scholarly journals Clinical study of non epidermoid malignancies of the paranasal sinuses

2019 ◽  
Vol 5 (2) ◽  
pp. 421
Author(s):  
Y. Prabhakar Rao ◽  
Punga Amreeta Kaur
Keyword(s):  
Ct Scan ◽  
Paranasal Sinuses ◽  
Nasal Endoscopy ◽  
Purulent Discharge ◽  
Age Group ◽  
Soft Tissue Density ◽  
Female Ratio ◽  
Non Hodgkins Lymphoma ◽  
Male To Female

<p class="abstract"><strong>Background:</strong> Malignancy of paranasal sinuses post challenging issues not only for surgeons but also for radiologists. Patients also try to avoid and neglect the condition. Hence clinical studies are more pertinent on this issue. Objective was to study clinical picture of non epidermoid malignancies of the paranasal sinuses.</p><p class="abstract"><strong>Methods:</strong> This was a retrospective hospital based study of 30 patients with non epidermoid malignancies of the paranasal sinuses from two hospitals over a period of more than four years. Clinical characteristics were studied. CT scan, diagnostic nasal endoscopy, histopathology was done for all patients. Data was analyzed using proportions.  </p><p class="abstract"><strong>Results:</strong> Majority affected were males. The male to female ratio was 2:1. Maximum cases were found in the age group of 51-60 years and all of them were males. Left side was most commonly affected. The most common presenting feature was nasal obstruction in 50% of the cases. Nasal endoscopy findings has shown that there were five cases each of pinkish red polypoid mass, pinkish grey fleshy mass, pinkish red proliferative mass, pink fleshy mass, purulent discharge and fleshy pinkish red mass. Heterogeneous soft tissue density was the most common CT scan finding. Non Hodgkins lymphoma was more common. Half of the cases were managed by maxillectomy and half of the cases were managed by radiotherapy. There was no recurrence of the tumor after 6-9 months of follow up.</p><p class="abstract"><strong>Conclusions:</strong> Males are more commonly affected than females. Appropriate management of cases prevents recurrence of the tumors.</p>

scholarly journals Follow-up of the air pollution and the human male-to-female ratio analysis in São Paulo, Brazil: a times series study

BMJ Open ◽  
2013 ◽  
Vol 3 (7) ◽  
pp. e002552 ◽  
Author(s):  
Simone Georges El Khouri Miraglia ◽  
Mariana Matera Veras ◽  
Luis Fernando Amato-Lourenço ◽  
Fernando Rodrigues-Silva ◽  
Paulo Hilário Nascimento Saldiva
Keyword(s):  
Air Pollution ◽  
Sao Paulo ◽  
Ratio Analysis ◽  
São Paulo ◽  
Female Ratio ◽  
Times Series ◽  
Human Male ◽  
Male To Female ◽  
Series Study

scholarly journals Role of Multi Detector Computed Tomography Cervicocerebral Angiography in Evaluation of Patients with Stroke

2020 ◽  
Vol 8 (1) ◽  
pp. 93-99
Author(s):  
Balaji Varaprasad Mallula ◽  
Jithender Reddy Chintala ◽  
Srinadh Boppanna ◽  
S. Annapurna
Keyword(s):  
Prospective Observational Study ◽  
Hemorrhagic Stroke ◽  
Accurate Diagnosis ◽  
Age Group ◽  
Common Risk Factor ◽  
Female Ratio ◽  
The World ◽  
Male To Female ◽  
Multi Detector Computed Tomography

Background: Stroke is the second single most common cause of death in the world causing approximately 6.7 million deaths each year. It has a greater disability impact on an individual than any other chronic disease. The aim of the study is to review the value of CTA in detection and evaluation of non-traumatic cervicocerebral vascular disease (stroke). Subjects & Methods: A prospective observational study conducted in the Department of Radiodiagnosis, Kamineni Hospitals, L.B. Nagar, Hyderabad over 60 patients during April 2016 to May 2017. Results: Out of 60 patients, 35(58.3%) patients had ischemic stroke, 25(41.6%) had hemorrhagic stroke. Overall stroke was seen mostly in the age group of 61-70 (28.3%) years, with a Male to female ratio of 3:2. Conclusion: Hypertension was the most common risk factor associated with this disease, followed by diabetes. CTA helps in accurate diagnosis, risk stratification and planning management protocols.

scholarly journals Ascitic Fluid Cytology Seen in a Tertiary Hospital in Nigeria

2020 ◽  
pp. 345-350
Author(s):  
CC Nwafor ◽  
K Obioha ◽  
TO Akhiwu
Keyword(s):  
Sex Ratio ◽  
Patient Care ◽  
Ascitic Fluid ◽  
Age Groups ◽  
Tertiary Hospital ◽  
Age Group ◽  
Malignant Cells ◽  
Female Ratio ◽  
Male To Female ◽  
Fluid Cytology

Ascites is a symptom that can originate due to diverse pathologies. A lot of investigations including ascitic fluid cytology (AFC) can be done on it to help determine its origin. The aim of this study, is to document the findings and highlight the importance of AFC in patient care in Uyo. All AFC reports and slides in the Department of Histopathology, University of Uyo were retrieved, reviewed and used for this study. The age ranged from 1.5 – 80 years with mean age, 41.79 (±17.23) years. About 71.8% of the ascitic fluid (AF) specimens were from patients between the 3rd and 6th decade. Females predominated in all age groups expect 10-19 year's group, with a male to female sex ratio of 1:2.4. Malignant cells were seen in 28.7% of all the samples, while 51.2% were negative for malignant cells. Malignant cells were seen in 4 (6.7%), 11 (18.3%) and 6 (10%) of the AFC performed due to various liver pathologies, ovarian malignancies and intra-abdominal malignancies respectively. Malignant cells were found more in females with a male to female ratio of 1: 3.6. Age group 40-49 years accounted for most of the malignant cases (26.6%). The pattern of AFC in Uyo is similar to the pattern in other parts of Nigeria

scholarly journals Effectiveness of Liraglutide in Type II Diabetes Mellitus Management: Experience in Emirati Patients

2015 ◽  
Vol 8 ◽  
pp. CMED.S31756 ◽  
Author(s):  
Nasrullah K. Ghuman ◽  
Loai M. Saadah ◽  
Majdi S. Al Najjar ◽  
Duha Y. Shaheen ◽  
Shady I. AM ◽  
...  
Keyword(s):  
Standard Form ◽  
Type Ii Diabetes Mellitus ◽  
Military Hospital ◽  
Patient Visit ◽  
Female Ratio ◽  
P Values ◽  
Patients Âgés ◽  
Male To Female ◽  
Univariate Analyses

Objective To measure effectiveness of liraglutide in reducing glycated hemoglobin (HbA1C), weight, and systolic blood pressure (SBP) in Emirati patients. Design A retrospective cohort study. Setting Endocrinology clinic in a 300-bed military hospital. Patients A total of 152 patients who qualified for liraglutide between September 21, 2012, (first patient visit) and May 5, 2014 (last patient visit). Methods Team collected demographic and clinical data using a standard form. Data keeper performed univariate analyses to measure the effect of liraglutide in reducing the three outcomes of interest; namely, HbA1C, weight, and SBP. Results One hundred patients had at least the first visit in the clinic and 98 patients came for a second follow-up visit while on the medication. Adherence of clinicians to the internal criteria for prescribing liraglutide was 92%. Patients' ages were 47.9 ± 11.7 years. Male-to-female ratio was almost 1:1. Overall, in the paired analyses, HbA1C decreased from first to second visits (8.7 ± 1.9 vs. 7.6 ± 1.8, P < 0.0001) and remained unchanged in subsequent visits (eg, in visit 3, HbA1C was 7.4 ± 1.8). Patients lost an average of 1.3 kg between the first and second visits (99.3 ± 19.3 vs. 98.0 ± 19.5, P = 0.0003). The reduction in SBP between visits 1 and 2 was less (130.9 ± 15.8 vs. 129.9 ± 16.5, P = 0.5896). ANOVA yielded a significant reduction in HbA1C at 4 months and 6 months ( P values < 0.05). SBP dropped by about 3.6 mmHg and weight by about 2.3 kg ( P values > 0.05). Conclusions Liraglutide is effective in reducing HbA1C, weight, and to a lesser extent, SBP in Emirati patients.

scholarly journals Outcome of Probing for Congenital Naso-Lacrimal Duct Obstruction

2015 ◽  
Vol 14 (1) ◽  
pp. 36-37
Author(s):  
Mozammel Hoq Sharife ◽  
M Jalal Uddin ◽  
Mostak Ahmed
Keyword(s):  
Nasolacrimal Duct ◽  
Age Group ◽  
Lacrimal Duct ◽  
Female Ratio ◽  
Congenital Nasolacrimal Duct Obstruction ◽  
Duct Obstruction ◽  
Male Female Ratio ◽  
Group A ◽  
Level Hospital

Objective: The study was conducted to evaluate outcome of probing for congenital nasolacrimal duct obstruction. It was an interventional study at a tertiary level hospital of Chittagong. Methods: The study was conducted during April 2009 to March 2013 (04 years). Total 120 eyes of 102 children of 1-3 years age group were probed. Minimum follow up time was 01 year. Results: 110 eyes fully cured, 05 eyes needed re-probing, 03 eyes needed Dacrocystorhinostomy operation (DCR) and 02 cases were dropped out. Male female ratio was 72 (60%) and 48 (40%). Conclusion: Outcome of probing is better among 1-2 years age group than that of 2- 3 years age group. A discussion is made with updated literature review. DOI: http://dx.doi.org/10.3329/cmoshmcj.v14i1.22879 Chatt Maa Shi Hosp Med Coll J; Vol.14 (1); Jan 2015; Page 36-37

Primary non-Hodgkin's lymphoma of the nose and nasopharynx: clinical features, tumor immunophenotype, and treatment outcome in 113 patients.

1998 ◽  
Vol 16 (1) ◽  
pp. 70-77 ◽  
Author(s):  
M M Cheung ◽  
J K Chan ◽  
W H Lau ◽  
W Foo ◽  
P T Chan ◽  
...  
Keyword(s):  
Clinical Features ◽  
Survival Rates ◽  
Chinese Patients ◽  
Female Ratio ◽  
Cd56 Expression ◽  
T Lymphomas ◽  
Hodgkin's Lymphomas ◽  
Male To Female ◽  
Disease Free

PURPOSE To study the clinical features and outcome for primary non-Hodgkin's lymphomas of the nose/nasopharynx (NNP-NHLs) according to immunophenotype. PATIENTS AND METHODS One hundred thirteen Chinese patients with primary NNP-NHLs that belonged to the categories E, F, G, or H according to the Working Formulation (WF), with full immunophenotypic data and complete clinical follow-up data, were analyzed in this retrospective study. RESULTS Ninety (79.6%) patients had localized (stage I or II) disease, while 23 (20.4%) had stage III or IV disease. The lymphomas in 51 (45.1%), 24 (21.3%), and 38 (33.6%) patients showed natural killer (NK)/T- (CD56-positive), T-cell, and B-cell immunophenotype, respectively. Seventy-three patients (65.8%) achieved a complete remission, of whom 34 (46.6%) subsequently relapsed. The median follow-up time for those alive was 88 months. The 5-year actuarial disease-free and overall survival rates were 34.4% and 37.9%, respectively. Multivariate analysis showed that only stage and immunophenotype were significant for survival. NK/T lymphomas were distinctive among the three immunophenotypes in the following aspects: the highest male-to-female ratio, more frequent involvement of the nasal cavity alone, higher risk of dissemination to the skin, more frequent development of hemophagocytic syndrome, and the worst prognosis (overall median survival, 12.5 months). CONCLUSION The three immunophenotypes studied are shown to exhibit different clinical patterns. Since the NK/T phenotype carries the worst prognosis, patients who present with NNP-NHL should have their tumors analyzed for CD56 expression.

Incidence of Guillain–Barre's Syndrome in Children under 15 Years of Age in Oman

2018 ◽  
Vol 17 (06) ◽  
pp. 206-209
Author(s):  
Roshan Koul ◽  
Amna Al-Fuitaisi ◽  
Nabil Macki ◽  
Prakash Kurubarahalli Patel ◽  
Haleema Al-Balushi ◽  
...  
Keyword(s):  
Adult Population ◽  
Intravenous Immunoglobulins ◽  
Population Based ◽  
Age Group ◽  
Microsoft Excel ◽  
Female Ratio ◽  
Immune Mediated ◽  
Gulf Country ◽  
Male To Female ◽  
Excel Format

Objective Guillain–Barre's syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy seen in all ages but mostly in the adult population. We aim to report the incidence of GBS in children under 15 years of age in Oman, a Gulf country. Materials and Methods All children with GBS under 15 years of age were included in the study from January 2002 to December 2016. The data were compiled in Microsoft Excel format and analysis was performed using SPSS, version 17.0. Population-based age- and sex-specific rates of GBS were calculated using the estimated population for each 5-year period based on 2004, 2009, and 2014 mid-year population, respectively. Relative risk and 95% confidence intervals of GBS at different age categories were calculated using the overall incidence of GBS in those under 15 years as reference. Results The average annual incidence in those under 15 years was 3.1/100,000. Age-specific incidence was 4.0/100,000 in the age group 0 to 9 years and 4.7/100,000 in age group 0 to 4 years. Sixty percent had evidence of preceding infections, and the male to female ratio was 1.8:1. Fifty percent had cranial nerve involvement and 18% needed mechanical ventilation. Five percent had residual weakness. Intravenous immunoglobulins (IVIGs) were used in all, and 3.3% required plasmapheresis when they did not improve with IVIG. Clinical profile of the GBS was not different from the rest reported in the literature. Conclusion The incidence of GBS in Oman was 3.1/100,000 (range: 2.7–3.5 cases/100,000) in children under 15 years of age. The GBS is a smaller proportion among the total acute flaccid paralysis cases.

High Incidence of False Positive PET Scans in Patients with Aggressive Non-Hodgkins Lymphoma Treated with Rituximab-Containing Regimens.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 2401-2401
Author(s):  
Hyo S. Han ◽  
Maricer P. Escalon ◽  
Aldo Serafini ◽  
Izidore S. Lossos
Keyword(s):  
Ct Scan ◽  
Predictive Value ◽  
Cell Lymphoma ◽  
The Other ◽  
Non Hodgkins Lymphoma ◽  
Residual Masses ◽  
Therapy Completion ◽  
Pet Scans ◽  
Post Therapy

Abstract Introduction: 18F-Fluorodeoxyglucose positron emission tomography (PET) is increasingly used for initial staging and response assessment in patients with Non-Hodgkins lymphoma (NHL) and is a powerful predictor of relapse and survival in this setting. All reported PET studies, however, were performed in the pre-rituximab era. Little is known about the predictive abilities of PET in rituximab-treated patients. Patients and Methods: Patients with aggressive NHL treated at the University of Miami between September 2002 and January 2006 that had baseline and follow-up PET studies were included in the study. Clinical characteristics at presentation, PET and CT scan results, and outcomes were reviewed. PET studies were defined as positive if greater than physiological activity was observed. Results: A total of 33 patients with the following histologies were included: diffuse large B cell lymphoma (23 patients), Mantle-cell lymphoma (5), Peripheral T-cell lymphoma (3) and NK/T cell lymphoma (2). The median age was 54 years (range 21–92) and 19 were male (58%). Six patients had an IPI of 0, 13 an IPI of 1, 10 an IPI of 2, 3 an IPI of 3, and 1 an IPI of 4. All patients with CD 20+ lymphomas were treated with rituximab containing regimens. Median follow up was 18 months (range 6–47). All patients had positive PET scans at diagnosis. Nine of 25 (36%) mid-therapy PET studies were positive. Four of these patients exhibited persistent PET positivity, of which 2 eventually died of progressive disease. In the other 2 patients, disease recurrence was biopsy-proven in one patient, while the other received further chemotherapy and is presently alive and in CR. Upon therapy completion, the remaining 5 converted to negative studies and 4 of these patients are in continuous complete remission (CR) for 8 to 19 months. The fifth patient relapsed 6 month after treatment. The relapse positive predictive value (PPV), negative predictive value (NPV), sensitivity (Se) and specificity (Sp) of the mid-therapy PET were 55.5% (95% CI 23–85%), 81.2% (95% CI 53–95%), 62.5% (95% CI 26–90%), and 76.4% (95% CI 50–92%), respectively. Upon therapy completion, 5 patients with residual masses on CT scans had positive PET scans, including 2 patients with positive mid-therapy PET scans. Biopsy was performed in 1 and did not demonstrate lymphoma, 1 was followed-up for 10 months without evidence of disease and 3 demonstrated disease progression and were salvaged with additional therapy. Seven patients with a negative post-therapy PET demonstrated residual masses by CT scan criteria. Two of these patients relapsed while the remaining 5 are in CR for 8 to 19 months. In two of these patients in CR, PET scans performed 3 to 6 months after therapy completion became positive. However, biopsy revealed inflammatory changes with no evidence of lymphoma. Collectively, for the post-therapy PET: PPV, NPV, Se, Sp were 71.4% (95% CI 30–95%), 79.2% (95% CI 57–92%), 50% (95% CI 20–80%), and 90.4% (95% CI 68–98%), respectively. Conclusions: Our study demonstrated an acceptable NPV and Sp but low PPV and Se for mid- and post- therapy PET in patients with aggressive NHL treated with rituximab. Furthermore, negative mid-therapy PET did not assure continuous response to therapy. Our findings also emphasize the importance of confirmatory biopsies in patients with post-therapy positive PET scans prior to initiation of second line therapy.

Histopathological Profile of Non-Haematological Paediatric Neoplasms in Hadoti Region of Rajasthan

2020 ◽  
Vol 7 (43) ◽  
pp. 2453-2457
Author(s):  
Praveen Kumar Bairwa ◽  
Neelu Vashist ◽  
Deepti Sukheeja
Keyword(s):  
Epidemiological Data ◽  
Developed Countries ◽  
Bone Tumours ◽  
Age Group ◽  
Malignant Tumours ◽  
Female Ratio ◽  
Paediatric Tumours ◽  
Haematological Neoplasms ◽  
Benign Tumours ◽  
Male To Female

BACKGROUND Malignancy is a major cause of childhood death in developed countries. In developing countries like India, paediatric tumours are rising day by day. Proper management of paediatric tumours needs epidemiological data in various geographical areas. The present study was carried out to classify and find out the histopathological profile of solid tumours of childhood and infancy in 0 - 14 years age group from 1st January 2015 to 31st December 2017. METHODS We studied histopathology reports of 173 paediatric tumours over a period of 3 years. All the biopsy cases of solid neoplasms in the age group 0 - 14 years were included. RESULTS In our study of 173 paediatric tumours, 133 (76.87 %) were benign and 40 (23.12 %) were malignant. Maximum incidence of malignant paediatric tumours was seen in the age group of 0 - 14 years [12.13 % (21 out of 173)], with male to female ratio of (1:1.3). Amongst the benign tumours, vascular tumours were most common [27.74 % (48 of 173 cases)], with highest incidence of haemangioma [68.75 % (33 of 48 cases)]. Amongst the malignant tumours, most common were bone tumours [6.35 % (11 of 173 cases)] and amongst bone tumours, Ewing’s sarcoma accounted for 63.63 % cases (7 of 11 cases). CONCLUSIONS The incidence of paediatric neoplasms in Hadoti region of Rajasthan is 0.75 % and the majority (54.33 %) of neoplasms occurred in 10 - 14 yrs. age group. KEYWORDS Histopathology, Paediatric, Non-Haematological Neoplasms

Is pharyngeal pouch stapling superior to open pharyngeal pouch repair? An analysis of a single institution's series

2016 ◽  
Vol 130 (9) ◽  
pp. 873-877 ◽  
Author(s):  
E Agalato ◽  
J Jose ◽  
R J England
Keyword(s):  
Surgical Procedures ◽  
Symptom Control ◽  
Open Approach ◽  
Pharyngeal Pouch ◽  
Female Ratio ◽  
Open Procedure ◽  
Long Term Follow Up ◽  
Male To Female

AbstractBackground:Endoscopic stapling has become the primary procedure for pharyngeal pouch surgery because it is quick, less invasive and safe, but less is known about long-term outcomes.Method:Medical records were reviewed to compare rates of morbidity, operative failure, symptom control and revision surgery between open and closed procedures.Results:A total of 120 pharyngeal pouch procedures, carried out on 97 patients from 2000 to 2014, were studied. These included 80 endoscopic stapling and 40 open procedures. Twelve patients had complications (15 per cent) and there was one mortality (1.2 per cent) in the endoscopic stapling group. Ten patients (25 per cent) developed complications in the open procedure group, with no mortalities. Symptom recurrence was significantly greater in the endoscopic stapling group (26 per cent) than in the open procedure group (7.5 per cent). Multiple surgical procedures were required for 22 endoscopically stapled patients (32 per cent); none were required in the open procedure group. Although the male-to-female ratio for pharyngeal pouch incidence was 2:1, the ratio for multiple surgical procedures was 10:1.Conclusion:Endoscopic stapling outcomes are not as good as those following an open approach on long-term follow up, and the early advantages are eliminated if pouch excision is avoided.

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