scholarly journals Nutritional dermatoses and its association with anemia and systemic illness

2018 ◽  
Vol 4 (3) ◽  
pp. 306
Author(s):  
Som J. Lakhani ◽  
Nishit K. Surti ◽  
Mrugal V. Doshi ◽  
Sanket R. Panchasera ◽  
Vivek N. Vasvani ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Nutrient Deficiency ◽  
General Medicine ◽  
Clinical History ◽  
Nutritional Deficiencies ◽  
Deficiency Anemia ◽  
Elderly Age ◽  
Systemic Involvement ◽  
History Of ◽  
Morbid Conditions

<p class="abstract"><strong>Background:</strong> Mucocutaneous changes may be a “tell-tale” signs of multi nutrional deficiency including anemia. Some are very characteristic of a specific nutrient deficiency, while other signs may overlap and will reflect multiple deficiency states.</p><p class="abstract"><strong>Methods:</strong> To scrutinize clinical signs of multi nutritional deficiencies accompanied with anemia, this observational clinical study of 75 patients (adult and adolescents) was undertaken. Patients were selected from out-patient and in-patient department (OPD and IPD) of dermatology as well as General Medicine ward including medical ICU. Relevant investigations were carried out whenever required. Detail clinical history of diet, tuberculosis as well as HIV disease, worm infestation, other co-morbid conditions and alcohol intake were taken. Clinical signs of nutritional deficiencies like of Pellagra, Kwashiorkor, Beriberi, Ariboflavinosis and other signs of avitaminosis and micronutrient deficiency were looked for in all such patients.<strong></strong></p><p class="abstract"><strong>Results:</strong> Of 75 patients, 37 were male (M) and 38 female (F). One of the important findings was that one third patients were admitted in ICU and in 60 of 75 patients risk factors could be identified. Mental illness, ICU admission, elderly age, systemic illness and alcohol consumption were the predisposing factors. Iron deficiency anemia was the commonest anemia followed by dimorphic anemia with other multinutrional manifestations. Clinical signs which were observed due to multinutritional deficiency were of pellagra dermatosis, kwashiorkor, koilonychia with pale tongue and mucous membranes, angular cheilosis, hair changes of various types and other signs due to systemic involvement.</p><p class="abstract"><strong>Conclusions:</strong> Anemia may be associated with other nutritional abnormality which is reflected in changes in the skin, mucous membrane, hairs and nails. Nutritional dermatosis and anemia can be part of systemic illness which maybe reflected as deficiency of multiple nutritive factors.</p>

scholarly journals Clinicohaematological study of anaemia in antenatal patients

2020 ◽  
Vol 9 (4) ◽  
pp. 1603
Author(s):  
Veena Gupta ◽  
Karishma Sharma ◽  
Amrita Chaurasia
Keyword(s):  
Analytical Study ◽  
Economic Status ◽  
Clinical Signs ◽  
Developed Countries ◽  
Nutritional Deficiencies ◽  
Deficiency Anemia ◽  
Third Trimester ◽  
Maternal Morbidity And Mortality ◽  
Different Types ◽  
Socio Demographic Factors

Background: According to WHO, approximately 75% of pregnant women in developing countries and 18% in developed countries are anaemic. In India prevalence of anaemia is reported to be 33%-89% and is one of the important causes of maternal morbidity and mortality. The present study was done with the objective to study the socio-demographic factors related to anemia and the distribution of different types of anaemia in antenatal patients.Methods: A prospective analytical study was done on 205 pregnant females who presented with anemia (Hb <11 gm/dl) in 1st, 2nd and early 3rd trimester (up to 30 weeks of gestation) in the department of obstetrics and gynecology of Swaroop Rani Nehru Hospital, Prayagraj from September 2017 to September 2018.Results: The rural background with lower socio-economic status comprised majority of the anemic patients (65.9%) with the major cause being iron deficiency anemia (68.8%). The patients mainly presented with anemia at late second or early third trimester (82.4%). Clinical signs like pallor, oedema and symptoms like palpitations and dyspnoea were more associated with severe anemia than mild and moderate anemia.Conclusions: Anemia prevention and prompt detection is the need of the hour with effective management. In India, major cause of anaemia are nutritional deficiencies which can be treated by proper diet and medications. The advises of routine iron supplementation during pregnancy, regardless of whether the mother is anemic or not, is strongly recommended by this study. 

scholarly journals Histopathological findings in horses with and without clinical signs of rhabdomyolysis with special reference to polysaccharide storage myopathy

2008 ◽  
Vol 53 (No. 12) ◽  
pp. 660-667 ◽  
Author(s):  
E. Ludvikova ◽  
I.D. Wijnberg ◽  
P. Fictum ◽  
Z. Lukas ◽  
J.H. van der Kolk ◽  
...  
Keyword(s):  
Special Reference ◽  
Clinical Signs ◽  
Size Variation ◽  
Clinical History ◽  
Histopathological Findings ◽  
Exertional Rhabdomyolysis ◽  
Fibre Size ◽  
Significant Difference ◽  
Polysaccharide Storage Myopathy ◽  
History Of

Objective of the study was to assess histopathological changes in horses with a clinical history of exertional rhabdomyolysis (ER) with special reference to polysaccharide storage myopathy and to compare histopathological findings in horses with and without a clinical history of ER. In total 39 muscle samples were collected, from horses with a history of repeated episodes of exertional rhabdomyolysis (test group, 10 horses) and from horses without clinical signs of muscular disorders in their history (control group, 29 horses). Frozen muscle samples were stained with haematoxylin and eosin and periodic acid-Schiff with and without amylase digestion. Histopathologic changes (amylase resistant polysaccharide, subsarcolemmal glycogen, intracytoplasmic masses, subsarcolemmal vacuoles, fibre size variation and internal nuclei) were evaluated. There was a statistically significant difference between groups in the presence of subsarcolemmal amylase sensitive glycogen deposits (P ≤ 0.0001), the risk ratio was 5.22. Statistically significant differences between groups were not found regarding the presence of intracytoplasmic masses, subsarcolemmal vacuoles, amylase resistant polysaccharide, fibre size variation and internal nuclei. Presence of amylase resistant polysaccharide within muscle fibres of apparently healthy horses could be a manifestation of different phenotype expression of PSSM but also the insufficient specificity of this diagnostic criterion.

Anemia ferropénica crónica: síndrome de Plummer-Vinson (Paterson-Brown-Kelly)

2021 ◽  
Vol 64 (2) ◽  
pp. 22-25
Author(s):  
Adriana Zapata González ◽  
María Elena Uc Miam ◽  
Felipe Irineo Hernández Rosales ◽  
Alberto Mandujano González ◽  
Karime Berenice Ramos Santos
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Clinical History ◽  
Deficiency Anemia ◽  
Precancerous Condition ◽  
Esophageal Web ◽  
Squamous Cell Esophageal Cancer ◽  
Plummer Vinson Syndrome ◽  
History Of ◽  
First Contact

Plummer-Vinson syndrome (Paterson-Brown-Kelly) is a rare entity, characterized by dysphagia, esophageal web formation, and iron deficiency anemia. We present the case of a 46-year-old woman with a clinical history of iron deficiency anemia who subsequently presents dysphagia and odynophagia. A subcricoid web that was successfully broken with the endoscope was found. First contact doctors should be familiar with the symptoms of Plummer-Vinson syndrome, and take them into account, when addressing a patient with the classic triad. Since the syndrome is a precancerous condition with high malignant potential, early diagnosis and treatment is of utmost importance for better prognosis. Keywords: Plummer-Vinson syndrome; chronic iron deficiency anemia; esophageal membrane; squamous cell esophageal cancer; Paterson-Brown-Kelly syndrome.

scholarly journals Upper Extremity Compartment Syndrome in a Patient with Acute Gout Attack but without Trauma or Other Typical Causes

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
John G. Skedros ◽  
James S. Smith ◽  
Marshall K. Henrie ◽  
Ethan D. Finlinson ◽  
Joel D. Trachtenberg
Keyword(s):  
Compartment Syndrome ◽  
Upper Extremity ◽  
General Medicine ◽  
Clinical History ◽  
Acute Gout ◽  
Exertional Compartment Syndrome ◽  
Concurrent Infections ◽  
History Of ◽  
Multiple Symptoms ◽  
Gout Flare

We report the case of a 30-year-old Polynesian male with a severe gout flare of multiple joints and simultaneous acute compartment syndrome (ACS) of his right forearm and hand without trauma or other typical causes. He had a long history of gout flares, but none were known to be associated with compartment syndrome. He also had concurrent infections in his right elbow joint and olecranon bursa. A few days prior to this episode of ACS, high pain and swelling occurred in his right upper extremity after a minimal workout with light weights. A similar episode occurred seven months prior and was attributed to a gout flare. Unlike past flares that resolved with colchicine and/or anti-inflammatory medications, his current upper extremity pain/swelling worsened and became severe. Hand and forearm fasciotomies were performed. Workup included general medicine, rheumatology and infectious disease consultations, myriad blood tests, and imaging studies including Doppler ultrasound and CT angiography. Additional clinical history suggested that he had previously unrecognized recurrent exertional compartment syndrome that led to the episode of ACS reported here. Chronic exertional compartment syndrome (CECS) presents a difficult diagnosis when presented with multiple symptoms concurrently. This case provides an example of one such diagnosis.

scholarly journals Association of Equine Herpesvirus 5 with Mild Respiratory Disease in a Survey of EHV1, -2, -4 and -5 in 407 Australian Horses

Animals ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 3418
Author(s):  
Charles El-Hage ◽  
Zelalem Mekuria ◽  
Kemperly Dynon ◽  
Carol Hartley ◽  
Kristin McBride ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Quantitative Difference ◽  
Clinical Signs ◽  
Clinical Importance ◽  
Clinical History ◽  
Respiratory Pathogens ◽  
Equine Influenza ◽  
Influenza Outbreak ◽  
Clinically Normal ◽  
History Of

Equine herpesviruses (EHVs) are common respiratory pathogens in horses; whilst the alphaherpesviruses are better understood, the clinical importance of the gammaherpesviruses remains undetermined. This study aimed to determine the prevalence of, and any association between, equine respiratory herpesviruses EHV1, -2, -4 and -5 infection in horses with and without clinical signs of respiratory disease. Nasal swabs were collected from 407 horses in Victoria and included clinically normal horses that had been screened for regulatory purposes. Samples were collected from horses during Australia’s equine influenza outbreak in 2007; however, horses in Victoria required testing for proof of freedom from EIV. All horses tested in Victoria were negative for EIV, hence archived swabs were available to screen for other pathogens such as EHVs. Quantitative PCR techniques were used to detect EHVs. Of the 407 horses sampled, 249 (61%) were clinically normal, 120 (29%) presented with clinical signs consistent with mild respiratory disease and 38 (9%) horses had an unknown clinical history. Of the three horses detected shedding EHV1, and the five shedding EHV4, only one was noted to have clinical signs referable to respiratory disease. The proportion of EHV5-infected horses in the diseased group (85/120, 70.8%) was significantly greater than those not showing signs of disease (137/249, 55%). The odds of EHV5-positive horses demonstrating clinical signs of respiratory disease were twice that of EHV5-negative horses (OR 1.98, 95% CI 1.25 to 3.16). No quantitative difference between mean loads of EHV shedding between diseased and non-diseased horses was detected. The clinical significance of respiratory gammaherpesvirus infections in horses remains to be determined; however, this survey adds to the mounting body of evidence associating EHV5 with equine respiratory disease.

scholarly journals Renal toxic disease in a cat

2021 ◽  
Vol 14 (2) ◽  
pp. 142-144
Author(s):  
Alex dos Santos ◽  
◽  
Mariana Martins ◽  
Keyword(s):  
Epithelial Cells ◽  
Abdominal Cavity ◽  
Clinical Signs ◽  
Clinical History ◽  
Abdominal Ultrasound ◽  
Tubular Epithelial Cells ◽  
Moderate Amount ◽  
Laboratory Findings ◽  
Hospitalization Period ◽  
History Of

Clinical History: This 8-month-old, male, mixed breed domestic shorthaired cat had a recent history of acute apathy and anorexia. It remained under hospital care for two days, during which it did not produce any urine. On the second day of hospitalization, another cat from the same household was brought in with similar clinical signs. These cats did not have any history of recent ingestion of antibiotics or other medication. Furthermore, they did not have any street or yard access since they were kept in an apartment. Both cats died spontaneously after a brief hospitalization period. Laboratory Findings: Marked increase of urea and creatinine in both cats was reported (values not informed). On abdominal ultrasound, both cats had perirenal edema, and small amount of free abdominal effusion was observed in this cat. Necropsy Findings: There was moderate amount of translucent, slightly yellowish fluid within the abdominal cavity, thoracic cavity and pericardial sac. There was moderate diffuse pulmonary edema. Moderate perirenal edema was observed bilaterally. The kidneys were diffusely swollen and pale (Fig. 1). On histopathologic exam, the cortical tubular epithelial cells were swollen, with hypereosinophilic cytoplasm and nuclear changes (karyolysis, pyknosis and karyorrhexis). These cells were frequently detached from the basement membrane. Some other tubular epithelial cells were swollen and markedly vacuolated. Accompanying these changes, multiple granular casts filled the tubular lumens in the cortical and medullar regions (Fig. 2).

scholarly journals Causes of Anemia in Polish Older Population—Results from the PolSenior Study

Cells ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 2167
Author(s):  
Arkadiusz Styszyński ◽  
Jerzy Chudek ◽  
Małgorzata Mossakowska ◽  
Krzysztof Lewandowski ◽  
Monika Puzianowska-Kuźnicka ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Complete Blood Count ◽  
Nutrient Deficiency ◽  
The Elderly ◽  
Serum Folate ◽  
Nutritional Deficiencies ◽  
Deficiency Anemia ◽  
Who Criteria ◽  
Nationally Representative ◽  
Anemia Of Inflammation

Vitamin B12, folate, iron deficiency (IDA), chronic kidney disease (CKD), and anemia of inflammation (AI) are among the main causes of anemia in the elderly. WHO criteria of nutritional deficiencies neglect aging-related changes in absorption, metabolism, and utilization of nutrients. Age-specific criteria for the diagnosis of functional nutritional deficiency related to anemia are necessary. We examined the nationally representative sample of Polish seniors. Complete blood count, serum iron, ferritin, vitamin B12, folate, and renal parameters were assessed in 3452 (1632 women, 1820 men) participants aged above 64. Cut-off points for nutritional deficiencies were determined based on the WHO criteria (method-A), lower 2.5 percentile of the studied population (method-B), and receiver operating characteristic (ROC) analysis (method-C). Method-A leads to an overestimation of the prevalence of vitamin B12 and folate deficiency, while method-B to their underestimation with over 50% of unexplained anemia. Based on method-C, anemia was classified as nutritional in 55.9%. In 22.3% of cases, reasons for anemia remained unexplained, the other 21.8% were related to CKD or AI. Mild cases were less common in IDA, and more common in non-deficiency anemia. Serum folate had an insignificant impact on anemia. It is necessary to adopt the age-specific criteria for nutrient deficiency in an old population.

scholarly journals Large Hiatal Hernia Associated with Cameron Ulcers and Consecutive Sideropenic Anemia: Case Presentation

2021 ◽  
Vol 9 (C) ◽  
pp. 167-169
Author(s):  
Zaim Gashi ◽  
Arjeta Gashi ◽  
Fadil Sherifi ◽  
Fitore Komoni
Keyword(s):  
Hiatal Hernia ◽  
Clinical Signs ◽  
Refractory Anemia ◽  
Deficiency Anemia ◽  
Case Presentation ◽  
Large Hiatal Hernia ◽  
Conservative And Operative Treatment ◽  
Retrosternal Pain ◽  
History Of ◽  
Cameron Lesions

BACKGROUND: Cameron lesions are seen in 5.2% of patients with hiatal hernia who undergo esophagogastroduodenoscopic examinations. The prevalence of Cameron lesions seems to be dependent on the size of the hernial sac, with an increased prevalence in the larger-sized sac. In about two-thirds of the cases, multiple Cameron lesions are noted rather than a solitary erosion or ulcer. AIM: The aim of this case report is to present the patient with Cameron ulcers associated with hiatal hernia. CASE PRESENTATION: Our patient presented with postprandial retrosternal pain, especially immediately after eating, vomiting, dyspnea, weight loss, fatigue, signs, and symptoms of severe hypochromic microcytic anemia without signs of acute gastrointestinal bleeding. No history of gastroesophageal disease. Colonoscopy was done and eliminate colic cause of anemia. The endoscopy showed a large hiatal hernia and linear erosions and ulcerations at the level of gastrodiaphragmatic contact (Cameron ulcers) and one non-sanguinant subcardial elipsoid ulceration. After conservative and operative treatment, there was significant clinically and laboratory improvement definitively, after 6 months. Cameron lesion is a rare cause of refractory sideropenic anemia. Diagnosis is very difficult in developing countries, where iron deficiency anemia is more common. A history of disease, clinical course, and laboratory findings are the important facts for diagnosis. CONCLUSION: Endoscopy is the gold standard for diagnosis, although it is not uncommon to overlook these lesions due to their unique location. There are two modalities for the treatment of Cameron lesions: Medical or surgical, which should be individualized for each patient. By severe refractory anemia and large hiatal hernia, associated with clinical signs, surgical approach is very important.

Bilateral juvenile renal dysplasia in a Norwegian Forest Cat

2009 ◽  
Vol 11 (4) ◽  
pp. 326-329 ◽  
Author(s):  
Luca Aresu ◽  
Renato Zanatta ◽  
Paola Pregel ◽  
Diego Caliari ◽  
Massimiliano Tursi ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Histological Examination ◽  
Biochemical Parameters ◽  
Clinical Signs ◽  
Clinical History ◽  
Renal Dysplasia ◽  
Intact Male ◽  
Ultrasonographic Examination ◽  
History Of

Renal dysplasia is defined as a condition of disorganised development of renal parenchyma due to abnormal differentiation. The case of a 5-month-old intact male Norwegian Forest Cat with a history of polyuria and polydipsia is reported. Ultrasonographic examination showed a slight enlargement of kidneys. Biochemical parameters, haematological examinations and clinical signs were compatible with chronic renal failure (CRF). Histological examination was correlated with a primary tubular disorganisation and modification of glomerular compartment. The clinical history together with the histological lesions is consistent with bilateral juvenile renal dysplasia in this cat. To our knowledge, feline renal dysplasia has been reported in fetal infections with panleukopenia virus; no reports indicate the idiopathic origin in feline dysplastic lesions.

scholarly journals Case report on Plummer Vinson syndrome

2019 ◽  
Vol 8 (10) ◽  
pp. 2334
Author(s):  
Chanukya Vanam ◽  
Durga Prasad Thammisetty
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Supplementation ◽  
General Medicine ◽  
Deficiency Anemia ◽  
Systemic Effects ◽  
Plummer Vinson Syndrome ◽  
History Of ◽  
Male Patients

Plummer Vinson syndrome or Paterson-Brown-Kelly syndrome is a rare disorder is characterized by a triad of iron deficiency anemia, post-cricoid dysphagia and upper oesophageal web. This is a condition that is hypothesized to occur in people with long-term iron-deficiency anemia. It is more prevalent in females than in male patients. This disorder is characterized by iron deficiency anemia, post-cricoid dysphagia and oesophageal webs, symptoms typically progress over a period of six months and often include other systemic effects such as angular cheilitis, glossitis, and spooning of the fingernails. Here we report a case of 38 years female admitted in general medicine female with complaints of breathlessness and tightness of chest relieving after vomiting and had history of anemia, dysphagia insidious in onset and dysphagia associated with solid food over a year on examination patient was found to be gross pallor, angular cheilitis, spoon-shaped nails of fingers and toes. The lab findings were hemoglobin of 7.8 g/dl, serum ferritin levels 7.23 ng/ml, vitamin B12 175.2 pg/ml and upper oesophageal endoscopy revealed oesophageal web in the post-cricoid region. Treatment of Plummer Vinson syndrome includes iron supplementation followed by endotracheal dilation if necessary.

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