scholarly journals Intravitreal dexamethasone as an adjunct for the treatment of dengue virus related maculopathy: a case report

2018 ◽  
Vol 5 (6) ◽  
pp. 1525
Author(s):  
Jimmy Joseph ◽  
Sathiyan Karunanidhi ◽  
Lally Alexander ◽  
Imran Ahmad Khan ◽  
Jishnu Narayanan Nair
Keyword(s):  
Visual Field ◽  
Dengue Virus ◽  
Dengue Infection ◽  
Young Female ◽  
Endemic Region ◽  
Dengue Virus Infection ◽  
Pulse Steroid Therapy ◽  
Intravitreal Dexamethasone ◽  
Pulse Steroid

Dengue infection related ocular pathology whether as a direct manifestation of coagulopathy or as a sequale of immunological reaction is being increasingly recognized in endemic regions and has expanded out into a spectrum with pan ocular presentation. Authors present a case of a young female from an endemic region who developed visual field abnormality and loss of vision several days after onset of fever. She was diagnosed with dengue virus infection and subsequently went on to develop thrombocytopenia requiring transfusion. Detailed ophthalmological evaluation revealed maculae edema, and changes consistent with neuroretinitis and posterior segment vasculitis. She was treated with a combination of pulse steroid therapy and intravitreal dexamethasone injection. Patient went on to have excellent visual recovery on follow up with no persisting visual field deficit.

scholarly journals NS-1 antigen positive Dengue Infection and molecular characterization of Dengue Viruses in a private Medical College Hospitalin Dhaka, Bangladesh

2018 ◽  
Vol 17 (4) ◽  
pp. 669-673
Author(s):  
Mahmuda Siddiqua ◽  
Ahmed Nawsher Alam ◽  
AKM Muraduzzaman ◽  
Tahmina Shirin
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Dengue Infection ◽  
Medical Science ◽  
Cost Effective ◽  
Rt Pcr ◽  
Dengue Virus Infection ◽  
Medical College ◽  
Virus Serotype ◽  
Ns1 Antigen

Introduction: Detection of dengue virus infection as soon as possible is critical for management of dengue virus infected patients. Immuno-chromatographic (ICT) tests are easy, cost effective method for dengue virus antigen detection.The sensitivity and specificity of ICT should compare with a gold standard test like RT-PCR. Aim of this study was to compare two test methods (ICT and RT-PCR), observe dengue serotype and seasonal impact on dengue infection.Methodology & result: The patients of Ibn Sina Medical College Hospital from October 2015 to October 2017 were tested for dengue NS1 antigen by ICT method. Out of 3201 sample tested 32.39% were found positive and 89 of which were re-tested for RT-PCR for comparison. Eighty eight of 89 NS1 positive cases showed positive by RT-PCR method giving an accuracy of 98.87%. Among the RT-PCR positive cases 45 were further analyzed for serotype. DEN-1, DEN-2 or both DEN- 1 and DEN-2 were found in 21, 23 and 1cases respectively. No cases of DEN-3 or DEN-4 were detected.Conclusion: This study showed that easily available and cost effective dengue NS1 antigen detection method (ICT) is as effective as molecular test (RT-PCR). DEN-1 and DEN-2 serotype were prevalent during last few years in Bangladesh. Continuous monitoring of dengue virus serotype is important for prevention and control of sudden epidemic by other serotype. Alert to be more during post monsoon when the peak of dengue virus infection was observed.Bangladesh Journal of Medical Science Vol.17(4) 2018 p.669-673

A SPATIAL CLUSTERING APPROACH TO IDENTIFY RISK AREAS OF DENGUE INFECTION AFTER INSECTICIDE SPRAYING

2016 ◽  
Vol 78 (5-3) ◽  
Author(s):  
Napadol Sudsom ◽  
Suwich Thammapalo ◽  
Theerakamol Pengsakul ◽  
Kuaanan Techato
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Spatial Clustering ◽  
Dengue Infection ◽  
Spatial Association ◽  
Dengue Vector ◽  
Dengue Virus Infection ◽  
Spatial Analyst ◽  
Risk Areas ◽  
Clustering Approach

This study aims to demonstrate a spatial clustering approach for identifying risk households of dengue virus infection during the period of insecticide spraying-ultra low volume (ULV). All households located within 100 m radius of spraying area were recorded with geographic coordinates and divide into three groups of spraying (unsprayed, only outdoor and indoor plus outdoor sprayed house). A total of 45 households with geographic coordinates, were randomly selected to monitor ovitrap index, the percentage of positive ovitraps and the number of eggs per trap, in pre- and post-ULV spraying. Application of spatial analyst tools and spatial statistics tools in ArcGIS 10.1 were used to determine mosquito density and identify risk households using ovitrap index. The prediction maps of Aedes aegypti vector abundance were illustrated by kriging technique. Base on the results, the cluster of Ae. aegypti populations were detected on four day after the spraying. This finding shows the significant spatial pattern of dengue vector populations which may cause high risk areas of dengue virus infection after insecticide treatment. This methodological framework could be used for improving the strategy of dengue vector and outbreak control. The spatial association between dengue vector and the coverage of space spraying requires further study.

Neonate with haemophagocytic lymphohistiocytosis secondary to dengue infection: a case report

2016 ◽  
Vol 47 (3) ◽  
pp. 253-255 ◽  
Author(s):  
MV Krithika ◽  
Prakash Amboiram ◽  
Sneha M Latha ◽  
Binu Ninan ◽  
Febe Renjitha Suman ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Case Report ◽  
Virus Infection ◽  
Dengue Virus ◽  
Dengue Infection ◽  
Haemophagocytic Lymphohistiocytosis ◽  
Dengue Virus Infection ◽  
The Third ◽  
First Case

We report the first case of haemophagocytic lymphohistiocytosis (HLH) in a neonate secondary to primary Dengue virus infection. This neonate presented in the third week of life with fever, shock and hepatosplenomegaly and was diagnosed to have Dengue infection by serology and HLH was confirmed on bone marrow.

scholarly journals Detection of Proteinuria by Colorimetric Method and Correlation with Disease Severity in Patients Dengue

2021 ◽  
Vol 27 (3) ◽  
pp. 244
Author(s):  
Acivrida Mega Charisma ◽  
Elis Anita Farida ◽  
Farida Anwari
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Disease Severity ◽  
Dengue Infection ◽  
Urine Samples ◽  
P Value ◽  
Urine Protein ◽  
Dengue Virus Infection ◽  
Chi Square ◽  
Chi Square Test

Severe dengue virus infection often causes proteinuria through several mechanisms, such as leakage of plasma proteins caused by higher protein filtering in the kidneys. The condition of proteinuria in patients with dengue shock syndrome will affect the management, prognosis, and mortality of patients with dengue virus infection. The objectives of this study were to determine the presence of protein in urine samples in patients in which IgG/IgM dengue was detected, to determine the presence of protein in urine samples in patients without dengue infection, and to determine the relationship between proteinuria in dengue patients and the degree of disease severity. The study was conducted in March-June 2020 at the Clinical Laboratory and Inpatient Clinic of Vita Medika Kepung, Kediri Regency. The method used was the consecutive sampling technique. The minimum sample size was 100 respondents with criteria for suspected dengue infection, onset fever > 4 days, age > 2 years, and no indication of other infectious diseases (blood and urine), divided into two groups, group with positive dengue infection and non-dengue group. The results showed that proteinuria was detected in 26% of respondents, secondary dengue infection and positive serological test of IgG, IgM only IgG were detected in 24 (92.3%) respondents and positive IgG and IgM were found in 2 (7.7%) respondents, this was shown by the p-value = 0.000 in the Chi-Square test with a Prevalence Ratio (PR) value of 11,987. In addition, Chi-Square test results indicated that a higher urine protein/albumin led to more severe disease, with p-value = 0.012 and 0.025 (p <0.05) and PR values of 3.333 and 2.800. The results of this study concluded that there was a close relationship between high levels of protein/albumin in the urine with the degree of disease severity in patients with dengue infection. In addition, an increase in urine protein/albumin levels is always followed by a decrease in serum protein/albumin levels.

scholarly journals 1768. Dengue Virus Infection in Solid-Organ Transplant Recipients: Case Series and Literature Review

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S651-S652
Author(s):  
Fernando Rosso ◽  
Ana M Sanz ◽  
Luis Gabriel Parra-Lara ◽  
Pablo A Moncada ◽  
Juan D Vélez ◽  
...  
Keyword(s):  
Virus Infection ◽  
Literature Review ◽  
Dengue Virus ◽  
Dengue Infection ◽  
Organ Transplant ◽  
Case Series ◽  
Solid Organ Transplant ◽  
Severe Dengue ◽  
Solid Organ ◽  
Dengue Virus Infection

Abstract Background Dengue fever is the most prevalent arbovirus among humans, its incidence has increased since the re-emergence, and Colombia is a hyperendemic country for this infection. The number of solid-organ transplant (SOT) recipients, at risk of acquiring dengue virus infection, is constantly increasing, and there are few data regarding the clinical course and outcomes of dengue infection among this population. The aim of this study was to describe dengue virus infection in SOT recipients in Cali, Colombia. Methods We present a case series of SOT recipients with dengue virus infection, diagnosed by World Health Organization criteria and a positive NS1 and/or IgM dengue antibodies, which were attended at the FVL from 2001 to 2018. Furthermore, we performed a literature review regarding dengue infection in SOT recipients. Results A total of 20 patients were included: 17 kidney and 3 liver recipients. The median age was 50.5 years (IQR = 31–63.5), 65% were female. The median time from transplant to dengue was 27.6 months (IQR = 3.82–59.12), and 3 patients had the infection in the first month after the transplant. The most common symptoms were fever (95%), myalgia, headache, and abdominal pain. Warning signs were present in 75% of patients, thrombocytopenia and hemorrhagic manifestations were present in 30% and 15%, respectively. 35% of patients were classified as severe dengue, and 45% were managed at the intensive care unit. Regarding laboratory findings, six patients had transaminases elevation more than three times the upper limit and 7 had serum creatinine elevation, which returned to normal levels. All patients were discharged and none of them had alterations in the graft function. To date, there are approximately 180 reported cases of dengue in SOT recipients (Table 2). Conclusion Dengue represents a threat among SOT recipients. Unlike other reports, all patients in this series had a full recovery after the infection, suggesting that timely and effective management of patients and the access to high complexity services could prevent fatal cases. Disclosures All authors: No reported disclosures.

Cardiac evaluation in adults with dengue virus infection by serial echocardiography

2020 ◽  
Author(s):  
Chayasin Mansanguan ◽  
Borimas Hanboonkunupakarn ◽  
Sant Muangnoicharoen ◽  
Arun Huntrap ◽  
Akkapon Poolcharoen ◽  
...  
Keyword(s):  
Pericardial Effusion ◽  
Virus Infection ◽  
Dengue Virus ◽  
Cardiac Function ◽  
Cardiac Involvement ◽  
Troponin T ◽  
Left Ventricular ◽  
Dengue Virus Infection ◽  
Cardiac Biomarker

Abstract Background Dengue virus infection (DVI) is a major health problem in many parts of the world. Its manifestations range from asymptomatic infections to severe disease. Although cardiac involvement has been reported in DVI, its incidence has not yet been well established. Methods From July 2016 to January 2018, patients hospitalized at the Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, with dengue virus infection confirmed by positive NS1 or positive dengue immunoglobulin M findings, participated in the study. We characterized the incidence and change in cardiac function by serial echocardiography and levels of troponin-T and creatinine kinase-myocardial band (CK-MB) on the day of admission, the day of defervescence, the first day of hypotension (if any), and at 2-week follow-up. Results Of the 81 patients evaluated, 6 (7.41%) exhibited elevated biomarker levels. There was no difference in clinical presentation amongst dengue fever, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) except the amount of bleeding. Cardiac involvement was found in 22% of patients: 3 (3.70%) had left ventricular systolic dysfunction, 3 (3.70%) had transient diastolic dysfunction, 6 (7.41%) had increased levels of at least one cardiac biomarker (troponin-T or CK-MB), and 6 (7.41%) had small pericardial effusion. Myocarditis was suspected in only two patient (with DHF); thus, myocarditis was uncommon in patients with dengue virus infection. Three patients developed DSS during admission and transfer to the intensive care unit. Conclusion Cardiac involvement in adults with dengue infection was found in 22.22% of cases, ranging from elevated cardiac biomarker, transient left ventricular systolic and diastolic dysfunction and pericardial effusion. We found that DHF was the significant risk factor for cardiac involvement (p < 0.001). Abnormalities in cardiac function had resolved spontaneously by the day of follow-up without specific treatment.

scholarly journals Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation

Blood ◽  
2013 ◽  
Vol 122 (20) ◽  
pp. 3405-3414 ◽  
Author(s):  
Eugenio D. Hottz ◽  
Juliana F. Lopes ◽  
Carla Freitas ◽  
Rogério Valls-de-Souza ◽  
Marcus F. Oliveira ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Vascular Permeability ◽  
Nlrp3 Inflammasome ◽  
Dengue Infection ◽  
Inflammasome Activation ◽  
Dengue Virus Infection ◽  
Nlrp3 Inflammasome Activation ◽  
Key Points ◽  
Endothelium Permeability

Key Points Dengue infection triggers functional inflammasome assembly in platelets. Platelets may contribute to increased vascular permeability in dengue virus infection by synthesis and release of IL-1β.

scholarly journals The 1993 dengue 2 epidemic in Charters Towers, North Queensland: clinical features and public health impact

1998 ◽  
Vol 121 (1) ◽  
pp. 151-156 ◽  
Author(s):  
W. J. H. McBRIDE ◽  
H. MULLNER ◽  
J. T. LaBROOY ◽  
I. WRONSKI
Keyword(s):  
Dengue Virus ◽  
Dengue Fever ◽  
Dengue Infection ◽  
Neutralizing Antibody ◽  
Symptomatic Patient ◽  
Health Impact ◽  
Subclinical Infection ◽  
Dengue Virus Infection ◽  
Dengue Virus Type 2

In 1993 an epidemic caused by dengue virus type 2 occurred in several North Queensland population centres. Charters Towers, estimated population 10000, had 155 officially notified cases. An analysis of symptoms was undertaken using a random sample of 1000 residents to determine specificity of symptoms, the subclinical infection rate, and to establish the true extent of the epidemic. Retrospective diagnoses of dengue fever were based on the presence of both serum dengue 2 neutralizing antibody and presence of symptoms. An estimated 20% of the population had dengue fever. The rate of subclinical infections in this epidemic was 14·6%. There were no symptoms that were specific for dengue fever. Bleeding occurred more frequently in people who recalled a previous dengue infection during a dengue 1 epidemic 12 years earlier (55·6% vs. 16·8%, P=0·003). Surveillance for future epidemics should be based on serological and virological confirmation of dengue virus infection amongst symptomatic patient.

scholarly journals Clinico-haematological profile of dengue virus infection at rural tertiary care centre in North India

2017 ◽  
Vol 5 (8) ◽  
pp. 3329
Author(s):  
Vidyasagar Ram ◽  
Khwaja Saifullah Zafar ◽  
Manoj Kumar ◽  
Ganga Prasad Vaishya ◽  
Ejaz Ahmad ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Dengue Fever ◽  
Indian Subcontinent ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Laboratory Data ◽  
North India ◽  
Dengue Virus Infection ◽  
Haematological Profile

Background: In India, dengue epidemics are becoming more frequent. Dengue viral infections are among the most important mosquito-borne disease of the Indian subcontinent. The study aimed to compare the clinical and haematological profile of all patients diagnosed with dengue viral infection. Patient with confirmed infection with dengue virus were prospectively evaluated for disease progression and to determine their final clinical outcome. The objective of the study was to study the clinico-haematological profile of dengue infection at rural tertiary care centre.Methods: This prospective study included 456 clinically suspected cases of dengue infection of ages more than 14 years of age. Dengue was confirmed by serological methods. Confirmed cases of dengue infection were analyzed according to age, sex and education. Clinical and hematological data were compared between dengue fever and dengue hemorrhagic fever.Results: Serologic dengue infection was positive in 220 (48%) out of 456 clinically suspected cases of the dengue infection. 127 (57.73%) patients were males and 93 (42.27%) were females. 149 (67.72%) patient had dengue fever while 71 (32.27%) had dengue hemorrhagic fever. The proportion of dengue cases was highest among male aged 15 to 24 years-old. A gradual decrease occurred in the percentage of dengue cases in the population aged 44 years-old or more. Common clinical symptoms were fever, headache, abdominal pain, myalgia, joint pain and retro-orbital pain. Common haematological abnormalities were thrombocytopenia, leukopenia and elevated alanine aminotransferase (SGOT).Conclusions: Differences in the clinical, biochemical and haematological profile of dengue virus infection, indicative of a variation in disease severity from DF to DHF. In this study, we present recent data on readily obtained clinical and laboratory data that can be used for early diagnosis and earlier appropriate treatment of dengue virus infection.

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