scholarly journals The study of correlation between vitamin D and tuberculosis in newly detected tuberculosis - pulmonary and extra pulmonary patients attending to K R hospital, Mysuru, Karnataka, India

2019 ◽  
Vol 7 (1) ◽  
pp. 34 ◽  
Author(s):  
Vandana Balgi ◽  
Sanjana J. M. ◽  
Suneetha D. K. ◽  
Amrudha Surendran ◽  
Chandrashekar G. S.
Keyword(s):  
Vitamin D ◽  
Pulmonary Tuberculosis ◽  
Extrapulmonary Tuberculosis ◽  
P Value ◽  
Host Immune System ◽  
Tuberculosis Patients ◽  
Pulmonary Tb ◽  
Vitamin D Levels ◽  
The Mean ◽  
Extra Pulmonary

Background: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, which has posed a constant challenge to mankind in its treatment due to increasing resistance and longer duration of treatment. The newer approach is to look towards strengthening host immune system along with suppressing the organism. Aim of the study was to assess the existence of Vitamin D deficiency in TB patients and aid in the strategies and development of newer improvised approaches in the treatment of TB. Objectives of the study was to estimate vitamin D levels in Tuberculosis (pulmonary and extrapulmonary) patients, assess Correlation between vitamin D and   pulmonary tuberculosis and to assess correlation between Vitamin D and extrapulmonary Tuberculosis.Methods: This is a descriptive cross-sectional study. The study consisted of 80 tuberculosis patients both extrapulmonary and pulmonary. Blood samples was analysed for Vitamin D levels and results were compared with age and sex matched controls. Results was analysed using SPSS software.Results: The cases included patient in the age group of 18-60 year with the mean age being 42.34±14.65 year. Of the 80 tuberculosis patients 42 were diagnosed with pulmonary tuberculosis and 38 constituted extrapulmonary tuberculosis. The mean Vitamin D in cases was 24.82±12.33 and controls was 34.41±6.19. Among the cases 25 (31.3%) subjects had Vitamin D levels <20 pg/ml and none of the controls had levels <20 pg/ml. The mean Vitamin D level in pulmonary Tb patients was found to be 24.29±11.86 pg/ml and Extra-pulmonary Tb was 25.40±12.96 pg/ml. The unpaired t-test was statistically significant with p value of 0.005.Conclusions: This study has emphasized on the presence of nutritional deficiency in TB patients and necessity to correct them to achieve a better cure rate.

scholarly journals Impact of vitamin D status and cathelicidin antimicrobial peptide on adults with active pulmonary TB globally: A systematic review and meta-analysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252762
Author(s):  
Ester Lilian Acen ◽  
Irene Andia Biraro ◽  
William Worodria ◽  
Moses L. Joloba ◽  
Bill Nkeeto ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Pulmonary Tuberculosis ◽  
Meta Analysis ◽  
Vitamin D Status ◽  
Tuberculosis Patients ◽  
Pulmonary Tb ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Tuberculosis Disease

Background Tuberculosis remains a global threat and a public health problem that has eluded attempts to eradicate it. Low vitamin D levels have been identified as a risk factor for tuberculosis infection and disease. The human cathelicidin LL-37 has both antimicrobial and immunomodulatory properties and is dependent on vitamin D status. This systematic review attempts to compare vitamin D andLL-37 levels among adult pulmonary tuberculosis patients to non-pulmonary TB individuals between 16–75 years globally and to determine the association between vitamin D and cathelicidin and any contributing factor among the two study groups. Methods/Design We performed a search, through PubMed, HINARI, Google Scholar, EBSCOhost, and databases. A narrative synthesis through evaluation of vitamin D and LL-37 levels, the association of vitamin D and LL-37, and other variables in individual primary studies were performed. A random-effect model was performed and weighted means were pooled at a 95% confidence interval. This protocol is registered under the International Prospective Register of Systematic Reviews (PROSPERO), registration number CRD42019127232. Results Of the 2507 articles selected12 studies were eligible for the systematic review and of these only nine were included in the meta-analysis for vitamin D levels and six for LL-37 levels. Eight studies were performed in Asia, three in Europe, and only one study in Africa. The mean age of the participants was 37.3±9.9 yrs. We found low vitamin D and high cathelicidin levels among the tuberculosis patients compared to non-tuberculosis individuals to non-tuberculosis. A significant difference was observed in both vitamin D and LL-37 levels among tuberculosis patients and non-tuberculosis individuals (p = < 0.001). Conclusion This study demonstrated that active pulmonary tuberculosis disease is associated with hypovitaminosis D and elevated circulatory cathelicidin levels with low local LL-37 expression. This confirms that vitamin D status has a protective role against tuberculosis disease.

To screen or not to screen? Vitamin D deficiency in chronic mental illness

2017 ◽  
Vol 26 (1) ◽  
pp. 56-59
Author(s):  
Ivana Goluza ◽  
Jay Borchard ◽  
Nalin Wijesinghe ◽  
Kishan Wijesinghe ◽  
Nagesh Pai
Keyword(s):  
Vitamin D ◽  
Length Of Stay ◽  
P Value ◽  
Hydroxyvitamin D ◽  
Psychiatric Setting ◽  
Retrospective Audit ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
25 Hydroxyvitamin D ◽  
The Mean

Objectives: The objective of the current study was to examine the pathology test utilisation of 25-hydroxyvitamin D (25(OH)D) within an Australian inpatient psychiatric setting. Method: A retrospective audit of 300 random hospital files of those admitted as inpatients between Nov 2014 and Nov 2015 was undertaken. Data was quantitatively analysed and described. Results: The number of inpatients who had a vitamin D determination during their admission was 37/300 (12.33%). The mean vitamin D level of those tested was 51.63 nmol/l. Of those that were tested, 18/37 (48.6%) were mildly to moderately deficient. There was a statistically significant difference in age and length of stay between those that were and were not tested for vitamin D levels, p-value <0.001 and 0.017, respectively. In addition, a simple linear regression indicated a weak association between length of stay and vitamin D levels. Conclusion: This audit highlights vitamin D screening inadequacy. More research is recommended to establish tangible benefits of supplementation, while local practice provides valuable data for education and policy purposes.

scholarly journals STUDY OF VITAMIN D LEVELS IN PULMONARY TUBERCULOSIS PATIENTS AT A TERTIARY CARE HOSPITAL

2017 ◽  
Vol 6 (44) ◽  
pp. 3424-3426
Author(s):  
Rohit Vasant Deshpande ◽  
Bharat Sing Rathod ◽  
Parag Nemant Rahtekar ◽  
Amol Dandurang Bhore ◽  
Swati Harish Sharma ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pulmonary Tuberculosis ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Tuberculosis Patients ◽  
Vitamin D Levels

scholarly journals Analysis of Serum 25– (OH) D Levels status in Subjects Suffering from Pulmonary Tuberculosis: A Teaching Hospital Based study in Western Uttar Pradesh Region

2020 ◽  
Vol 9 (1) ◽  
pp. PM01-PM04
Author(s):  
Shailendra Kumar Jain
Keyword(s):  
Vitamin D ◽  
Pulmonary Tuberculosis ◽  
Uttar Pradesh ◽  
Case Control ◽  
The Other ◽  
Healthy Controls ◽  
Female Ratio ◽  
Tuberculosis Patients ◽  
Male Female Ratio ◽  
The Mean

Background: This report analyses the outcomes of a case control investigation shelled in an eventual legion learning of domestic contamination (HHCs) of TB patients. Further, these data was pooled with other available probable learning of status of vitamin D and TB hazard to demeanor asingle-participant data (IPD). Subjects and Methods: In the study recently diagnosed pulmonary tuberculosis patients were involved with a total number of 28 with a male female ration of 18 : 10 and on the other side  28 healthy controls were selected with a male female ratio of 16:12 according to inclusion and elimination criterion through non-probability purposive sampling.Results: The mean age of cases with tuberculosis was 38.8±7.5years whereas the represent age of controls was 36±5.04 years. Remarkable differences were observed between the patients with tuberculosis and controls. The differences were very significant in RBC counts, Hemoglobin,and Platelet counts. Squat standard hemoglobin values were found in the majority of study subjects in common and specifically in patients with pulmonary tuberculosis.Conclusion: It has been found in the study that squat serum 25– (OH) D levels were related through amplified threat of future succession to TB disease in a dose-depending method.

scholarly journals DIFFERENCES OF INTERLEUKIN-18 AND INTERLEUKIN-10 LEVELS IN RIFAMPICIN RESISTANT AND RIFAMPICIN SENSITIVE PULMONARY TUBERCULOSIS PATIENTS IN DR. SOETOMO HOSPITAL SURABAYA

2020 ◽  
Vol 8 (2) ◽  
pp. 116
Author(s):  
Audrey Gracelia Riwu ◽  
Jusak Nugaraha ◽  
Yoes Prijatna Dachlan
Keyword(s):  
Pulmonary Tuberculosis ◽  
Inflammatory Cytokine ◽  
Interleukin 10 ◽  
Interleukin 18 ◽  
Research Subjects ◽  
Short Term Treatment ◽  
Tuberculosis Patients ◽  
Pulmonary Tb ◽  
Significant Difference ◽  
The Mean

Rifampicin is an anti-tuberculosis drug which has an efficient antimicrobial effect and the basis of a short-term treatment regimen for tuberculosis (TB) patients. Rifampicin plays an important role against the growth and slow metabolism of Bacilli M. tuberculosis. Resistance to rifampicin causes the duration of tuberculosis treatment to be longer. Interleukin-18 (IL-18) is a pro-inflammatory cytokine which plays a role in controlling the growth of M. tuberculosis through its ability to induce IFN-γ, while Interleukin-10 (IL-10) is an anti-inflammatory cytokine which plays a role in limiting tissue damage due to the inflammatory process and maintain tissue homeostasis. IL-18 and IL-10 has an important role in explaining the different degrees of inflammation in rifampicin resistant (RR) and rifampicin sensitive (RS) pulmonary tuberculosis patients. The purpose of this study is to determine different levels of IL-18 and IL-10 in new TB patients with RR and RS. This study was a retrospective cohort study with a cross-sectional design carried out from August-November 2018 in the TB-DOTS/MDR clinic at Dr. Soetomo Hospital, Surabaya. 50 research subjects were examined and grouped into two groups, namely pulmonary TB with RR (n = 25) and pulmonary TB with RS (n = 25) based on GeneXpert examination and anti-tuberculosis drug therapy ≤ 1 month. IL-18 and IL-10 were measured using the ELISA Method. Differences in IL-18 and IL-10 levels between groups were analyzed using the Mann-Whitney test. The mean level of IL-18 (pg/ml) in RR and RS pulmonary TB patients were 1273.53±749.86 and 787.96 ±589.28 respectively. The mean level of IL-10 (pg/ml) in RR and RS pulmonary TB patients were 125.25±118.32 and 128.81±135.77 repectively. The mean level of IL-18 in RR and RS pulmonary TB patients were found to have a significant difference, while the mean level of IL-10 did not have a significant difference. Keywords: Interleukin-18, Interleukin-10, Tuberculosis, Rifampicin Resistant, Rifampicin Sensitive

scholarly journals Association of Vitamin D Deficiency and Newly Diagnosed Pulmonary Tuberculosis

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Vijay Jaimni ◽  
Barkur Ananthakrishna Shasty ◽  
Sharath P. Madhyastha ◽  
Ganesh V. Shetty ◽  
Raviraja V. Acharya ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pulmonary Tuberculosis ◽  
Vitamin D Deficiency ◽  
Immune Defense ◽  
Sputum Smear ◽  
Care Hospital ◽  
Healthy Controls ◽  
Newly Diagnosed ◽  
Tuberculosis Patients ◽  
Vitamin D Levels

Introduction. Vitamin D has a significant role in host immune defense against Mycobacterium tuberculosis. It has been suggested that pulmonary tuberculosis may be associated with lower levels of vitamin D. Present study was therefore undertaken to identify the association between vitamin D deficiency and pulmonary tuberculosis. Methods. A case-control study was conducted in a tertiary care hospital from 2014 to 2016, including 50 adult newly diagnosed sputum positive pulmonary tuberculosis patients as cases and 50 age and sex-matched healthy participants as control groups. All participants in the study group had undergone detailed clinical examination and routine laboratory investigations, including vitamin D, calcium, and sputum for AFB. The clinical characteristics, X-ray findings, sputum AFB, and vitamin D levels were analyzed and compared with data obtained from healthy controls. Results. In both groups, the majority were men (88%). BMI was significantly (<0.0001 ∗ ) lower in the tuberculosis group (19.40 (17.20, 22.0) vs. 24.00 (22.50, 25.47)). Serum vitamin D levels were significantly lower ( P = 0.012 ) in the tuberculosis group (19 (7.75, 27.25) ng/dl) as compared to the control group (25 (19.75, 32.00) ng/dl). Out of 50 TB patients, 27 (54%) had vitamin D deficiency, while among healthy controls, only 13 (26%) had vitamin D deficiency. Among vitamin D deficient PTB patients, 44% had 3+/hpf AFB in sputum smear examination. Conclusion. The prevalence of vitamin D deficiency in pulmonary tuberculosis cases is very high. Hypovitaminosis D was associated with more severe clinical symptoms, higher sputum smear positivity, and extensive lesions in chest radiograph among pulmonary tuberculosis patients.

scholarly journals A study of vitamin D supplementation with directly observed treatment short course for Pulmonary Tuberculosis

2017 ◽  
Vol 6 (6) ◽  
pp. 1377
Author(s):  
Gurpreet Kaur Randhawa ◽  
Suneet Jindal ◽  
Jaswant Rai ◽  
Nirmal Chand Kajal
Keyword(s):  
Vitamin D ◽  
Pulmonary Tuberculosis ◽  
Vitamin D3 ◽  
Vitamin D Supplementation ◽  
Newly Diagnosed ◽  
Tuberculosis Patients ◽  
Short Course ◽  
Vitamin D Levels ◽  
Directly Observed Treatment ◽  
Group A

Background: Tuberculosis remains one of major global health problems due to growing resistance in TB bacilli against anti-tubercular treatment (ATT). Vitamin D3 has been reported to have immunostimulatory effect. Aim was to study effect of Vitamin D3 on efficacy and safety of ATT / Directly Observed Treatment, short course regimen.Methods: Prospective, randomized and interventional study of 90 days was carried out in 60 newly diagnosed sputum positive pulmonary tuberculosis patients on DOTS strategy. Study was conducted in Government Medical College, Amritsar, Punjab, India. 30 patients each were randomly divided into two groups, A and B, with group A - vitamin D3 and DOTS regimen and Group B - DOTS alone. Patients were evaluated on day 0, 30, 60 and 90 by TB score, sputum microscopy, laboratory investigations, and adverse drug events. At the end of 90 days, results were tabulated and data analyzed statistically applying relevant tests.Results: Statistically non-significant improvement in symptoms, sputum conversion and decrease in mean TB scores was seen in Group A vs B at 90 days. Significant increase in mean Vitamin D levels was seen in Group A at end of study. Insignificant difference in safety profile was observed in group A which showed additional adverse events suspected to be due to Vitamin D. Equivocal hepatoprotective effect of Vitamin D was observed.Conclusions: Vitamin D as adjuvant to ATT does not confer additional benefit to newly diagnosed pulmonary tuberculosis patients. Large multi-centric trials are required to find any benefit of Vitamin D supplementation with ATT.

scholarly journals FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KUALITAS HIDUP PASIEN TB PARU DI RUMAH SAKIT KHUSUS PARU LUBUK ALUNG SUMATERA BARAT

2018 ◽  
Vol 2 (1) ◽  
pp. 29-38
Author(s):  
Melti Suriya
Keyword(s):  
Quality Of Life ◽  
Pulmonary Tuberculosis ◽  
Family Support ◽  
P Value ◽  
Tuberculosis Patients ◽  
Pulmonary Tb ◽  
West Sumatra ◽  
Special Hospital ◽  
Relationship Of

Quality of life is a person's perception and expectations of living standards, poor quality of life is often experienced by chronic diseases, especially pulmonary TB. Special Hospital Pulmonary Hospital West Sumatra is the number of visits pulmonary tuberculosis patients most in 2016 is 1016 people. The aim of research to determine the factors associated with pulmonary TB Patient Quality of Life in Lung Special Hospital West Sumatra Lubuk Alung. This type of research is analytic with cross sectional design. The population in this study were all pulmonary TB patients who seek treatment at Special Hospital Pulmonary West Sumatra. Data research collection was performed on 21 June to 21 July 2017 data was collected using a questionnaire. The sampling technique is simple random block sampling with a sample of 96 peolpe. Data was analyzed by univariate and bivariate with Chi-Square test. The study found that more than half (63.5%) continued treatment, more than half (66.7%) did not receive the support of the family, more than half (57.3%) experienced depression, more than half (62.5% ) quality of life of poor TB patients. There is a long-standing relationship with the treatment of pulmonary tuberculosis patients' life quality p value of 0.000 (p <0.05). There is a relationship of family support and quality of life of patients with pulmonary TB p value of 0.000 (p <0.05). There is a relationship of depression with quality of life of patients with pulmonary tuberculosis in the lungs Special Hospital West Sumatra Lubuk Alung  p value (p <0.05). Duration of treatment, family support and depression affect the quality of life of patients with TB. To improve the quality of life of TB patients need the support of family, treatment according to the rules and avoid depression in patients with TB so that TB patients will receive optimal health both physically and psychologically. It is expected that further research can continue this research with other factors that affect the quality of life of patients with TB.

scholarly journals A study of extra-pulmonary tuberculosis and its outcome

2017 ◽  
Vol 4 (1) ◽  
pp. 209 ◽  
Author(s):  
Ravikumar P. ◽  
Priyadarshini Bai G.
Keyword(s):  
Alcohol Abuse ◽  
Pulmonary Tuberculosis ◽  
Common Site ◽  
Extra Pulmonary Tuberculosis ◽  
Tuberculosis Patients ◽  
Pulmonary Tb ◽  
Medical College ◽  
Extra Pulmonary ◽  
One Year ◽  
Tuberculosis Disease

Background: Pulmonary tuberculosis being the predominant manifestation of the disease extra-pulmonary sites can also involve as a result of dissemination from a chief focus. Extra- pulmonary tuberculosis is more common in HIV cases. The present study aims to determine the presentation and outcome of patients with extra-pulmonary tuberculosis treated with DOTS and to assess any difference in outcome of treatment in HIV positive extra-pulmonary tuberculosis.Methods: Data was collected from cases of tuberculosis patients diagnosed and treated under DOTS at Sri Siddhartha Medical College for the period of one year (during 2015). We evaluated extra-pulmonary cases and recorded sites of involvement in order of frequency. We also studied treatment outcome by recording as per definitions given by the WHO and also evaluated any difference in outcome of extra-pulmonary tuberculosis disease with HIV co-infection.Results: Extra-pulmonary cases accounted for 30.5% of total TB cases. Among 224 cases of extra-pulmonary TB studied, 136 (60.7%) were males and 88 (39.3%) were females. Most common site of extra-pulmonary tuberculosis was pleura (29.9%) followed by meninges (22.5%), abdomen (19.6%) and lymph node (10.7%) tuberculosis. Among these patients 82.2% completed treatment, 7.5% were defaulted, 9.9% died and 0.4% treatment failure. The most common reason for default was irregular treatment (29.5%) followed by alcohol abuse (23.5%). Among 8 HIV reactive patients, 5 patients completed treatment and the remaining 3 patients died during the course of treatment.Conclusions: Extra-pulmonary Tuberculosis accounts for 30.5% of the total cases studied. Pleura is most common site of extra-pulmonary TB in our study. Treatment irregularities and alcohol abuse are the two most common reasons for default.   Co-infection with HIV seems to have a poor outcome on patients with extra-pulmonary TB and needs to be studied in large number of samples.

Sign in / Sign up

Export Citation Format

Share Document