scholarly journals Histopathological findings in horses with and without clinical signs of rhabdomyolysis with special reference to polysaccharide storage myopathy

2008 ◽  
Vol 53 (No. 12) ◽  
pp. 660-667 ◽  
Author(s):  
E. Ludvikova ◽  
I.D. Wijnberg ◽  
P. Fictum ◽  
Z. Lukas ◽  
J.H. van der Kolk ◽  
...  
Keyword(s):  
Special Reference ◽  
Clinical Signs ◽  
Size Variation ◽  
Clinical History ◽  
Histopathological Findings ◽  
Exertional Rhabdomyolysis ◽  
Fibre Size ◽  
Significant Difference ◽  
Polysaccharide Storage Myopathy ◽  
History Of

Objective of the study was to assess histopathological changes in horses with a clinical history of exertional rhabdomyolysis (ER) with special reference to polysaccharide storage myopathy and to compare histopathological findings in horses with and without a clinical history of ER. In total 39 muscle samples were collected, from horses with a history of repeated episodes of exertional rhabdomyolysis (test group, 10 horses) and from horses without clinical signs of muscular disorders in their history (control group, 29 horses). Frozen muscle samples were stained with haematoxylin and eosin and periodic acid-Schiff with and without amylase digestion. Histopathologic changes (amylase resistant polysaccharide, subsarcolemmal glycogen, intracytoplasmic masses, subsarcolemmal vacuoles, fibre size variation and internal nuclei) were evaluated. There was a statistically significant difference between groups in the presence of subsarcolemmal amylase sensitive glycogen deposits (P ≤ 0.0001), the risk ratio was 5.22. Statistically significant differences between groups were not found regarding the presence of intracytoplasmic masses, subsarcolemmal vacuoles, amylase resistant polysaccharide, fibre size variation and internal nuclei. Presence of amylase resistant polysaccharide within muscle fibres of apparently healthy horses could be a manifestation of different phenotype expression of PSSM but also the insufficient specificity of this diagnostic criterion.

scholarly journals Supplement Usage Pattern in a Group of COVID- 19 Patients in Tehran

2020 ◽  
Author(s):  
Maryam Bagheri ◽  
Fedyeh Haghollahi ◽  
Mamak Shariat ◽  
Mina Jafarabadi ◽  
Parastoo Aryamloo ◽  
...  
Keyword(s):  
Vitamin D3 ◽  
Past History ◽  
Clinical Signs ◽  
Clinical Findings ◽  
Usage Pattern ◽  
Cross Sectional ◽  
Outpatient Group ◽  
Significant Difference ◽  
Supplement Usage ◽  
History Of

Objective: The coronavirus disease 19 (COVID-19) is a highly transmittable and pathogenic viral infection, causes severe acute respiratory syndrome and was spread throughout the world in early 2020. The effects of vitamin and micronutrient supplements on the prevention and treatment of COVID- 19 seems challenging in scientific considerations. On the other side generally, experts warn against over-consumption of these supplements. Materials and methods: This study aimed to investigate the vitamin and micronutrient supplementation usage pattern in past history of patients with COVID-19 via a cross-sectional inquiry. Totally 510 patients referring to the infectious disease clinic of Imam Khomeini Hospital in Tehran from March 2020 to May 2020 were recruited. The inclusion criterion was suspected patients for COVID-19 based on clinical findings and CT scans of the lung. The infected patients included both inpatients (171) and outpatients (339). Demographic information, clinical signs, and the supplement pattern use were collected through a questionnaire and the data were statistically analyzed. Results: Vitamin D3 intake was reported in 30% (103 patients) of outpatients and 16.5% (28 patients) of hospitalized patients, which is statistically significant (P=0.001). It shows that, the frequency of vitamin D3 consumption in the outpatient group was higher than inpatient group. This significant difference has also been shown in zinc consumption, in 29 patients (9%) outpatients versus 4 patients (2%) inpatients were reported (P=0.007). Multi nominal regression showed that vitamin D3 intake has a supportive effect and reduces the risk of exacerbation and worsening of the disease. (OR=0.291; 95% CI 0.102-.0834, P=0.022). Conclusion: According to the results of the present study and the findings of other studies, considering the supportive effect of vitamin D3 in reducing the severity of infectious diseases; Clinical trials with an appropriate sample size are recommended to investigate the functional role of this vitamin in improving viral diseases of the respiratory tract.

Sarcomas Arising in Paget Disease of Bone: A Clinicopathologic Analysis of 70 Cases

2007 ◽  
Vol 131 (6) ◽  
pp. 942-946 ◽  
Author(s):  
Andrea T. Deyrup ◽  
Anthony G. Montag ◽  
Carrie Y. Inwards ◽  
Zhiheng Xu ◽  
Ronald G. Swee ◽  
...  
Keyword(s):  
Rare Complication ◽  
Clinical History ◽  
Axial Skeleton ◽  
Clinical Findings ◽  
Paget Disease Of Bone ◽  
Paget Disease ◽  
Significant Difference ◽  
History Of ◽  
Age Range

Abstract Context.—Sarcomatous transformation is a rare complication of Paget disease of bone. Prognosis in patients with other types of sarcomas arising in bone has improved in the last several decades because of therapeutic advances. However, because of the rarity of Paget sarcoma, outcome studies in these patients are limited. Objective.—To determine whether prognosis for Paget sarcoma has improved. Design.—Seventy cases of sarcomas arising in the setting of Paget disease were collected, and the histologic and clinical findings were reviewed. Clinical follow-up was obtained in 67 cases. Results.—Sarcoma arising in Paget disease tended to arise in older men (46 men, 24 women; age range, 31–88 years; mean age, 66 years) and predominated in the axial skeleton (n = 37), especially in the pelvis. Thirty-three patients had a clinical history of Paget disease ranging in duration from 16 months to 30 years (mean, 15 years). No significant difference in incidence between monostotic (n = 33) and polyostotic (n = 36) disease was noted. Most tumors were osteosarcomas (88%). All tumors were high grade. Follow-up information was obtained in 67 of 70 cases (range of follow-up, 1–252 months). Survival ranged from 1 month to 20 years, with a 5-year survival rate of 10%. Conclusions.—Prognosis remains poor in patients with Paget sarcoma. There is no significant correlation between the number of bones involved with Paget disease or the duration of disease and development of Paget sarcoma. Poor prognosis in Paget sarcoma is unrelated to site or stage at presentation.

scholarly journals The Determination of the Intellectual Equipment Is Imperative: Mental Hygiene, Problem Children, and the History of the Provincial Child Guidance Clinic of British Columbia, 1932–1958

2019 ◽  
pp. 48-78
Author(s):  
Gerald Thomson
Keyword(s):  
British Columbia ◽  
Mental Hygiene ◽  
Clinical History ◽  
Child Guidance Clinic ◽  
Social Service Agencies ◽  
Guidance Clinic ◽  
Child Guidance ◽  
Significant Difference ◽  
History Of

The founding in 1932 of British Columbia’s provincial Child Guidance Clinic by Dr. A. L. Crease of Essondale Mental Hospital was seen as a medically progressive measure in the preventive work to stem mental ailments in children and prevent future adult mental illness. The clinic’s history and the influence of mental hygiene on early twentieth-century medical, educational, and social service agencies in BC that dealt with so-called “problem children” has received limited scholarly attention. This paper argues that the mental hygiene agenda was cultivated by psychiatrists working at mental asylums, teachers of “subnormal” children, child welfare advocates, and university-trained social workers, all of whom increasingly shaped child-saving policy in British Columbia. However, from its beginnings, the British Columbia provincial Child Guidance Clinic had an unstable clinical history and it was completely reorganized in 1946 and subsequently closed in 1958. The clinic’s history stood in stark contrast to Alberta’s child guidance clinics, which applied a rigid mental hygiene policy of eugenic sterilization until the early 1970s. This significant difference indicates the need for other detailed microhistories of child psychiatry and child guidance clinics across Canada.

scholarly journals Association of Equine Herpesvirus 5 with Mild Respiratory Disease in a Survey of EHV1, -2, -4 and -5 in 407 Australian Horses

Animals ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 3418
Author(s):  
Charles El-Hage ◽  
Zelalem Mekuria ◽  
Kemperly Dynon ◽  
Carol Hartley ◽  
Kristin McBride ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Quantitative Difference ◽  
Clinical Signs ◽  
Clinical Importance ◽  
Clinical History ◽  
Respiratory Pathogens ◽  
Equine Influenza ◽  
Influenza Outbreak ◽  
Clinically Normal ◽  
History Of

Equine herpesviruses (EHVs) are common respiratory pathogens in horses; whilst the alphaherpesviruses are better understood, the clinical importance of the gammaherpesviruses remains undetermined. This study aimed to determine the prevalence of, and any association between, equine respiratory herpesviruses EHV1, -2, -4 and -5 infection in horses with and without clinical signs of respiratory disease. Nasal swabs were collected from 407 horses in Victoria and included clinically normal horses that had been screened for regulatory purposes. Samples were collected from horses during Australia’s equine influenza outbreak in 2007; however, horses in Victoria required testing for proof of freedom from EIV. All horses tested in Victoria were negative for EIV, hence archived swabs were available to screen for other pathogens such as EHVs. Quantitative PCR techniques were used to detect EHVs. Of the 407 horses sampled, 249 (61%) were clinically normal, 120 (29%) presented with clinical signs consistent with mild respiratory disease and 38 (9%) horses had an unknown clinical history. Of the three horses detected shedding EHV1, and the five shedding EHV4, only one was noted to have clinical signs referable to respiratory disease. The proportion of EHV5-infected horses in the diseased group (85/120, 70.8%) was significantly greater than those not showing signs of disease (137/249, 55%). The odds of EHV5-positive horses demonstrating clinical signs of respiratory disease were twice that of EHV5-negative horses (OR 1.98, 95% CI 1.25 to 3.16). No quantitative difference between mean loads of EHV shedding between diseased and non-diseased horses was detected. The clinical significance of respiratory gammaherpesvirus infections in horses remains to be determined; however, this survey adds to the mounting body of evidence associating EHV5 with equine respiratory disease.

scholarly journals Renal toxic disease in a cat

2021 ◽  
Vol 14 (2) ◽  
pp. 142-144
Author(s):  
Alex dos Santos ◽  
◽  
Mariana Martins ◽  
Keyword(s):  
Epithelial Cells ◽  
Abdominal Cavity ◽  
Clinical Signs ◽  
Clinical History ◽  
Abdominal Ultrasound ◽  
Tubular Epithelial Cells ◽  
Moderate Amount ◽  
Laboratory Findings ◽  
Hospitalization Period ◽  
History Of

Clinical History: This 8-month-old, male, mixed breed domestic shorthaired cat had a recent history of acute apathy and anorexia. It remained under hospital care for two days, during which it did not produce any urine. On the second day of hospitalization, another cat from the same household was brought in with similar clinical signs. These cats did not have any history of recent ingestion of antibiotics or other medication. Furthermore, they did not have any street or yard access since they were kept in an apartment. Both cats died spontaneously after a brief hospitalization period. Laboratory Findings: Marked increase of urea and creatinine in both cats was reported (values not informed). On abdominal ultrasound, both cats had perirenal edema, and small amount of free abdominal effusion was observed in this cat. Necropsy Findings: There was moderate amount of translucent, slightly yellowish fluid within the abdominal cavity, thoracic cavity and pericardial sac. There was moderate diffuse pulmonary edema. Moderate perirenal edema was observed bilaterally. The kidneys were diffusely swollen and pale (Fig. 1). On histopathologic exam, the cortical tubular epithelial cells were swollen, with hypereosinophilic cytoplasm and nuclear changes (karyolysis, pyknosis and karyorrhexis). These cells were frequently detached from the basement membrane. Some other tubular epithelial cells were swollen and markedly vacuolated. Accompanying these changes, multiple granular casts filled the tubular lumens in the cortical and medullar regions (Fig. 2).

IMMUNOLOGIC AND BIOCHEMICAL STUDIES IN INFANTS AND CHILDREN, WITH SPECIAL REFERENCE TO RHEUMATIC FEVER

PEDIATRICS ◽  
1948 ◽  
Vol 2 (4) ◽  
pp. 410-414
Author(s):  
PAUL F. DEGARA
Keyword(s):  
Rheumatic Fever ◽  
Special Reference ◽  
High Titer ◽  
Infants And Children ◽  
Significant Difference ◽  
Biochemical Studies ◽  
History Of ◽  
Group A ◽  
Different Strains ◽  
In Infants And Children

Agglutinative antibodies for three different strains Str. hemolyticus, beta, group A, were studied in 497 sera from 372 children. A high titer was found in approximately 9% of well children. There was no significant difference between rheumatic and non-rheumatic subjects in the incidence of high agglutinin titers for Str. hemolyticus. Following infections, presumably streptococcal in origin, approximately 46% of the children examined had high agglutinin titers for Str. hemolyticus. In active rheumatic fever, agglutinins were present in high titers in nine out of 11 patients who had experienced an antecedent illness, presumably streptococcal in origin. Of 23 patients with no history of such an infection, only three had streptococcal agglutinins.

Basal Chronic Villitis and Disorders of the Placental Basal Plate: A Possible Immunological Link Between Hypertensive Disorders of Pregnancy and Morbidly Adherent Placenta

2019 ◽  
Vol 22 (4) ◽  
pp. 334-339 ◽  
Author(s):  
Philip J Katzman ◽  
Joseph Blitman ◽  
Leon A Metlay
Keyword(s):  
Clinical History ◽  
Basal Plate ◽  
Intrauterine Fetal Death ◽  
Hypertensive Disorders Of Pregnancy ◽  
Morbidly Adherent Placenta ◽  
Hypertensive Disorders ◽  
Adherent Placenta ◽  
Significant Difference ◽  
History Of ◽  
Chronic Villitis

Background Hypertensive disorders of pregnancy (HDP) are a common cause for preterm delivery. Prior studies showed that chronic villitis (CV) is associated with intrauterine growth restriction, preeclampsia, intrauterine fetal death, and morbidly adherent placenta (MAP). The authors hypothesize that disorders of the placental basal plate, especially basal chronic villitis (BCV), are associated with HDP. Methods The laboratory information system was queried over 12 years to identify placentas with or without the clinical history of HDP and with or without multifocal/focal CV or BCV. As a control for tissue sampling, a similar search was performed over 5 years for placentas evaluated for MAP. Results Of 19,683 placentas identified, 14.8% had CV which was in 18.5% and 14.2% of placentas associated with or without HDP, respectively, a significant difference ( P < .0001). BCV was present in 6.0% and 3.9% of placentas with or without HDP, respectively, also a significant difference ( P < .0001). BCV was more likely than multifocal/focal CV to occur in HDP (32.4% vs 27.4%) when all cases of CV were analyzed ( P = .025). Of 221 placentas with MAP, 64% had multifocal/focal CV and 36% had BCV. Conclusions BCV and CV are more common in placentas with HDP than in normotensive pregnancies. They are also seen in MAP, as supported by another recent study.

Veno-arterial differences of immunoreactive and biologically active luteinizing hormone across the head in the cow

1989 ◽  
Vol 113 (1) ◽  
pp. 27-33
Author(s):  
R. J. van Aarde ◽  
R. B. Heap ◽  
M. Hamon ◽  
I. R. Fleet
Keyword(s):  
Luteinizing Hormone ◽  
Molecular Size ◽  
Clinical History ◽  
Biologically Active ◽  
Significant Difference ◽  
History Of ◽  
Biological Potency ◽  
Arterial Plasma ◽  
Carotid Arterial ◽  
Mouse Leydig Cell

SUMMARYImmunoreactive (I) and biologically active (B) luteinizing hormone (LH) was measured in jugular vein and carotid arterial plasma of four cows 110–140 min after luteinizing hormone releasing hormone (LHRH) injection. Plasma was separated on Ultragel AcA54 and fractions corresponding to those containing authentic bovine luteinizing hormone (bLH) were assayed. Immunoreactivity in venous or arterial plasma occurred mostly in fractions corresponding in molecular weight to bLH. Low activity was measured in several other fractions. Biological activity was also high in the same fractions from venous plasma, though it was not so pronounced in arterial plasma.A veno-arterial difference across the head for immunoreactive LH was found in all animals, and there was a significant difference in biologically active LH (mouse Leydig cell assay). The mean B:I value for immunoreactive LH was similar in venous and arterial plasma for three out of four animals, 0·72 and 0·66, respectively. In a fourth cow with a clinical history of infertility, the B:I value was low in both venous and arterial plasma, 0·19 and 0·08, respectively. The results indicate that infertility in this latter instance was associated with LHRH-induced secretion of a compound similar in molecular size and immunoreactivity to LH but deficient in biological potency.

A retrospective study of canine hip dysplasia in 116 military working dogs. Part II: Clinical signs and performance data

1996 ◽  
Vol 32 (5) ◽  
pp. 423-430 ◽  
Author(s):  
CM Banfield ◽  
JE Bartels ◽  
JA Hudson ◽  
JC Wright ◽  
RD Montgomery ◽  
...  
Keyword(s):  
Hip Dysplasia ◽  
Clinical Signs ◽  
Clinical History ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Significant Difference ◽  
Working Dogs ◽  
And Performance ◽  
Student’S T ◽  
Military Working Dogs

The progression of hip dysplasia was investigated in 116 military working dogs. Medical records were reviewed for any clinical history of hind-limb lameness. Pelvic radiographs were studied for evidence and degree of hip dysplasia, degenerative joint disease, or both. The number of months each dog worked was determined. Each dog's age at termination from service and cause of death (or euthanasia) were recorded. The mean months of work for normal and dysplastic dogs were evaluated using the Student's t-test. No significant difference was found in the total number of months worked between normal and dysplastic dogs (p greater than 0.05).

Symptoms and treatment of whooping cough, 1980–82

1987 ◽  
Vol 76 (02) ◽  
pp. 66-67
Author(s):  
J.M. English
Keyword(s):  
Whooping Cough ◽  
Clinical History ◽  
Significant Difference ◽  
History Of

AbstractQuestionnaires were obtained from the parents of 71 children who contracted pertussin in 1980–82. They sought to confirm the typical clinical history of the disease, its severity, duration, method of treatment, and any effect this had on its course. They suggest that the disease is milder than it used to be and that whilst antibiotics, including erythromycin, make no significant difference to its course, homœopathic treatment reduces its duration and severity.

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