scholarly journals Clinical and aetiological study of chronic lower limb ulcers

2021 ◽  
Vol 8 (6) ◽  
pp. 1839
Author(s):  
Shrikant B. Kuntoji ◽  
Pavan Kumar Guduru
Keyword(s):  
Prospective Study ◽  
Lower Limb ◽  
Skin Diseases ◽  
Systemic Disease ◽  
Research Centre ◽  
Ageing Population ◽  
Obesity And Diabetes ◽  
Increased Risk ◽  
Vascular Insufficiency ◽  
Chronic Lower Limb Ulcers

Background: Chronic ulceration of the lower leg is a frequent condition, with a prevalence in the population over 60 years of age. The incidence of ulceration is rising as a result of the ageing population and increased risk factors for atherosclerotic occlusion such as smoking, obesity and diabetes. Ulcers can be defined as wounds with a ‘full thickness depth’ and a ‘slow healing tendency”. In general, the slow healing tendency is not simply explained by depth and size, but caused by an underlying pathogenetic factor that needs to be removed to induce healing. The main causes are venous valve insufficiency, lower extremity arterial disease and diabetes, less frequent conditions are infection, vasculitis, skin malignancies and ulcerating skin diseases such as pyoderma gangrenosum. For a proper treatment of patients with leg ulcers it is important to be aware of the large differential diagnosis of leg ulceration and to effectively manage the conditions.Methods: Prospective study of 80 cases of chronic lower limb ulcers admitted at S. Nijalingappa medical college and HSK hospital and research centre, Bagalkot during the period January 2019 to June 2020, with regular dressings, debridement, skin grafting’s, amputations, treating underlying systemic diseases were done.Results: In a study of 80 cases, most of the patients with lower limb ulcers had an underlying systemic disease like diabetes, vascular insufficiency both arterial and venous.Conclusions: In a prospective study of 80 patients having chronic lower limb ulcers the commonest ulcer was diabetic foot ulcers followed by arterial/ischemic ulcers. The highest incidence is seen in sixth decade of life with male predominance.  

Is cherubism a systemic disease? Prospective study about 9 patients

2017 ◽  
Author(s):  
Aline Joly ◽  
Gerard Maruani ◽  
Valerie Cormier Daire ◽  
Brigitte Fauroux ◽  
Ariane Berdal ◽  
...  
Keyword(s):  
Prospective Study ◽  
Systemic Disease

Importance of Avasthiki Chikitsa in Pakshaghata and its complications: A Clinical Case Report

2017 ◽  
Vol 2 (3) ◽  
Author(s):  
Vishwanath S. Wasedar ◽  
Shilpa S. Biradar
Keyword(s):  
Case Report ◽  
Lower Limb ◽  
Life Style ◽  
Occipital Lobe ◽  
Blood Parameters ◽  
Effective Control ◽  
Research Centre ◽  
Successful Case ◽  
Diet And Exercise ◽  
Loss Of Strength

Purpose: Life style disorders demand a strict regimen throughout one’s life among which Hypertension and Diabetes Mellitus are common. Hence the treatment aims an effective control along with Life style modification. The negligence towards the prescribed life style regimen would lead to many complications among which stroke are most prominent and the prevalence in India is 29%. Though the patient is under strict Anti hypertensive medications still one day he/she will land up in stroke hampering his rest of precious life. Aim: With this understanding a successful case report is presented to highlight the importance of Avasthiki Chikitsa with life style modification in controlling Hypertension and treating Pakshaghata from the root level. Materials and Methods: A 74 years old female patient, known case of HTN and DM was brought on a stretcher to the Panchakarma OPD of KLEU Ayurveda Hospital and Research Centre with the complain of loss of strength in left upper and lower limb associated with inability to speak since 9 days. Her MRI suggested Left Hemiplegia with B/L cerebellar hemorrhagic infract in occipital lobe. Initially treatment commenced with Shiromarmaghata Chikitsa with Shamanoushadhi along with modern medication which the patient had been advised. Later on when the patient started to improve in her blood parameters allied science medications were tapered and gradually stopped excluding her routine medication. After the clearance of Avarana, Panchakarma therapies were administered sequentially at various stage with a meticulous diet and exercise. Results: After 22 days of treatment Diabetes and Hypertension were under control, patient was able to walk with minimal support and speech also improved. Conclusion: A well planned diet along with Ayurvedic therapies based on the Awastha provides encouraging results in treating HTN, DM and Pakshaghata.

scholarly journals Left ventricular mechanical dispersion in a general population: Data from the Akershus Cardiac Examination 1950 study

2019 ◽  
Author(s):  
Erika N Aagaard ◽  
Brede Kvisvik ◽  
Mohammad O Pervez ◽  
Magnus N Lyngbakken ◽  
Trygve Berge ◽  
...  
Keyword(s):  
General Population ◽  
Global Longitudinal Strain ◽  
Population Data ◽  
Left Ventricular ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Clinical Model ◽  
Mechanical Dispersion ◽  
Obesity And Diabetes ◽  
Increased Risk

Abstract Aims Increased left ventricular mechanical dispersion by 2D speckle tracking echocardiography predicts ventricular arrhythmias in ischaemic heart disease and heart failure. However, little is known about mechanical dispersion in the general population. We aimed to study mechanical dispersion in the general population and in diseases associated with increased risk of cardiovascular disease. Methods and results The present cross-sectional study consists of 2529 subjects born in 1950 included in the Akershus Cardiac Examination (ACE) 1950 study. Global longitudinal strain (GLS) was assessed from 17 strain segments, and mechanical dispersion calculated as the standard deviation of contraction duration of all segments. The cohort was divided according to the median value of mechanical dispersion, and multivariable linear regression models were performed with mechanical dispersion as the dependent variable. The prevalence of coronary artery disease (CAD), hypertension, obesity, and diabetes (P < 0.01 for all) was significantly higher in subjects with supra-median mechanical dispersion. In a multivariable clinical model, CAD (B = 7.05), hypertension (B = 4.15; both P < 0.001), diabetes (B = 3.39), and obesity (B = 1.89; both P < 0.05) were independently associated with increasing mechanical dispersion. When echocardiographic indices were added to the multivariable model, CAD (B = 4.38; P < 0.01) and hypertension (B = 2.86; P < 0.001) remained significant in addition to peak early diastolic tissue velocity e’ (B = −2.00), GLS (B = 1.68), and ejection fraction (B = 0.22; P < 0.001 for all). Conclusion In a general middle-aged population, prevalent CAD and hypertension were associated with increasing mechanical dispersion, possibly indicating elevated risk of fatal arrhythmias and sudden cardiac death. Albeit weaker, systolic and diastolic dysfunction, were also associated with increasing mechanical dispersion.

scholarly journals The burden of periodontal disease

Dental Update ◽  
2019 ◽  
Vol 46 (10) ◽  
pp. 907-913
Author(s):  
Kasim Butt ◽  
Razia Butt ◽  
Praveen Sharma
Keyword(s):  
Quality Of Life ◽  
Periodontal Disease ◽  
Tooth Loss ◽  
Chronic Inflammatory Disease ◽  
Severe Form ◽  
Health Concern ◽  
Ageing Population ◽  
Obesity And Diabetes ◽  
The Uk

Periodontal disease is the most common chronic inflammatory disease seen in humans. It is a major public health concern, and in its severe form affects approximately 10.8% or 743 million people aged 15−99 worldwide. Trends such as the rise of smoking in developing countries, the obesity and diabetes epidemic, coupled with an ageing population with greater tooth retention, are all likely to increase the burden of periodontitis still further in the UK and worldwide. Consequences of periodontitis include hypermobility of teeth, tooth migration, drifting and eventual tooth loss. Tooth loss can directly affect the quality of life of a person in terms of reduced functional capacity, self-esteem and social relationships. CPD/Clinical Relevance: This article reports the prevalence of periodontal disease in the UK and worldwide, along with the consequences of periodontitis. The importance of timely diagnosis to avoid litigation is discussed, as is the importance of effective management of periodontitis in order to improve patients' oral health-related quality of life.

Vztah mezi presbyakuzí a poruchou kognitivních funkcí ve stáří PDF uzamčeno English info

2021 ◽  
Vol 70 (4) ◽  
pp. 223-233
Author(s):  
Jakub Fuksa ◽  
Milan Profant ◽  
Martin Chovanec ◽  
Josef Syka
Keyword(s):  
Hearing Loss ◽  
Cognitive Impairment ◽  
Hearing Aids ◽  
Cognitive Functions ◽  
Auditory Information ◽  
Ageing Population ◽  
Published Evidence ◽  
Age Related ◽  
Keywords Dementia ◽  
Increased Risk

Age-related hearing loss, presbycusis, is one of the most frequent sensory impairments in the ageing population. It is associated with pathologies of both inner ear and the central parts of the auditory system. Intact cognitive functions are necessary for the proper processing of complex auditory information. Since the beginning of the 80s, there is an increasing amount of evidence linking presbycusis to cognitive impairment and increased risk of dementia. The exact cause, which connects these two pathologies, is still unknown, although there are several hypotheses with various levels of evidence available. This review aims to describe the role of cognitive functions in the auditory processing, to summarize published evidence for a relationship between the hearing loss and cognitive impairment with a possible mechanism, which would explain this link. In addition, we discuss specific features of cognitive assessment in a person with hearing loss and describe the effect of hearing loss treatment, e. g. with hearing aids, cochlear implant and cognitive-hearing training on cognitive functions. Keywords: dementia – hearing loss – presbycusis – cognitive decline

Abstract P068: Obstructive Sleep Apnea is Associated with an Increase Risk of Osteoporosis

Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Anawin Sanguankeo ◽  
Sikarin Upala
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Primary Outcome ◽  
Meta Analysis ◽  
Systemic Disease ◽  
Obstructive Sleep ◽  
Increased Risk ◽  
Increase Risk ◽  
Osteoporosis Risk ◽  
Stimulation Of

Background: Obstructive sleep apnea (OSA) is thought to be a systemic disease and has been associated with many disorders such as metabolic, endocrine, and especially cardiovascular diseases. One of the consequences of OSA is hypoxia, which can lead to a reduction in growth of osteoblast and a stimulation of osteoclast. Our meta-analysis was conducted to determine the risk of osteoporosis in patients with OSA compared to controls. Objectives: Eligible studies assessing the effects of obstructive sleep apnea on osteoporosis risk were comprehensively searched in PubMed/MEDLINE, EMBASE, and CENTRAL from their inception to September 2014. Two authors independently assessed article quality and extracted the data. Primary outcome were number of participants, prevalence, or risk ratio of osteoporosis in OSA and controls. Results: From 40 full-text articles, 3 studies involving 113,090 participants were included in the meta-analysis that were based on the random effects model. Compared with controls, participants who were diagnosed with obstructive sleep apnea had increased risk of osteoporosis (pooled risks ratio, 1.85; 95% CI, 1.34, 2.56). Conclusion: Patients with OSA had a higher risk of developing osteoporosis. Further study is needed to evaluate the possible mechanisms between these two conditions and to find potential treatment for OSA that could prevent osteoporosis.

scholarly journals Lower-Limb Joint Coordination Pattern in Obese Subjects

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Alberto Ranavolo ◽  
Lorenzo M. Donini ◽  
Silvia Mari ◽  
Mariano Serrao ◽  
Alessio Silvetti ◽  
...  
Keyword(s):  
Lower Limb ◽  
Control Group ◽  
Coordination Pattern ◽  
Obese People ◽  
Joint Coordination ◽  
Increased Risk ◽  
Risk Of Falls ◽  
Coupling Parameters ◽  
Obese Subjects ◽  
Time Distance

The coordinative pattern is an important feature of locomotion that has been studied in a number of pathologies. It has been observed that adaptive changes in coordination patterns are due to both external and internal constraints. Obesity is characterized by the presence of excess mass at pelvis and lower-limb areas, causing mechanical constraints that central nervous system could manage modifying the physiological interjoint coupling relationships. Since an altered coordination pattern may induce joint diseases and falls risk, the aim of this study was to analyze whether and how coordination during walking is affected by obesity. We evaluated interjoint coordination during walking in 25 obese subjects as well as in a control group. The time-distance parameters and joint kinematics were also measured. When compared with the control group, obese people displayed a substantial similarity in joint kinematic parameters and some differences in the time-distance and in the coupling parameters. Obese subjects revealed higher values in stride-to-stride intrasubjects variability in interjoint coupling parameters, whereas the coordinative mean pattern was unaltered. The increased variability in the coupling parameters is associated with an increased risk of falls and thus should be taken into account when designing treatments aimed at restoring a normal locomotion pattern.

Post-stroke memory deficits and barriers to seeking help: views of patients and carers

2018 ◽  
Vol 36 (4) ◽  
pp. 506-510 ◽  
Author(s):  
Eugene Y H Tang ◽  
Christopher Price ◽  
Blossom C M Stephan ◽  
Louise Robinson ◽  
Catherine Exley
Keyword(s):  
Health Professionals ◽  
Health Care Professionals ◽  
Organizational Level ◽  
Stroke Survivors ◽  
Ageing Population ◽  
Family Carers ◽  
Post Stroke ◽  
North East ◽  
Increased Risk ◽  
Seeking Help

Abstract Background Memory and cognitive deficits post stroke are common and associated with increased risk of future dementia. Rehabilitation tends to focus on physical recovery; however, once in the community, it is unclear what happens in the longer term to the stroke-survivor with new memory difficulties. Objective The aim of this qualitative study was to examine in stroke-survivors what factors influence contact with health professionals. Method Semi-structured interviews were conducted with stroke-survivors and their family carers where memory difficulties were reported at 6 months post stroke. A topic guide was used which sought to critically examine participants care experience following their stroke diagnosis. All participants were interviewed at baseline (around 6 months post stroke) and offered an interview at around 12 months post stroke. All interviews were conducted in the North East of England. All transcripts were coded and thematically analysed. Results Ten stroke-survivors (age range 72–84 years) were interviewed alongside five carers at baseline; eight stroke-survivors and four carers agreed to a follow-up interview. Three main barriers were identified: (i) fear of a dementia diagnosis; (ii) denial or minimization of symptoms leading to adaptation and (iii) obstacles to seeking help in the community. Conclusions With an ageing population and increase in stroke-survival, the burden of post-stroke cognitive impairment and dementia will only increase. Stroke-survivors and their family carers in this study have identified issues that may hinder their presentation to health care professionals at a personal and organizational level. Health professionals need to be aware of these potential issues when planning services for stroke-survivors.

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