scholarly journals Hubungan antara kadar kalsium dengan serangan asma pada anak

2016 ◽  
Vol 8 (3) ◽  
Author(s):  
Ronald Rompies ◽  
Christine Sumampow ◽  
Audrey Wahani
Keyword(s):  
Vitamin D ◽  
Logistic Regression ◽  
Calcium Level ◽  
P Value ◽  
Inflammatory Disorder ◽  
Outpatient Services ◽  
Chronic Inflammatory Disorder ◽  
Asthmatic Children ◽  
Asthma Attack ◽  
Asthmatic Group

Abstract: Asthma is a chronic inflammatory disorder of the respiratory tract that can cause an increased response and activity within the airway which is characterized by the recurrent episodes of wheezing, shortness of breath, and cough accompanied by airway obstruction in varying degrees. Vitamin D plays a role in the pathogenesis of asthma. Many studies suggest a relation between vitamin D and calcium, which can be seen as a possible link between calcium levels and asthma. This study aimed to determine the correlation between the level of calcium and asthma attacks in children. This was a case-control study that gathered 21 asthmatic children and 19 non-asthmatic children with acute respiratory infections who did not use corticosteroids for the treatment at outpatient services Prof. Dr. R. D. Kandou Hospital Manado from January to June 2015. Calcium levels of asthmatic patients and non-asthmatic were noted. Statistical analysis using logistic regression with a P value < 0.05 were considered significant. The results of logistic regression analysis showed a significant association between calcium level and asthma attack (P = 0.04 with OR = 2.75). The average level of calcium in the asthmatic group was 9.2 mg/dL (0.81, 95% CI 8.91 to 9.64) and the non-asthmatic group was 8.7 mg/dL (0.72, 95% CI 8.38-9.07). Conclusion: There was a correlation between calcium level and asthma attack in children. The lower the level of calcium, the higher the chance of asthma attack.Keywords: children, asthma, calciumAbstrak: Asma adalah kelainan inflamasi kronis saluran pernapasan yang dapat menyebabkan peningkatan respon dan aktivitas jalan napas, ditandai dengan episode mengi berulang, sesak napas, dan batuk yang disertai obstruksi jalan napas dalam derajat bervariasi. Vitamin D berperan dalam patogenesis asma. Banyak penelitian mengatakan bahwa terdapat hubungan antara vitamin D dan kalsium, sehingga diduga adanya hubungan antara kadar kalsium dan asma. Penelitian ini bertujuan untuk mengetahui hubungan kadar kalsium dengan serangan asma pada anak. Jenis penelitian ialah kasus kontrol dimana dikumpulkan 21 anak dengan asma dan 19 anak non-asma dengan infeksi saluran napas akut dan tidak menggunakan kortikosteroid yang datang berobat di pelayanan rawat jalan RSUP Prof. Dr. R. D. Kandou Manado dari Januari sampai Juni 2015. Kadar kalsium pasien asma dan non-asma dicatat. Analisis statistik menggunakan regresi logistik dengan nilai P < 0,05 dianggap bermakna. Hasil analisis regresi logistik menunjukkan hubungan bermakna antara kadar kalsium dengan serangan asma (P = 0,04 dengan OR = 2,75). Rerata kadar kalsium pada kelompok asma 9,2 mg/dL (0,81, 95% CI 8,91-9,64) dan kelompok non asma 8,7 mg/dL (0,72, 95% CI 8,38-9,07). Simpulan: Terdapat hubungan antara kadar kalsium dan serangan asma pada anak. Makin rendah kadar kalsium, makin tinggi peluang terjadinya serangan asma.Kata kunci: anak, asma, kalsium

scholarly journals Vitamin D levels in children with bronchial asthma

2020 ◽  
Vol 7 (11) ◽  
pp. 2163
Author(s):  
Kaisar R. Wani ◽  
Reyaz A. Malik Malik ◽  
Asif Ahmed
Keyword(s):  
Vitamin D ◽  
Bronchial Asthma ◽  
Serum Vitamin ◽  
Inflammatory Disorder ◽  
Healthy Children ◽  
Chronic Inflammatory Disorder ◽  
Asthmatic Children ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
The Mean

Background: Bronchial asthma is a common chronic inflammatory disorder of the airways in childhood. Vitamin D, initially described as a vitamin that regulated calcium homeostasis, has also been shown to exert important antimicrobial effects and is also a potent immune system regulator having a potential role in various allergic diseases. The main objective of this study was to look the levels of vitamin D in children with bronchial asthma and to study the co relationship between vitamin D levels and severity of asthma.Methods: This study included 80 (40 asthmatic children and 40 healthy controls) children aged between 4 and 15 year. Serum vitamin D levels where determined and compared between the two groups. The association between vitamin D levels and severity of asthma was studied in the asthmatic children.Results: Among 40 asthmatic children the mean serum vitamin D level was 16.6±11.56 ng/ml, while as the mean vitamin D levels in healthy control subjects was 24.225±2.764 ng/ml and the difference between the two groups was statistically significant (p=0.001). Vitamin D deficiency was highly prevalent in asthmatic patients and there was a direct and a significant relationship between serum vitamin D levels and severity of asthma.Conclusion: In this study, vitamin D levels were considerably lower in children with asthma than in healthy children. Also, in this study vitamin D deficient asthma patients have more severe asthma than the patients who have sufficient vitamin D levels.

scholarly journals Correlation between vitamin D serum level and total IgE in asthmatic children

2020 ◽  
Vol 12 (2) ◽  
pp. 37-45
Author(s):  
Vesna Micevska ◽  
Tatjana Jakovska Mareti ◽  
Ilija Kirovski ◽  
Olivera Jordanova
Keyword(s):  
Vitamin D ◽  
Serum Level ◽  
P Value ◽  
Healthy Children ◽  
Total Ige ◽  
Asthmatic Children ◽  
Significant Difference ◽  
Children With Asthma ◽  
The Mean ◽  
Chronical Disease

Asthma is a chronical disease of the airways characterized by reversible obstruction of the bronchi and airway inflammation. In recent decades, the scientific interest of the vitamin D system and its role in development of asthma and other alergic diseases has been increased. Aims of this study are to mesure and compare the serum level of 25 OHD in asthmatic and healthy children and corelate the level of 25OHD and total IgE in asthmatic children. This prospective study includes 70 children at age 2 to 14, of which 32 are children with diagnosed asthma and 38 healthy children. In both  of the groups the serum level of 25 OHD was measured  and by the results 18 % of the healthy children (C) and 28% of the asthma children (E) had 25OHD  deficiency, 45%  of C and 50% of E were insufficient and 37 % of C / 22% of E were with normal 25 OHD serum level. The mean level of 25OHD in C was 27,83 +/- 10,24 and in E 20,9 ng/ml +/- 10,72. The mean levels in both groups had statistic significant difference with p-value < 0,05. According to age no statistic significant difference was found in both of the groups. There was a statisticaly significant decreased serum level of 25 OHD in asthmatic females.In the examined group (children with asthma) there was a negative linear correlation (association) of the level of 25OHD and total IgE serum level with r=- 0,55  Vitamin D serum level measurements in asthma patients gives the possibility for discovering the connection between its deficiency and development of asthma symptoms.

scholarly journals Vitamin D level as a predictor of pneumonia and asthma in children less than 5 years of age

2020 ◽  
Vol 7 (7) ◽  
pp. 1593
Author(s):  
Neha Sharma ◽  
Anuj Shamsher Sethi ◽  
R. S. Sethi
Keyword(s):  
Vitamin D ◽  
P Value ◽  
Healthy Children ◽  
Outpatient Services ◽  
Common Chronic Disease ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Asthma Patients ◽  
Asthma In Children ◽  
Deficient Level

Background: Childhood pneumonia is a global health problem .It the leading cause of death for children under the age of five years. 95% of all pneumonia cases under the age of five occurs in developing countries. Asthma remains the most common chronic disease of childhood in the world. The observation that vitamin D deficiency and asthma share risk factors such as urban residence, obesity and African American ethnicity has generated interest in exploring a link between these two conditions. This study was taken up to assess the role of vitamin D as a predictor of pneumonia and asthma in children less than 5 years of age.Methods: A prospective observational case control study was conducted in MLB Medical college, Jhansi from January 2015 to December 2016 (1 year 11 months). A total of 60 children including 30 asthma cases, 20 pneumonia cases and 10 controls, aged, 6-60 months were enrolled. Controls were healthy children attending outpatient services for immunization.Results: The mean age of the pneumonia patient was 1.5 years, while mean age in asthma patients was 3.1yrs. Ratio of male and female in pneumonia cases was1.5:1, while is asthma ratio was 2:1. In our study 45% pneumonia cases had deficient level of vitamin D (<20ng/ml) and mean level was 11.08±4.68 while 40% of control had deficient level of vitamin D and mean level was 16.04±1.61, p value was 0.0166 and there was significant difference in both the groups. In Asthma cases 53.33% patient had deficient level of vitamin-D and mean level was 10.62±2.908 as compared to 40% control (mean : 16.04±1.62) ‘p’ value was <0.0001 and was highly significant.Conclusions: Our study has illustrated that vitamin-D levels were significantly low in pneumonia and asthma patients as compared to control.

scholarly journals Diffusion Lung Capacity of Carbon Monoxide: A Novel Marker of Airways Remodeling in Asthmatic Children?

2012 ◽  
Vol 3 (2) ◽  
pp. ar.2012.3.0033 ◽  
Author(s):  
Giorgio L. Piacentini ◽  
Giovanna Tezza ◽  
Elena Cattazzo ◽  
Ahmad Kantar ◽  
Vincenzo Ragazzo ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Mean Value ◽  
Inflammatory Disorder ◽  
Exhaled Breath ◽  
Chronic Inflammatory Disorder ◽  
Asthmatic Children ◽  
Lung Capacity ◽  
Noninvasive Markers ◽  
Free Environment

Asthma is universally considered a chronic inflammatory disorder of the airways. Several noninvasive markers, such as exhaled nitric oxide (FeNO) and exhaled breath temperature (PletM), have been proposed to evaluate the degree of airway inflammation and remodeling in asthmatic children. The aim of this study was to evaluate the relationship between diffusion lung capacity of carbon monoxide (DLCO) and these inflammatory markers in asthmatic children. We compared data of FeNO, PletM, and DLCO collected in 35 asthmatic children at admission (T0) and discharge (T1) after a period spent in a dust-mite–free environment (Misurina, Italian Dolomites, 1756 m). PletM showed a reduction from 29.48°C at T0 to 29.13°C at T1 (p = 0.17); DLCO passed from 93 to 102 (p = 0.085). FeNO mean value was 29.7 ppb at admission and 18.9 ppb at discharge (p = 0.014). Eosinophil mean count in induced sputum was 4 at T0 and 2 at T1 (p = 0.004). Spearman standardization coefficient beta was 0.414 between eosinophils and FeNO and −0.278 between eosinophils and DLCO. Pearson's correlation index between DLCO and PletM was −0.456 (p = 0.019). A negative correlation between DLCO and PletM was found. However, DLCO did not show a significant correlation with FeNO and eosinophils in the airways. Additional studies are needed to clarify the role of DLCO as a potential tool in monitoring childhood asthma.

scholarly journals Knowledge, attitude and practices among parents of asthmatic children in Rajasthan: a hospital based descriptive observational study

2020 ◽  
Vol 7 (4) ◽  
pp. 770
Author(s):  
Prerna Vaishnav ◽  
Gaurav Ameta
Keyword(s):  
Observational Study ◽  
Parental Education ◽  
Clinical Symptoms ◽  
Airflow Obstruction ◽  
Inflammatory Disorder ◽  
Chi Square ◽  
Chronic Inflammatory Disorder ◽  
Asthmatic Children ◽  
Medication Side ◽  
Gina Guidelines

Background: Asthma is chronic inflammatory disorder associated with variable airflow obstruction and bronchial hyper responsiveness with different phenotypes. The objective of this study was to study the knowledge, attitude and practices among parents of Asthmatic children.Methods: It was a prospective observational study, conducted at Fortis Hospital Jaipur, from April 2016 to March 2018. All Asthmatic children fulfilling inclusion were included, 120 children were studied. A detailed interview of all the children/parents was conducted by pre-validated KAP questionnaire. Subjects were labelled as Bronchial Asthma in children above 5 years of age on the basis of symptoms and measurement of Peak Expiratory Flow (PEF) both baseline and post bronchodilator by PEF meter and in children less than 5 years of age by clinical symptoms, family history and response to bronchodilator according to GINA guidelines. Statistical analysis was done by one-way ANOVA test and Chi-square test.Results: In this study 26.4% parents were ignorant about etiology, 32% believed it to be allergy and 39.62% believed it to be hereditary. 1.9% had misconception of contagious. 68% parents know that their child have asthma while 32% parents did not know. Majority (52.1%) attributed it to cold air and rainy season followed by Dust mite and pollution in (42%).Conclusions: Knowledge about Asthma has improved over last few decades but still needs replenishment. Knowledge gap between recommended and actual practices, lack of adherence to aerosol therapy and fear of medication side-effects still persists. Parental education is important part of management of Asthma.

Abstract P111: Relationship of Vitamin D Status to Cardiac Arrhythmias in Veterans

2011 ◽  
Vol 4 (suppl_2) ◽  
Author(s):  
Tareq M Islam ◽  
Beth Bailey ◽  
Chowdhury Ferdous ◽  
Chris Finton ◽  
Todd Manning ◽  
...  
Keyword(s):  
Vitamin D ◽  
Logistic Regression ◽  
Cardiac Arrhythmias ◽  
Odds Ratio ◽  
Ventricular Arrhythmias ◽  
Continuous Variable ◽  
P Value ◽  
Vitamin D Status ◽  
Relationship Of ◽  
Deficient Group

Relationship of Vitamin D status to cardiac arrhythmias in Veterans Islam T. MD MPH, Bailey B. PhD, Ferdous C. MD, Finton C. MD, Manning T. and Peiris A.N. MD PhD Introduction. Vitamin D deficiency is widespread and is associated with coronary artery disease. However, few studies have examined the link between Vitamin D status and cardiac arrhythmias. The present study was undertaken to explore this relationship. Method. We studied 34580 veterans in the southeastern USA and evaluated the relationship of Vitamin D status to both atrial and ventricular arrhythmias by retrospective chart review. Approximately 34.8 % (12030) patient were Vitamin D deficient (25(OH)D < 20 ng/ml). This group was more likely to be younger, have a significantly greater body mass index, more likely to be female and belong to a racial minority when compared to the Vitamin D replete group. The Vitamin D deficient group was also more likely to have hyperlipidemia, diabetes, hypertension and be tobacco users. Result. The presence of arrhythmias varied between 0.3 % (ventricular) to 25 % (Any arrhythmia plus heart block). Atrial and ventricular arrhythmias were significantly greater in the vitamin D deficient group. Vitamin D deficiency remained significantly associated with atrial and ventricular arrhythmias after adjusting for other variables through multivariate logistic regression analysis. Conclusion. To our knowledge, this is the first report indicating a significant link between vitamin D status and cardiac arrhythmias in Veterans. Vitamin D remained a significant predictor of this relationship even after adjusting for other variables. Emerging evidence suggest that Vitamin D replacement can improve cardiac ejection fraction. The potential for Vitamin D replacement to reduce an underlying arrythmogenic propensity is an exciting area for future research. Adjusted logistic regression model predicting atrial and ventricular arrhythmia by vitamin D level. Atrial Arrhythmia Present Absent p-value Vitamin D treated as Continuous variable, beta estimate -0.006 0 (ref.) 0.001 Categorical (low versus replete), odds ratio 1.18 1.00 (ref.) <0.001 Ventricular Arrhythmia Present Absent p-value Vitamin D treated as Continuous variable, beta estimate -0.020 0 (ref.) 0.042 Categorical (low versus replete), odds ratio 1.48 1.00 (ref.) 0.055

scholarly journals Vitamin D Increases CTLA-4 Gene Expression in Patients with Mild to Moderate Ulcerative Colitis

2019 ◽  
Vol 11 (4) ◽  
pp. 199-204
Author(s):  
Amrollah Sharifi ◽  
Homayoon Vahedi ◽  
Mohammad Reza Honarvar ◽  
Behnam Alipoor ◽  
Zeinab Nikniaz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ulcerative Colitis ◽  
Vitamin D ◽  
Cytotoxic T Lymphocyte ◽  
Serum Vitamin ◽  
Immunoglobulin Superfamily ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Serum Vitamin D ◽  
Antigen Presenting

BACKGROUND Ulcerative colitis (UC) is a chronic inflammatory disorder of the large intestine. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a member of the immunoglobulin superfamily, which binds B7-1 and B7-2 on APCs (antigen-presenting cells), and induces APCs to produce an inhibitory signal to T cells. The aim of this study was to investigate the effect of vitamin D on CTLA-4 gene expression in whole blood samples of patients with UC. METHODS 90 patients with mild to moderate UC were randomized to receive either a single injection of 7.5 mg vitamin D3 or 1 mL normal saline. 90 days following the intervention fold changes in CTLA-4 mRNA expression were determined and statistical comparisons between the two groups were performed. RESULTS Serum vitamin D increased significantly only in the vitamin D group. CTLA-4 fold changes were significantly higher in the vitamin D group compared with the placebo group (median ± IQR: 1.21 ± 2.3 vs. 1.00 ± 1.5, respectively; p = 0.007). CONCLUSION The results of this study revealed that vitamin D administration in patients with UC enhances the CTLA-4 gene expression.

scholarly journals Association between Vitamin D and Dental Caries in a Sample of Canadian and American Preschool-Aged Children

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4465
Author(s):  
Tiffany L. Williams ◽  
Joseph Boyle ◽  
Betty-Anne Mittermuller ◽  
Caroline Carrico ◽  
Robert J. Schroth
Keyword(s):  
Vitamin D ◽  
Logistic Regression ◽  
Early Childhood Caries ◽  
P Value ◽  
Multiple Logistic Regression ◽  
Case Control Studies ◽  
Hydroxyvitamin D ◽  
Biological Variables ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D

Background: Inadequate vitamin D levels may increase the risk of caries during childhood. The purpose of this study was to investigate the association between 25-hydroxyvitamin D (25(OH)D) status and severe early childhood caries (S-ECC) in preschool children. Methods: Data were obtained from children <72 months of age in two case–control studies in Winnipeg, Manitoba and Richmond, Virginia. Serum analysis assessed 25(OH)D, calcium and parathyroid concentrations. Data on demographics, dental history and oral hygiene were obtained via questionnaires. Bivariate and multiple logistic regression analyses were performed to assess the relationships between demographic and biological variables and S-ECC. A p-value of ≤0.05 was significant. Results: Data were available for 200 children with S-ECC and 144 caries-free controls. Children with S-ECC had significantly lower 25(OH)D levels than those who were caries-free (p < 0.001), and children with deficient 25(OH)D levels were 10 times more likely to have S-ECC (p < 0.001). Multiple logistic regression revealed that having higher 25(OH)D and calcium concentrations (p = 0.019 and p < 0.0001, respectively), as well as being breastfed in infancy (p < 0.001), were significantly and independently associated with lower odds of S-ECC, while dental insurance (p = 0.006) was associated with higher odds of S-ECC. Conclusions: This study provides additional evidence of an association between nutritional status, specifically vitamin D and calcium levels, and S-ECC.

Association of Vitamin D Levels and Other Risk Factors with Asthma Exacerbations in Children

2020 ◽  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Serum Vitamin ◽  
Persistent Asthma ◽  
Food Allergies ◽  
P Value ◽  
Serum Vitamin D ◽  
Asthma Exacerbations ◽  
Vitamin D Levels ◽  
Animal Dander

Background: The risk factors for asthma exacerbations are well understood. However, the effect of vitamin D levels on number of asthma exacerbations per year is not clearly studied. The objective of the study was to find out the association of serum vitamin D levels and asthma risk factors on asthma exacerbations. Methods: In this study, ninety-nine subjects from 5 to 15 years of age were recruited at an episode of acute exacerbation. It was a cross sectional study and carried out from 2012 to 2015. Pulmonary function test was done by spirometry. Asthma exacerbation was labeled when forced expiratory volume/ forced vital capacity (FEV1/FVC) ratio was less than 80% (American Thoracic Society). Global Initiative for Asthma (GINA) guidelines were used to classify asthma into mild, moderate and severe persistent asthma. Serum vitamin D levels were measured by chemiluminescence method. Pearson Chi-square test was applied and p value (p<0.05) was considered as statistically significant. Results: Children who had exposure to animal dander had significantly lower asthma exacerbations per year (p-value <0.046). There was no significant association between vitamin D levels and number of exacerbations per years (p-value <0.099). Asthma was prevalent in girls of low socioeconomic status (SES) compared to males. However, there was no significant association between smoke, exercise, home environment, food allergies, weather, pollen and dust with asthma exacerbations. Conclusion: Low levels of vitamin D were not associated with increased number of asthma exacerbations per year. However, children exposed to animal dander had lesser number of exacerbations per year (p-value <0.046). Keywords: Asthma; Vitamin D; Children; Exacerbations, Risk factors.

The impact of SPY angiography on intraoperative decision making and outcomes for post-mastectomy reconstruction

2019 ◽  
pp. 1-5
Keyword(s):  
Decision Making ◽  
Logistic Regression ◽  
Skin Necrosis ◽  
Regression Models ◽  
Multivariable Analysis ◽  
P Value ◽  
Flap Necrosis ◽  
Single Institution ◽  
Logistic Regression Models ◽  
The Impact

Objective: While the use of intraoperative laser angiography (SPY) is increasing in mastectomy patients, its impact in the operating room to change the type of reconstruction performed has not been well described. The purpose of this study is to investigate whether SPY angiography influences post-mastectomy reconstruction decisions and outcomes. Methods and materials: A retrospective analysis of mastectomy patients with reconstruction at a single institution was performed from 2015-2017.All patients underwent intraoperative SPY after mastectomy but prior to reconstruction. SPY results were defined as ‘good’, ‘questionable’, ‘bad’, or ‘had skin excised’. Complications within 60 days of surgery were compared between those whose SPY results did not change the type of reconstruction done versus those who did. Preoperative and intraoperative variables were entered into multivariable logistic regression models if significant at the univariate level. A p-value <0.05 was considered significant. Results: 267 mastectomies were identified, 42 underwent a change in the type of planned reconstruction due to intraoperative SPY results. Of the 42 breasts that underwent a change in reconstruction, 6 had a ‘good’ SPY result, 10 ‘questionable’, 25 ‘bad’, and 2 ‘had areas excised’ (p<0.01). After multivariable analysis, predictors of skin necrosis included patients with ‘questionable’ SPY results (p<0.01, OR: 8.1, 95%CI: 2.06 – 32.2) and smokers (p<0.01, OR:5.7, 95%CI: 1.5 – 21.2). Predictors of any complication included a change in reconstruction (p<0.05, OR:4.5, 95%CI: 1.4-14.9) and ‘questionable’ SPY result (p<0.01, OR: 4.4, 95%CI: 1.6-14.9). Conclusion: SPY angiography results strongly influence intraoperative surgical decisions regarding the type of reconstruction performed. Patients most at risk for flap necrosis and complication post-mastectomy are those with questionable SPY results.

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