care Center in Chitwan, Nepal

2019 ◽  
Vol 15 (2) ◽  
pp. 84-92
Author(s):  
Kushal Bhattarai ◽  
Nilu Manandhar ◽  
Sarita Dhakal
Keyword(s):  
Vitamin D ◽  
Care Center ◽  
Tertiary Care ◽  
Large Body ◽  
Serum Vitamin ◽  
Hypovitaminosis D ◽  
Demographic Variables ◽  
High Rate ◽  
Care Hospital ◽  
Serum Vitamin D

Background: As documented by a large body of evidences, Hypovitaminosis D prevails both in the general and the hospitalized populations. We conducted this study to determine the prevalence of hypovitaminosis D amongst the patients visiting a tertiary care hospital and compare the rate gender-wise, across different categories of socio-demographic variables. Methods: It was a cross-sectional study (retrospective chart review) based on the hospital registry of patients at College of Medical Sciences and Teaching Hospital, Bharatpur, Chitwan, Nepal. From the registry, we retrieved the socio-demographic variables (age, gender, ethnicity and season) along with serum vitamin D (25-hydroxy-cholecalciferol) concentrations of the study subjects from January 2015 to August 2018, for our analysis. Hypovitaminosis D was defined as serum vitamin D <30 ng/mL (insufficiency: 20-30ng/mL and deficiency: <20 ng/mL). Results: The overall prevalence of hypovitaminosis D was 70.7% (insufficiency: 35.9% and deficiency: 34.8%), 72.4% (females), 64.2% (males), 76.3% (first age-quartile), 74.5% (miscellaneous ethnic group), and 73.9% (Spring). Females had higher prevalence rates of hypovitaminosis D (and lower median serum 25-hydroxy-cholecalciferol lev-els) as compared to males, in overall participants, and those under each category of age, ethnicity and season (except Winter). Conclusions: The greater prevalence of hypovitaminosis D in the females than the males in the face of high rate in the overall hospital-visiting clearly calls for necessary strategies in the form of further studies and judicious prescription of supplementary vitamin D in the target population.

scholarly journals Vitamin D: A Silent Cofactor for Allergic Rhinitis

2019 ◽  
Vol 27 (2) ◽  
pp. 107-112
Author(s):  
Rabi Hembrom ◽  
Somnath Patra ◽  
Rupam Sinha ◽  
Indranil Sen ◽  
Satadal Mandal ◽  
...  
Keyword(s):  
Vitamin D ◽  
Allergic Rhinitis ◽  
Tertiary Care ◽  
Serum Vitamin ◽  
Blood Eosinophil ◽  
Cell Mediated Immunity ◽  
Care Hospital ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Low Serum

Introduction   Allergic rhinitis affects around 50% of atopies in India. Vitamin D is related to both humoral and cell mediated immunity and its receptors are found in inflammatory mediators. This study was conducted to assess any possible association between Allergic rhinitis and serum Vitamin D. Materials and Methods A cross sectional study was conducted amongst 41patients with Allergic rhinitis as per ARIA guidelines attending the Otolaryngology outpatient Department of a peripheral tertiary care hospital. Vitamin D levels were assessed in patients with allergic rhinitis in terms of serum Ig-E level and absolute blood eosinophil count (ABEC). Results Among 41 patients, 31 patients (75.6%) had deficiency of vitamin D with mean Vitamin D level of 14.87±1.56ng/ml (normal vitamin D level-30-100ng/ml and low <20ng/ml), mean serum Ig-E level was 1040±303.83Iu/ml (normal-1.90-170 IU/ml by CLIA method) and mean ABEC 1226.77±397.89 (normal-30-350/ml). Conclusion Low serum Vitamin D is common in Allergic rhinitis patients. Low serum Vitamin D seems to be a significant cofactor in aetiopathogenesis of Allergic rhinitis in most of the cases.

scholarly journals Evaluation of vitamin D status in suspected cases of metabolic syndrome

2019 ◽  
Vol 7 (5) ◽  
pp. 1515
Author(s):  
Radhika Krishnaswamy ◽  
Shelomith K. Chawang ◽  
Priyadharshini Krishnaswamy
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Tertiary Care ◽  
Fasting Blood Glucose ◽  
Age Groups ◽  
Serum Vitamin ◽  
Care Hospital ◽  
Serum Vitamin D ◽  
Increased Risk ◽  
Vitamin D Levels

Background: Metabolic syndrome is associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. Vitamin D has been linked to glucose metabolism and insulin regulation. Hence, this study aims to evaluate the association between the serum level of vitamin D and metabolic syndrome. This may help generate additive strategies in the prevention and management of this syndrome. The objective of the study was to compare the levels of serum vitamin D in subjects with metabolic syndrome and subjects without metabolic syndrome.Methods: A prospective study with 80 subjects was conducted at a tertiary care hospital in Southern India. The sample comprised 40 subjects in the age group of (18-60 years) with metabolic syndrome as cases and 40 subjects without metabolic syndrome in the age groups of (18-60 years) as controls. The presence of any 3 of the following- fasting blood glucose (FBS ≥100mg/dl), triglycerides (TGL≥150mg/dl) and high-density lipoprotein cholesterol (HDL-C ≤40mg/dl-men, ≤50mg/dl-women) levels, blood pressure (≥130/85mmHg or drug treatment) and abdominal waist circumference (>94 cm (37 in) in men and >80 cm (31 in) in women) were used as criteria to screen for the presence (cases) or absence (controls) of metabolic syndrome. Serum vitamin D (25-hydroxy vitamin D) levels were compared between the two groups.Results: Mann Whitney U test was used to compare the vitamin D levels between the two groups. Significantly (p=0.05) lower vitamin D levels were seen in the cases compared to the controls.Conclusions: Metabolic syndrome is associated with significantly lower serum vitamin D levels. We suggest that further studies with a larger sample size be undertaken to confirm the same.

scholarly journals Correlation between Asthma Severity and Serum Vitamin D Levels: Experience from a Tertiary Care Centre in North India

2018 ◽  
Vol 07 (03) ◽  
Author(s):  
Haider Guru ◽  
Sonaullah Shah ◽  
Roohi Rasool ◽  
Qurteeba Qadri ◽  
Faisal R Guru ◽  
...  
Keyword(s):  
Vitamin D ◽  
Tertiary Care ◽  
Serum Vitamin ◽  
Asthma Severity ◽  
North India ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Serum Vitamin D ◽  
Vitamin D Levels

scholarly journals Nutritional Status and Micro Nutrient Deficiencies Among adolescents: A Pilot Study from Northern India (P18-101-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Ankita Kankaria ◽  
Mona Duggal ◽  
Parul Chawla Gupta ◽  
Limalemla Jamir ◽  
Akash Kumar ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pilot Study ◽  
Nutritional Status ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Folate Deficiency ◽  
Serum Folate ◽  
Care Hospital ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Abstract Objectives To study the nutritional status and prevalence of RBC folate, Serum folate and vitamin D deficiency among adolescents. Methods A cross sectional pilot study was carried out among 96 adolescents visiting outpatient department for refraction at tertiary care hospital in North India. Anthropometric data was obtained for height in centimetres and weight in kilograms. A pretested questionnaire was used to capture quantitative data. Venous blood samples were collected where red blood cell (RBC), serum folate and serum Vitamin D concentrations were measured. Anaemia was defined as normal, mild, moderate and severe as Hb > 12gm/dl, 11–11.9 gm/dl, 8–10.9 gm/dl and < 8 gm/dl respectively. Serum folate deficiency was defined as serum folate < 7 nmol/l, and RBC folate deficiency and insufficiency were defined as RBC folate < 305 nmol/l and & < 748 nmol/l, respectively. Vitamin D deficiency, insufficiency and sufficiency was defined as 25(OH)D < 20 ng/ml, 20–29 ng/ml and ≥ 30 ng/ml respectively. Descriptive statistics and inferential statistics were used. Results Almost 46% of adolescents were malnourished (10.4% were underweight, 35.4% were overweight or obese) and mean BMI was 19.7 kg/meter2 however it did not differ significantly across gender. As compared to boys more girls were vegetarian by diet. The mean concentrations for Hb, serum folate and RBC folate were 12.7 (95% CI: 12.4, 13.0) gm/dl, 15.1 (95% CI 12.5, 17.7) nmol/L and 492.9 (95% CI 431.9, 553.9) nmol/L, respectively. Mean concentration for Hb was significantly different across gender (p – 0.0). Around 17% of adolescents were anaemic, 60% were deficient for serum folate and 79% were deficient for RBC folate. Mean serum vitamin D levels were 18 ng/dl (95% CI: 17.0, 22.3) no significant difference found across gender. A total of 62.5% were deficient and 28% were insufficient for vitamin D (ng/ml). Around 50% of the adolescents lack adequate sleep (<8 hours) and increase vitamin D levels were associated with increase sleep duration (r-0.02, p-0.02). Conclusions The nutritional status of adolescents in this study is poor and reflects a need to conduct a community-based study which can help in planning strategies to improve nutritional status during critical period of adolescence Funding Sources nil. Supporting Tables, Images and/or Graphs

Bone mineral density and its influencing factors in children with idiopathic nephrotic syndrome: a prospective observational study

2019 ◽  
Vol 49 (4) ◽  
pp. 292-298
Author(s):  
Indar K Sharawat ◽  
Lesa Dawman ◽  
Merabhai V Kumkhaniya ◽  
Kusum Devpura ◽  
Amarjeet Mehta
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Nephrotic Syndrome ◽  
Bone Mineral ◽  
Idiopathic Nephrotic Syndrome ◽  
Serum Vitamin ◽  
Z Score ◽  
Mineral Density ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Glucocorticoids are first-line therapy for children with idiopathic nephrotic syndrome (INS). These children are at risk of deranged bone metabolism and low bone mineral density (BMD). We studied 60 children with INS and divided them into two groups. Group 1 included 21 children (initial and infrequent relapsing) and group 2 included 39 children (frequent relapsing, steroid dependent and steroid resistant). Dual-energy X-ray absorptiometry of the lumbar spine was performed to assess BMD. Mean BMD Z-score was compared in both groups; this correlated significantly on univariate analysis with cumulative steroid dose, serum vitamin D levels and calcium supplementation. However, on multivariate analysis, serum vitamin D level was the only factor significantly predictive of low z-score.

scholarly journals Serum Vitamin D Level in Patients with Coronary Artery Disease and Association with Sun Exposure: Experience from a Tertiary Care, Teaching Hospital in India

2019 ◽  
Vol 2019 ◽  
pp. 1-4 ◽  
Author(s):  
Tauseef Akhtar ◽  
Ramesh Aggarwal ◽  
Sachin Kumar Jain
Keyword(s):  
Coronary Artery Disease ◽  
Vitamin D ◽  
Coronary Artery ◽  
Vitamin D Deficiency ◽  
Tertiary Care ◽  
Serum Vitamin ◽  
Sun Exposure ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Artery Disease

Background. Vitamin D, a fat-soluble vitamin, has various extraskeletal effects, and several human and animal studies have suggested that vitamin D deficiency may be a contributory factor in the pathogenesis of coronary artery disease (CAD). However, such studies in the Indian subcontinent are either lacking or have shown conflicting results. Methods. This was a descriptive cross-sectional study involving 121 patients with CAD from a tertiary care center and their 80 age-matched healthy controls. Serum vitamin D levels along with serum and urine chemistries were measured in both the groups. The average duration of sun exposure/day and use of sunscreen were also considered in the study cohort using a questionnaire. Serum vitamin D levels were categorized into deficient (<30 nmol/lit), insufficient (30–75 nmol/lit), and sufficient (>75 nmol/lit) groups. Results. Among the cases, 51.2% of the patients were vitamin D deficient and 44.6% patients had insufficient vitamin D levels, whereas among controls, 40% and 31% of the population had deficient and insufficient levels of vitamin D, respectively. However, the mean value of the serum vitamin D level was not statistically different in the cases as compared to that of the controls (34.06 vs 40.19 nmol/lit) (P=0.08). Corrected serum calcium (9.26 vs 9.59 mg%) (P≤0.0001) and serum albumin levels (4.21 vs 4.75 gm%) (P≤0.0001) were lower in the cases than those of the controls. The average sun exposure/day was higher among the cases than that among the controls (2.93 vs 1.85 hours) (P=0.001). Conclusion. Vitamin D deficiency is widely prevalent in Indian population despite abundant sunshine, and the duration of sun exposure is not correlated with serum vitamin D levels. Vitamin D deficiency is not associated with CAD. However, serum calcium is deficient in CAD patients as compared to the controls. Large-scale studies are required to explore the association further to evaluate the benefits of screening and correction of vitamin D deficiency in patients with CAD.

scholarly journals Comparison of Vitamin D Levels, Bone Metabolic Marker Levels, and Bone Mineral Density among Patients with Thyroid Disease: A Cross-Sectional Study

Diagnostics ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1075
Author(s):  
Masliza Hanuni Mat Ali ◽  
Tuan Salwani Tuan Ismail ◽  
Wan Norlina Wan Azman ◽  
Najib Majdi Yaacob ◽  
Norhayati Yahaya ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Thyroid Diseases ◽  
Z Score ◽  
Sectional Study ◽  
Mineral Density ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Thyroid hormones have a catabolic effect on bone homeostasis. Hence, this study aimed to evaluate serum vitamin D, calcium, and phosphate and bone marker levels and bone mineral density (BMD) among patients with different thyroid diseases. This cross-sectional study included patients with underlying thyroid diseases (n = 64, hyperthyroid; n = 53 euthyroid; n = 18, hypothyroid) and healthy controls (n = 64). BMD was assessed using z-score and left hip and lumbar bone density (g/cm2). The results showed that the mean serum vitamin D Levels of all groups was low (<50 nmol/L). Thyroid patients had higher serum vitamin D levels than healthy controls. All groups had normal serum calcium and phosphate levels. The carboxy terminal collagen crosslink and procollagen type I N-terminal propeptide levels were high in hyperthyroid patients and low in hypothyroid patients. The z-score for hip and spine did not significantly differ between thyroid patients and control groups. The hip bone density was remarkably low in the hyperthyroid group. In conclusion, this study showed no correlation between serum 25(OH)D levels and thyroid diseases. The bone markers showed a difference between thyroid groups with no significant difference in BMD.

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