scholarly journals Iron deficiency in febrile seizures: a prospective case control study

2020 ◽  
Vol 7 (12) ◽  
pp. 2267
Author(s):  
Vasanth N. Kumar ◽  
Farogh Hassan ◽  
Lata Jha ◽  
Abnish Kumar ◽  
Chandreyi Bandopadhyay ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Mean Corpuscular Volume ◽  
Case Control Study ◽  
Febrile Seizures ◽  
Case Control ◽  
Care Hospital ◽  
Age Group ◽  
Corpuscular Volume ◽  
Control Study

Background: The objective of the study was to evaluate the role of iron deficiency in febrile seizures.Methods: Case control study conducted at Pediatric department of Tertiary care hospital. A total 70 cases and 70 controls were included in the study. Consecutive cases and controls were selected. Cases were children of age group 6 months to 5 years with simple febrile seizures and controls were children of same age group with short febrile illness without any seizures. After consent, detailed history was taken and clinical examination were carried out for both groups. Blood investigations were done to diagnose iron deficiency in both cases and controls. Iron deficiency was diagnosed as per WHO criteria haemoglobin <11 g/dl in cases <5 years mean corpuscular volume<70 fl, mean corpuscular haemoglobin <27 pg and serum ferritin<30 microgram/dl.Results: Mean corpuscular volume was less than 70 fl/ml in 51% cases and 31% controls and mean corpuscular hemoglobin was less than 27 pg/ml in 84% cases and 40% of controls indicating statistically significant association of MCV and MCH between cases and controls .Serum ferritin was less than 30 ng/ml in 44% in cases as compared to 26% of controls, there was statistically significant difference between serum ferritin levels in cases and controls. From the above findings, study showed statistically significant association between iron deficiency anaemia and febrile seizures (p value <0.01; OR- 8.05 (3.6-17.93) (df-1).Conclusions: Iron deficiency is a major risk factor for simple febrile seizures in age group of 6 months to 60 months.

scholarly journals CASE-CONTROL STUDY OF IRON DEFICIENCY ANAEMIA IN FEBRILE SEIZURES

2017 ◽  
Vol 6 (65) ◽  
pp. 4717-4719
Author(s):  
Shailaja Potdar ◽  
Sunil Junagade ◽  
Jayesh Panot ◽  
Vandana Kumavat ◽  
Mohit Rojekar V ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Case Control Study ◽  
Febrile Seizures ◽  
Case Control ◽  
Deficiency Anaemia ◽  
Control Study

scholarly journals Diarrhoea and Associated Clinical Features in Different Pathotypes of Diarrheagenic E. coliIsolated in Children: A Case-Control Study in a Tertiary Care Hospital

2021 ◽  
Vol 53 (03) ◽  
pp. 250-258
Author(s):  
Tapas Ranjan Behera ◽  
Keyword(s):  
Clinical Features ◽  
Case Control Study ◽  
Case Control ◽  
Watery Diarrhoea ◽  
Correct Identification ◽  
Care Hospital ◽  
Age Group ◽  
Major Health Problem ◽  
Childhood Diarrhoea ◽  
Control Study

Background: Acute gastroenteritis remains to be a major health problem in children causing high morbidity and mortalityIn India, diarrhoea is the third most common cause of death in children younger than 5 years of age, with an estimation of 300,000 deaths each year. Diarrheagenic Escherichia coli (DEC) being one of the important bacterial agents, the present hospital-based study was done to enlighten on the occurrence of different pathotypes and clinical features associated with DEC related diarrhoea. Methods:The case-control study was carried out in SCB Medical College, Odisha from October 2014 to September 2016 on the childhood diarrhoea cases (≤ 14 years of age). Stool samples were collected and processed to isolate the causative bacterial agent by standard biochemical test, serotyping and multiplex PCR. Results: 350 cases and 100 controls were included in the study. The different pathotypes of DEC were isolated significantly more in cases than control group (P value = 0.0205) with an isolation rate of 7.4% in cases. 12 (46.2%) of DEC were in 0-1 year age group followed by 1-5 year of age group i.e. 11 (42.3%) and least in 5-14 years of age group i.e. 3 (11.5%). The most common pathotype was Enterotoxigenic E. coli (ETEC) followed by Enteropathogenic E.coli (EPEC). Fever is the most common symptom associated with DEC diarrhoea; the other two common symptoms were watery diarrhoea and vomiting. Exclusive breastfeeding was the protective factor. Seasonal variation of DEC was found more among the cases in the rainy season. Conclusion: Different pathotypes of DEC being associated commonly with childhood diarrhoea, the correct identification of various types of DEC along with the clinical knowledge is important to reduce the morbidity and mortality caused by it.

scholarly journals Low Serum Ferritin is a Risk for Febrile Convulsion in Children

2017 ◽  
Vol 11 (2) ◽  
pp. 44-46
Author(s):  
Aloke Kumar Saha ◽  
Md Kamrul Hassan ◽  
Lakshman Chandra Kundu ◽  
Shyamal Kumar Saha ◽  
Poly Begum ◽  
...  
Keyword(s):  
Serum Ferritin ◽  
Serum Iron ◽  
Case Control Study ◽  
Febrile Convulsion ◽  
Febrile Seizures ◽  
Case Control ◽  
Control Group ◽  
College Hospital ◽  
Medical College ◽  
Control Study

Iron deficiency anaemia and febrile seizures are two common diseases in children worldwide as well as in developing country. A prospective case-control study was carried out in the Department of Paediatrics, Faridpur Medical College Hospital. The study was done during the period from January'2015 to September'2015 with 50 children with first simple febrile seizure as cases and other 50 controls. There were no significant differences in terms of ESR, WBC, platelets, RBC, MCHC, and TIBC levels between the cases and the control group. HB, HCT, MCH, mean serum ferritin and serum iron, were significantly low in the febrile convulsion group as compared to control group.Faridpur Med. Coll. J. Jul 2016;11(2): 44-46

scholarly journals Association of vitamin D levels with simple febrile seizures in under five children: a case control study

2019 ◽  
Vol 6 (2) ◽  
pp. 365
Author(s):  
Virender Singh ◽  
Preeti Sharma ◽  
Deepika Dewan
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Febrile Seizure ◽  
Case Control Study ◽  
Febrile Seizures ◽  
Case Control ◽  
First Episode ◽  
Age Group ◽  
Vitamin D Levels ◽  
Control Study

Background: There is increasing concern that vitamin D deficiency may play etiological role in Febrile seizures. Few studies have reported vitamin D deficiency in children with recurrent febrile seizures and hypocalcemia seizures.  The objective of this study is to explore vitamin D status in children aged 6 months to 5 years with first episode of febrile seizure and to find the association between vitamin D levels and febrile seizure.Methods: A hospital-based case control study was conducted in sub district hospital, Katra over a period of three years. Cases were children of age group 6 months to 5 years presenting with first episode of simple febrile seizure to the casualty or OPD. For each case, a control was selected with similar age group and same sex who came for short duration fever (<2 days) but without seizures. A 5ml of blood sample for measurement of 25 hydroxy vitamin D was taken from the peripheral vein of each participant by trained laboratory technician. In order to categorise various degrees of vitamin D deficiency, Indian Academy of paediatrics criteria was used. Results were presented in the form of percentages and Odds ratio was calculated as measure of association.Results: A total of 75 cases and 75 controls were included in the study. Cases and controls were comparable as per baseline characteristics. Strong and significant (p<0.01) association of febrile seizures with vit D levels was observed.Conclusions: There was a high prevalence of vitamin D insufficiency among cases of simple febrile seizure.

scholarly journals Evaluation of Iron Status in Children with Autism Spectral Disorder: A Case-control Study

2021 ◽  
Author(s):  
Pritam Prakash ◽  
Rekha Kumari ◽  
Niska Sinha ◽  
Santosh Kumar ◽  
Poonam Sinha
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Case Control Study ◽  
Iron Status ◽  
Children With Autism ◽  
Case Control ◽  
Control Groups ◽  
Ferritin Iron ◽  
And Control ◽  
Control Study

Introduction: Iron is an important factor in neural development. Iron Deficiency (ID) and Iron Deficiency Anaemia (IDA) anaemia is highly prevalent in patients of autism. There are a very small number of studies to show association between iron profile and autism. Aim: To investigate factors affecting iron status such as hemoglobin (%), serum iron, ferritin, and Total Iron Binding Capacity (TIBC) level in children with Autism Spectral Disorder (ASD) and healthy control. Materials and Methods: It was a case-control study done from April 2018 to April 2019. Total 100 participants were recruited of which 50 autistic patients were taken as cases, and 50 healthy subjects were taken as control. Childhood Autism Rating Scale (CARS) was used to evaluate the severity of autistic symptoms. Cut-off value of serum ferritin was <10 ng/mL for preschoolers (<6 years) and <12 ng/mL for school-aged (>6 years) children to evaluate ID. Anaemia was defined as haemoglobin <11.0 g/dL for preschoolers and <12.0 g/dL for school-aged categorical variables and were compared by using chi-square test. Normally distributed parametric variables were compared between groups by using independent samples t-test. Serum ferritin, iron, TIBC values were compared between severe, mild-moderate and control groups with ANOVA. The p-value <0.05 was accepted to be statistically significant. Results: Mean serum levels of ferritin iron TIBC were significantly reduced in ASD patients (p<0.001). The level of haemoglobin was also lower in ASD patients but it was not significant. Risk of ID and IDA was higher than normal subjects (RR for ID 1.74). Level of serum ferritin, iron and TIBC was lowest in severe autism as compared to mild-moderate autism and control groups. Conclusion: These findings suggest iron and ferritin levels should be measured in autistic patients as a baseline investigation and it may be used as a screening test for ASD.

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