Assessment of pulmonary function test in type 2 diabetes mellitus and its correlation with their HbA1c levels

Background: Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia and deranged metabolism of carbohydrates, lipids and protein that result from insensitivity to endogenous insulin. It is a substantial global health problem and markedly increases morbidity and mortality of the affected people.Methods: The present study was conducted in the Department of medicine Dr. B.R.A.M. Hospital, Raipur. Total 67 subjects with type II diabetes mellitus as per WHO criteria of diabetes mellitus, aged between 18-60years of both sexes were included in the study. Patients FBS, PPBS were analysed by glucose oxidase (GOD), peroxidase (POD) methods in ILAB 650 analyser and HbA1C was analysed using HPLC. Pulmonary function test was conducted in all the subjects using the spirometer which is the gold standard for accurate and repeatable measurement of lung function.Results: Majority of the subjects were male (36, 53.7%) and belonged to age group of 51-60years (n=34, 50.7%), Duration of DM </=10years (n=47, 70.1%), restrictive pulmonary function in 10 (14.9%) subjects. Correlation of age with a restrictive pattern of PFT (P=0.013*) and with duration of diabetes (P<0.0001**). Pulmonary function test parameters having mild downstream correlation with diabetes mellitus.Conclusions: Diabetes was more common in the sixth decade of life with slight male preponderance. The short-term indicators of glycaemic controls were not significantly associated with a restrictive pattern of PFT. Despite the best effort, there are limitations of this study, which includes small sample size, author have not taken general population, and lack of a control group. These limitations can be overcome in the future studies.

Download Full-text

A Study of Pulmonary Function Test in Type II Diabetes Mellitus-Spirometry Based

International Journal of Physiology ◽

10.5958/2320-608x.2018.00074.4 ◽

2018 ◽

Vol 6 (3) ◽

pp. 1

Author(s):

S Suguna ◽

R Vinodha

Keyword(s):

Diabetes Mellitus ◽

Pulmonary Function ◽

Pulmonary Function Test ◽

Type Ii Diabetes ◽

Type Ii Diabetes Mellitus ◽

Type Ii ◽

Function Test

Download Full-text

The study of pulmonary function tests in patients with hypothyroidism

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20195225 ◽

2019 ◽

Vol 6 (6) ◽

pp. 1774

Author(s):

Sivaranjani H. ◽

Chaitra K. R.

Keyword(s):

Pulmonary Function ◽

Pulmonary Function Test ◽

The Body ◽

Exercise Intolerance ◽

Control Group ◽

P Value ◽

Common Disease ◽

Respiratory Dysfunction ◽

Organ Systems ◽

Function Test

Background: Hypothyroidism is a common disease with a prevalence rate of 11% in India. It affects all organ systems in the body. Patients with hypothyroidism frequently have symptoms of fatigue and exercise intolerance. These symptoms could arise from a reduced pulmonary reserve, cardiac reserve or decreased muscle strength or increased muscle fatigue. This study aims to study the pulmonary function test in patients with hypothyroidism.Methods: This is a cross sectional study conducted on 100 patients divided into 2 groups (a) newly detected hypothyroids (b) normal control group. Cases were matched with controls in having similar environment exposure and age group. All patients had routine symptom and clinical assessment. Laboratory investigations such as complete blood picture, pulmonary function test, chest x ray and thyroid function test were done. Data was entered and analysed.Results: In this study conducted on 100 patients, case group had symptoms of easy fatiguability (36%), breathlessness (20%), menstrual abnormality (20%), weight gain (7%) and generalised body aches (5%). Mean FEV1 levels between cases and controls were 1.34 and 1.72 (p value 0.00), mean FVC were 1.88 and 2.09 (p value 0.114), FEV1/FVC ratio of 70.56, 81.98 respectively (p value 0.00). The distribution of PFT pattern was 32% obstructive, 28% mixed pattern and 22% restrictive pattern.Conclusions: This study shows that hypothyroidism causes significant decrease in FEV1 and FEV1/FVC ratio, thereby suggesting obstructive patterns of lung involvement .Therefore PFT can be used routinely as a screening test for all hypothyroid patients to detect early respiratory dysfunction and thereby optimise treatment especially in obese patients and patients with pre-existing lung disease as hypothyroidism adds to their respiratory dysfunction.

Download Full-text

Pulmonary function test in patients of type 2 diabetes mellitus

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20192505 ◽

2019 ◽

Vol 7 (6) ◽

pp. 2240

Author(s):

Amit Agarwal ◽

Ankit Grover ◽

Amresh Agarwal

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Pulmonary Function ◽

Pulmonary Function Test ◽

General Medicine ◽

Uttar Pradesh ◽

Diabetic Patients ◽

Function Test

Background: We are today witnessing a pandemic of diabetes mellitus (DM), globally and nationally. DM and its complications have become the most important contemporary and challenging health problems. Diabetes is not associated with any specific pulmonary symptom and hence periodic screening for lung disease is not done in diabetic patients. However, an extensive microvascular circulation and an abundant connective tissue in the lung raise the possibility that the lung may also be a target organ in diabetic patients. The aim and objectives were to study the pulmonary function of individual with type 2 diabetes mellitus patients by performing spirometry.Methods: Study included non-smoker diabetic patients, who had no history of respiratory disease, were selected for this study and undergone pulmonary function test by spirometry. The study was conducted at department of General Medicine Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh, India.Results: Present study, author found that there was significant derangement in the spirometric readings in the diabetic patients. The FEV1/FVC values further declines as the duration of diabetes increased.Conclusions: Spirometric values (FVC, FEV1, FEV1/FVC) were consistently lower in subjects with type 2 diabetes mellitus. The effect on FVC predicted % was found to be more pronounced in subjects whose duration of DM was more than 5 years.

Download Full-text

Medium-Term Pulmonary Function Test After Thoracoscopic Lobectomy and Segmentectomy for Congenital Lung Malformation: A Comparative Study With Normal Control

Frontiers in Pediatrics ◽

10.3389/fped.2021.755328 ◽

2021 ◽

Vol 9 ◽

Author(s):

Jin-Xi Huang ◽

Song-Ming Hong ◽

Jun-Jie Hong ◽

Qiang Chen ◽

Hua Cao

Keyword(s):

Pulmonary Function ◽

Pulmonary Function Test ◽

Small Airway ◽

Normal Lung ◽

Control Group ◽

Medium Term ◽

Thoracoscopic Lobectomy ◽

Congenital Lung Malformation ◽

Significant Difference ◽

Function Test

Purpose: This study aimed to compare the outcomes and pulmonary function test (PFT) of thoracoscopic segmentectomy and lobectomy in infants with congenital lung malformation and study the result of PFT on a medium-term basis.Methods: The clinical data of 19 infants with congenital lung malformation who underwent thoracoscopic surgery in our hospital from January 2018 to March 2019 were retrospectively studied; these infants were paired with another 19 infants who underwent thoracoscopic lobectomy during the same period using propensity score matching. Age-matched healthy individuals with similar body sizes were recruited for PFT as the control group. Patient characteristics, postoperative PFT, and outcomes were extracted for statistical analysis.Results: The average length of hospital stay did not significantly differ between segmentectomy and lobectomy groups. The segmentectomy group had more chest tube drainage than the lobectomy group. PFT 1 month after the operation showed that the tidal volume of the lobectomy group was lower than that of the segmentectomy group. Time to peak expiratory flow/time of expiration and peak flow/terminal airway velocity (V25%) indicated small airway dysfunction in the lobectomy group, and no obvious abnormalities were found in “time of inspiratory/time of expiration” in either group. Reexamination of pulmonary function 2 years after the operation showed that the small airway function of the segmentectomy group returned to normal, and no significant difference in pulmonary function was noted among the three groups.Conclusion: The short-term pulmonary function recovery was better after segmentectomy than after lobectomy. Patients who underwent thoracoscopic lobectomy and segmentectomy have normal lung function 2 years after the operation.

Download Full-text

A Study of Effect of Glycaemic Status on Pulmonary Function Test in Type 2 Diabetes Mellitus

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2021/283 ◽

2021 ◽

Vol 10 (18) ◽

pp. 1343-1346

Author(s):

Basavaraj G.T ◽

Mudassir Indikar ◽

Malingaraya Negali

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Pulmonary Function ◽

Pulmonary Function Test ◽

Pulmonary Complications ◽

The Other ◽

Duration Of Diabetes ◽

Function Test

BACKGROUND Diabetes mellitus is a metabolic disorder precipitating micro vascular, macro vascular complications and peripheral vascular diseases. Pulmonary complications of diabetes mellitus have been poorly characterised. Glycaemic status has shown varied impact on lung functions. In type-2 diabetes there is resistance to insulin action and also inadequate insulin secretion. Diabetes mellitus is associated with morphological and functional abnormalities. Several studies have shown that diabetes is associated with impaired pulmonary function. Pulmonary complications of diabetes mellitus (DM) have been poorly characterised. Some authors have reported normal pulmonary functions and even concluded that spirometry is not at all necessary in diabetic patients. We wanted to highlight the evidence-based significance of spirometry. METHODS This cross-sectional study was done for a period of 1 year from September 2017 to July 2018. The study sample consisted of 50 type-2 diabetes patients and 50 controls. RESULTS A total of 100 subjects were included in the present study; 50 of them were diabetics and the other 50 were non-diabetic controls matched by age, sex and body mass index (BMI). The range of forced vital capacity (FVC) in diabetic group was from 1.36 litres, which is lesser than range in controls (2.06 litres). Forced expiratory volume (FEV1) / FVC ranged from 0.59 in diabetics compared to 0.84 in controls. Mean FVC value was higher in diabetics with a duration of diabetes of less than 5 years (2.72) as compared to those with diabetes of more than 5 years (2.03) with a P value of 0.0004 which is statistically significant. CONCLUSIONS Type 2 diabetes mellitus is associated with restrictive pattern of respiratory abnormality. As the duration of diabetes increases the restrictive profile was more prominent. There was inverse relation between glycaemic status and spirometric indices FEV1 and FVC. Thus, an intensive glycaemic management may reduce the risk of death through an improved ventilator function which is independent of the other beneficial effects. KEY WORDS Pulmonary Function Test, Type 2 Diabetes Mellitus, Glycaemic Status

Download Full-text

A Possible Association Between Suspected Restrictive Pattern as Assessed by Ordinary Pulmonary Function Test and the Metabolic Syndrome

CHEST Journal ◽

10.1378/chest.07-3003 ◽

2008 ◽

Vol 134 (4) ◽

pp. 712-718 ◽

Cited By ~ 53

Author(s):

Kei Nakajima ◽

Yoichi Kubouchi ◽

Toshitaka Muneyuki ◽

Midori Ebata ◽

Satoko Eguchi ◽

...

Keyword(s):

Metabolic Syndrome ◽

Pulmonary Function ◽

Pulmonary Function Test ◽

The Metabolic Syndrome ◽

Function Test ◽

Restrictive Pattern

Download Full-text

Significance of frequent spirometry test in treated pulmonary tuberculosis patients in tertiary care teaching hospital

IP Indian Journal of Immunology and Respiratory Medicine ◽

10.18231/j.ijirm.2021.017 ◽

2021 ◽

Vol 6 (2) ◽

pp. 75-79

Author(s):

Jaykumari Choudhary ◽

Suprova Chakraborty ◽

Prasanta Kumar De

Keyword(s):

Pulmonary Tuberculosis ◽

Pulmonary Function ◽

Pulmonary Function Test ◽

Communicable Disease ◽

Tertiary Care ◽

Normal Lung ◽

Test Results ◽

Duration Of Symptoms ◽

Function Test ◽

Restrictive Pattern

Tuberculosis is one of the most important communicable disease, which poses a global public health threat and remains the leading cause of death among infectious diseases, especially in undeveloped and developing countries.It was a prospective, observational, hospital based study conducted in the department of Respiratory Medicine, IPGMER SSKM Hospital, Kolkata from January 2020 to December 2020. Atotal of 80 cases, with history of adequately treated one episode of pulmonary tuberculosis, were included in this study.According to pulmonary function test results, 30(37.5%) patients had obstructive pattern and 11(13.8%) had restrictive pattern, in spirometry. Another 15(18.8%) patients had, mixed obstructive/restrictive pattern, while in rest 24 (30%) patients, spirometry test results were normal. The distribution of various pulmonary function test results among patients with obstructive pattern (N=30), ATT completion history was 7.57 ± 2.77 years back in average. Whereas average duration of symptoms in them was found to be 4.03 ± 1.96 years. For patients with restrictive pattern (N=11), these durations were 10.91 ± 2.51years and 7.59 ± 2.35 years respectively. Patients with mixed pattern (N=15), both durations were 11.33 ± 3.50 years and 7.33 ± 2.94 years respectively. Whereas among patients with normal lung function (N=24), ATT completion duration was 2.83 ± 2.21 years and symptom onset duration was 0.63 ± 0.34 years.There was emphatically found thatduration of anti-tubercular treatment, duration of symptoms and pulmonary function abnormalities. Hence clinical suspicion, early diagnosis and early treatment strategy are required to prevent further deterioration of pulmonary function in treated Pulmonary tuberculosis (PTB) patients. So, frequent or annual spirometry is required in these patients.

Download Full-text

Study of clinical and nerve conduction study correlation in patients of diabetic neuropathy in diabetes mellitus type 2

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20183120 ◽

2018 ◽

Vol 5 (4) ◽

pp. 922

Author(s):

Manish Patil ◽

Avon Kumar Dhruw ◽

Shashank Gupta

Keyword(s):

Diabetes Mellitus ◽

Diabetic Neuropathy ◽

Nerve Conduction ◽

Small Sample Size ◽

Small Sample ◽

Control Group ◽

Chronic Hyperglycemia ◽

Increased Risk ◽

Tingling Sensation

Background: Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia with disturbance of carbohydrate, fat, and protein metabolism resulting from defects in insulin secretion, insulin action or both with an increased risk of neuropathy. Early diagnosis and management of diabetic polyneuropathy (DPN) are crucial as failure to diagnose can lead to serious consequences, including disability and amputation. Present study aimed at investigating the demographic profile and correlation of clinical features with nerve conduction studies in patients with diabetic neuropathy in type 2 diabetes mellitus.Methods: The cross-sectional study design with total 66 patients of type 2 DM were selected in 30 to 60-year age groups, from Pt. Jawaharlal Nehru Memorial Medical College, Department of Medicine, Raipur (C.G.) (Pt. JNMMC) and associated hospital. Descriptive statistics and χ2 test were used for analysing the data.Results: Total 66 patients were selected, Most of the patients are presenting with tingling sensation (n=64, 97.0%) and burning feet (n=52, 78.8%), NCV is mostly absent in the tibial nerve (n=52, 78%), sural nerve (n=63, 95.5%) and planter nerve (n=41, 62.1%) while it is largely normal in median nerve (n=54, 81.8%) and ulner nerve (n=61, 92.4%). Tingling sensation, burning feet, diminished vibration sensation and diminished light touch are significantly associated (p=0.00) with NCV in different nerves.Conclusions: Limitations of study includes small sample size, lack of general population, and a control group. Diabetes mellitus is a chronic illness with an increased risk of neuropathy. NCS having high sensitivity and specificity for detection of DPN. Understanding the NCS and its correlates in patients with DPN is crucial for early detection and development of effective management and strategies to prevent its complications.

Download Full-text

EFFECTS OF HIGH-INTENSITY INSPIRATORY MUSCLE TRAINING IN RUGBY PLAYERS

Revista Brasileira de Medicina do Esporte ◽

10.1590/1517-869220182403166216 ◽

2018 ◽

Vol 24 (3) ◽

pp. 216-219 ◽

Cited By ~ 2

Author(s):

Adauto de Oliveira Nunes Júnior ◽

Marina Andrade Donzeli ◽

Suraya Gomes Novais Shimano ◽

Nuno Miguel Lopes de Oliveira ◽

Gualberto Ruas ◽

...

Keyword(s):

Pulmonary Function ◽

Pulmonary Function Test ◽

High Intensity ◽

Inspiratory Muscle ◽

Inspiratory Muscle Training ◽

Control Group ◽

Muscle Training ◽

Level Of Evidence ◽

Function Test ◽

Rugby Players

ABSTRACT Introduction: Rugby is a sport characterized by high and low intensity motor action. Therefore, the respiratory muscles need adequate work to maintain sustained effective breathing. Objective: To analyze the effects of high-intensity inspiratory muscle training (IMT) in amateur rugby players from the city of Uberaba, Minas Gerais, Brazil. Methods: This is a clinical study in which 20 amateur players underwent a pulmonary function test, respiratory muscle strength and physical capacity assessment. The participants were divided into two groups: 10 volunteers in the IMT group (G1) and 10 in the control group (G2). All the assessments were carried out before and after 12 weeks of IMT. Results: No significant changes were observed in the pulmonary function test. However, maximal voluntary ventilation, maximal inspiratory pressure, maximal expiratory pressure and distance increased significantly after IMT. Conclusion: IMT had beneficial effects on amateur rugby players. Level of evidence I; Therapeutic studies - Investigation of treatment results.

Download Full-text