scholarly journals Study of clinical spectrum of hyperbilirubinemia with frequency of glucose six phosphate dehydrogenase deficiency in neonates

2021 ◽  
Vol 9 (6) ◽  
pp. 1674
Author(s):  
Keshawati Goel ◽  
Anshuman Srivastava
Keyword(s):  
G6pd Deficiency ◽  
Prospective Observational Study ◽  
Dehydrogenase Deficiency ◽  
Uttar Pradesh ◽  
Neurological Deficits ◽  
Medical College ◽  
Abo Incompatibility ◽  
Mucous Membranes ◽  
Rh Incompatibility ◽  
Breast Fed

Background: Jaundice is defined as visible reflexion of serum hyperbilirubinemia on mucous membranes and skin as yellowish discoloration. The frequency of icterus among neonates is about 1 in 2500-5000 live births. When there is disparity between the production of bilirubin, conversion from unconjugated to conjugated bilirubin and excretion of bilirubin results in jaundice. Unconjugated bilirubin is usually harmless but it can also cross blood-brain barrier causing neurotoxicity or kernicterus.Methods: A hospital based prospective observational study which is carried out in the department of paediatrics of Teerthanker Mahaveer Medical College, Moradabad, Uttar Pradesh from December 2019 to November 2020 on 74 neonates who required admission for hyperbilirubinemia.Results: The most common jaundice occurred in neonates were idiopathic or breastfeeding jaundice as the neonates were breast fed (47.29%). The second most common cause was ABO incompatibility leading to jaundice in 27 (36.48%) neonates. Incidence of neonatal Sepsis, G6PD deficiency, hypothyroidism and cephalhematoma was 22.9%, 4.1%, 2.70% and 4.1% respectively. Polycythemia contributed to 1.35% and the frequency of hyperbilirubinemia in infants of diabetic mother’s or GDM was 10.8%. Rh incompatibility was seen in 13.5%.Conclusions: G6PD deficiency is a significant cause for NNHB and the cases with pathological jaundice if left untreated may lead to severe neurological deficits and lifelong disabilities, hearing impairment, mental retardation, seizures and movement disorders. Hence we recommend G6PD screening in every newborn with significant hyperbilirubinemia to reduce morbidity and mortality.

scholarly journals A prospective observational study conducted in tertiary teaching hospital of Uttar Pradesh to compare safety and efficacy of PPIUCD and interval IUCD (380A)

2018 ◽  
Vol 8 (1) ◽  
pp. 295
Author(s):  
Nidhi Gupta ◽  
Akanksha .
Keyword(s):  
Observational Study ◽  
Prospective Observational Study ◽  
Uttar Pradesh ◽  
P Value ◽  
Efficacy And Safety ◽  
Puerperal Sepsis ◽  
Medical College ◽  
Tertiary Teaching ◽  
Reversible Method ◽  
Tertiary Teaching Hospital

Background: The objective of this study was to compare the efficacy and safety of PPIUCD and interval IUCD.Methods: This was a prospective observational study conducted on women attending the OPD and indoor services of S.N. Medical college, Agra. 800 women willing for PPIUCD insertion were included in the study after informed consent excluding chorioamnionitis, PROM>18 hours, unresolved PPH and puerperal sepsis. Another 200 willing women were inserted interval IUCD according to MEC criteria of WHO. All were followed up for 1 year.Results: It was found that rate of expulsion was more in PPIUCD group compared to interval IUCD group (6%vs 1.5% p value <.05),rate of removal was almost similar in both groups (11.5%inPPIUCD and 14%in interval IUCD group), cause of removal was mainly social in PPIUCD group while bleeding was more in interval IUCD group compared to PPIUCD (85.7%vs26%).Conclusions: Postpartum insertion of IUCD is a safe effective, feasible and reversible method of contraception.

scholarly journals Prevalence and Genetic Characterization of Glucose-6-Phosphate Dehydrogenase Deficiency in Anemic Subjects from Uttar Pradesh, India

2019 ◽  
Vol 08 (02) ◽  
pp. 047-053 ◽  
Author(s):  
Poonam Tripathi ◽  
Sarita Agarwal ◽  
Srinivasan Muthuswamy
Keyword(s):  
G6pd Deficiency ◽  
Dehydrogenase Deficiency ◽  
Genetic Characterization ◽  
Gene Mutations ◽  
Uttar Pradesh ◽  
Chromosome X ◽  
G6pd Gene ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Fluorescent Spot

AbstractGlucose-6-phosphate dehydrogenase (G6PD) deficiency is caused by one or more mutations in the G6PD gene on chromosome X. It affects approximately 400 million people worldwide. The purpose of this study was to detect the prevalence of G6PD deficiency and G6PD gene mutations in the hospital-based settings in patients referred for suspected G6PD deficiency. A qualitative fluorescent spot test and dichlorophenol-indolphenol (DCIP) test were performed. G6PD-deficient, positive samples were further processed for mutation analysis by Sanger sequencing. Out of 1,069 cases, 95 (8.8%) were detected as G6PD deficient (by DCIP test) and were sent for molecular analysis. The G6PD Mediterranean mutation (563C > T) is the most common variant among G6PD-deficient individuals followed by the Coimbra (592C→T) and Orissa (131C→G) variants. We concluded that all symptomatic patients (anemic or jaundiced) should be investigated for G6PD deficiency. Our findings will inform our population screening approach and help provide better management for G6PD-deficient patients.

scholarly journals Prevalence of glucose 6 phosphate dehydrogenase (G6PD) deficiency in a community by newborn screening

2017 ◽  
Vol 4 (3) ◽  
pp. 1018
Author(s):  
Md Khaja Moinuddin ◽  
Vijayalaxmi Gagandeep ◽  
Seeta Mutalik
Keyword(s):  
Newborn Screening ◽  
G6pd Deficiency ◽  
Prospective Observational Study ◽  
Genetic Disorder ◽  
Molecular Heterogeneity ◽  
Medical College ◽  
Fava Beans ◽  
The Difference ◽  
Severe Jaundice ◽  
Glucose 6 Phosphate Dehydrogenase

Background: Glucose 6 phosphate dehydrogenase deficiency is a genetic disorder and incidence 400 million per year globally. It is X-linked inherited disorder affect males and rarely females also by lyonisation. Characterized by significant biochemical and molecular heterogeneity. Known for its grave complications like hemolysis, severe anemia, failure and severe jaundice following ingestion of fava beans and certain drugs. Prevalent in certain communities of India, hence routine newborn screening and Detection of g6pd deficiency is important to prevent grave complications.Methods: Prospective observational study carried out at Vani Vilas Children’s hospital attached Bangalore Medical college and research institute, from January 2016 to September 2016. All the newborns born at Vani Vilas Hospial included in the study by routine newborn screening.Results: A total of 9,136 neonates were included in this study. There were 5,013 males and 4,123 females. 37 neonates were found to be G-6-PD deficient, prevalence being 0.40%. The difference in the prevalence of G-6-PD deficiency in males 0.57% (n=29) and females 0.19% (n=8) was significant (p <0.002).Conclusions: Significant prevalence of g6pd in India. In our study, we found 1 G6PD deficiency in per 1000 population. Hence, we recommend screening for G6PD deficiency in all the newborns to prevent complications in future. 

scholarly journals Association of ABO and Rh incompatibility with neonatal hyperbilirubinaemia

2017 ◽  
Vol 6 (4) ◽  
pp. 1368 ◽  
Author(s):  
Apexa S. Patel ◽  
Deepak A. Desai ◽  
Aneri R. Patel
Keyword(s):  
Prospective Observational Study ◽  
Proper Time ◽  
Treated Group ◽  
Incompatibility Group ◽  
Haemolytic Disease ◽  
New Born ◽  
Physiological Limits ◽  
Abo Incompatibility ◽  
Rh Incompatibility ◽  
Clinically Significant

Background: 60% of term new-born have clinical jaundice, in the first week of life. ABO incompatibility is the most common cause of haemolytic disease of the new-born. So early intervention, at proper time, is mandatory to prevent these sequelae.Methods: This study was done at Dhiraj Hospital in Obstetrics and Gynecology Department. It was prospective observational study. 200 new-born with ABO incompatibility and 20 new-born with Rh incompatibility, causing clinically significant neonatal hyperbilirubinemia, were recruited for the clinical study noted.Results: The incidence of ABO incompatibility in our study was 13.79% and of Rh incompatibility was 1.37%. In ABO incompatibility group, 90% new born developed clinical jaundice. In treated group, out of 88 new born, 82 were from O-A and O-B incompatibility group. In ABO incompatibility DCT was positive in only 9%, whereas in Rh incompatibility it was 25%. In ABO incompatibility group, majority, 56% did not require treatment, whereas in Rh incompatibility group 65% required treatment. In ABO incompatibility group only 1% required exchange transfusion whereas in Rh incompatibility, it was required in 10%. In ABO incompatibility, all new-born treated well except, 0.5% developed kernicterus. In Rh incompatibility group, 10% new-born developed kernicterusConclusions: In ABO incompatibility, if jaundice develops, it remains in physiological limits. In presence of some aggravating conditions may present as pathological jaundice. It results in significant morbidity but no mortality. So prevention of aggravating factors is very important, in case of ABO incompatibility. 

scholarly journals Clinical profile and aetiological factors of neonatal jaundice from a rural area of Kutch, Gujarat, India

2020 ◽  
Vol 8 (1) ◽  
pp. 143
Author(s):  
Avinash Patel ◽  
Karan Saradava ◽  
Hasmukh Chauhan
Keyword(s):  
Birth Weight ◽  
Neonatal Intensive Care ◽  
Neonatal Jaundice ◽  
Prospective Observational Study ◽  
Medical Science ◽  
Clinical Profile ◽  
Rural Setting ◽  
Abo Incompatibility ◽  
Rh Incompatibility ◽  
Blood Grouping

Background: Etiology of hyperbilirubinemia is not only crucial for optimal management of the patient but also it may have implications for subsequent pregnancies. The objective of this study was to study the clinical profile and the underlying aetiological factors leading to neonatal jaundice in this rural setting of Kutch District, Gujarat, India.Methods: This prospective observational study was conducted in the neonatal intensive care unit (NICU) and Post Natal ward Gujarat Adani Institute of Medical Science, Bhuj, Kutch, Gujarat. Total of 150 cases were enrolled for the study. Blood grouping and Rh typing of baby and mother were done. Cord blood bilirubin and haemoglobin, direct coomb's test (DCT) and bilirubin monitoring were done whenever there was a setting for Rh incompatibility.Results: Among 150 neonates studied, majority had birth weight between 2501g and 3000g. Only 21 babies had birth weight <2.5kg (14%) (Table 2). Of the 150 neonates 85 were males and 65 were females.Conclusions: This study concludes that physiological jaundice is the most common cause of neonatal jaundice in our hospital. This is followed by ABO incompatibility, sepsis, Rh incompatibility and idiopathic cases.

scholarly journals Epidemiological Study of Glucose-6-phosphate Dehydrogenase Deficiency in Scheduled Caste Population of India

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Vandana Rai ◽  
Pradeep Kumar
Keyword(s):  
G6pd Deficiency ◽  
Dehydrogenase Deficiency ◽  
Uttar Pradesh ◽  
Healthy Individuals ◽  
Successful Management ◽  
Institutional Ethics ◽  
Eastern Uttar Pradesh ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
And Control ◽  
Early Detection And Prevention

The aim of the present study was to determine the glucose-6-phostphate dehydrogenase (G6PD) deficiency in scheduled caste (SC) population of eastern Uttar Pradesh, India. After taking clearance certificate from the Institutional Ethics Committee, blood samples were collected from total 200 healthy individuals belonging to scheduled caste. G6PD deficiency analysis was done by methemoglobin test according to the method of Brewer et al. (1962). Out of 200 samples, 20 individuals were glucose-6-phosphate dehydrogenase deficient and 22 samples were heterozygous that is, carriers. The percentage of G6PD deficient (Gd+/+) and G6PD carrier (Gd+/Gd−) phenotypes were 10% and 11%, respectively. The frequency of mutant allele (Gd−) was observed 0.172. Early detection and prevention is the key strategy for successful management and control of this genetic disease.

scholarly journals Assessment of existing referral system of newborn in Madhya Pradesh, India

2019 ◽  
Vol 6 (4) ◽  
pp. 1466
Author(s):  
Avadhesh Verma ◽  
Ajay Gaur ◽  
Ravi Ambey
Keyword(s):  
Prospective Observational Study ◽  
Newborn Care ◽  
Case Fatality ◽  
Uttar Pradesh ◽  
Madhya Pradesh ◽  
Referral System ◽  
Bed Occupancy ◽  
Medical College ◽  
Optimum Utilization ◽  
One Year

Background: Objectives of present study was to assess receiving system of newborns, bed occupancies of referring facilities and receiving facility and assessment of rationality of referrals made by referring facilities to receiving facility leading to congestion at receiving facility. The study was conducted in Department of Pediatrics, Special Newborn Care Unit, Kamla Raja Hospital, Gajra Raja Medical College, Gwalior, Madhya Pradesh.Methods: This study was a prospective observational study which was conducted for a period of one year. Referred newborns fulfilling inclusion criteria were enrolled in study, and their receiving characteristics, bed occupancies of referring facilities and receiving facility, number of rationale and irrational referrals at receiving facility were statistically analysed.Results: Total referred newborns enrolled in the study was 2000. As receiving SNCU, of institute caters not only its nearby places, but also to distant districts of Madhya Pradesh, Rajasthan and Uttar Pradesh. SNCU wise receiving was in order of SNCU Morar (20.60%), Morena (19.40%), Bhind (5.70%), Dholpur (5.35%), Shivpuri (4.40%), Chattarpur (3.10%), Datia (1.20%), Sheopur (0.40%) and Jhansi (0.30%). Referring SNCU wise bed occupancy was in order of SNCU Guna (189.16%), Shivpuri (154%), Morena (72.33%), Bhind (71.63%), Sheopur (69.32%), Morar (64.15%) and Datia (62.11%). Referring SNCU wise case fatality was in order of SNCU Jhansi (100%), Sheopur (100%), Chattarpur (56.45%), Bhind (38.59%), Shivpuri (35.22%), Morena (33.76%), Dholpur (27.10%), Datia (25%), Morar (22.08%).Conclusions: Discordant bed occupancy at referring SNCU and receiving SNCU and low rationality of referrals are reason for congestion at receiving SNCU. Optimum utilization of beds and cordant bed occupancy between referring and receiving SNCU may improve the working conditions in SNCU and newborn outcome. Referral system should be close loop systemwith the provision of Down Referral.

scholarly journals Neonates with Jaundice A Clinical Profile

2020 ◽  
Vol 8 (1) ◽  
pp. 21-23
Author(s):  
Davis Manuel ◽  
Shajahan R A
Keyword(s):  
Breast Feeding ◽  
Neonatal Intensive Care ◽  
Neonatal Jaundice ◽  
Prospective Observational Study ◽  
Clinical Profile ◽  
Abo Incompatibility ◽  
Common Causes ◽  
Rh Incompatibility ◽  
Preterm Babies ◽  
Haemolytic Anemia

Background: In the first week of child birth, neonatal jaundice is the most common problem which leads to delayed hospital discharge and re-admissions. Recognising early neonatal hyperbilirubenemia plays a pivotal role in preventing serious complications. The aim of this study was to study the clinical profile and the aetiological factors leading to neonatal jaundice in rural areas.Subject and Method:This study is a prospective observational study  conducted in neonatal intensive care unit (NICU) and post natal ward . This study was conducted during the period of February 2017 to July 2017. Total 400 neonates were admitted in NICU and post natal ward during this period. Out of them, 100 newborns were having jaundice (Serum bilirubin > 10 mg/dl). 100 cases in total were enrolled in the study. Result:In this study,out of 100 neonates, 70% were males and 30% were females. , 92 were born at term (92%) and remaining 10 were preterm babies (10%). Physiological jaundice constituted 45%, followed by ABO incompatibility constituted 25%, followed by sepsis(1%), Rh incompatibility (8%), idioapathy (8%), prematurity (5%), cephalhematoma (4%), breast feeding (2%), haemolytic anemia (2%) were diagnosed as hereditary spherocytosis. Conclusion:Physiological jaundice is the most common cause of neonatal jaundice followed by ABO incompatibility, sepsis, Rh incompatibility and idiopathic cases. Cephalhematoma, breast feeding jaundice and haemolytic anaemia are the less common causes. Hence, it is required to monitor neonates more appropriately and accurately.

scholarly journals Common Causes of Neonatal Jaundice –A Study of 100 Cases at Neonatal Unit of Rajshahi Medical College Hospital

2018 ◽  
Vol 26 ◽  
pp. 1-2
Author(s):  
M Sanaul Haque ◽  
PK Paul ◽  
KI Jahan
Keyword(s):  
Perinatal Asphyxia ◽  
Cross Sectional Study ◽  
Neonatal Unit ◽  
Medical College Hospital ◽  
College Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Abo Incompatibility ◽  
Common Causes ◽  
Rh Incompatibility

A prospective cross sectional study was done at Neonatal unit of Rajshahi Medical College Hospital, from 01/01/15 to 30/06/15 period. Total 100 neonates with jaundice were included in this study. Causes of Jaundice were physiological 35%, sepsis 20%, prematurity 15%, perinatal asphyxia 8%, ABO incompatibility 8%, Rh-incompatibility 5%, unknown 9%.TAJ 2013; 26: 1-2

scholarly journals Risk Factors and Causes of Neonatal Hyperbilirubinemia: A Systematic Review Study

2020 ◽  
Vol 8 (4) ◽  
pp. 211-222
Author(s):  
Hassan Boskabadi ◽  
◽  
Forough Rakhshanizadeh ◽  
Ali Moradi ◽  
Maryam Zakerihamidi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Birth Weight ◽  
G6pd Deficiency ◽  
Neonatal Jaundice ◽  
Diabetic Mother ◽  
Neonatal Hyperbilirubinemia ◽  
Abo Incompatibility ◽  
Rh Incompatibility ◽  
Review Study

Context: Jaundice is a common problem and the most common risk factor for hospitalization during the neonatal period.      Objective: The prevention of neonatal hyperbilirubinemia would not be possible without identifying its predisposing risk factors. The present systematic review study aims to determine the risk factors of neonatal jaundice. Data Sources: Databases including Science Direct, Cochrane Library, Web of Science (ISI), PubMed, and Google Scholar were searched to identify all eligible papers concerning the risk factors of neonatal hyperbilirubinemia.  Study Selection: This systematic review was performed to review the causes and risk factors of neonatal hyperbilirubinemia. Finally, 18 articles were defined as eligible for further review. Data Extraction: The keywords included neonates, jaundice, hyperbilirubinemia, and risk factors. The inclusion criteria were studies determining jaundice risk factors, while papers with only published abstracts were excluded. Results: A total of 18 eligible articles (3 retrospective, 4 prospective, 10 cross-sectional, and 1 historical cohort) out of 421 retrieved articles were included in this review. The etiologic causes for neonatal jaundice were ABO incompatibility (24.6%), infection (including UTI and sepsis) (13.7%), G6PD deficiency (9.4%), Rh incompatibility (7%), and cephalohematoma (2.9%), while, known predisposing factors for neonatal jaundice included unknown (33.2%), low birth weight (30.9%), hyperbilirubinemia in siblings (22.7%), prematurity (20.1%), and infant of diabetic mother (6.7%). Conclusion: According to our review with considering the studies, the etiologic causes for neonatal jaundice are ABO incompatibility, infection (including UTI and sepsis), G6PD deficiency, Rh incompatibility, and cephalohematoma. While, known predisposing factors for neonatal jaundice include low birth weight, hyperbilirubinemia in siblings, prematurity, and infant of diabetic mother.

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