scholarly journals Knowledge, attitude and practices among parents of asthmatic children in Rajasthan: a hospital based descriptive observational study

2020 ◽  
Vol 7 (4) ◽  
pp. 770
Author(s):  
Prerna Vaishnav ◽  
Gaurav Ameta
Keyword(s):  
Observational Study ◽  
Parental Education ◽  
Clinical Symptoms ◽  
Airflow Obstruction ◽  
Inflammatory Disorder ◽  
Chi Square ◽  
Chronic Inflammatory Disorder ◽  
Asthmatic Children ◽  
Medication Side ◽  
Gina Guidelines

Background: Asthma is chronic inflammatory disorder associated with variable airflow obstruction and bronchial hyper responsiveness with different phenotypes. The objective of this study was to study the knowledge, attitude and practices among parents of Asthmatic children.Methods: It was a prospective observational study, conducted at Fortis Hospital Jaipur, from April 2016 to March 2018. All Asthmatic children fulfilling inclusion were included, 120 children were studied. A detailed interview of all the children/parents was conducted by pre-validated KAP questionnaire. Subjects were labelled as Bronchial Asthma in children above 5 years of age on the basis of symptoms and measurement of Peak Expiratory Flow (PEF) both baseline and post bronchodilator by PEF meter and in children less than 5 years of age by clinical symptoms, family history and response to bronchodilator according to GINA guidelines. Statistical analysis was done by one-way ANOVA test and Chi-square test.Results: In this study 26.4% parents were ignorant about etiology, 32% believed it to be allergy and 39.62% believed it to be hereditary. 1.9% had misconception of contagious. 68% parents know that their child have asthma while 32% parents did not know. Majority (52.1%) attributed it to cold air and rainy season followed by Dust mite and pollution in (42%).Conclusions: Knowledge about Asthma has improved over last few decades but still needs replenishment. Knowledge gap between recommended and actual practices, lack of adherence to aerosol therapy and fear of medication side-effects still persists. Parental education is important part of management of Asthma.

Asthma

2007 ◽  
pp. 117-126
Keyword(s):  
Chronic Inflammation ◽  
Discharge Planning ◽  
Acute Asthma ◽  
Airflow Obstruction ◽  
Early Morning ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Cellular Components ◽  
Symptoms And Signs ◽  
In Pregnancy

Definition 118 Symptoms and signs 118 Diagnosis 119 Management of acute asthma 120 Asthma in pregnancy 125 Discharge planning 125 ‘Asthma is a chronic inflammatory disorder of the airways in which many cells and cellular components play a role. The chronic inflammation causes an associated increase in airway hyper-responsiveness that leads to recurrent episodes of wheezing, breathlessness, chest tightness and coughing, particularly at night or in the early morning. These episodes are usually associated with widespread but variable airflow obstruction that is often reversible either spontaneously or with treatment.’...

scholarly journals Diffusion Lung Capacity of Carbon Monoxide: A Novel Marker of Airways Remodeling in Asthmatic Children?

2012 ◽  
Vol 3 (2) ◽  
pp. ar.2012.3.0033 ◽  
Author(s):  
Giorgio L. Piacentini ◽  
Giovanna Tezza ◽  
Elena Cattazzo ◽  
Ahmad Kantar ◽  
Vincenzo Ragazzo ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Mean Value ◽  
Inflammatory Disorder ◽  
Exhaled Breath ◽  
Chronic Inflammatory Disorder ◽  
Asthmatic Children ◽  
Lung Capacity ◽  
Noninvasive Markers ◽  
Free Environment

Asthma is universally considered a chronic inflammatory disorder of the airways. Several noninvasive markers, such as exhaled nitric oxide (FeNO) and exhaled breath temperature (PletM), have been proposed to evaluate the degree of airway inflammation and remodeling in asthmatic children. The aim of this study was to evaluate the relationship between diffusion lung capacity of carbon monoxide (DLCO) and these inflammatory markers in asthmatic children. We compared data of FeNO, PletM, and DLCO collected in 35 asthmatic children at admission (T0) and discharge (T1) after a period spent in a dust-mite–free environment (Misurina, Italian Dolomites, 1756 m). PletM showed a reduction from 29.48°C at T0 to 29.13°C at T1 (p = 0.17); DLCO passed from 93 to 102 (p = 0.085). FeNO mean value was 29.7 ppb at admission and 18.9 ppb at discharge (p = 0.014). Eosinophil mean count in induced sputum was 4 at T0 and 2 at T1 (p = 0.004). Spearman standardization coefficient beta was 0.414 between eosinophils and FeNO and −0.278 between eosinophils and DLCO. Pearson's correlation index between DLCO and PletM was −0.456 (p = 0.019). A negative correlation between DLCO and PletM was found. However, DLCO did not show a significant correlation with FeNO and eosinophils in the airways. Additional studies are needed to clarify the role of DLCO as a potential tool in monitoring childhood asthma.

scholarly journals Vitamin D levels in children with bronchial asthma

2020 ◽  
Vol 7 (11) ◽  
pp. 2163
Author(s):  
Kaisar R. Wani ◽  
Reyaz A. Malik Malik ◽  
Asif Ahmed
Keyword(s):  
Vitamin D ◽  
Bronchial Asthma ◽  
Serum Vitamin ◽  
Inflammatory Disorder ◽  
Healthy Children ◽  
Chronic Inflammatory Disorder ◽  
Asthmatic Children ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
The Mean

Background: Bronchial asthma is a common chronic inflammatory disorder of the airways in childhood. Vitamin D, initially described as a vitamin that regulated calcium homeostasis, has also been shown to exert important antimicrobial effects and is also a potent immune system regulator having a potential role in various allergic diseases. The main objective of this study was to look the levels of vitamin D in children with bronchial asthma and to study the co relationship between vitamin D levels and severity of asthma.Methods: This study included 80 (40 asthmatic children and 40 healthy controls) children aged between 4 and 15 year. Serum vitamin D levels where determined and compared between the two groups. The association between vitamin D levels and severity of asthma was studied in the asthmatic children.Results: Among 40 asthmatic children the mean serum vitamin D level was 16.6±11.56 ng/ml, while as the mean vitamin D levels in healthy control subjects was 24.225±2.764 ng/ml and the difference between the two groups was statistically significant (p=0.001). Vitamin D deficiency was highly prevalent in asthmatic patients and there was a direct and a significant relationship between serum vitamin D levels and severity of asthma.Conclusion: In this study, vitamin D levels were considerably lower in children with asthma than in healthy children. Also, in this study vitamin D deficient asthma patients have more severe asthma than the patients who have sufficient vitamin D levels.

scholarly journals Hubungan antara kadar kalsium dengan serangan asma pada anak

2016 ◽  
Vol 8 (3) ◽  
Author(s):  
Ronald Rompies ◽  
Christine Sumampow ◽  
Audrey Wahani
Keyword(s):  
Vitamin D ◽  
Logistic Regression ◽  
Calcium Level ◽  
P Value ◽  
Inflammatory Disorder ◽  
Outpatient Services ◽  
Chronic Inflammatory Disorder ◽  
Asthmatic Children ◽  
Asthma Attack ◽  
Asthmatic Group

Abstract: Asthma is a chronic inflammatory disorder of the respiratory tract that can cause an increased response and activity within the airway which is characterized by the recurrent episodes of wheezing, shortness of breath, and cough accompanied by airway obstruction in varying degrees. Vitamin D plays a role in the pathogenesis of asthma. Many studies suggest a relation between vitamin D and calcium, which can be seen as a possible link between calcium levels and asthma. This study aimed to determine the correlation between the level of calcium and asthma attacks in children. This was a case-control study that gathered 21 asthmatic children and 19 non-asthmatic children with acute respiratory infections who did not use corticosteroids for the treatment at outpatient services Prof. Dr. R. D. Kandou Hospital Manado from January to June 2015. Calcium levels of asthmatic patients and non-asthmatic were noted. Statistical analysis using logistic regression with a P value < 0.05 were considered significant. The results of logistic regression analysis showed a significant association between calcium level and asthma attack (P = 0.04 with OR = 2.75). The average level of calcium in the asthmatic group was 9.2 mg/dL (0.81, 95% CI 8.91 to 9.64) and the non-asthmatic group was 8.7 mg/dL (0.72, 95% CI 8.38-9.07). Conclusion: There was a correlation between calcium level and asthma attack in children. The lower the level of calcium, the higher the chance of asthma attack.Keywords: children, asthma, calciumAbstrak: Asma adalah kelainan inflamasi kronis saluran pernapasan yang dapat menyebabkan peningkatan respon dan aktivitas jalan napas, ditandai dengan episode mengi berulang, sesak napas, dan batuk yang disertai obstruksi jalan napas dalam derajat bervariasi. Vitamin D berperan dalam patogenesis asma. Banyak penelitian mengatakan bahwa terdapat hubungan antara vitamin D dan kalsium, sehingga diduga adanya hubungan antara kadar kalsium dan asma. Penelitian ini bertujuan untuk mengetahui hubungan kadar kalsium dengan serangan asma pada anak. Jenis penelitian ialah kasus kontrol dimana dikumpulkan 21 anak dengan asma dan 19 anak non-asma dengan infeksi saluran napas akut dan tidak menggunakan kortikosteroid yang datang berobat di pelayanan rawat jalan RSUP Prof. Dr. R. D. Kandou Manado dari Januari sampai Juni 2015. Kadar kalsium pasien asma dan non-asma dicatat. Analisis statistik menggunakan regresi logistik dengan nilai P < 0,05 dianggap bermakna. Hasil analisis regresi logistik menunjukkan hubungan bermakna antara kadar kalsium dengan serangan asma (P = 0,04 dengan OR = 2,75). Rerata kadar kalsium pada kelompok asma 9,2 mg/dL (0,81, 95% CI 8,91-9,64) dan kelompok non asma 8,7 mg/dL (0,72, 95% CI 8,38-9,07). Simpulan: Terdapat hubungan antara kadar kalsium dan serangan asma pada anak. Makin rendah kadar kalsium, makin tinggi peluang terjadinya serangan asma.Kata kunci: anak, asma, kalsium

A Review on Rheumatoid Arthritis Interventions and Current Develop-ments

2020 ◽  
Vol 21 ◽  
Author(s):  
Nikita Khanna ◽  
Anil Kumar ◽  
Sandip Pawar
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Development ◽  
Clinical Symptoms ◽  
Superparamagnetic Iron Oxide ◽  
Autoimmune Disorder ◽  
Nano Particles ◽  
Treat To Target ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Innovative Approaches

Abstract:: Rheumatoid arthritis is a chronic autoimmune disorder characterized by inflammation, swelling and joint de-struction primarily affecting the peripheral joints. In the recent years, RA has become an alarming concern affecting more than 1.5% of the population worldwide. Majority of the drugs in clinical trial for rheumatoid arthritis are immunomodula-tory. The development of novel drugs for RA is impending and scientists are exploring new strategies through various innovative approaches for RA drug development. Treat-to-target and window of opportunity hypothesis are the new ap-proaches that are used to treat, improve outcomes and prevent long-term use of ineffective therapy, respectively. Novel therapeutic agents (e.g. GM-CSF inhibitors, Matrix metalloproteinase inhibitors) and delivery systems (e.g. Liposomes, Superparamagnetic iron oxide nano particles (SPIONs)) are under investigation for more target based therapy with reduced side effects and toxicity. The new drug discovery and repositioning of previously FDA-approved drugs are also being con-sidered for the chronic inflammatory disorder. The review encompasses a vast array of information including genetics, etiology, clinical symptoms, current treatment, and newer therapeutics approaches focused on the development of RA in-terventions. The introduction of bioinformatics based approach in RA has also been significantly discussed in the review. This review provides a general understanding about the challenges and uncertainties in treatment of RA and summarizes the evolving scenario as well as innovative approaches taken into consideration for drug development in rheumatoid arthri-tis.

scholarly journals Modulating P2X7 Receptor Signaling during Rheumatoid Arthritis: New Therapeutic Approaches for Bisphosphonates

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Alberto Baroja-Mazo ◽  
Pablo Pelegrín
Keyword(s):  
Rheumatoid Arthritis ◽  
P2x7 Receptor ◽  
Clinical Symptoms ◽  
Purinergic Signaling ◽  
Interleukin 1 ◽  
Extracellular Atp ◽  
Inflammatory Disorder ◽  
Receptor Antagonists ◽  
Chronic Inflammatory Disorder ◽  
Anti Inflammatory

P2X7 receptor-mediated purinergic signaling is a well-known mechanism involved in bone remodeling. The P2X7 receptor has been implicated in the pathophysiology of various bone and cartilage diseases, including rheumatoid arthritis (RA), a widespread and complex chronic inflammatory disorder. The P2X7 receptor induces the release into the synovial fluid of the proinflammatory factors (e.g., interleukin-1β, prostaglandins, and proteases) responsible for the clinical symptoms of RA. Thus, the P2X7 receptor is emerging as a novel anti-inflammatory therapeutic target, and various selective P2X7 receptor antagonists are under clinical trials. Extracellular ATP signaling acting through the P2X7 receptor is a complex and dynamic scenario, which varies over the course of inflammation. This signaling is partially modulated by the activity of ectonucleotidases, which degrade extracellular ATP to generate other active molecules such as adenosine or pyrophosphates. Recent evidence suggests differential extracellular metabolism of ATP during the resolution of inflammation to generate pyrophosphates. Extracellular pyrophosphate dampens proinflammatory signaling by promoting alternative macrophage activation. Our paper shows that bisphosphonates are metabolically stable pyrophosphate analogues that are able to mimic the anti-inflammatory function of pyrophosphates. Bisphosphonates are arisingper seas promising anti-inflammatory drugs to treat RA, and this therapy could be improved when administrated in combination with P2X7 receptor antagonists.

ADOLESCENT BEHAVIOR IN UNWANTED PREGNANCY PREVENTION

2019 ◽  
Vol 1 (1) ◽  
pp. 41-46
Author(s):  
Arip Ambulan Panjaitan
Keyword(s):  
Sexual Behavior ◽  
Reproductive Health ◽  
Risky Sexual Behavior ◽  
Parental Education ◽  
Unwanted Pregnancy ◽  
Sampling Technique ◽  
Adolescent Behavior ◽  
Cluster Sampling ◽  
Chi Square ◽  
Cross Sectional

Introduction: Adolescent are at high risk of unwanted pragnency, including abortion, STIs, HIV/AIDS. Risky sexual behavior is one of the entrance transmissions of unwanted pregnancy. Such behavior can be influenced by various factors, beyond and within the individual factors. Teens need the support and motivation in deciding not to do risky sexual behavior. The purpose of this study was to investigate the determinants of adolescent behavior in the prevention of unwanted pregnancy.Methods: This research used cross-sectional design. The populations were students of senior high school in District Sintang. The were 123 respondents chosen by cluster sampling technique for this study. All data were collected using questionnaires and then analysed using bivariate (chi square) and multivariate analysis (logistic regression).Results: The results showed that the majority of respondents did not have good knowledge about the prevention of unwanted pregnancy. Related variable is the level of parental education (p=0.001), the support of parents/guardians (p=0.009), support teachers (p=0.005), peer support (p=0.039), residency (p=0.009), a pastime activity (p=0.000), knowledge of adolescents about reproductive health (p=0.016), perception ability of adolescents (p=0.006) and attitude of adolescents (p=0.049). Adolescent self-perception abilities are variables that most influence on the behavior of adolescents in the prevention of unwanted pregnancy.Conclusions: Efforts to improve reproductive health programs should be early and adolescent have responsibilities as well as healthy behaviors.

scholarly journals Redox Imbalance in T Cell-Mediated Skin Diseases

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Saveria Pastore ◽  
Liudmila Korkina
Keyword(s):  
Oxidative Stress ◽  
Atopic Dermatitis ◽  
Contact Dermatitis ◽  
Skin Diseases ◽  
Redox Balance ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Physical Chemical ◽  
Chemical Oxidants ◽  
Beneficial Outcome

The skin is permanently exposed to physical, chemical, and biological aggression by the environment. In addition, acute and chronic inflammatory events taking place in the skin are accompanied by abnormal release of pro-oxidative mediators. In this paper, we will briefly overview the homeostatic systems active in the skin to maintain the redox balance and also to counteract abnormal oxidative stress. We will concentrate on the evidence that a local and/or systemic redox dysregulation accompanies the chronic inflammatory disorder events associated to psoriasis, contact dermatitis, and atopic dermatitis. We will also discuss the fact that several well-established treatments for the therapy of chronic inflammatory skin disorders are based on the application of strong physical or chemical oxidants onto the skin, indicating that, in selected conditions, a further increase of the oxidative imbalance may lead to a beneficial outcome.

scholarly journals Changes in cannabis use according to socioeconomic status among Finnish adolescents from 2000 to 2015

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Noora Knaappila ◽  
Mauri Marttunen ◽  
Sari Fröjd ◽  
Nina Lindberg ◽  
Riittakerttu Kaltiala
Keyword(s):  
Socioeconomic Status ◽  
Parental Education ◽  
Population Based ◽  
Cannabis Use ◽  
Chi Square ◽  
Socioeconomic Groups ◽  
Parental Unemployment ◽  
The Usa ◽  
Chi Square Test ◽  
School Survey

Abstract Background Despite reduced sanctions and more permissive attitudes toward cannabis use in the USA and Europe, the prevalences of adolescent cannabis use have remained rather stable in the twenty-first century. However, whether trends in adolescent cannabis use differ between socioeconomic groups is not known. The aim of this study was to examine trends in cannabis use according to socioeconomic status among Finnish adolescents from 2000 to 2015. Methods A population-based school survey was conducted biennially among 14–16-year-old Finns between 2000 and 2015 (n = 761,278). Distributions for any and frequent cannabis use over time according to socioeconomic adversities were calculated using crosstabs and chi-square test. Associations between any and frequent cannabis use, time, and socioeconomic adversities were studied using binomial logistic regression results shown by odds ratios with 95% confidence intervals. Results At the overall level, the prevalences of lifetime and frequent cannabis use varied only slightly between 2000 and 2015. Cannabis use was associated with socioeconomic adversities (parental unemployment in the past year, low parental education, and not living with both parents). The differences in any and frequent cannabis use between socioeconomic groups increased significantly over the study period. Conclusions Although the overall changes in the prevalence of adolescent cannabis use were modest, cannabis use increased markedly among adolescents with the most socioeconomic adversities. Socioeconomic adversities should be considered in the prevention of adolescent cannabis use.

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